Wyeth Reports Earnings Results for the 2006 Fourth Quarter and Full Year

- Worldwide Net Revenue for the 2006 Fourth Quarter and Full Year Increased 10% and 9% to $5.2 Billion and $20.4 Billion, Respectively

MADISON, N.J., January 30, 2007 /PRNewswire-FirstCall/ -- Wyeth today reported results for the 2006 fourth quarter and full year ended December 31, 2006. Worldwide net revenue increased 10% to $5.2 billion for the 2006 fourth quarter and 9% to $20.4 billion for the 2006 full year. Excluding the favorable impact of foreign exchange, worldwide net revenue increased 7% for the 2006 fourth quarter and 8% for the 2006 full year.

"In 2006, we made strategic investments in our future, while simultaneously delivering strong financial results. Net revenue, operating income and net income all increased significantly during the year, while pro forma EPS increased 14% over 2005," said Robert Essner, Chairman and Chief Executive Officer.

"We achieved strong growth with all of our major products in 2006 and achieved a billion or multi-billion dollar status in annual sales in six product franchises. With six regulatory filings involving four new pharmaceutical products completed during the year, combined with continued investments in R&D, Wyeth is positioned for strong growth in 2007 and beyond."

2006 Product Highlights

Set forth below is a table of net revenue for Wyeth's principal products for the 2006 fourth quarter and full year together with the percentage changes from the comparable period in the prior year:

                                                (UNAUDITED)

                                 Three Months Ended        Full Year Ended

                                    12/31/2006               12/31/2006

    Principal Products      ($ in millions) Increase  ($ in millions) Increase



    Effexor                       $936.1      11%        $3,722.1        8%

    Prevnar                        501.7      25%         1,961.3       30%

    Protonix                       419.6       1%         1,795.0        7%

    Enbrel (outside of the

     U.S. and Canada)              416.1      40%         1,499.6       38%

    Alliance Revenue(1)            370.4       6%         1,339.2       17%

    Nutritionals                   306.7      20%         1,200.8       15%

    Premarin Family                262.4      20%         1,050.9       16%

    Zosyn/Tazocin                  248.8      21%           972.0        9%

    Centrum                        181.2       5%           657.1        4%

    Advil                          172.3      16%           620.2       14%


    (1) Alliance revenue reflects revenue to Wyeth derived from sales of

        Enbrel (in the U.S. and Canada), Altace and the CYPHER stent.


Enbrel(R) continued to post strong global revenue growth in 2006. Enbrel sales in the U.S. and Canada, reported by Wyeth's marketing partner Amgen, Inc., were $792 million for the 2006 fourth quarter and $2,879 million for the 2006 full year, increases of 18% and 12% respectively, over the comparable prior periods. Wyeth has exclusive rights to Enbrel outside of the U.S. and Canada.

Enbrel is a breakthrough product approved for the treatment of chronic inflammatory diseases, including rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis. Enbrel finished the year tenth among the top pharmaceutical products ranked globally by sales and as the second fastest growing product in the top 10. It also ranked among the top 10 best selling pharmaceutical products in 11 different countries.

Enbrel achieved important milestones in Europe and the U.S. during 2006. Pre-filled 25mg and 50mg syringes gained EU approval and were launched in 10 countries; and the Committee for Medicinal Products for Human Use in Europe endorsed new product labeling, citing improved physical function and lower rates of progressive peripheral joint damage in patients with psoriatic arthritis. Data presented in November at the of Rheumatology meeting showed efficacy improvements were sustained by rheumatoid arthritis patients after nine years of therapy.

Prevnar(R), Wyeth's vaccine to prevent invasive pneumococcal disease in infants and young children, continues to be the world's best-selling vaccine. It is available in 73 countries worldwide and is now included in 15 national immunization programs. More than 130 million doses of Prevnar have been distributed globally since it was launched in 2000.

Effexor(R) (Effexor and Effexor XR), continues to be the number one selling antidepressant globally and an important therapy in treating adult patients with major depressive disorder, generalized anxiety disorder, social anxiety disorder and panic disorder.

Additional information regarding Wyeth's product sales may be accessed on the Company's Internet Web site at www.wyeth.com by clicking on the "Investor Relations" hyperlink.

R&D Update

In 2006, Wyeth submitted six key regulatory filings involving four new pharmaceutical products. In June, Wyeth submitted New Drug Applications (NDA) to the U.S. Food and Drug Administration (FDA) for PRISTIQ(TM) (desvenlafaxine succinate), a non-hormonal agent to treat severe vasomotor symptoms; and for VIVIANT(TM) (bazedoxifene) for the prevention of postmenopausal osteoporosis. In October, Wyeth filed its dossier in Europe for Pristiq to treat vasomotor symptoms; registration submissions were filed in the U.S. and Europe for TORISEL(TM) (temsirolimus) for the treatment of renal cell carcinoma; and Wyeth and its partner Solvay Pharmaceuticals submitted an NDA to the FDA for bifeprunox for the treatment of schizophrenia. Torisel was granted priority review status by the FDA in December. On January 22, 2007, Wyeth received an approvable letter from the FDA for Pristiq as a treatment for adult patients with major depressive disorder.

Wyeth R&D also achieved a number of key clinical milestones during 2006. In July, the intravenous formulation of methylnaltrexone received fast track designation from the FDA for the treatment of post-operative ileus. Wyeth, with its partner Progenics Pharmaceuticals, Inc., also initiated two global Phase 3 clinical trials with intravenous methylnaltrexone for post-operative ileus. In addition, Wyeth initiated a global Phase 3 clinical trial for its 13-valent pneumococcal conjugate vaccine in infants and continued to make progress with its 11 clinical development programs for Alzheimer's disease, as well as its 10 oncology programs. In December, the Wyeth R&D Executive Team was honored by Scrip, a top pharmaceutical industry trade publication, as "Best Pharmaceutical Management Team."

2006 Fourth Quarter Results

Net income and diluted earnings per share for the 2006 fourth quarter were $855.4 million and $0.63, respectively, compared with $731.7 million and $0.54 for the 2005 fourth quarter. Effective January 1, 2006, the Company adopted Statement of Financial Accounting Standards (SFAS) No. 123R, which requires the expensing of stock options. The 2006 fourth quarter results included stock option expense, which reduced diluted earnings per share by approximately $0.02. The 2005 fourth quarter results, which have not been restated to include the impact of expensing stock options, would have been lower by approximately $0.04 per share had stock options been expensed.

The 2006 fourth quarter results also included net charges of $63.8 million ($48.1 million after-tax or $0.03 per share-diluted) related to the Company's productivity initiatives. The 2005 fourth quarter results included net charges of $94.8 million ($73.7 million after-tax or $0.05 per share-diluted) related to the Company's productivity initiatives. The 2006 and 2005 productivity initiatives charges are considered to be certain significant items for purposes of analyzing the Company's results of operations. For the 2006 fourth quarter, net income and diluted earnings per share, before certain significant items, were $903.5 million and $0.66, respectively. For the 2005 fourth quarter, net income and diluted earnings per share, before certain significant items and assuming stock option expensing, would have been $746.9 million and $0.55, respectively.

To assist in performing fourth quarter comparisons, a pro forma presentation is provided under "Results of Operations - As Adjusted" at the end of this press release.

The increases in net income and diluted earnings per share for the 2006 fourth quarter, before certain significant items and assuming the expensing of stock options in the 2005 fourth quarter, resulted from higher net revenue; lower cost of goods sold and lower selling, general and administrative expenses, both as a percentage of net revenue; lower interest expense, net and higher other income, net, offset, in part, by higher research and development spending. Included in other income, net were pre-tax gains from product divestitures amounting to approximately $5.4 million and $5.1 million in the 2006 and 2005 fourth quarter, respectively.

2006 Full Year Results

Net income and diluted earnings per share for the 2006 full year were $4,196.7 million and $3.08, respectively, compared with $3,656.3 million and $2.70 for the 2005 full year. The 2006 full year results included stock option expense, which reduced diluted earnings per share by approximately $0.12. The 2005 full year results, which have not been restated to include the impact of expensing stock options, would have been lower by approximately $0.17 per share had stock options been expensed.

The 2006 full year results also included net charges of $218.6 million ($154.5 million after-tax or $0.11 per share-diluted) related to the Company's productivity initiatives and a favorable income tax adjustment of $70.4 million ($0.05 per share-diluted) related to a reduction of certain deferred tax asset valuation allowances. The 2005 full year results included net charges of $190.6 million ($137.1 million after-tax or $0.10 per share- diluted) related to the Company's productivity initiatives and an income tax charge of $170.0 million ($0.12 per share-diluted) recorded in connection with the Company's decision to repatriate foreign earnings. The 2006 and 2005 productivity initiatives charges, the 2006 favorable income tax adjustment and the 2005 income tax charge are considered to be certain significant items for purposes of analyzing the Company's results of operations. For the 2006 full year, net income and diluted earnings per share, before certain significant items, were $4,280.8 million and $3.14, respectively. For the 2005 full year, net income and diluted earnings per share, before certain significant items and assuming stock option expensing, would have been $3,735.8 million and $2.75, respectively.

In order to assist in performing full year comparisons, a pro forma presentation is provided under "Results of Operations - As Adjusted" at the end of this press release.

The increases in net income and diluted earnings per share for the 2006 full year, before certain significant items and assuming the expensing of stock options in the 2005 full year, resulted from higher net revenue; lower cost of goods sold and lower selling, general and administrative expenses, both as a percentage of net revenue; and lower interest expense, net offset, in part, by higher research and development spending and lower other income, net. Included in other income, net were pre-tax gains from product divestitures amounting to approximately $44.1 million and $185.1 million in the 2006 and 2005 full year, respectively.

Provision for Income Taxes

The 2006 fourth quarter and full year Provision for Income Taxes includes a tax benefit of $75.0 million as a result of the renewal by Congress of the Research and Development Tax Credit legislation. Since the law allowing such credits expired in December 2005, the effective tax rate for the 2006 first nine months did not include this benefit. This tax benefit was partially offset by net tax charges relating to various other tax matters.

Productivity Initiatives

The Company continues with its long-term global productivity initiatives, which were launched in 2005, to adapt to the changing pharmaceutical industry environment. The guiding principles of these initiatives include innovation, cost savings, process excellence and accountability, with an emphasis on improving productivity. In July 2006, the Company established the Global Business Operations initiative as part of the productivity initiatives and signed a global services agreement with Accenture to deliver transactional and administrative support services beginning in 2007 for certain process areas within Wyeth's finance and accounting, information services, human resources and procurement functions. The Company recorded the following charges related to these productivity initiatives for the 2006 and 2005 fourth quarter and full year:

                                                   (UNAUDITED)

                                    Three Months Ended     Full Year Ended

    (In millions, except per

     share amounts)              12/31/2006  12/31/2005 12/31/2006 12/31/2005


    Total Productivity Initiatives

      Charges                         $63.8       $94.8     $218.6     $190.6

    Productivity Initiatives

      Charges, After-tax              $48.1       $73.7     $154.5     $137.1

    Decrease in Diluted

      Earnings per Share              $0.03       $0.05      $0.11      $0.10



    The productivity initiative charges were recorded as follows:



                                                    (UNAUDITED)

                                    Three Months Ended     Full Year Ended


    (In millions)                12/31/2006  12/31/2005 12/31/2006 12/31/2005


    Cost of Goods Sold                $42.7       $68.4     $129.2     $137.7

    Selling, General and

       Administrative                  23.2        24.1       78.0       85.6

    Research and Development           (2.1)        2.3       11.4        7.5

    Other Income, net(1)                  -           -          -      (40.2)

                                      $63.8       $94.8     $218.6     $190.6


    (1) Reflects asset sale gains.

Since inception of the Company's productivity initiatives, total net pre-tax charges of $409.2 million have been recorded with respect to these initiatives. Additional costs such as asset impairment, accelerated depreciation, personnel costs and other exit costs, as well as certain implementation costs associated with these initiatives, are expected to continue for several years as additional strategic decisions are made and are projected to total approximately $750.0 million to $1,000.0 million, on a pre-tax basis.

A reconciliation of net income and diluted earnings per share as reported under generally accepted accounting principles (GAAP) to net income and diluted earnings per share, before certain significant items and assuming stock option expensing for the 2005 fourth quarter and full year, is presented in the following table:

                                                   (UNAUDITED)

    (In millions, except per share

     amounts)                      Three Months Ended      Full Year Ended


    Item Description              12/31/2006 12/31/2005 12/31/2006 12/31/2005


    Net income, as reported           $855.4     $731.7   $4,196.7   $3,656.3


    Productivity initiatives            48.1       73.7      154.5      137.1


    Income tax (adjustment) charge         -          -      (70.4)     170.0


    Net income, as adjusted, before

     certain significant items(1)     $903.5     $805.4   $4,280.8   $3,963.4


    Stock-based employee compensation,

     not included in net income            -      (58.5)         -     (227.6)


    Net income, as adjusted, including

     all stock-based compensation

     awards(2)                        $903.5     $746.9   $4,280.8   $3,735.8



    Diluted earnings per share, as

     reported                          $0.63      $0.54      $3.08      $2.70


    Productivity initiatives            0.03       0.05       0.11       0.10


    Income tax (adjustment) charge         -          -      (0.05)      0.12


    Diluted earnings per share, as

     adjusted, before certain

     significant items(1)              $0.66      $0.59      $3.14      $2.92


    Stock-based employee compensation,

     not included in net income            -      (0.04)         -      (0.17)


    Diluted earnings per share, as

     adjusted, including all

     stock-based compensation

     awards(2)                         $0.66      $0.55      $3.14      $2.75



    (1) Wyeth calculates net income before certain significant items by

        excluding the after-tax effect of items considered by management to be

        unusual from the net income reported under GAAP.  Wyeth's management

        uses this measure to manage and evaluate the Company's performance and

        believes it is appropriate to disclose this non-GAAP measure to assist

        investors with analyzing business performance and trends.  The

        productivity initiatives charges, which include costs associated with

        the Global Business Operations initiative, the costs of closing

        certain manufacturing facilities, including accelerated depreciation,

        certain reorganization costs and the elimination of certain positions

        at the Company's facilities, have been excluded, as these charges are

        not considered to be indicative of continuing operating results.  The

        income tax adjustment, which relates to the reduction of certain

        deferred tax asset valuation allowances, and the income tax charge,

        which relates to the repatriation of foreign earnings, have been

        excluded due to their nature and magnitude.  Wyeth's management

        believes that excluding these items from the Company's results

        provides a more appropriate view of the Company's operations for the

        accounting periods presented.


    (2) Stock-based compensation expense for the 2006 fourth quarter and full

        year has been recorded in accordance with SFAS No. 123R, which the

        Company adopted as of January 1, 2006.  In order to present the

        results for the 2006 and 2005 fourth quarter and full year on a

        comparable basis, the 2005 fourth quarter and full year results have

        been adjusted in the above table to reflect the pro forma effect of

        expensing stock options in 2005.

These measures should not be considered in isolation or as a substitute for the results of operations and diluted earnings per share prepared in accordance with GAAP.

Gains from product divestitures are not considered certain significant items because they constitute an integral part of the Company's analysis of divisional performance. However, they are important to understanding changes in our reported net income. Excluding the certain significant items and the gains from product divestitures described above, as well as assuming stock option expensing for the 2005 fourth quarter and full year, net income and diluted earnings per share were $899.7 million and $0.66, respectively, for the 2006 fourth quarter as compared with $742.6 million and $0.55 for the 2005 fourth quarter, and $4,251.0 million and $3.12, respectively, for the 2006 full year as compared with $3,614.4 million and $2.67 for the 2005 full year.

Segment Information

    The following table sets forth worldwide net revenue by reportable segment

together with the percentage changes from the comparable period in the prior

year:



                                             (UNAUDITED)

                             Three Months Ended      Full Year Ended

                                12/31/2006             12/31/2006


    Net Revenue By                                               Increase/

     Reportable Segment   ($ in 000's) Increase   ($ in 000's)  (Decrease)


    Pharmaceuticals       $4,301,925     11%      $16,884,190      10%

    Consumer Healthcare      714,636      2%        2,530,168     (1)%

    Animal Health            203,618     11%          936,297       6%


    Consolidated Total    $5,220,179     10%      $20,350,655       9%



    Pharmaceuticals

Worldwide Pharmaceuticals net revenue increased 11% for the 2006 fourth quarter and 10% for the full year due primarily to higher sales of Prevnar, Enbrel, Effexor, Nutritionals, the Premarin(R) family of products, Protonix(R) and Zosyn(R), offset, in part, by lower sales of Zoton(R), which is experiencing generic competition. Additionally, alliance revenue increased 6% to $370.4 million for the 2006 fourth quarter and increased 17% to $1,339.2 million for the 2006 full year due primarily to higher sales of Enbrel in the United States and Canada. Excluding the favorable impact of foreign exchange, worldwide Pharmaceuticals net revenue increased 8% for the 2006 fourth quarter and 9% for the 2006 full year.

Consumer Healthcare

Worldwide Consumer Healthcare net revenue increased 2% for the 2006 fourth quarter and decreased 1% for the 2006 full year. The increase in the 2006 fourth quarter was due primarily to an increase in sales of Advil(R), offset, in part, by lower sales of Advil Cold & Sinus(R). The decrease in the 2006 full year was due primarily to the absence of 2006 sales of Solgar products, which were divested in the 2005 third quarter, lower sales of Robitussin(R) and Advil Cold & Sinus due to the impact of retailer actions and state legislation related to pseudoephedrine-containing products, offset, in part, by an increase in sales of Advil and Centrum(R). Excluding the favorable impact of foreign exchange, worldwide Consumer Healthcare net revenue was flat for the 2006 fourth quarter and decreased 2% for the 2006 full year.

Animal Health

Worldwide Animal Health net revenue increased 11% for the 2006 fourth quarter and 6% for the 2006 full year. The increase in the 2006 fourth quarter was due primarily to higher sales of equine, companion animal and livestock products. The increase in the 2006 full year was due primarily to higher sales of companion animal and livestock products, partially offset by lower sales of equine products. Excluding the favorable impact of foreign exchange, worldwide Animal Health net revenue increased 7% for the 2006 fourth quarter and increased 5% for the 2006 full year.

2007 Earnings Guidance

The Company estimates pro forma diluted earnings per share for 2007 will be $3.40 to $3.50. This estimate is considered pro forma as it excludes potential charges resulting from the Company's ongoing productivity initiatives. Net revenue is expected to grow at mid-to-high single digits and gross margin is expected to be approximately 72% to 74%. Selling, general and administrative expenses are expected to increase at a significantly lower rate than net revenue, and research and development expenses are projected to grow at a mid single digit rate. Net interest is expected to be income in 2007. The tax rate is expected to be approximately 27% to 29%.

Share Repurchase Program

On January 25, 2007, the Company's Board of Directors approved an increase to the Company's previously authorized share repurchase program, which inclusive of the 1.9 million shares remaining under the existing program, will allow for the future repurchase of up to 30 million shares of the Company's common stock, subject to price and market conditions.

Wyeth is one of the world's largest research-driven pharmaceutical and health care products companies. It is a leader in the discovery, development, manufacturing and marketing of pharmaceuticals, vaccines, biotechnology products and non-prescription medicines that improve the quality of life for people worldwide. The Company's major divisions include Wyeth Pharmaceuticals, Wyeth Consumer Healthcare and Fort Dodge Animal Health.

The statements in this press release that are not historical facts, including the entire section under the caption "2007 Earnings Guidance," are forward-looking statements based on current expectations of future events and are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include risks associated with the inherent uncertainty of the timing and success of product research, development and commercialization (including with respect to our pipeline products), drug pricing and payment for our products by government and third-party payers, manufacturing, data generated on the safety and efficacy of our products, economic conditions including interest and currency exchange rate fluctuations, changes in generally accepted accounting principles, the impact of competitive or generic products, trade buying patterns, global business operations, product liability and other types of litigation, the impact of legislation and regulatory compliance, intellectual property rights, strategic relationships with third parties, environmental liabilities, and other risks and uncertainties, including those detailed from time to time in our periodic reports filed with the Securities and Exchange Commission, including our current reports on Form 8-K, quarterly reports on Form 10-Q and annual report on Form 10-K, particularly the discussion under the caption "Item 1A, Risk Factors." We assume no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise.

The Company will hold a conference call with research analysts at 8 a.m. Eastern Standard Time today. The purpose of the call is to review the financial results of the Company for the fourth quarter and full year of 2006. Interested investors and others may listen to the call live or on a delayed basis through the Internet webcast, which may be accessed by visiting the Company's Internet Web site at www.wyeth.com and clicking on the "Investor Relations" hyperlink. Also, for recent announcements and additional information including product sales information, please refer to the Company's Internet Web site.


    Results of Operations


    The comparative results of operations are as follows:

    (In thousands except per share amounts)


                                               (UNAUDITED)

                               Three Months Ended         Full Year Ended

                             12/31/2006  12/31/2005   12/31/2006   12/31/2005


    Net Revenue              $5,220,179  $4,746,696  $20,350,655  $18,755,790


    Cost of Goods Sold(1)     1,490,920   1,383,613    5,587,851    5,431,200


    Selling, General and

     Administrative           1,796,036   1,630,459    6,501,976    6,117,706

      Expenses(1)


    Research and Development

     Expenses(1)                911,094     875,731    3,109,060    2,749,390


    Interest (Income)

     Expense, Net                (6,524)      7,400       (6,646)      74,756


    Other Income, Net (1)(2)    (65,951)    (49,477)    (271,490)    (397,851)



    Income Before Income

     Taxes                    1,094,604     898,970    5,429,904    4,780,589


    Provision for Income

     Taxes (3)                  239,189     167,274    1,233,198    1,124,291


    Net Income(4)              $855,415    $731,696   $4,196,706   $3,656,298



    Basic Earnings Per

     Share(5)                     $0.64       $0.55        $3.12        $2.73


    Average Number of Common

     Shares

      Outstanding During

       Each Period - Basic    1,346,087   1,342,468    1,345,386    1,339,718


    Diluted Earnings Per

     Share(5)                     $0.63       $0.54        $3.08        $2.70


    Average Number of Common

     Shares

      Outstanding During

       Each Period - Diluted  1,379,180   1,367,840    1,374,053    1,363,417



    (1) The 2006 fourth quarter included charges of $63,830 ($48,025 after-tax

        or $0.03 per share-diluted) related to activities associated with the

        Company's productivity initiatives.  Charges of $42,691 were included

        in Cost of Goods Sold, $23,269 in Selling, General and Administrative

        Expenses, and ($2,130) in Research and Development Expenses.  The 2006

        full year included charges of $218,580 ($154,438 after-tax or $0.11

        per share-diluted) related to activities associated with the Company's

        productivity initiatives.  Charges of $129,199 were included in Cost

        of Goods Sold, $78,033 in Selling, General and Administrative

        Expenses, and $11,348 in Research and Development Expenses.


        The 2005 fourth quarter included charges of $94,830 ($73,724 after-tax

        or $0.05 per share-diluted) related to activities associated with the

        Company's productivity initiatives.  Charges of $68,369 were included

        within Cost of Goods Sold, $24,142 within Selling, General and

        Administrative Expenses and $2,319 within Research and Development

        Expenses.  The 2005 full year included net charges of $190,616

        ($137,128 after-tax or $0.10 per share-diluted) related to activities

        associated with the Company's productivity initiatives.  Charges of

        $137,749 were included within Cost of Goods Sold, $85,555 within

        Selling, General and Administrative Expenses and $7,519 within

        Research and Development Expenses, offset, in part, by asset sale

        gains of $40,207 included within Other Income, Net.


    (2) Other income, net included royalty income for the 2006 fourth quarter

        and full year of $68,764 and $262,628, respectively, compared with

        $68,217 and $292,708 for the prior year.


    (3) The 2006 full year included a favorable income tax adjustment of

        $70,363 ($0.05 per share-diluted) related to the reduction of certain

        deferred tax asset valuation allowances.  The 2005 full year included

        an income tax charge of $170,000 ($0.12 per share-diluted) related to

        the repatriation of foreign earnings.


    (4) Stock-based compensation expense for the 2006 fourth quarter and full

        year has been recorded in accordance with SFAS No. 123R, which the

        Company adopted as of January 1, 2006.  The 2006 fourth quarter and

        full year results included net stock-based compensation expense for

        stock options, restricted stock and performance share awards totaling

        $64,469 and $276,905, respectively.  The 2005 fourth quarter and full

        year results included net stock-based compensation expense only for

        restricted stock and performance share awards of $21,070 and $72,285,

        respectively.  Prior to the adoption of SFAS No. 123R, no expense was

        recorded for stock options.


    (5) The average number of common shares outstanding for diluted earnings

        per share is higher than for basic earnings per share due to the

        assumed conversion of the Company's outstanding convertible senior

        debentures, outstanding stock options, deferred contingent common

        stock awards, restricted stock awards and convertible preferred stock

        into common stock equivalents using the treasury stock method.  For

        purposes of calculating diluted earnings per share, interest expense,

        net of capitalized interest and taxes related to the Company's

        outstanding convertible senior debentures is added back to reported

        net income, and the additional common shares (assuming conversion) are

        included in total shares outstanding.  Interest expense, net of

        capitalized interest and taxes was $8,168 and $30,009 for the 2006

        fourth quarter and full year, respectively, compared with $5,801 and

        $19,798 for the comparable periods in 2005.


    Results of Operations - As Adjusted

The 2005 fourth quarter and full year results, as reported above, do not include the impact of expensing stock options. In order to assist in performing year-over-year comparisons during 2006, Wyeth has prepared the following presentation of its results of operations for the three months and full year ended December 31, 2006 and 2005, adjusted where noted below, to exclude certain significant items during the 2006 and 2005 fourth quarter and full year and to reflect the 2005 fourth quarter and full year pro forma effect of expensing stock options.

    The comparative results of operations - as adjusted are as follows:

    (In thousands except per share amounts)


                                        (UNAUDITED) - AS ADJUSTED

                               Three Months Ended        Full Year Ended

                             12/31/2006  12/31/2005   12/31/2006   12/31/2005


    Net Revenue              $5,220,179  $4,746,696  $20,350,655  $18,755,790


    Cost of Goods Sold(1)(2)  1,448,229   1,322,052    5,458,652    5,319,095


    Selling, General and

     Administrative

      Expenses(1)(2)          1,772,767   1,649,870    6,423,943    6,209,631


    Research and Development

     Expenses(1)(2)             913,224     894,629    3,097,712    2,828,895


    Interest (Income)

     Expense, Net                (6,524)      7,400       (6,646)      74,756


    Other Income, Net(1)(3)     (65,951)    (49,477)    (271,490)    (357,644)


    Income Before Income

     Taxes                    1,158,434     922,222    5,648,484    4,681,057


    Provision for Income

     Taxes (1)(2)               254,994     175,284    1,367,703      945,231


    Net Income(1)(2)           $903,440    $746,938   $4,280,781   $3,735,826



    Basic Earnings Per

     Share(4)                     $0.67       $0.56        $3.18        $2.79


    Average Number of Common

     Shares

      Outstanding During

       Each Period - Basic    1,346,087   1,342,468    1,345,386    1,339,718


    Diluted Earnings Per

     Share(4)                     $0.66       $0.55        $3.14        $2.75


    Average Number of Common

     Shares

      Outstanding During

       Each Period - Diluted  1,379,180   1,367,840    1,374,053    1,363,417



    (1) Charges of $63,830 ($48,025 after-tax or $0.03 per share-diluted)

        related to activities associated with the Company's productivity

        initiatives were excluded from the results of operations for the 2006

        fourth quarter.  These charges are considered certain significant

        items and have been excluded above as follows: $42,691 from Cost of

        Goods Sold, $23,269 from Selling, General and Administrative Expenses,

        and ($2,130) from Research and Development Expenses.  Charges of

        $218,580 ($154,438 after-tax or $0.11 per share-diluted) related to

        activities associated with the Company's productivity initiatives were

        excluded from the results of operations for the 2006 full year.  These

        charges are considered certain significant items and have been

        excluded above as follows: $129,199 from Cost of Goods Sold, $78,033

        from Selling, General and Administrative Expenses, and $11,348 from

        Research and Development Expenses.


        The 2005 fourth quarter included charges of $94,830 ($73,724 after-tax

        or $0.05 per share-diluted) related to activities associated with the

        Company's productivity initiatives.  Charges of $68,369 were included

        within Cost of Goods Sold, $24,142 within Selling, General and

        Administrative Expenses and $2,319 within Research and Development

        Expenses.  The 2005 full year included net charges of $190,616

        ($137,128 after-tax or $0.10 per share-diluted) related to activities

        associated with the Company's productivity initiatives.  Charges of

        $137,749 were included within Cost of Goods Sold, $85,555 within

        Selling, General and Administrative Expenses and $7,519 within

        Research and Development Expenses, offset, in part, by asset sale

        gains of $40,207 included within Other Income, Net.


        A favorable income tax adjustment of $70,363 ($0.05 per share-diluted)

        related to the reduction of certain deferred tax asset valuation

        allowances was excluded from the results of operations for the 2006

        full year and an income tax charge of $170,000 ($0.12 per share-

        diluted) related to the repatriation of foreign earnings was excluded

        from the 2005 full year.  Both are considered certain significant

        items.


        Wyeth calculates net income before certain significant items by

        excluding the after-tax effect of items considered by management to be

        unusual from the net income reported under GAAP.  Wyeth's management

        uses this measure to manage and evaluate the Company's performance and

        believes it is appropriate to disclose this non-GAAP measure to assist

        investors with analyzing business performance and trends.  The

        productivity initiatives charges, which include costs associated with

        the Global Business Operations initiative, the costs of closing

        certain manufacturing facilities, including accelerated depreciation,

        certain reorganization expenses and the elimination of certain

        positions at the Company's facilities have been excluded as these

        charges are not considered to be indicative of continuing operating

        results.  The favorable income tax adjustment, which relates to the

        reduction of certain deferred tax asset valuation allowances, and the

        income tax charge, which relates to the repatriation of foreign

        earnings, have been excluded due to their nature and magnitude.

        Wyeth's management believes that excluding these items from the

        Company's results provides a more appropriate view of the Company's

        operations for the accounting periods presented.


        These measures should not be considered in isolation or as a

        substitute for the results of operations and diluted earnings per

        share prepared in accordance with GAAP.


    (2) The adjusted results of operations for the 2005 fourth quarter include

        the pro forma effect of expensing stock options relating to the

        Company's stock compensation plans of $6,808 in Cost of Goods Sold,

        $43,553 in Selling, General and Administrative Expenses, and $21,217

        in Research and Development Expenses, as well as a related tax benefit

        of $13,096.  The adjusted results of operations for the 2005 full year

        reflect the pro forma effect of expensing stock options relating to

        the Company's stock compensation plans of $25,644 in Cost of Goods

        Sold, $177,480 in Selling, General and Administrative Expenses, and

        $87,024 in Research and Development Expenses, as well as a related tax

        benefit of $62,548.


    (3) Other income, net included royalty income for the 2006 fourth quarter

        and full year of $68,764 and $262,628, respectively, compared with

        $68,217 and $292,708 for the comparable periods in 2005.


    (4) The average number of common shares outstanding for diluted earnings

        per share is higher than for basic earnings per share due to the

        assumed conversion of the Company's outstanding convertible senior

        debentures, outstanding stock options, deferred contingent common

        stock awards, restricted stock awards and convertible preferred stock

        into common stock equivalents using the treasury stock method.  For

        purposes of calculating diluted earnings per share, interest expense,

        net of capitalized interest and taxes related to the Company's

        outstanding convertible senior debentures is added back to reported

        net income, and the additional common shares (assuming conversion) are

        included in total shares outstanding.  Interest expense, net of

        capitalized interest and taxes was $8,168 and $30,009 for the 2006

        fourth quarter and full year, respectively, compared with $5,801 and

        $19,798 for the comparable periods in 2005.

The pro forma presentation of the Company's 2005 quarterly and full year results of operations reflecting the pro forma effect of stock option expensing within the appropriate line of the results of operations and the pro forma effect on earnings per share for the period presented may be accessed on the Company's Internet Web site at www.wyeth.com by clicking on the "Investor Relations" hyperlink.

CONTACT: Media, Douglas Petkus, +1-973-660-5218, or Investors, JustinVictoria, +1-973-660-5340, both of Wyeth

Web site: http://www.wyeth.com/

Ticker Symbol: (NYSE:WYE)

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A United Business Media Company

Posted: January 2007


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