Lilly Outlines Innovation Strategy, Reviews Promising Pipeline of Potential Medicines and Sets 2010 Financial Guidance
-- Company remains focused on speeding innovation to patients and
delivering greater value to customers.
-- Five strategic business units prepared to maximize growth
opportunities in multiple therapeutic areas and geographies.
-- Lilly advances ranking to ninth in worldwide pharmaceutical sales;
fastest growing top 10 pharma company in the U.S., major Europe and
globally.
-- R&D pipeline boasts more than 60 molecules in clinical development,
including 25 in Phases II and III.
-- Company expects 10 Phase III molecules in 2011, plans to launch 2 new
medicines per year beginning in 2013.
-- Continued strong cash flow expected to fund R&D investment and
business development transactions, while at least maintaining the
current dividend.
-- 2010 EPS guidance set at $4.65 to $4.85, excluding the potential
impact of health care reform in the U.S.
-- Longer-term guidance reconfirmed at low double-digit compound annual
EPS growth between 2007 and 2011
NEW YORK, Dec. 10 /PRNewswire-FirstCall/ -- At its
annual meeting today with the investment community, Eli Lilly and
Company (NYSE:LLY)
highlighted how its innovation-based strategy will enable it to
better serve patients and compete effectively in a challenging
health care environment. The company also detailed the progress
being made in its labs and across its five new business units on an
expanding pipeline of innovative molecules and marketed medicines,
and provided investors with the company's financial guidance for
2010.
"In 2009, Lilly has once again exhibited strong performance in a
tough environment, and we've continued with a series of actions
aimed at speeding innovation to patients and delivering greater
value to our customers," said John C. Lechleiter, Ph.D., Lilly's
president and chief executive officer. "Through these actions and
more, we are transforming Lilly to compete and to win in an ever
more demanding and challenging environment. We see a divergence of
strategies among our peers to deal with these challenges, including
the wave of consolidation this year. Many companies are seeking to
lower risk by reducing their focus on innovative medicines. This is
not our path. Our strategy is to create value by accelerating the
flow of innovative new medicines that provide improved outcomes for
individual patients. We aim to discover, develop, or acquire
innovative new therapies - medicines that make a real difference
for patients and deliver clear value for payers."
Steven M. Paul, M.D., executive vice president, science and
technology and president of Lilly Research Laboratories, reinforced
the company's commitment to innovation. "I believe that there's
never been a more compelling case for innovative medicines. Our
strategy is dependent upon our pipeline of potential medicines. I
am encouraged by the fact that today we have the strongest pipeline
in our history. We currently have more than 60 new molecules in
clinical development, including 25 in Phases II and III, targeting
unmet medical needs in areas such as Alzheimer's disease, cancer
and diabetes, among others. We are excited by both the quantity and
the quality of these molecules, and their potential to improve
patient's lives."
Paul expanded on the efforts being made in Lilly's research and
development organization. "By ramping up our efforts in discovery
research, we have nearly doubled the number of new molecules moving
into the clinic each and every year. As a result, we have tripled
the number of potential new medicines in our clinical pipeline
since 2004. Through the acquisition of ImClone and other actions,
we have increased our portfolio of biotechnology-based molecules,
which now represents over one-third of our clinical-stage pipeline.
We are also applying creative approaches to every point in the
R&D chain to develop more medicines more quickly at lower cost.
Initiatives such as our phenotypic drug discovery program (PD2),
numerous risk-sharing collaborations, the early-stage work of our
virtual Chorus team and our new Development Center of Excellence
will further accelerate development, and increasingly tailor
molecules for those patients most likely to benefit from them.
Through these efforts, we expect to have at least 10 molecules in
Phase III clinical development by the end of 2011 and plan to
launch two new medicines per year beginning in 2013 and to sustain
a steady flow of innovation thereafter."
Derica Rice, Lilly senior vice president and chief financial
officer, provided commentary on the company's current financial
performance and forward-looking expectations. "Lilly is completing
another year of strong operating performance, delivering solid
earnings growth resulting from volume-based sales growth, improving
gross margins and tightening control of operating expenses. Looking
ahead to 2010, we expect to once again deliver good sales and
earnings growth, excluding the potential impact of health care
reform legislation in the U.S. We also expect to generate solid
cash flow in the coming years to fund continued investment in
research and development, as well as to fund our dividend and
anticipated business development activity. We continue to expect to
deliver low double-digit compound annual earnings-per-share growth
between 2007 and 2011. We are taking the steps necessary to prepare
our operations for the upcoming challenges of patent expiries. We
are committed to becoming leaner, more focused, more
customer-oriented and more competitive."
Based on IMS Health data(1), for the 12 months ending June 2009,
Lilly has moved into the ninth spot among the top 10 companies
ranked by worldwide pharmaceutical sales. Among these top 10
companies, Lilly was the fastest growing globally and the fastest
growing in the United States and major Europe; the fourth-fastest
growing in the pharmerging markets; and the sixth-fastest growing
in Japan.
The company recently refocused its operations around five
business units to create a clear line of sight to the customer. The
five business units cover oncology, diabetes, established markets,
emerging markets and animal health. The following sections
highlight each of these five business units, including the
performance of key marketed products and updates on the status of
select late-stage and mid-stage pipeline molecules.
(1) IMS Health data for Europe does not include Spain hospital
data. IMS Health data for the pharmerging mar-kets does not include
India, Russia or hospital data for Brazil, Mexico or Turkey.
Established Markets
The established markets business unit is the company's largest.
It will operate in the U.S., Europe, Japan, Canada, Australia and
New Zealand, and includes the neuroscience, cardiovascular and
musculoskeletal therapeutic areas, as well as the autoimmune
disease platform. Currently, this unit accounts for more than half
of the company's revenues and more than half of its clinical stage
pipeline. The company's two best-selling medicines, Zyprexa®
and Cymbalta®, are part of this business unit, as are several
important growth products, including Cialis® and Effient(TM).
The established markets pipeline includes Phase II and Phase III
molecules targeting Alzheimer's disease, schizophrenia, depression
and rheumatoid arthritis, among others.
Cymbalta sales for the first three quarters of 2009 have grown
13 percent in the U.S. and 15 percent internationally. The U.S.
demand for Cymbalta has been aided by improved payer access in
2009, due in large part to achieving Tier 2 unrestricted status
with two significant commercial payers. In the U.S., Cymbalta
continues to outperform other promoted medicines in an
antidepressant and pain market that has seen increasing use of
generics and relatively modest growth overall. Cymbalta's
international growth has been driven by recent approvals for
depression in new markets, complemented by growth from other
indications in existing markets. Plans are in place to enter the
Japanese market in the near future. Cymbalta is under regulatory
review for chronic pain in the U.S., and was recently approved by
both Mexico and Brazil for this indication. The company expects
additional international regulatory submissions in 2010.
Zyprexa continues to be the company's best-selling medicine.
More than half of Zyprexa's sales now come from international
markets, although U.S. Zyprexa sales still grew 4 percent in the
first nine months of 2009. Zyprexa has obtained approvals for
additional indications in the U.S. in 2009, and awaits final action
from the FDA on Zyprexa Relprevv®, or long-acting injection.
Lilly re-launched Zyprexa in Germany in early 2009 after the
successful appeal of a patent decision. Share of market is stable
in other EU countries and continues to grow in Japan. In other
Asian nations, including China, the company expects current strong
sales trend to continue.
Cialis (tadalafil) continues to demonstrate solid growth. Over
the first three quarters of 2009, Cialis has grown 4 percent to
$1.1 billion in sales worldwide, while the global ED market has
grown only 1 percent. In the U.S., Cialis has grown 17 percent and
has achieved market leadership with urologists. Internationally,
Cialis is now available in more than 100 countries and is the
market leader in more than 20, including 6 of the top 8
international markets. Tadalafil also has been studied for
pulmonary arterial hypertension (PAH) and benign prostatic
hyperplasia (BPH). The PAH indication was approved by the FDA in
May and launched in August by Lilly's partner, United Therapeutics,
under the brand name Adcirca(TM). In October, Lilly received PAH
approval in Japan, where it has partnered with Nippon Shinyaku. In
November, Lilly received PAH approval in Europe and Canada. Lilly
maintains full rights to the PAH indication in all markets outside
of the U.S. and Japan. The BPH Phase III program is ongoing and
will complete recruitment late next year. The company expects to
submit for approval of the BPH indication in the U.S. and Japan in
2011, and in the EU in 2012.
With the launches of Effient in the U.S. and Europe earlier this
year for treatment of patients with acute coronary syndrome (ACS)
undergoing percutaneous coronary intervention (PCI), the company is
optimistic about its potential in this important market segment. In
the U.S., Lilly and Daiichi-Sankyo launched Effient in early August
and are diligently executing sales and marketing plans to gain
payer and hospital formulary access. Outside the U.S., Lilly and
Daiichi Sankyo launched Efient in Germany and the U.K. in April
2009. The companies anticipate launches in France, Italy and Spain
in 2010. Lilly has also launched Efient in Australia and Argentina,
and anticipates launching the medicine in 24 additional countries
outside of the U.S. and Europe in 2010. Lilly and Daiichi-Sankyo
are also pursuing additional ongoing studies, including the TRILOGY
ACS study in medically managed patients.
Key molecules in the established markets business unit pipeline include:
-- Semagacestat - This gamma secretase inhibitor is currently being
studied in two large multi-national pivotal Phase III trials -
IDENTITY and IDENTITY-2 - to assess its effect on the progression of
Alzheimer's disease. Enrollment in the IDENTITY trial was completed in
the third quarter of 2009 and includes over 1,500 patients in 20
different countries. Enrollment in IDENTITY-2 is progressing rapidly
and is expected to be completed in the first half of 2010.
-- Solanezumab - A monoclonal antibody, the company's A-beta antibody
holds the potential for slowing down the progression of Alzheimer's
disease. Enrollment began in May 2009 in two multi-national Phase III
registration studies - EXPEDITION and EXPEDITION 2. Each study will
enroll 1,000 subjects for an 18-month treatment duration.
-- mGlu 2/3 Prodrug - An open-label study continues for this potential
schizophrenia compound currently in Phase II of clinical development.
The company plans to proceed with further efficacy testing, and
anticipates initiating two large studies in the first half of 2010.
-- iGluR5 Receptor Antagonist - Work on this pain compound continues to
progress. Phase II studies began in osteoarthritis and diabetic
peripheral neuropathic pain in the second quarter of 2009. Other pain
indications are also being considered, including migraine prevention.
-- Insomnia Compound LY2624803 - A Phase II study is ongoing and recently
completed enrollment ahead of plan. Results are expected in the first
half of 2010.
-- IL-17 antibody - This molecule continues to be studied for its
potential in rheumatoid arthritis (RA) and in other autoimmune
disorders. In August, a Phase IIb trial for IL-17 was initiated in RA
designed to further elucidate the molecule's safety and efficacy and
to establish a dosing regimen for Phase III trials. This trial is
expected to conclude in early 2011.
-- BAFF antagonist - Enrollment was recently completed in two Phase II
clinical trials for rheumatoid arthritis and, earlier this year, a
Phase II study was initiated in patients with relapsing-remitting
multiple sclerosis.
Oncology
With the acquisition of ImClone and the progression of its own
pipeline, Lilly is well along the way to building an oncology
powerhouse. Within the oncology business unit, Lilly's three key
cancer medicines - Alimta®, Gemzar® and Erbitux® -
account for 14 percent of the company's worldwide revenue. Lilly
also has one of the largest clinical stage oncology pipelines in
the industry, with 23 assets - more than one-third of the total
pipeline. The need for new and better treatments is staggering: the
World Health Organization estimates 12 million cancer-related
deaths per year by 2030.
Over the first three quarters of 2009, Alimta has been the
company's fastest growing product, reaching worldwide sales of $1.2
billion. U.S. sales have grown 46 percent, driven by market share
growth in nonsquamous non-small cell lung cancer (NSCLC). Outside
the U.S., Alimta has grown 37 percent. The company plans to pursue
additional indications for Alimta, either as monotherapy, or in
combination with other oncolytics.
Gemzar sales have exceeded $1.0 billion in the first three
quarters of 2009. In the U.S., Gemzar remains the standard of care
for pancreatic cancer, and has held steady in NSCLC. Gemzar lost
patent exclusivity in Europe in March of 2009, resulting in rapid
generic penetration. Gemzar continues to grow in other markets,
including Japan and China.
The company continues to work with its partners, Bristol Myers
Squibb and Merck KGaA, to maximize the growth potential of Erbitux.
Erbitux is currently approved in certain indications for colorectal
cancer and head and neck cancer. It is being studied for additional
indications for these cancers, as well as lung cancer, gastric
cancer and others.
Key molecules in the oncology business unit pipeline include:
-- Ramucirumab (IMC-1121B) - Enrollment in a global Phase III study in
first-line breast cancer is ongoing, and a second Phase III study in
gastric cancer began enrollment in October 2009. Two to three
additional Phase III ramucirumab studies are projected to begin in
2010. Several additional Phase II trials are expected to be initiated
next year, including trials in brain and bladder cancers and
additional studies in colorectal and breast cancers. This is in
addition to Phase II trials that have been initiated in renal cancer,
melanoma, and cancers of the liver, lung, colon, ovary and prostate.
-- Necitumumab (IMC- 11F8) - Two Phase III studies of necitumumab have
been initiated in non-small cell lung cancer. The first of these
commenced dosing in November 2009 and the second study is expected to
commence before the end of 2009. A pivotal trial in colorectal cancer
will follow.
-- Cixutumumab (IMC-A12) - Phase II testing of cixutumumab continues in
breast, prostate, colorectal, liver, neuroendocrine and head and neck
cancers, as well as sarcoma. Phase III trials of cixutumumab in
various tumor types are planned to begin in 2010.
-- Enzastaurin - Enzastaurin is currently being evaluated in a Phase III
clinical trial for maintenance therapy for diffuse large B-cell
lymphoma. U.S. regulatory submission remains targeted for mid-2013.
Enzastaurin is also being evaluated in several Phase II studies for
hematologic malignancies and glioblastoma.
-- Tasisulam - A Phase III study of tasisulam in 2nd line metastatic
melanoma was initiated in the fourth quarter of 2009. Tasisulam was
also recently granted orphan drug designation for melanoma by the FDA.
Additional cancers being explored in tasisulam clinical trials include
breast, ovarian, lung and renal cancers as well as acute leukemia.
-- Survivin ASO - Currently in Phase II, this second-generation antisense
oligonucleotide (ASO) is being studied in prostate cancer and acute
myeloid leukemia. Additional Phase II studies in other tumor types are
expected to begin during the first half of 2010.
-- IMC-3G3 - A Phase II study of 3G3 was initiated in 2009 in ovarian
cancer and a second Phase II trial is planned in 2010 in lung cancer.
A Phase 1 trial was completed in 2009 in prostate cancer.
Diabetes
Lilly has long been a leader in diabetes care, and has refocused
its efforts in this important therapeutic area with the creation of
a diabetes business unit that includes a dedicated asset base and a
portfolio of commercially-successful products and promising
pipeline opportunities. Lilly is one of only a few companies
positioned to compete globally in the insulins business. The
company remains firmly committed to its insulins franchise and is
making the investments necessary in key geographies to further
strengthen its competitive position. In addition, Lilly intends to
maintain a leading role in the rapidly emerging area of GLP-based
therapy. The need for new and improved treatments for patients with
diabetes is great: an estimated 285 million people are expected to
be affected worldwide in 2010.
Humalog® sales for the first three quarters of 2009 have
grown 12 percent worldwide, including 21 percent growth in the U.S.
market. Humalog has continued to show growth in total prescriptions
in the U.S. over the past year. In addition, the company continues
to launch its flagship pre-filled pen, Humalog KwikPen(TM), in
markets around the world, and will continue to do so in 2010.
Byetta® remains the first and only GLP-1 receptor agonist
available in the U.S. market. Since the initial effects of last
year's FDA safety alert on Byetta's U.S. performance, the company
and its partner, Amylin Pharmaceuticals, have slowed the erosion of
prescriptions and are focused on returning Byetta to growth.
Internationally, Byetta has been launched in approximately 60
countries, including most major markets. The company is pleased
with the uptake of Byetta in many markets, including the major five
European markets. Byetta was recently launched in China and is
under regulatory review in Canada and Japan.
Key molecules in the diabetes business unit pipeline include:
-- Exenatide once weekly - The company continues to develop exenatide
once weekly with its partners, Amylin Pharmaceuticals, Inc. and
Alkermes, Inc. The companies submitted exenatide once weekly for U.S.
regulatory review in the second quarter of 2009. The application was
accepted for review by the FDA in the third quarter of 2009.
Regulatory action is expected by the end of the first quarter of 2010.
European submission is expected to occur by the end of the second
quarter of 2010.
-- GLP-Fc - An adaptive, seamless Phase II/III trial, comparing GLP-Fc
with both placebo and a positive control, sitagliptin, is proceeding.
The company is also finalizing its full Phase III clinical program,
known as AWARD, and will begin enrolling patients in the first quarter
of 2010. To address the recent FDA guidance regarding mitigation of
cardiovascular (CV) risk, a large CV outcomes trial is planned that
will likely begin in the first quarter of 2011. Based on the company's
current expectations, GLP-Fc could be submitted for U.S. regulatory
review as early as late-2012.
-- Teplizumab- The safety and efficacy of teplizumab is currently being
studied in both children and adults with newly-diagnosed type 1
diabetes mellitus in two global, pivotal Phase III clinical trials -
Protégé and Protégé Encore. The Protégé trial completed enrollment in
2009. Patients who have completed the two-year protocol are currently
transitioning into an extension phase evaluating the long-term safety
and durability of teplizumab. Protégé Encore, the second global
pivotal Phase III clinical trial began enrolling patients in June
2009. Regulatory submission could occur in 2012.
Emerging Markets
The emerging markets business unit will include many of the
world's fastest-growing markets, including six of the so-called
"pharmerging markets" - China, Russia, Brazil, Mexico, South Korea,
and Turkey. Lilly aims to increase its presence in these countries
and others where strong growth rates for pharmaceuticals are
projected over the next decade.
The creation of an emerging markets business unit will increase
the company's focus on these areas and best position Lilly to serve
growing patient needs among two-thirds of the world's population.
This opportunity comes as the established pharmaceutical markets
face slower growth. According to an analysis published by IMS, the
seven pharmerging markets (the six named above plus India) will
contribute over a third of global pharmaceutical market growth
through 2013. Currently, these markets accounted for 9 percent of
the company's revenue in the first nine months of 2009.
The company has a three-part strategy aimed at driving
profitable growth in the emerging markets:
1. Maximize Lilly's core assets, including both patented and post-patent
medicines. Two key tactics are to accelerate new product launches and
to capitalize on longer product lifecycles in select countries such as
China.
2. Add select non-Lilly medicines to build upon core therapeutic areas,
especially diabetes, oncology and neuroscience, to accelerate top-line
growth. This could include product acquisitions and co-promotion or
co-marketing agreements.
3. Establish local alliances to more effectively access fast-growing
market segments in select countries where the company's current
infrastructure is not well suited to capture growth.
The company's top emerging market priority is China. In 2009,
the company significantly expanded its presence in China. Lilly is
currently the 11th ranked multi-national pharmaceutical company in
China, with sales of over $200 million in 2008. Through the first
nine months of 2009, Lilly's sales in China grew 20 percent, the
company doubled the size of its affiliate from 1,100 to about 2,200
employees, and is currently building a second manufacturing plant
in Suzhou to produce insulin.
Animal Health
The animal health business unit provides both diversification
and growth potential to the company's operations. Elanco is
currently the sixth largest animal health company in the industry
and its sales continue to grow at a rate faster than the overall
animal health market, bolstered by recent acquisitions and the
launch of its companion animal business. Year-to-date 2009 animal
health sales exceeded $850.0 million.
Elanco maintains the top position in the medicated feed
additives and dairy segments and also ranks first in research and
development output in the U.S., delivering more new molecules over
the past six years than any other company in its industry. In the
companion animal segment, Elanco is growing faster than the
competition, driven by the growth of Comfortis®. In 2010,
Elanco is planning for 7 new product launches and expanded
indications, including two new companion animal products.
Elanco is positioned to double revenue in five years with five
strategic initiatives:
1. Increased investment and industry leadership in innovation;
2. Continued growth and increased presence in the companion animal
business,
3. Greater investment and focus on emerging market opportunities;
4. Transforming its manufacturing cost structure to better support
innovation growth and emerging market opportunities; and
5. A further-enhanced business unit model to amplify "best in industry"
employee engagement and focused execution.
With strategic investments in research and development, along
with focused efforts to accelerate growth in key emerging markets
and the companion animal segment, Elanco is positioned to deliver
double-digit annual income growth over the next five years.
2009 Financial Guidance
The company confirmed its current financial guidance for 2009.
The company expects its full-year 2009 earnings per share to be in
the range of $3.90 to $4.00 on a reported basis, or $4.30 to $4.40
on a pro forma non-GAAP basis.
2009 Earnings Per Share Expectations:
2009 2008
Expectations Results % Growth
------------ ------- --------
Earnings (Loss) per share
(reported) $3.90 to $4.00 ($1.89) NM
Financial impact of ImClone
acquisition, including in-
process research and
development and other charges - 4.46
Charges related to Zyprexa
litigation .13 1.20
Asset impairments and
restructuring charges
(included in asset
impairments, restructuring and
other special charges) .26 .30
Asset impairments (included in
cost of sales) - .04
In-process research and
development charges associated
with SGX acquisition and in-
licensing transactions with
BioMS and TransPharma - .10
Benefit from resolution of IRS
audit in the first quarter of
2008 - (.19)
Pro forma as if the ImClone
acquisition was completed on
January 1, 2008 - (.20)
-------------- -------
Earnings per share (pro forma
non-GAAP) $4.30 to $4.40 $3.82 13% to 15%
-------------- -------
NM - not meaningful
Numbers in the 2009 Expectations column do not add due to rounding
The company expects low- to mid-single digit total revenue
growth on a pro-forma basis and mid-single digit revenue growth on
a reported basis.
The company expects gross margin as a percent of total revenue
to increase for the full year, driven primarily by the beneficial
foreign exchange impact in the first nine months of 2009 compared
to the first nine months of 2008. For the fourth quarter of 2009,
the company expects a decrease in gross margin as a percent of
total revenue compared to the fourth quarter of 2008.
Marketing, selling, and administrative expenses are projected to
show flat to low-single digit growth. Research and development
expenses are projected to grow in the high-single digits on a pro
forma non-GAAP basis and in the low-double digits on a reported
basis.
Other income is expected to be a net loss of between $200
million and $250 million. The effective tax rate is expected to be
approximately 21 percent on a pro forma non-GAAP basis and
approximately 20 percent on a reported basis. Capital expenditures
are expected to be less than $1.0 billion. The company expects
continued strong operating cash flow.
2010 Financial Guidance
The company provided financial guidance for 2010, excluding the
potential impact of health care reform in the U.S. In 2010, the
company expects earnings per share of $4.65 to $4.85 on both a
reported and pro forma non-GAAP basis.
2010 Earnings Per Share Expectations:
2010 2009
Expectations Expectations % Growth
------------ ------------ --------
Earnings per share
(reported) $4.65 to $4.85 $3.90 to $4.00 16% to 24%
Charges related to Zyprexa
litigation - .13
Asset impairments and
restructuring charges
(included in asset
impairments, restructuring
and other special charges) - .26
-------------- --------------
Earnings per share (pro
forma non-GAAP) $4.65 to $4.85 4.30 to $4.40 6% to 13%
-------------- --------------
The company expects volume-driven revenue growth in the
high-single digits, driven primarily by Alimta, Cymbalta, Humalog,
Cialis, Effient and the exenatide franchise.
The company anticipates that gross margin as a percent of
revenue will be flat to declining. Excluding the effect of foreign
exchange rates on international inventories sold, the company
expects gross margin as a percent of revenue to increase.
Marketing, selling and administrative expenses are projected to
grow in the low- to mid-single digits while research and
development expenses are projected to grow in the low-double
digits.
Other income is expected to be a net loss of between $150.0 and
$200.0 million, and the tax rate is expected to be approximately 22
percent.
Cash flows are expected to be sufficient to fund capital
expenditures of approximately $1.0 billion, anticipated business
development activity and the company's dividend.
Longer-term Financial Commentary
The company reaffirmed its commitment to deliver low
double-digit compound annual earnings per share growth between 2007
and 2011, excluding the potential impact of health care reform in
the U.S.
Looking further out, the company also provided a general
perspective on possible financial performance during the major
patent expiry years of 2012 to 2014 and beyond.
During this time, the company anticipates annual revenue of at
least $20.0 billion. Gross margins as a percent of revenue could be
between 75 and 80 percent. Operating expenses, the sum of selling,
general and administrative expenses and research and development
expenses, as a percent of revenue could be in the mid 50s. The tax
rate could be higher than today, possibly 25 percent.
Under this scenario, net income would exceed $3.0 billion and
operating cash flow would exceed $4.0 billion. This level of
operating cash flow would solidly position the company to fund
research and development, capital expenditures and the
dividend.
As the company plans for this challenging time period, it
believes it will generate sufficient operating cash flow to enable
it to execute on its innovation-based strategy, reward shareholders
and successfully and independently emerge from the major patent
expiry years with bright prospects for future growth.
Webcast of Investment Community Meeting
A live webcast of the Lilly Investment Community meeting, along
with presentation slides, is available through a link on Lilly's
web site at www.lilly.com. The meeting will start today at 8:30
a.m. Eastern Time and last until approximately 12:30 p.m. The
webcast will be available for replay through January 8, 2010.
Lilly, a leading innovation-driven corporation, is developing a
growing portfolio of pharmaceutical products by applying the latest
research from its own worldwide laboratories and from
collaborations with eminent scientific organizations. Headquartered
in Indianapolis, Ind., Lilly provides answers - through medicines
and information - for some of the world's most urgent medical
needs. More information about Lilly is available at www.lilly.com.
C-LLY
This press release contains forward-looking statements that are
based on management's current expectations, but actual results may
differ materially due to various factors. There are significant
risks and uncertainties in pharmaceutical research and development.
There can be no guarantees with respect to pipeline products that
the products will receive the necessary clinical and manufacturing
regulatory approvals or that they will prove to be commercially
successful. The company's results may also be affected by such
factors as competitive developments affecting current products; the
rate of sales growth of recently launched products; the timing of
anticipated regulatory approvals and launches of new products;
other regulatory developments and government investigations; patent
disputes and other litigation involving current and future
products; the impact of governmental actions regarding pricing,
importation, and reimbursement for pharmaceuticals; business
development transactions; changes in tax law; asset impairments and
restructuring charges and the impact of exchange rates. For
additional information about the factors that affect the company's
business, please see the company's latest Form 10-K, filed February
2009, and Form 10-Q filed October 2009. The company undertakes no
duty to update forward-looking statements.
Alimta® (pemetrexed, Lilly) Adcirca(TM) (tadalafil, Lilly) Byetta® (exenatide injection, Amylin Pharmaceuticals) Cialis® (tadalafil, Lilly) Comfortis(TM) (Lilly) Cymbalta® (duloxetine hydrochloride, Lilly) Effient(TM) (prasugrel, Lilly) Erbitux® (cetuximab, ImClone Systems, Lilly) Gemzar® (gemcitabine hydrochloride, Lilly) Humalog® (insulin lispro injection of recombinant DNA origin, Lilly) KwikPen(TM) (Lilly) Zyprexa® (olanzapine, Lilly) Zyprexa Relprevv® (olanzapine depot injection, Lilly) (Logo: http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO )
Photo: http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO
Source: Eli Lilly and Company
CONTACT: Mark Taylor (media), +1-317-354-7045, Phil Johnson
(investors),
+1-317-655-6874, or Angela Sekston (media), +1-317-332-1593
Posted: December 2009
