Pharmaceutical News and Articles

Genentech Announces Second Quarter 2008 Results

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Jul 14, 2008 - Genentech, Inc. (NYSE: DNA) today announced financial results for the second quarter of 2008. Key results for the second quarter of 2008 include:

-- U.S. product sales of $2,351 million, a 9 percent increase from U.S. product sales of $2,149 million in the second quarter of 2007.

-- Non-GAAP operating revenue of $3,232 million(1), an 8 percent increase from operating revenue of $3,004 million in the second quarter of 2007; GAAP operating revenue of $3,236 million, an 8 percent increase from operating revenue of $3,004 million in the second quarter of 2007.

-- Non-GAAP net income of $871 million, a 4 percent increase from $834 million in the second quarter of 2007(1); GAAP net income of $782 million, a 5 percent increase from $747 million in the second quarter of 2007.

-- Non-GAAP earnings per share of $0.82, a 5 percent increase from $0.78 in the second quarter of 2007(1); GAAP earnings per share of $0.73, a 4 percent increase from $0.70 in the second quarter of 2007.

Reconciliations between non-GAAP and GAAP earnings per share for second quarters of 2008 and 2007 are provided in the following table: -0-

                                        Net Charges related Reported

        Non-GAAP                          to Redemption,      GAAP

         Diluted  Employee Stock-Based    Acquisition and    Diluted

           EPS     Compensation Expense    Special Items       EPS

----------------------------------------------------------------------

Q2 2008   $0.82          ($0.06)              ($0.02)         $0.73

----------------------------------------------------------------------

Q2 2007   $0.78          ($0.06)              ($0.02)         $0.70

----------------------------------------------------------------------

Note: Amounts may not sum due to rounding.

The company is currently forecasting that full-year 2008 non-GAAP earnings are likely to be in the range of $3.40 to $3.50 per share, revised from $3.35 to $3.45 per share.(1)

Product Sales and Royalty Revenue

Information on product sales for the three months ended June 30, 2008 and 2007, are provided in the following tables (dollars in millions): -0-

                                              Three Months

                                             Ended June 30,

                                            ----------------

                                              2008    2007   % Change

                                            --------------------------

Rituxan(R)                                      $651    $582       12%

Avastin(R)+                                      650     564        15

Herceptin(R)                                     338     329         3

Lucentis(R)                                      216     209         3

Xolair(R)                                        129     120         8

Tarceva(R)                                       119     102        17

Nutropin(R) Products                              89      94       (5)

Thrombolytics                                     68      67         1

Pulmozyme(R)                                      63      55        15

Raptiva(R)                                        28      27         4

                                            ----------------

Total U.S. product sales ++                   $2,351  $2,149         9


Net product sales to collaborators               185     294      (37)

                                            ----------------

Total product sales ++                        $2,536  $2,443         4

                                            ================

+ Second quarter 2008 Avastin U.S. product sales results include a net deferral of approximately $1 million in conjunction with the company's Avastin Patient Assistance Program. The net deferral related to the program in the second quarter of 2007 was not significant.

++ Amounts may not sum due to rounding.

Non-GAAP royalty revenue for the second quarter of 2008 was $625 million, a 29 percent increase over the second quarter of 2007.(1) Excluding the impact of a collaboration agreement in the second quarter of 2007, which resulted in one-time royalty revenue of approximately $65 million in that quarter, non-GAAP royalty revenue in the second quarter of 2008 increased 49 percent. GAAP royalty revenue of $629 million in the second quarter of 2008 increased 30 percent over the second quarter of 2007. The increase was primarily due to growth in ex-U.S. sales of Genentech's products by collaborators and related foreign exchange benefits of the weak dollar.

Total Costs and Expenses

Information on costs and expenses including cost of sales (COS), research and development (R&D) and marketing, general and administrative (MG&A) expenses for the three months ended June 30, 2008 and 2007, are provided in the following tables (dollars in millions)(2): -0-

                                         Three Months

                                        Ended June 30,

                                      -------------------

                                         2008     2007     % Change

                                      --------------------------------

non-GAAP(2)

--------------------------------------

COS                                         $423     $413           2%

R&D                                          611      564            8

MG&A                                         518      485            7

GAAP

--------------------------------------

COS                                          441      429            3

R&D                                          649      603            8

MG&A                                         559      532            5

Reported non-GAAP and GAAP COS for the second quarter of 2008 both include a charge of approximately $50 million, related to failed lots from a manufacturing start-up campaign at one of Genentech's facilities. -0-

                                                     Three Months

                                                     Ended June 30,

                                                     2008      2007

                                                  --------------------

non-GAAP(2)

--------------------------------------------------

COS as a % of product sales                              17%       17%

R&D as a % of operating revenue                          19%       19%

MG&A as a % of operating revenue                         16%       16%

GAAP

--------------------------------------------------

COS as a % of product sales                              17%       18%

R&D as a % of operating revenue                          20%       20%

MG&A as a % of operating revenue                         17%       18%

Other Financial Items

The non-GAAP and GAAP income tax rates of 40 percent for the second quarter of 2008 include a $33 million settlement with the Internal Revenue Service related to prior years that was resolved in the second quarter of 2008.

Clinical Development

Genentech announced that enrollment was completed in seven Phase II and Phase III studies during the second quarter of 2008. These studies included two combination Phase III studies for Avastin(R) (bevacizumab) and Tarceva(R) (erlotinib) in first-line and second-line metastatic non-squamous non-small cell lung cancer (NSCLC) and a Phase II study for Trastuzumab-DM1 in HER2-positive metastatic breast cancer patients who have progressed on HER2-directed therapy.

Genentech also announced that, with its collaborator Abbott, it initiated a Phase II trial of ABT-869, a VEGFR targeted kinase inhibitor, in combination with chemotherapy for patients with advanced NSCLC. In addition, Genentech initiated a Phase III combination study (BETH) of Avastin and Herceptin(R) (Trastuzumab) for patients with adjuvant HER2-positive breast cancer.

Webcast

Genentech will be offering a live webcast of a discussion by Genentech management of its financial and other business results on Monday, July 14, 2008, at 1:45 p.m. Pacific Time (PT). The live webcast may be accessed on Genentech's website at http://www.gene.com. This webcast will be available via the website until 5:00 p.m. PT on August 4, 2008. A telephonic audio replay of the webcast will be available beginning at 4:45 p.m. PT on July 14, 2008 through 4:45 p.m. PT on July 21, 2008. Access numbers for this replay are: 1-800-642-1687 (U.S./Canada) and 1-706-645-9291 (international); conference ID number is 49949746.

About Genentech

Founded more than 30 years ago, Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with significant unmet medical needs. The company has headquarters in South San Francisco, California and is listed on the New York Stock Exchange under the symbol DNA. For additional information about the company, please visit http://www.gene.com.

About Genentech's Commitment to Patient Access

Genentech is committed to patients having access to our therapies. Through its Genentech Access Solutions program, the company provides patients and healthcare providers with coverage and reimbursement support, patient assistance and informational resources. Patient assistance support is for those eligible patients in the United States who do not have insurance coverage or who cannot afford their out-of-pocket co-pay costs. Since 1985, when its first product was approved, Genentech has donated approximately $1 billion in free medicine to uninsured patients through the Genentech(R) Access to Care Foundation (GATCF) and other product donation programs. Since 2005, Genentech has also donated more than $140 million to various independent, non-profit organizations that provide financial assistance to eligible patients who cannot access needed medical treatment due to co-pay costs.

For information on Genentech's latest business and product development events please refer to http://www.gene.com/gene/news/press-releases/index.jsp.

This press release contains a forward-looking statement regarding expected growth in non-GAAP earnings per share for 2008. Such a statement is a prediction and involves risks and uncertainties such that actual results may differ materially. Such risks and uncertainties include, but are not limited to, the need for additional data, data analysis or clinical studies; the results of clinical trials; Biologics License Application preparation and decision making; U.S. Food and Drug Administration (FDA) actions or delays; failure to obtain or maintain FDA approval; difficulty in obtaining materials from suppliers; unexpected safety, efficacy or manufacturing issues for us or our contract/collaborator manufacturers; product withdrawals; competition; efficacy data concerning any of our products which shows or is perceived to show similar or improved treatment benefit at a lower dose or shorter duration of therapy; pricing decisions by us or our competitors; our ability to protect our proprietary rights; the outcome of, and expenses associated with, litigation or legal settlements; our cost of sales, other expenses and indebtedness; variations in collaborator sales and expenses; fluctuations in contract revenue and royalties; actions by Roche that are adverse to our interests; decreases in third party reimbursement rates; and changes in accounting or tax laws or the application or interpretation of such laws. Please also refer to Genentech's periodic reports filed with the Securities and Exchange Commission. Genentech disclaims, and does not undertake, any obligation to update or revise forward-looking statements in this press release.

(1) Genentech's non-GAAP royalty revenue and operating revenue for the second quarter of 2008 exclude recognition of deferred royalty revenue associated with the acquisition of Tanox, Inc. of $4 million. In the second quarter of 2008, GAAP royalty revenue and GAAP operating revenue were $629 million and $3,236 million, respectively. Genentech's non-GAAP net income and non-GAAP earnings per share exclude the after-tax impact of certain items associated with the acquisition of Tanox, Inc. (including recurring recognition of deferred royalty revenue and recurring amortization of intangible assets); recurring charges related to the 1999 redemption of Genentech's stock by Roche Holdings, Inc.; litigation-related and similar special items; and employee stock-based compensation expense. The differences in non-GAAP and GAAP amounts are reconciled in the accompanying tables and on http://www.gene.com.

(2) Genentech's second quarter 2008 non-GAAP reported COS, R&D and MG&A expenses exclude the effects of employee stock-based compensation expense of $18 million, $38 million, and $41 million, respectively. Second quarter 2007 non-GAAP reported COS, R&D and MG&A expenses exclude the effects of employee stock-based compensation expense of $16 million, $39 million, and $47 million, respectively. The differences in non-GAAP and GAAP amounts are reconciled in the accompanying tables and on http://www.gene.com. -0-

                           GENENTECH, INC.

                  CONSOLIDATED STATEMENTS OF INCOME

               (In millions, except per share amounts)

                             (Unaudited)


                                       Three Months      Six Months

                                      Ended June 30,   Ended June 30,

                                      --------------- ----------------

                                       2008    2007     2008    2007

                                      ------- ------- -------- -------

Revenues:

   Product sales                      $2,536  $2,443   $4,915  $4,773

   Royalties                             629     484    1,244     903

   Contract revenue                       71      77      140     171

                                      ------- ------- -------- -------

         Total operating revenues      3,236   3,004    6,299   5,847


Costs and expenses:

   Cost of sales (includes employee

    stock-based compensation expense:

    three months-2008-$18; 2007-$16;

    six months-2008-$41; 2007-$33)       441     429      831     821

   Research and development (includes

    employee stock-based compensation

    expense: three months-2008-$38;

    2007-$39; six months-2008-$80;

    2007-$77)                            649     603    1,266   1,213

   Marketing, general and

    administrative (includes employee

    stock-based compensation expense:

    three months-2008-$41; 2007-$47;

    six months-2008-$87; 2007-$93)       559     532    1,076   1,023

   Collaboration profit sharing          313     277      592     529

   Recurring charges related to

    redemption and acquisition            43      26       86      52

   Special items: litigation-related       2      13     (300)     26

                                      ------- ------- -------- -------

         Total costs and expenses      2,007   1,880    3,551   3,664


Operating income                       1,229   1,124    2,748   2,183


Other income (expense):

   Interest and other income, net(1)      93      75      166     149

   Interest expense                      (15)    (17)     (32)    (35)

                                      ------- ------- -------- -------

         Total other income, net          78      58      134     114


Income before taxes                    1,307   1,182    2,882   2,297

Income tax provision                     525     435    1,118     844

                                      ------- ------- -------- -------

Net income                            $  782  $  747   $1,764  $1,453

                                      ======= ======= ======== =======


Earnings per share:

   Basic                              $ 0.74  $ 0.71   $ 1.68  $ 1.38

                                      ======= ======= ======== =======

   Diluted                            $ 0.73  $ 0.70   $ 1.65  $ 1.36

                                      ======= ======= ======== =======


Weighted average shares used to

 compute earnings per share:

   Basic                               1,051   1,053    1,052   1,053

                                      ======= ======= ======== =======

   Diluted                             1,064   1,070    1,066   1,071

                                      ======= ======= ======== =======


----------------------------------------------------------------------


(1) "Interest and other income, net" includes interest income, net

     realized gains from the sale of certain biotechnology equity

     securities and write-downs for other-than-temporary impairments

     in the fair value of certain debt and biotechnology equity

     securities. For further detail, refer to our web site at

     www.gene.com.

-0-
                           GENENTECH, INC.

            RECONCILIATION OF GAAP TO NON-GAAP NET INCOME

               (In millions, except per share amounts)

                             (Unaudited)


                                        Three Months     Six Months

                                       Ended June 30,  Ended June 30,

                                       --------------- ---------------

                                        2008    2007    2008    2007

                                       ------- ------- ------- -------

GAAP net income                        $  782  $  747  $1,764  $1,453

Royalty revenue(1)                         (4)      -      (8)      -

Employee stock-based compensation

 expense under FAS 123R included in the

 following operating expenses:

   Cost of sales                           18      16      41      33

   Research and development                38      39      80      77

   Marketing, general and

    administrative                         41      47      87      93

Recurring charges related to redemption

 and acquisition(2)                        43      26      86      52

Special items: litigation-related(3)        2      13    (300)     26

Income tax effect(4)                      (49)    (54)     16    (107)

                                       ------- ------- ------- -------

Non-GAAP net income                    $  871  $  834  $1,766  $1,627

                                       ======= ======= ======= =======


Non-GAAP earnings per share:

   Diluted                             $ 0.82  $ 0.78  $ 1.66  $ 1.52

                                       ======= ======= ======= =======


Non-GAAP weighted average shares used

 to compute earnings per share(5):

   Diluted                              1,062   1,068   1,064   1,070

                                       ======= ======= ======= =======


----------------------------------------------------------------------


(1) Represents recognition of deferred royalty revenue.

(2) Represents the amortization of intangible assets related to the

     1999 redemption of our common stock by Roche Holdings, Inc. and

     our 2007 acquisition of Tanox, Inc.

(3) Includes accrued interest and bond costs in the second quarters

     and the first six months of 2008 and 2007 related to the City of

     Hope trial judgment. In addition, the amount for the first six

     months of 2008 includes a litigation settlement recorded as a

     result of the California Supreme Court ruling on the matter in

     April 2008.

(4) Reflects the income tax effects of excluding employee stock-based

     compensation expense under FAS 123R, recurring charges related to

     the redemption of our common stock, litigation-related special

     items and items related to our acquisition of Tanox, Inc.

(5) Weighted average shares used to compute non-GAAP diluted earnings

     per share were computed exclusive of the methodology used to

     determine dilutive securities under FAS 123R.


Reconciliation of 2008 GAAP and Non-GAAP EPS Estimates

----------------------------------------------------------------------

Our 2008 non-GAAP EPS estimate excludes the effects of: (i) recurring

 amortization charges related to the 1999 redemption of our common

 stock by Roche Holdings, Inc. and our acquisition of Tanox, Inc.,

 which the company forecasts to be approximately $172 million on a

 pretax basis in 2008, (ii) the net litigation settlement related to

 the City of Hope judgment which the company forecasts to be $300

 million on a pretax basis in 2008, (iii) recognition of deferred

 royalty revenue associated with the accounting for our acquisition of

 Tanox, Inc., which the company forecasts to be approximately $15

 million on a pretax basis in 2008, (iv) income tax effect on

 recurring charges related to the redemption of our common stock and

 our acquisition of Tanox, Inc., litigation-related and similar

 special items, and recognition of deferred royalty revenue, which the

 company forecasts to be approximately ($56) million in 2008, and (v)

 employee stock-based compensation expense, which the company

 forecasts to be in the range of $0.25 to $0.27 per share for 2008 on

 an after-tax basis. Our 2008 GAAP EPS would include the items listed

 above as well as any other potential special charges related to

 existing or future litigation or its resolution, or changes in or

 adoption of accounting principles, all of which may be significant.


The statements regarding the amounts relating to the 1999 Roche

 redemption of our common stock, amortization of intangible assets and

 recognition of deferred royalty revenue associated with the

 acquisition of Tanox, Inc., litigation-related and similar special

 items and employee stock-based compensation expense are forward-

 looking and such statements are predictions and involve risks and

 uncertainties such that actual results may differ materially. The

 amounts identified above could be affected by a number of factors,

 including a revaluation of certain intangible assets, greater than

 expected litigation-related and similar costs, changes in or adoption

 of accounting principles, the number of options granted to employees,

 our stock price and certain valuation assumptions concerning our

 stock. We disclaim, and do not undertake, any obligation to update or

 revise any of these forward-looking statements.

-0-
                           GENENTECH, INC.

                 SELECTED CONSOLIDATED FINANCIAL DATA

                            (In millions)

                             (Unaudited)


                                               June 30,   December 31,

                                                 2008         2007

                                             ------------ ------------

Selected consolidated balance sheet data:

Cash, cash equivalents and short-term

 investments                                     $ 4,505      $ 3,975

Accounts receivable - product sales, net             889          847

Accounts receivable - royalties, net                 732          620

Accounts receivable - other, net                     200          299

Inventories                                        1,406        1,493

Long-term marketable debt and equity

 securities                                        1,832        2,090

Property, plant and equipment, net                 5,266        4,986

Goodwill                                           1,577        1,577

Other intangible assets                            1,083        1,168

Other long-term assets                               308          366

Total assets                                      19,119       18,940

Total current liabilities                          2,705        3,918

Long-term debt(1)                                  2,475        2,402

Total liabilities                                  5,834        7,035

Total stockholders' equity                        13,285       11,905



                                             Six Months Ended June 30,

                                             -------------------------

                                                 2008         2007

                                             ------------ ------------

Selected consolidated cash flow data:

Capital expenditures(1)                          $   398      $   475


Total GAAP depreciation and amortization

 expense                                             285          215

   Less: redemption and acquisition related

    amortization expense(2)                          (86)         (52)

                                             ------------ ------------

Non-GAAP depreciation and amortization

 expense                                         $   199      $   163

                                             ============ ============


----------------------------------------------------------------------


(1) Capital expenditures exclude approximately $75 million for the six

     months ended June 30, 2008 and $101 million for the six months

     ended June 30, 2007 in capitalized costs related to our

     accounting for construction projects for which we are considered

     to be the owner during the construction period. We have

     recognized related amounts as a construction financing obligation

     in long-term debt. The balances in long-term debt related to the

     construction financing obligation are $466 million at June 30,

     2008 and $399 million at December 31, 2007.

(2) Represents the amortization of intangible assets related to the

     1999 redemption of our common stock by Roche Holdings, Inc. and

     our 2007 acquisition of Tanox, Inc.

Contact

Genentech, Inc.
Media Contact:
Geoff Teeter, 650-225-8171
Caroline Pecquet, 650-467-7078
Investor Contact:
Kathee Littrell, 650-225-1034
Sue Morris, 650-225-6523
http://www.gene.com

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