Experts Issue New Heart Disease Guidelines for Women

TUESDAY Feb. 15, 2011 -- Preventing heart attacks and strokes is very similar in women and men, with a few small but important differences, according to new guidelines from the American Heart Association.

Each year, 55,000 more U.S. women than men suffer a stroke, while men are more likely to have heart attacks.

One strong risk factor for stroke is atrial fibrillation, an abnormal heart rhythm that boosts women's risk of stroke by fourfold to fivefold. To prevent stroke, women should make sure they have consulted with their doctor and are taking the right medications to control atrial fibrillation, according to the guidelines.

Women also have other unique risk factors that can increase their chances of stroke, including pregnancy, taking birth control pills, and hormone replacement therapy during menopause.

Certain pregnancy complications including preeclampsia (high blood pressure and protein in the urine), preterm birth, having a baby that's small for its gestational age and gestational diabetes are associated with later heart problems -- something women and their doctors often don't know.

"We consider pregnancy like a physical and metabolic stress test, and complications are like failing the stress test," said Dr. Lori Mosca, chair of the guidelines writing committee and director of preventive cardiology at New York-Presbyterian Hospital. "It's an early indicator of a problem, and there is a common mechanism between pregnancy complications and cardiovascular disease, which is metabolic and vascular dysfunction."

The new guidelines for preventing heart disease in women are published online and in the March 21 print issue of Circulation.

Heart disease is the No. 1 killer of women, yet only 54 percent of women knew this in 2009, according to background information in the report. Still, awareness is up substantially from 1997, when only 30 percent realized heart disease wasn't primarily a "man's disease," the authors noted.

And rising rates of obesity and diabetes threaten to overwhelm the improvements.

Two in three women over the age of 20 are either overweight or obese, researchers have found. And after falling for four decades, death rates from heart disease appear to be rising among U.S. women aged 35 to 54.

Black women are especially hard hit by hypertension (high blood pressure) and heart disease, while Hispanic women have more than double the rates of diabetes as non-Hispanic white women (12.7 percent compared to 6.5 percent).

To reduce the risk of heart disease, women should keep their total cholesterol level at 200 milligrams per deciliter (mg/dL) or less; blood pressure at 120/80 mm Hg; and have a fasting blood glucose under 100 mg/dL.

Women should maintain a body mass index of less than 25, avoid smoking, cut down on salt, eat plenty of fruits, vegetables and whole grains, and do at least 150 minutes of moderate physical activity a week or 75 minutes of vigorous activity, according to the guidelines.

Studies have shown that only about 4 percent of women aged 50 to 79 do all of these things and are considered at the lowest risk for heart disease; 72 percent were at "some risk" of heart disease, while 11 percent were at high risk, defined as a 20 percent or greater chance of having a heart attack or stroke in the next 10 years.

Other updates in the 2011 guidelines include:

  • A recognition that diseases such as lupus and rheumatoid arthritis increase heart disease risk in women.
  • There is little evidence for the use of hormone replacement therapy, antioxidants and folic acid to prevent heart disease in women, and some evidence of potential harm. Nor is there good evidence that the routine use of low-dose aspirin to prevent heart attacks is effective in women.

Scientific evidence regarding women and heart disease is still limited. "The women we see are often sicker, older and have many more co-morbidities than women who participate in clinical trials," Mosca said. For example, women tend to have more side-effects from statins. "The evidence isn't all that strong for statin use as a primary prevention in women," she said. "We want future trials to publish data by gender not just for the benefits but also for the side effects."

Dr. Annabelle Volgman, medical director of the Rush Heart Center for Women in Chicago, said there's still a long way to go in making sure women understand their heart disease risk.

"Fifty-four percent of women know about the risk, but that means 46 percent of women still don't know it's the No. 1 killer," Volgman said. "And although there's been a decline in death rates from heart disease in women, we are seeing more young women 35 to 54 years old having strokes."

A newly approved drug, Pradaxa (dabigatran) is a good alternative to Coumadin (warfarin) for treating atrial fibrillation.

"I find women are more reluctant than men to take drugs. So I always say, "It's Prada with a 'xa,'" Volgman said.

More information

The American Heart Association has more on preventing heart disease in women.

Posted: February 2011


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