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Eisai Signs Exclusive Agreement to Commercialize NeuroBloc for Europe

TOKYO, May 15, 2007-Eisai Co., Ltd. (Headquarters: Tokyo, President & CEO: Haruo Naito) announced that the company has signed on May 14, 2007 (the U.S. Eastern Time) the exclusive agreement with Solstice Neurosciences, Inc. (Headquarters: Pennsylvania, U.S., President & CEO: Shawn Patrick O’Brien) for NeuroBloc® , an injectable form of botulinum toxin type B agent owned by Solstice. In this new agreement, Eisai gained the commercialization right over a total of 35 European countries, including the 27 EU countries, Norway, Iceland, Liechtenstein, Monaco, Switzerland, Croatia, Turkey, and Russia.

NeuroBloc® was approved for Cervical Dystonia through the centralized procedure by the European Medicines Evaluation Agency (EMEA) in January 2001 and has been made available in eight European countries so far. Treatment with NeuroBloc® interrupts cholinergic transmission between nerves and the affected muscle, causing it to relax.

For the Japanese Market, Eisai signed an exclusive agreement with Elan Corporation, plc.* for the development and marketing right of this product in September 2000. In December 2006, Eisai filed the new drug application for this product in Japan for the treatment of Cervical Dystonia.

Eisai is rapidly enhancing its neurology product lineup in Europe with its global products including Aricept® (symptomatic treatment of Alzheimer’s disease) as well as the anti-epilepsy agents Zonegran® and Inovelon®. With this strategic alliance for NeuroBloc®, Eisai expects to make further contributions to increasing the benefits to the patients and their families in Europe.

* Elan Corporation, plc. sold all assets of NeuroBloc® to Solstice Neurosciences, Inc. in July 2004.


[Please see the following notes for the information on Cervical Dystonia, product outline and information about Solstice Neurosciences, Inc.]

Contacts:
Corporate Communications Department
Eisai Co., Ltd.
81-3-3817-5120



< Note to Editor >

About Cervical Dystonia
Cervical Dystonia is a condition of abnormal muscle tone and movement that can result in painful abnormalities of posture or inability to flex and relax affected neck and shoulder muscles. The botulinum toxin type B compound is effective in the treatment of cervical dystonia by relaxing affected neck and shoulder muscles through blocking the neurotransmitter acetylcholine in those patients responsive to botulinum toxin therapy treatment.

Product Outline
  • Product Name: NeuroBloc®
  • Generic Name: botulinum toxin type B
  • Applied Indication: Cervical Dystonia
  • Dosage : 
    The dose and frequency of administration should be adjusted for each patient depending on the clinical response. The initial dose is 10,000 U and should be divided between the two to four most affected muscles.
  • Administration : Injection (5000 U/ml botulinum toxin type B)
    *The vial size available in 0.5 ml (2500 U), 1.0 ml (5000 U), and 2.0 ml (10,000U).

About Solstice Neurosciences, Inc.
  • Headquarters: Malvern, Pennsylvania, USA
  • Factory: South San Francisco, California, USA
  • Establishment: July 7, 2004*
  • Number of Employees: 142 including 33 Medical Representatives (as of May 2007).

Posted: May 2007


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