Bristol-Myers Squibb Continues Excellent Financial Performance Led By Double-Digit Global Net Sales Growth and Strong Earnings Results

Bristol-Myers Squibb Company (NYSE:BMY):

-- Reports Broad-Based Net Sales Growth of 14% from Continuing Operations

-- Records Growth in GAAP Diluted EPS of $1.29 Compared to $0.43 in 2007; Includes After-Tax Gain of $0.99 Per Share From Sale of ConvaTec

-- Posts 2008 GAAP Diluted EPS from Continuing Operations of $0.30 Compared to $0.38 in 2007

-- Posts Non-GAAP Diluted EPS Growth from Continuing Operations of $0.46 Compared to $0.33 in 2007

-- Raises 2008 GAAP EPS Guidance to $1.61 to $1.66, Subject to Receipt of Cash for ImClone Shares, and Refines 2008 Non-GAAP EPS Guidance to $1.65 to $1.70, Representing Upper Range of Previous Guidance

-- Strengthens Cash Position to $7.2 Billion From $4.0 Billion on June 30, 2008

NEW YORK--(BUSINESS WIRE)--Oct 23, 2008 - Consistent with recent performance, Bristol-Myers Squibb Company (NYSE:BMY) today reported strong sales growth and earnings performance for the third quarter 2008.

"Bristol-Myers Squibb continues to deliver excellent operating results. With double-digit sales growth in the third quarter and with strong financial results for the first nine months of 2008, we are refining our 2008 non-GAAP earnings-per-share guidance to between $1.65 to $1.70, which is the upper range of our prior guidance," said James M. Cornelius, chairman and chief executive officer.

"Our recent success gives us confidence that our BioPharma strategy is the right one to help us fulfill our commitments to patients and shareholders," Cornelius added. "As we continue to demonstrate strong performance in the marketplace, we're moving forward to attain our goals, both commercially and with the advancement of our new product pipeline. The strength of our balance sheet and cash position enables us to execute our strategy, including our ongoing business development activity." -0-


----------------------------------------------------------------------

                          Third Quarter 2008
----------------------------------------------------------------------

                                                  2008   2007   Change
                                                  ------ ------ ------
   Net Sales                                      $5,254 $4,601   14%
   Net Earnings                                   $2,578 $  858  200%
   Net Earnings From Continuing Operations        $  588 $  753  (22%)

   Net Earnings Per Common Share                    1.29   0.43  200%
   GAAP Diluted EPS From Continuing Operations      0.30   0.38  (21%)
   Non-GAAP Diluted EPS From Continuing
    Operations                                      0.46   0.33   39%
   ($ amounts in millions, except per share
    amounts)

----------------------------------------------------------------------

THIRD QUARTER RESULTS

-- Bristol-Myers Squibb posted third quarter 2008 net sales from continuing operations of $5.3 billion, an increase of 14%, including a 3% favorable foreign exchange impact, compared to the same period in 2007. Pharmaceutical net sales totaled $4.5 billion and sales of Nutritionals totaled $744 million in the third quarter of 2008, representing increases of 15% and 10%, respectively, compared to 2007.

-- U.S. pharmaceutical net sales increased 18% to $2.7 billion in the third quarter of 2008 compared to the same period in 2007, primarily due to strong performance from PLAVIX(R) and ABILIFY(R), and strong results from the HIV and hepatitis portfolio as well as ORENCIA(R).

-- International pharmaceutical net sales increased 11%, including a 7% favorable foreign exchange impact, to $1.8 billion in the third quarter of 2008 compared to the same period in 2007. The increase was primarily due to the strong performance of BARACLUDE(R), ABILIFY(R), SPRYCEL(TM) and the HIV portfolio.

-- Gross profit as a percentage of net sales improved to 68.9% in the third quarter 2008 compared to 67.9% in 2007. This increase of 1.0% was driven by favorable product mix, cost improvement from productivity initiatives and favorable foreign exchange, partially offset by higher manufacturing rationalization charges in 2008, which accounted for a 0.7% decrease.

-- Marketing, selling and administrative expenses increased by 9%, including an unfavorable 3% foreign exchange impact, to $1.2 billion in the third quarter of 2008 compared to the same period in 2007.

-- Advertising and product promotion spending increased by 7%, including an unfavorable 2% foreign exchange impact, to $362 million in the third quarter of 2008 compared to the same period in 2007.

-- Research and development expenses increased 4%, including an unfavorable 1% foreign exchange impact, to $834 million in the third quarter of 2008 compared to the same period in 2007.

-- The effective tax rate on earnings from continuing operations before minority interest and income taxes was 26.7% for the third quarter of 2008, compared with 23.2% in the third quarter of 2007. The company expects the full year 2008 non-GAAP effective tax rate from continuing operations to be in line with the previously issued guidance of approximately 24%.

-- The company reported third quarter net earnings of $2.6 billion or $1.29 per diluted share, compared to net earnings of $858 million or $0.43 per diluted share for the same period in 2007. The third quarter 2008 net earnings includes a $2.0 billion after-tax gain, or $0.99 per share, attributed to the sale of the company's ConvaTec business which is recorded in discontinued operations. In addition, the third quarter of 2008 and 2007 net earnings include the impact of specified items as discussed under "Use of Non-GAAP Financial Information."

-- The company reported earnings from continuing operations of $588 million or $0.30 per diluted share which represented a 21% decrease from prior year primarily due to the impact of specified items.

-- Non-GAAP earnings from continuing operations excluding specified items amounted to $910 million, or $0.46 per diluted share, which represents a 39% increase from the prior year. This increase is driven by higher sales growth, improved gross margins and execution of cost-containment measures.

SELECTED BALANCE SHEET AND CASH UPDATES

-- The company's financial condition improved significantly during the quarter as a result of $1.4 billion of cash generated from operating activities as well as $4.1 billion in proceeds from the sale of ConvaTec. Cash and cash equivalents were $7.2 billion as of September 30, 2008 of which a significant majority was invested in U.S. Treasury Bills and Treasury-backed securities, consistent with the more conservative approach the company announced it would take earlier in 2008.

-- Net debt, which is defined as short-term borrowings and long-term debt less cash and cash equivalents and marketable securities, was reduced by $4.6 billion to a net cash position of $1.2 billion.

-- An impairment charge of $224 million, $184 million net of tax, related to certain auction rate securities (ARS) was recognized during the three months ended September 30, 2008. The charge was required after an analysis of other-than-temporary impairment factors, including the severity of decline in the securities and current financial market conditions. The carrying value of the $811 million of principal invested in ARS as of December 31, 2007 has been reduced to a remaining amount of $213 million as of September 30, 2008.

BUSINESS DEVELOPMENT UPDATE

Eli Lilly commenced a tender offer to acquire ImClone on October 14, 2008. Based on Bristol-Myers Squibb's ownership of 14.4 million shares of ImClone, the company expects to receive approximately $1.0 billion in cash upon the closing of the transaction. Bristol-Myers Squibb continues to have long-term marketing rights to ERBITUX in the U.S. and Canada and believes it has rights to ImClone's investigational compound IMC-11F8.

The company is executing on its strategic priorities for its healthcare group. On August 1, the company announced that it had completed the divestiture of the ConvaTec business unit to Nordic Capital Fund VII and Avista Capital Partners. On September 25, the company announced that Mead Johnson Nutrition Company had filed a registration statement with the U.S. Securities and Exchange Commission for an initial public offering of its Class A common stock.

Bristol-Myers Squibb is focusing on supplementing its internal research and development portfolio with strategic partnerships and acquisitions. In August, the company announced a global alliance with PDL BioPharma to develop and commercialize elotuzumab, an anti-CS1 antibody currently in Phase I development for multiple myeloma.

NEW PRODUCT PIPELINE UPDATE

Bristol-Myers Squibb and its partner AstraZeneca announced on July 23 that the regulatory submissions for ONGLYZA (saxagliptin) were made in both the United States and in Europe on June 30 and July 1, respectively. On September 2, the U.S. Food and Drug Administration (FDA) announced it had accepted the filing.

The following regulatory and data milestones occurred in the third quarter or in October:

-- On October 1, the FDA approved the use of REYATAZ(R) (atazanavir sulfate) 300 milligram once-daily boosted with ritonavir 100 milligram as part of combination therapy in previously untreated (treatment-naive) HIV-1 infected patients. This use of once-daily REYATAZ/ritonavir in HIV-1 infected treatment-naive adult patients is based upon 48-week results from the CASTLE study, which demonstrated similar antiviral efficacy of REYATAZ/ritonavir to twice-daily lopinavir/ritonavir, each as part of HIV combination therapy in treatment-naive HIV-1 infected adult patients. Data from the CASTLE study were published in the August 23 issue of The Lancet.

-- Bristol-Myers Squibb and its development partner Pfizer announced in August that the primary endpoint was not met in a Phase III study of apixaban - a novel anticoagulant - for prevention of venous thromboembolism (VTE) in patients undergoing total knee replacement. The rate of the primary efficacy endpoint on apixaban was numerically similar to that observed with enoxaparin, but did not meet the pre-specified statistical criteria for non-inferiority compared to enoxaparin. The results of the trial do not necessitate any changes in protocols of any other ongoing apixaban studies. The companies are considering further studies in preventing VTE in knee surgery and will not submit the U.S. filing for VTE prevention in the second half of 2009, as had been previously communicated. Programs directed toward prevention of VTE including EMEA registrational studies, treatment of VTE, and in the prevention of stroke in atrial fibrillation continue as planned.

-- A Phase II study of apixaban (APPRAISE-1) provided encouraging trends suggesting that anticoagulation with apixaban on top of current standards of care and continued beyond the initial hospitalization for acute coronary syndrome may reduce the risk of a second heart attack, stroke or death.

-- The company and its development partner AstraZeneca announced results of phase III studies of ONGLYZA(TM) (saxagliptin), a potential treatment for type 2 diabetes, in September at the European Association for the Study of Diabetes. Data showed ONGLYZA, used in combination with metformin as initial therapy, when added to a sulfonylurea or thiazolidinedione in patients with inadequately controlled type 2 diabetes significantly lowered A1C and demonstrated significant improvements across key measures of glucose control.

-- Bristol-Myers Squibb and its development partner ImClone Systems announced ERBITUX(R) five-year data showing significant improvement in overall survival for patients with locally or regionally advanced head and neck cancer. In the September 10 issue of the New England Journal of Medicine, the EXTREME study was published and it showed that ERBITUX improved survival in first-line recurrent and/or metastatic head and neck cancer.

-- Bristol-Myers Squibb and its development partner Medarex, Inc. announced in September updated survival data from three phase 2 studies of ipilimumab in patients with advanced metastatic melanoma (state III or IV) who had been previously treated. Study results showed that approximately half of patients who received ipilimumab (10 mg/kg) remained alive beyond one year.

2008 GUIDANCE

Bristol-Myers Squibb is raising its 2008 earnings guidance for fully diluted earnings per share from continuing operations on a GAAP basis to between $1.61 and $1.66, reflecting an estimated $900 million pre-tax gain ($0.29 per share after tax) from Eli Lilly's acceptance of the company's tender of its ImClone shares. If the company does not receive such cash from the tender, the company expects to lower 2008 guidance on a GAAP basis to between $1.32 to $1.37 per share. The company is also refining its 2008 fully diluted earnings per share from continuing operations guidance on a non-GAAP basis to be between $1.65 and $1.70, which is the upper end of its previous guidance. The non-GAAP guidance excludes specified items as discussed under "Use of Non-GAAP Financial Information." Details reconciling the GAAP and non-GAAP bases are provided in supplemental materials available on the company's website.

The company reaffirms guidance that it expects non-GAAP earnings per share from continuing operations to grow at a minimum of 15 percent compounded annual growth rate, from the 2007 base through 2010 without rebasing for the agreement to sell the ConvaTec business, excluding costs associated with the Productivity Transformation Initiative and other specified items that have not yet been identified and quantified.

The non-GAAP 2008 guidance and the three-year compound annual growth rate exclude other specified items such as gains or losses from sale of businesses and product lines; from sale of equity investments and from discontinuations of operations; restructuring and other exit costs; accelerated depreciation charges; asset impairments; charges and recoveries relating to significant legal proceedings; upfront and milestone payments for licensing arrangements; payments for in-process research and development; debt retirement costs; impairments to investments; and significant tax events.

The financial guidance for 2008 and the three-year compound annual growth rate exclude the impact of any potential strategic acquisitions and divestitures and further assume that the company and its product partner, sanofi-aventis, maintain U.S. exclusivity for the PLAVIX(R) patent through at least 2010.

Use of Non-GAAP Financial Information

This press release contains non-GAAP financial measures, including non-GAAP earnings and earnings per share information, adjusted to exclude certain costs, expenses, gains and losses and other specified items. Among the items in GAAP measures but excluded for purposes of determining adjusted earnings and other adjusted measures are: charges related to implementation of the Productivity Transformation Initiative and the company's strategy for Mead Johnson Nutritionals; gains or losses from sale and leaseback of properties and from discontinuations of operations; restructuring and other exit costs; accelerated depreciation charges; asset impairments; charges relating to significant legal proceedings; upfront and milestone payments for in-licensing of products that have not achieved regulatory approval that are immediately expensed; payments for in-process research and development; impairments to investments; and significant tax events. This information is intended to enhance an investor's overall understanding of the company's past financial performance and prospects for the future. For example, non-GAAP earnings and earnings per share information is an indication of the company's baseline performance before items that are considered by the company to be not reflective of the company's ongoing results. In addition, this information is among the primary indicators the company uses as a basis for evaluating company performance, allocating resources, setting incentive compensation targets, and planning and forecasting of future periods. This information is not intended to be considered in isolation or as a substitute for net earnings or diluted earnings per share prepared in accordance with GAAP.

Statement on Cautionary Factors

This press release contains certain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans and projections regarding the company's financial position, results of operations, market position, product development and business strategy. These statements may be identified by the fact that they use words such as "anticipate", "estimates", "should", "expect", "guidance", "project", "intend", "plan", "believe" and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes and results to differ materially from current expectations. These factors include, among other things, market factors (including whether uncertainties in the credit and capital markets or a further deterioration of these markets will lead to future impairments to the company's investment portfolio), competitive product development and approvals, pricing controls and pressures (including changes in rules and practices of managed care groups and institutional and governmental purchasers), economic conditions such as interest rate and currency exchange rate fluctuations, judicial decisions and governmental laws and regulations related to Medicare, Medicaid and healthcare reform, pharmaceutical rebates and reimbursement, claims and concerns that may arise regarding the safety and efficacy of in-line products and product candidates, changes to wholesaler inventory levels, variability in data provided by third parties, changes in, and interpretation of, governmental regulations and legislation affecting domestic or foreign operations, including tax obligations, difficulties and delays in product development, manufacturing or sales, patent positions and the ultimate outcome of any litigation matter, including whether Apotex will prevail in its appeal of the District court's decision in the PLAVIX(R) patent litigation. These factors also include the company's ability to execute successfully its strategic plans, including its Productivity Transformation Initiative, the expiration of patents or data protection on certain products (including the expiration of data protection for PLAVIX(R) in the European Union), and the impact and result of governmental investigations. There can be no guarantees with respect to pipeline products that future clinical studies will support the data described in this release, that the products will receive necessary regulatory approvals, or that they will prove to be commercially successful; nor are there guarantees that regulatory approvals will be sought, or sought within currently expected timeframes, or that contractual milestones will be achieved. For further details and a discussion of these and other risks and uncertainties, see the company's periodic reports, including the annual report on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K, filed with or furnished to the Securities and Exchange Commission. The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.

Statement on Mead Johnson Nutrition Company Registration Statement

A registration statement relating to the securities of Mead Johnson Nutrition Company has been filed with the U.S. Securities and Exchange Commission but has not yet become effective. These securities may not be sold nor may offers to buy these securities be accepted before the time the registration statement becomes effective. This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Company and Conference Call Information

Bristol-Myers Squibb is a global biopharmaceutical and company whose mission is to extend and enhance human life.

There will be a conference call on October 23, 2008 at 10:30 a.m. (EDT) during which company executives will address inquiries from investors and analysts. Investors and the general public are invited to listen to a live web cast of the call at www.bms.com/ir or by dialing 913-312-9330, confirmation code 7242577. Materials related to the call will be available at the same website prior to the call.

For more information, contact: Brian Henry, 609-252-3337, Communications, Tracy Furey, 609-252-3208, Communications, John Elicker, 212-546-3775, Investor Relations, or Suketu Desai, 609-252-5796, Investor Relations.

ABILIFY(R) is the trademark of Otsuka Pharmaceutical Co., Ltd.

ATRIPLA(TM) is a trademark of both Bristol-Myers Squibb Co. and Gilead Sciences, Inc.

AVAPRO(R), AVALIDE(R) and PLAVIX(R) are trademarks of sanofi-aventis

ERBITUX(R) is a trademark of ImClone Systems Incorporated -0-



                     BRISTOL-MYERS SQUIBB COMPANY
                   NET SALES BY OPERATING SEGMENTS
   FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                   (Unaudited, dollars in millions)

                                  Three Months         Nine Months
                               Ended September 30, Ended September 30,
                               ---------------------------------------
                                 2008       2007     2008      2007
                               --------   -------- --------- ---------

Pharmaceuticals                 $ 4,510    $ 3,926  $ 13,173  $ 11,234

Nutritionals                        744        675     2,175     1,901
                               ---------------------------------------

Net Sales                       $ 5,254    $ 4,601  $ 15,348  $ 13,135
                               =======================================

-0-



                     BRISTOL-MYERS SQUIBB COMPANY
                          SELECTED PRODUCTS
   FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                   (Unaudited, dollars in millions)

  The following table sets forth worldwide and U.S. reported net sales
   for selected products for the three and nine months ended September
   30, 2008 compared to the three and nine months ended September 30,
   2007. In addition, the table includes, where applicable, the
   estimated total U.S. prescription change for the retail and mail-
   order channels for the comparative periods presented for certain of
   the company's U.S. pharmaceutical products based on third-party
   data. A significant portion of the company's U.S. pharmaceutical
   sales is made to wholesalers. Where changes in reported net sales
   differ from prescription growth, this change in net sales may not
   reflect underlying prescriber demand.

-0-


               Worldwide Net Sales     U.S. Net Sales
               -------------------- --------------------
                                                         % Change in
                                                           U.S. Total
                               %                    %    Prescriptions
                2008   2007  Change  2008   2007  Change    vs. 2007
               ------ ------ ------ ------ ------ ------ -------------

Three Months
 Ended
 September 30,
---------------

Pharmaceuticals
---------------
Cardiovascular
   Plavix      $1,439 $1,254    15% $1,263 $1,080    17%       7%
   Avapro/
    Avalide       334    309     8%    189    176     7%      (7)%
   Pravachol       34     86  (60)%   (18)     17   *        (52)%
Virology
   Reyataz        342    273    25%    176    141    25%      18%
   Sustiva
    Franchise
    (total
    revenue)      294    237    24%    185    151    23%      15%
   Baraclude      144     72   100%     36     22    64%      59%
Oncology
   Erbitux        184    185   (1)%    182    183   (1)%     N/A
   Taxol           91    102  (11)%    (1)      1 (200)%     N/A
   Sprycel         82     46    78%     21     17    24%      29%
   Ixempra         25    ---    ---     24    ---    ---     N/A
Affective
 (Psychiatric)
 Disorders
   Abilify        564    420    34%    435    329    32%      26%
Immunoscience
   Orencia        119     60    98%     97     57    70%     N/A
Nutritionals
---------------
   Enfamil        295    281     5%    178    195   (9)%     N/A

* In excess of +/- 200% -0-

               Worldwide Net Sales     U.S. Net Sales
               -------------------- --------------------
                                                         % Change in
                                                           U.S. Total
                               %                    %    Prescriptions
                2008   2007  Change  2008   2007  Change    vs. 2007
               ------ ------ ------ ------ ------ ------ -------------

Nine Months
 Ended
 September 30,
---------------

Pharmaceuticals
---------------
Cardiovascular
   Plavix      $4,134 $3,381    22% $3,609 $2,882    25%       26%
   Avapro/
    Avalide       974    876    11%    547    509     7%       (7)%
   Pravachol      176    353  (50)%      7    121  (94)%      (78)%
Virology
   Reyataz        963    790    22%    495    422    17%       15%
   Sustiva
    Franchise
    (total
    revenue)      849    696    22%    531    442    20%       14%
   Baraclude      388    176   120%    100     59    69%       60%
Oncology
   Erbitux        567    507    12%    560    501    12%      N/A
   Taxol          286    308   (7)%      2      9  (78)%      N/A
   Sprycel        224    102   120%     62     41    51%       42%
   Ixempra         76    ---    ---     75    ---    ---      N/A
Affective
 (Psychiatric)
 Disorders
   Abilify      1,547  1,198    29%  1,186    944    26%       20%
Immunoscience
   Orencia        312    156   100%    257    150    71%      N/A
Nutritionals
---------------
   Enfamil        872    802     9%    536    543   (1)%      N/A

-0-



                     BRISTOL-MYERS SQUIBB COMPANY
                 CONSOLIDATED STATEMENTS OF EARNINGS
   FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
        (Unaudited, amounts in millions except per share data)

                                  Three Months         Nine Months
                               Ended September 30, Ended September 30,
                               ------------------- -------------------
                                  2008      2007      2008      2007
                               ----------- ------- ---------- --------

Net Sales                          $5,254  $4,601    $15,348  $13,135
                               ----------- ------- ---------- --------
Cost of products sold               1,634   1,478      4,874    4,152
Marketing, selling and
 administrative                     1,208   1,105      3,507    3,260
Advertising and product
 promotion                            362     338      1,101      950
Research and development              834     802      2,442    2,338
Acquired in-process research
 and development                       --      --         32       --
Provision for restructuring,
 net                                   26      --         67       44
Litigation expense, net                30      --         32       14
Gain on sale of product assets         --    (247)        --     (273)
Equity in net income of
 affiliates                          (164)   (139)      (478)    (393)
Other expense, net (a)                169       8        188       29
                               ----------- ------- ---------- --------
Total expenses                      4,099   3,345     11,765   10,121
                               ----------- ------- ---------- --------
Earnings from Continuing
 Operations
Before Minority Interest and
 Income Taxes                       1,155   1,256      3,583    3,014
Provision for income taxes            308     292        896      535
Minority interest, net of
 taxes                                259     211        730      546
                               ----------- ------- ---------- --------
Net Earnings from Continuing
 Operations                           588     753      1,957    1,933
                               ----------- ------- ---------- --------

Discontinued Operations:
Earnings, net of taxes                  8     105        107      321
Gain on Disposal, net of taxes      1,982      --      1,939       --
                               ----------- ------- ---------- --------
                                    1,990     105      2,046      321
                               ----------- ------- ---------- --------
Net Earnings                       $2,578  $  858    $ 4,003  $ 2,254
                               =========== ======= ========== ========
Earnings per Common Share
Basic:
  Net Earnings from Continuing
   Operations                      $ 0.30  $ 0.38    $  0.99  $  0.98
  Discontinued Operations:
     Earnings, net of taxes            --    0.05       0.06     0.17
     Gain on Disposal, net of
      taxes                          1.00      --       0.98       --
                               ----------- ------- ---------- --------
  Net Earnings per Common
   Share                           $ 1.30  $ 0.43    $  2.03  $  1.15
                               =========== ======= ========== ========
Diluted:
  Net Earnings from Continuing
   Operations                      $ 0.30  $ 0.38    $  0.98  $  0.98
  Discontinued Operations:
     Earnings, net of taxes            --    0.05       0.05     0.16
                               -----------
     Gain on Disposal, net of
      taxes                          0.99      --       0.97       --
                               ----------- ------- ---------- --------
  Net Earnings per Common
   Share                           $ 1.29  $ 0.43    $  2.00  $  1.14
                               =========== ======= ========== ========

Average Common Shares
 Outstanding:
Basic                               1,977   1,974      1,976    1,968
Diluted                             2,004   2,012      2,006    2,005

(a) Other expense, net
     Interest expense              $   84  $  109    $   237  $   325
     Interest income                  (37)    (69)      (111)    (184)
     Impairment charge of
      marketable securities           224      --        247       --
     Foreign exchange
      transaction
      (gains)/losses                  (51)     21        (34)      24
     Other, net                       (51)    (53)      (151)    (136)
                               ----------- ------- ---------- --------
                                   $  169  $    8    $   188  $    29
                               =========== ======= ========== ========

-0-



                     BRISTOL-MYERS SQUIBB COMPANY
                           SPECIFIED ITEMS
        FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                   (Unaudited, dollars in millions)

Three months ended
 September 30, 2008
-----------------------

                        Mark-
                        eting,
                        sell-          Pro-
                         ing          vision
                  Cost    and   Re-     for
                   of    ad-   search   re-    Liti-     Other
                  pro-  mini-   and   struct-  gation  (income)/
                  ducts stra-  devel- uring,  expense, expense,
                  sold   tive  opment   net     net       net    Total
                  ----------------------------------------------------
Productivity
 Transformation
 Initiative:
Downsizing and
 streamlining of
 worldwide
  operations       $ -   $ -    $ -    $ 26     $  -    $   -    $26
Accelerated
 depreciation and
 other
 shutdown costs     53     -      -       -        -        -     53
Process
 standardization
 implementation
  costs              -     28     -       -        -        -     28
                  ----------------------------------------------------
                    53     28     -      26        -        -     107

Litigation
 Matters:
Litigation
 settlement          -     -      -       -       30        -     30

Other:
Mead Johnson
 Nutritionals
 charges             -     9      -       -        -        -      9
Product liability    -     -      -       -        -        2      2
Upfront and
 milestone
 payments            -     -      37      -        -        -     37
Auction rate
 securities
 impairment          -     -      -       -        -       224    224
                  ----------------------------------------------------
                   $53   $ 37   $ 37   $ 26     $ 30    $  226    409
                  ==============================================
Income taxes on
 items above                                                      (87)
                                                                 -----
(Increase)/Decrease to Net Earnings
 from Continuing Operations                                      $322
                                                                 =====

-0-


Three months ended September
 30, 2007
-------------------------------

                                              Gain
                                             on sale   Other
                       Cost of                  of    (income)/
                      products  Research and product expense,
                        sold    development   assets     net    Total
                      ------------------------------------------------
Litigation Matters:
Insurance recovery      $  -        $   -     $   -   $  (11)   $ (11)
Product liability          -            -         -        5        5
                      ------------------------------------------------
                           -            -         -       (6)      (6)

Other:
Upfront and milestone
 payments                  -           60         -        -       60
Accelerated
 depreciation and
 asset impairment          17                     -        -       17
Gain on sale of
 product assets            -            -      (247)       -     (247)
                      ------------------------------------------------
                        $  17       $  60     $(247)  $   (6)    (176)
                      =========================================
Income taxes on items
 above                                                             82
                                                                ------
(Increase)/Decrease to Net Earnings from Continuing
 Operations                                                     $ (94)
                                                                ======

-0-



                     BRISTOL-MYERS SQUIBB COMPANY
                           SPECIFIED ITEMS
        FOR THE NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                   (Unaudited, dollars in millions)

Nine months ended
 September 30, 2008
----------------------

                       Mark-
                       eting,
                       sell-          Pro-
                        ing          vision
                 Cost   and    Re-     for
                   of   ad-   search   re-    Liti-     Other
                 pro-  mini-   and   struct-  gation  (income)/
                 ducts strat- devel- uring,  expense, expense,
                 sold   ive   opment   net     net       net    Total
                 -----------------------------------------------------
Productivity
 Transformation
 Initiative:
Downsizing and
 streamlining of
 worldwide
  operations     $ -   $  -    $ -     $ 67    $  -     $   -   $  67
Accelerated
 depreciation
 and other
 shutdown costs   207     -      -       -        -         -     207
Process
 standardization
 implementation
  costs            -     64      -       -        -         -      64
Gain on sale and
 leaseback of
 properties        -      -      -       -        -        (9)     (9)
                 -----------------------------------------------------
                  207    64      -       67       -        (9)    329


Litigation
 Matters:
Litigation
 settlement        -      -      -       -       32         -      32

Other:
Mead Johnson
 Nutritionals
 charges           -     10      -       -        -         -      10
Product
 liability         -      -      -       -        -        18      18
Upfront and
 milestone
 payments          -      -      88      -        -         -      88
Acquired in-
 process
 research &
 development       -      -      32      -        -         -      32
Auction rate
 securities
 impairment        -      -      -       -        -       247     247
                 -----------------------------------------------------
                 $207  $ 74    $120    $ 67    $ 32     $256      756
                 ==============================================
Income taxes on
 items above                                                     (154)
                                                                ------
(Increase)/Decrease to
 Net Earnings from
 Continuing Operations                                          $ 602
                                                                ======

-0-


Nine months ended
 September 30, 2007
---------------------

                              Pro-
                             vision
                Cost   Re-     for
                  of  search   re-    Liti-     Other   Gain on
                pro-   and   struct-  gation  (income)/ sale of
                ducts devel- uring,  expense, expense,  product
                sold  opment   net     net       net    assets  Total
                ------------------------------------------------------
Litigation
 Matters:
Litigation
 settlement      $ -   $  -    $  -    $   14  $    -   $    -  $  14
Insurance
 recovery          -      -       -        -      (11)       -    (11)
Product
 liability         -      -       -        -        5        -      5
                ------------------------------------------------------
                   -      -       -        14      (6)       -      8

Other:
Upfront and
 milestone
 payments          -     157      -        -        -        -    157
Downsizing and
 streamlining
 of worldwide
 operations        -      -       44       -        -        -     44
Accelerated
 depreciation
 and asset
 impairment        46     -       -        -        -        -     46
Gain on sale of
 product assets    -      -       -        -        -     (273)  (273)
                ------------------------------------------------------
                 $ 46  $ 157   $  44   $   14  $   (6)  $ (273)   (18)
                ===============================================
Income taxes on
 items above                                                       37
Change in estimate for taxes on prior year items                  (39)
                                                                ------
(Increase)/Decrease to Net Earnings from Continuing
 Operations                                                     $ (20)
                                                                ======

-0-



                     BRISTOL-MYERS SQUIBB COMPANY
       RECONCILIATION OF GAAP RESULTS OF CONTINUING OPERATIONS
             TO NON-GAAP RESULTS OF CONTINUING OPERATIONS
        FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
        (Unaudited, amounts in millions except per share data)

                            Q3 2008                   Q3 2007
                           Specified   Non           Specified   Non
                    GAAP    Items*    GAAP    GAAP    Items*    GAAP
                   -------                   -------------------------

Net Sales          $5,254            $5,254  $4,601            $4,601
Cost of Products
 Sold               1,634     (53)    1,581   1,478     (17)    1,461
                   -------           ------- -------           -------
  Gross Profit      3,620      53     3,673   3,123      17     3,140
     Gross Margin
      as % of
      Sales          68.9%    1.0%     69.9%   67.9%    0.3%     68.2%

Marketing Selling
 and Admin          1,208     (37)    1,171   1,105             1,105
Advertising and
 Product Promotion    362               362     338               338
                   -------           ------- -------           -------
  Total SGA         1,570     (37)    1,533   1,443             1,443
     SG&A as % of
      Sales          29.9%   (0.7%)    29.2%   31.4%             31.4%

R&D                   834     (37)      797     802     (60)      742
     R&D as % of
      Sales          15.9%   (0.7%)    15.2%   17.4%   (1.3%)    16.1%

Provision for
 restructuring,
 net                   26     (26)        -       -       -         -
Litigation
 expense, net          30     (30)        -       -       -         -
Gain on sale of
 Product Assets         -       -         -    (247)    247         -
Equity in Net
 Income of
 Affiliates          (164)      -      (164)   (139)      -      (139)
Other
 expense/(income),
 net                  169    (226)      (57)      8       6        14
                   -------           ------- -------           -------

Earnings from
 Continuing
 Operations
Before Minority
 Interest & Taxes  $1,155     409    $1,564  $1,256    (176)   $1,080

Provision for
 income taxes         308      87       395     292     (82)      210

Minority Interest,
 net of taxes         259               259     211               211
                   -------           ------- -------           -------

Net Earnings -
 Continuing
 Operations           588     322       910     753     (94)      659

  Net Earnings -
   Discontinued
   Ops              1,990             1,990     105               105
                   -------           ------- -------           -------
Net Earnings       $2,578     322    $2,900  $  858     (94)   $  764
                   =======           ======= =======           =======

  Interest Exp on
   Conv. Of Conv
   Debt Bonds           4                 4      10                10
Net Earnings used
 for Diluted EPS
 Calc - Continuing
 Operations.       $  592     322    $  914  $  763     (94)   $  669

Avg Shares
 (Diluted)          2,004             2,004   2,012             2,012

Diluted EPS -
 Continuing
 Operations        $ 0.30    0.16    $ 0.46  $ 0.38   (0.05)   $ 0.33

      Net Earnings
       -
       Continuing
       Operations
       as a % of
       sales         11.2%    6.1%     17.3%   16.4%   (2.1%)    14.3%

       Effective
        Tax Rate     26.7%   (1.4%)    25.3%   23.2%   (3.8%)    19.4%

* Please refer to the Specified Items schedules for further details.

-0-



                     BRISTOL-MYERS SQUIBB COMPANY
                         NET DEBT CALCULATION
              AS OF SEPTEMBER 30, 2008 AND JUNE 30, 2008
                   (Unaudited, dollars in millions)


                                      September 30, 2008 June 30, 2008
                                      ------------------ -------------
Cash and cash equivalents                $    7,173       $   4,047
Marketable securities-current                   258             355
Short-term borrowings                          (135)         (1,799)
Long-term debt                               (6,120)         (6,021)
                                      ------------------ -------------
Net cash / (debt)                        $    1,176       $  (3,418)
                                      ================== =============

Contact

Bristol-Myers Squibb Company
Communications:
Brian Henry, 609-252-3337
Tracy Furey, 609-252-3208
or
Investor Relations:
John Elicker, 212-546-3775
Suketu Desai, 609-252-5796

Posted: October 2008


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