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AstraZeneca PLC - Fourth Quarter and Full Year Results 2006

“AstraZeneca reports strong financial results for 2006, with EPS up 34 percent, and progress in strengthening the pipeline; Company continues to drive productivity improvements.”

Financial Highlights

Group 4th Quarter 2006 $m 4th Quarter 2005 $m Actual % CER % Full Year  2006 $m Full Year  2005 $m Actual % CER %
Sales  7,154  6,286 +14 +11 26,475 23,950 +11 +11
Operating Profit 2,003  1,636 +22 +24 8,216 6,502 +26 +28
Profit before Tax 2,103  1,689 +25 +26 8,543  6,667 +28 +29
Earnings per Share $0.93 $0.77 +21 +22 $3.86 $2.91 +33 +34
Adjusted to exclude Toprol-XLTM in US**
Sales 6,878  5,940 +16  +13 25,093 22,659 +11  +11
Earnings per Share $0.83 $0.66 +26 +29  $3.36 $2.50 +35 +36

** This Non-GAAP presentation excludes US sales and earnings contribution from Toprol-XLTM from both current year and prior year periods.
All narrative in this section refers to growth rates at constant exchange rates (CER) unless otherwise indicated

Sales for the full year increased by 11 percent to $26,475 million.

Strong performance of five key growth products (NexiumTM, SeroquelTM, CrestorTM, ArimidexTM and SymbicortTM) with combined sales reaching $13,318 million, up 23 percent for the full year.

Operating profit increased by 28 percent for the full year to $8,216 million. Operating margin improved by 3.8 percentage points to 31.0 percent of sales.

Free cash flow of $6,788 million for the full year. Returns to shareholders totalled $5,382 million (dividends $2,220 million; net share repurchases $3,162 million).

Since December 2005, the Company has entered into twelve significant licensing and acquisition projects and nine significant research collaborations.

On 11 January 2007, AstraZeneca announced a worldwide collaboration with Bristol-Myers Squibb to develop and commercialise two diabetes compounds, including saxagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in Phase III development.

The Company continues to drive productivity; initiative to improve asset utilisation announced (see page 3).

The Company anticipates earnings per share for 2007 (excluding any contribution from US sales of Toprol-

XLTM and excluding any one-off costs associated with productivity initiatives) in the range of $3.80 to $4.05 (compared with EPS in 2006 excluding Toprol-XLTM of $3.36).

Dividend increased by 32 percent to $1.72 for the full year. Net share repurchases for 2007 set at $4 billion.


LONDON, 1 February 2007-David Brennan, Chief Executive Officer, said
: “In 2006, AstraZeneca reported another strong set of financial results and progress in strengthening the pipeline, but more remains to be done. Our agenda is clear. We are determined to maintain the sales momentum of our current product portfolio and to continue to build a pipeline to sustain our growth, while driving further productivity improvements and enhancing cash  returns to shareholders.”

Media Enquiries: Steve Brown/Edel McCaffrey (London) (020) 7304 5033/5034

Staffan Ternby (Södertälje) (8) 553 26107

Emily Denney (Wilmington) (302) 886 3451

Analyst/Investor Enquiries: Mina Blair/Jonathan Hunt/Karl Hård (London) (020) 7304 5084/5087/5322

Staffan Ternby (Södertälje) (8) 553 26107

Ed Seage/Jörgen Winroth (US) (302) 886 4065/(212) 579 0506

Pictures of senior executives are available on www.newscast.co.uk. Broadcast footage of AstraZeneca products and activities is available on www.thenewsmarket.com/astrazeneca. Interviews with David Brennan, Chief Executive Officer, Jon Symonds, Chief Financial Officer and John Patterson, Executive Director Development are available on www.astrazeneca.com


For full report, see attachments

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