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All News Consumer Pharma New Drugs Pipeline Clinical Trials

June 2007

June 1

Bristol-Myers Squibb Awards Immunicon New Research Services Agreement for Oncology Biomarker Development Isogenica Enters into Research and License Agreement with Wyeth Mylan Wins Omeprazole Patent Litigation Jazz Pharmaceuticals, Inc. Announces Initial Public Offering Nventa Consolidates Offices Into San Diego Black Horse Capital Opposes the Strategic Direction of Cypress Bioscience MOLOGEN AG Sells Spanish Subsidiary Revision - Decision Fails Patients with Transfusion-Dependent Anemia Termination of Development of Fixed Dose Combination Product of Actos + TAK-536 AstraZeneca’s Prilosec Patents Upheld By Court Barr Confirms Decision in Azithromycin Inventorship Suit Pharmaceutical Blog Chatter Continues About Dr. Steven Nissen’s Avandia Revelations, Most Bloggers Refute Transition Therapeutics Acquires All Remaining Shares of NeuroMedix Inc. ImpaxX Announces Decision on Generic Prilosec Litigation

June 4

Bayer Schering Pharma AG Will Terminate Registration With the U.S. SEC Final Data from a Phase 2 Trial Presented at ASCO Specifies Dose-dependent Activity of Adecatumumab (MT201) AstraZeneca Acquires Biologics Manufacturing Facility in Canada Cell Genesys and Medarex Report Follow-Up Data From a Phase 1 Combination Therapy Trial With GVAX Immunotherapy for Prostate Cancer and Ipilimumab (MDX-010) Antibody New Data Evaluating Sutent, CP-751,871 and Axitinib in Patients with Non-Small Cell Lung Cancer Phase III Study Shows Avastin Plus Interferon Therapy Nearly Doubled Median Progression-Free Survival in Patients With Previously Untreated Advanced Kidney Cancer GlaxoSmithKline Reports Positive New Data on Tykerb at the 2007 ASCO Annual Meeting Phase III Ixabepilone Study Demonstrated Significant Improvement in Progression-Free Survival in Patients With Advanced Metastatic Breast Cancer Telik Announces Top-Line Results of TELCYTA ASSIST-2 Trial Telik Reports Results of TELCYTA ASSIST-1 Trial Telik Reports Results of TELCYTA Assist-3 Trial Barr and Eli Lilly Voluntarily Dismiss Patent Litigation on Prozac Weekly DTC Advertising Improvements Observed In Two New Reports FDA Announces New Advisory Committee to Address Risk Communication

June 5

Neurogen Announces Continuing Preclinical and Clinical Development Work and Conclusion of Research Component of Collaboration for Investigational Pain Drug APT Acquires Exclusive Worldwide Rights to Develop and Commercialize Inhalable Cyclosporine to Prevent Lung Transplant Rejection Eurand and GSK Reach Development Milestone Telik Announces Clinical Hold on TELCYTA Trials Corautus Genetics Stockholders Approve Merger with VIA Pharmaceuticals and Related Proposals Amgen to Acquire Ilypsa, a Private San Francisco Bay Area Biotechnology Company Focused on Kidney Disease Care Inovio Biomedical Stops Enrollment of Phase III Clinical Trials for Head & Neck Cancer Valeant Pharmaceuticals Agrees to Sell Manufacturing Facilities in Basel, Switzerland and Humacao, Puerto Rico Enzo Life Sciences, Inc., Completes Acquisition of Axxora Life Sciences, Inc. Mylan Wins Its Amlodipine Case With Pfizer

June 11

ZARS, Inc. Files Registration Statement for Initial Public Offering Announcement of the Launch of the Selective COX-2 Inhibitor Celecox Tablets in Japan Kurve Technology and Schering-Plough Sign Expanded Technology Agreement Archemix and Merck KGaA Sign Strategic Alliance AMRI Receives Milestone Payment From Licensing Agreement with Bristol-Myers Squibb Archemix and Takeda to Enter into Collaboration for Discovery and Development of Aptamer Therapeutics Merck Signs Strategic Alliance With Archemix Pediatric Inhaled Corticosteroid Asthma Medication Features New Dose Counters to Help Track Usage Barr Announces Withdrawal of Zyprexa Zydis Patent Litigation Teva Receives Favorable Court Decision Regarding Generic Lotrel; Novartis' Motion for Preliminary Injunction Denied US Court Allows Teva to Resume US Sales of Its Generic Version of Lotrel Athersys Raises $65 Million in Concurrent Reverse Merger and Private Equity Offering U.S. Department of Justice Investigation of Bristol-Myers Squibb in Proposed Plavix Patent Settlement Is Resolved

June 19

Roche Acquires NimbleGen to Gain Entry Into High-Growth Research Microarrray Market Regulatory Cooperation Expanded Verispan Reports: Biotech Companies Cut Sales Forces, but Managed Care Execs Want More Contact Bayer Raises Guidance for 2007 and 2009 Diamyd Continues Invalidated Study ZymoGenetics Establishes Global Collaboration With Bayer HealthCare for Development and Commercialization of Recombinant Human Thrombin Safety Measures for Oseltamivir Phosphate and Chugai's Future Approach Impax Announces Lawsuit Related to Generic Version of Depakote ER Imaging Agent from Avid Radiopharmaceuticals to Be Licensed by Bayer Schering Pharma for Early Detection of Alzheimer's Disease Sanofi-Aventis and Bristol-Myers Squibb Prevail in U.S. Plavix Patent Litigation Myriad Genetics Collaborates With AstraZeneca on Phase 2 Trials CuraGen to Close Pilot Manufacturing Plant

June 25

AstraZeneca Announces Symbicort Is Now Available In The U.S. European Medicines Agency Recommends Restricted Use for Piroxicam Biodel Inc. Announces VIAject(TM) Data at Oral Presentation at the American Diabetes Association Meeting New Data Show Patients Treated With Avandia (Rosiglitazone Maleate) Incurred Lower Medical Costs and Used Fewer Healthcare Resources When Compared to Patients Treated With Sulphonylureas Roche and Toyama Chemical Enter Licensing Agreement to Develop Potential Breakthrough Drug to Treat Rheumatoid Arthritis Apidra Improved A1C In People With Type 2 Diabetes When Added to Basal Insulin and Oral Antidiabetic Treatments (BOT) Generex Biotechnology to Initiate Phase III Clinical Trial of Generex Oral-lyn in 2007 Third Quarter Diabetes Patients Make Significant Gains in Disease Control; Still, Nearly Half Fail to Reach ADA Treatment Goals Coalition Urges American Medical Association to Halt Sale of Physician Data to Pharmaceutical Marketing Firms New Findings Show Half of Americans Surveyed Importing Drugs without a Prescription U.S. Supreme Court Denies Review of Tamoxifen Citrate Antitrust Lawsuits

June 26

Ventana Advises Shareholders to Defer Taking Any Action in Response to Roche Offer UCB and Biogen Idec's Oral VLA-4 Antagonist Enters Phase II Development for Multiple Sclerosis Encysive Pharmaceuticals Appoints New Chief Executive and Announces Restructuring of Company Operations Pharma ChemOutsourcing Conference Posts Attendee List for September Custom Synthesis Blockbuster Show in New Jersey Commonly Prescribed Antidepressants Associated with Lower Bone Density in Older Men and Women NextBio Announces License Agreement with Genzyme Wyeth Licenses Drug Targets from Osteoporosis Collaboration with Galapagos Abbott and Genentech Announce Global, Integrated Research, Development and Commercialization Collaboration in Oncology Daiichi Sankyo Commences Patent Litigation Against Mylan in the United States Organon Announces Acquisition of Kadmus Pharmaceuticals' FAAH Inhibitor Technology Pharsight Invited to Present on Oncology Modeling and Simulation at AAPS National Biotechnology Conference on June 28, 2007 Biotechnology Council of New Jersey and Pennsylvania Bio to Host Seventh Annual Biosciences Symposium Amgen Submits Testimony to House Ways & Means Committee First Consulting Group Acquires Zorch, Inc. Clinquest Takes Stake in Enceladus Physicians Favor a DTC Moratorium More Strongly Than Consumers, though Both Groups Cite Public Safety as the Key Benefit, according to New TNS Healthcare Research

June 27

inVentiv Health to Acquire AWAC, Leader in Providing Medical Cost Containment Services to Payors inVentiv Health to Acquire Chandler Chicco Agency FDA Grants Fast Track Status for HCV-796 for Treatment of Hepatitis C Virus Infection Cardinal Health Reaffirms Fiscal 2008 Outlook; Raises Long-Term Profit Goals Vasogen Reports on Outcome of FDA Meeting Vermont Attorney General Sorrell Releases Pharmaceutical Company Report Nuvelo Resumes Development of Alfimeprase in Multiple Blood-Clot Related Indications Biogen Idec Announces Preliminary Results of Its Modified ''Dutch Auction'' Tender Offer Roche Commences Tender Offer for Ventana for $75 Per Share in Cash Update on Migenix Agreement with Schering-Plough for Hepatitis C Virus Treatment VASTox Announces Significant Progress in Pharmaceutical Services Business Guideline and Med Ad News Host Panel to Discuss Issues Surrounding Patient Compliance MichBio Announces Its 2007 Expo; Bio CEO to be Keynote Speaker Spherix Signs Definitive Agreement for Sale of Information Subsidiary

June 28

Pharsight Preferred Stockholders Elect to Convert Preferred Shares Into Common Stock Materia Licenses Metathesis Catalyst Platform to Eisai Pfizer Board of Directors to Initiate Face-to-Face Meetings with Company's Institutional Investors on Corporate Governance Policies and Practices Isotechnika Will Be Represented at the Canadian Dermatology Annual Conference Bespak plc Exubera Update The General Public Supports Breaking Drug Patents To Ensure Access To HIV/AIDS Drugs In Poorer Countries Lawmakers Praise Committee Passage of Biologics Legislation Bioscience Leaders Discuss Strategies to Propel Industry, Innovations Throughout Southern California Cardinal Health Completes Subsequent Tender Offer for VIASYS Healthcare Thallion Announces Sale of Majority Stake in Caprion Proteomics to Great Point Partners

June 29

Genmab Regains Rights to HuMax-CD4 Lorus Therapeutics Announces Receipt of Court Approval for Proposed Plan of Arrangement Prescription Access Litigation: Federal Judge Allows Zyprexa Class Action to Go Forward Urigen N.A., Inc. Completes Shareholder Meeting Karo Bio Announces Delay in KB5359 Development Yet Another Pfizer Whistleblower Comes Forth Through Blogs, CME Criticism Continues, and Dr. Rost Gains Access to Astrazeneca Ethics Violation Website The International Society for Medical Publication Professionals (ISMPP) Publishes Position Paper on the Role of the Professional Medical Writer Combination of Sartorius Biotech Division and Stedim Completed Merck Names Peter Kellogg as Executive Vice President and Chief Financial Officer RAPS Holds Japan Seminar, High-Ranking Officials Participate

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