Generic Name: epinephrine injection (EP i NEF rin)
Brand Name: Adrenaclick, Adrenaclick Two-Pack, Adrenalin, Auvi-Q, EpiPen 2-Pak, EpiPen Auto-Injector, EpiPen JR 2-Pak, EpiPen JR Auto-Injector, Twinject Auto-Injector, Twinject Auto-Injector Two Pack
What is Twinject Auto-Injector (epinephrine injection)?
Epinephrine is a chemical that narrows blood vessels and opens airways in the lungs. These effects can reverse severe low blood pressure, wheezing, severe skin itching, hives, and other symptoms of an allergic reaction.
Epinephrine injection is used to treat severe allergic reactions (anaphylaxis) to insect stings or bites, foods, drugs, and other allergens. Epinephrine is also used to treat exercise-induced anaphylaxis.
Epinephrine auto-injectors such as EpiPen and EpiPen Jr. may be kept on hand for self-injection by a person with a history of an severe allergic reaction.
Epinephrine injection may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Twinject Auto-Injector (epinephrine injection)?
Epinephrine injection is used to treat severe allergic reactions (anaphylaxis).
Seek emergency medical attention even after you use epinephrine to treat a severe allergic reaction. The effects of epinephrine may wear off after 10 or 20 minutes. You will need to receive further treatment and observation.
Before using epinephrine a second time, tell your doctor if your first injection caused a serious side effect such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
What should I discuss with my healthcare provider before using Twinject Auto-Injector (epinephrine injection)?
To make sure epinephrine is safe for you, tell your doctor if you have:
heart disease or high blood pressure;
a heart rhythm disorder;
coronary artery disease;
a thyroid disorder.
FDA pregnancy category C. It is not known whether epinephrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether epinephrine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.
How should I use Twinject Auto-Injector (epinephrine injection)?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Seek emergency medical attention even after you use this medication to treat a severe allergic reaction. The effects of epinephrine may wear off after 10 or 20 minutes. You will need to receive further treatment and observation.
The auto-injector device this medicine comes in is a disposable single-use system that contains a spring-loaded needle. Epinephrine injection comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Do not remove the safety cap until you are ready to use the auto-injector. Never put your fingers over the tip when removing the safety cap or after the safety cap has been removed.
To use an epinephrine auto-injector:
Form a fist around the auto-injector with the black tip pointing down. Pull off the safety cap.
Place the black tip against the fleshy portion of your outer thigh. You may give the injection directly through your clothing. Do not put your thumb over the end of the unit.
With a quick motion, push the auto-injector firmly against your thigh. This will release the spring-loaded needle that injects the dose of epinephrine. Hold the auto-injector in place for a few seconds after activation.
Remove the auto-injector from your thigh. Carefully re-insert the used device needle-first into the carrying tube. Re-cap the tube and take it with you to the emergency room so that anyone who treats you will know how much epinephrine you have received.
Use each auto-injector only one time. Throw away after one use, even if there is still some medicine left in it.
Do not use the medication if it has changed colors or has any particles in it, or if the expiration date on the label has passed. Call your doctor for a new prescription.
Store at room temperature away from moisture, heat, and light. Do not refrigerate this medication, and do not store it in a car.
What happens if I miss a dose?
Since epinephrine is normally used only as needed in an emergency, you are not likely to be on a dosing schedule. Do not use repeat doses of epinephrine without a doctor's advice.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Twinject Auto-Injector (epinephrine injection)?
Do not inject epinephrine into a vein or into the muscles of your buttocks, or it may not work as well. Inject it only into the fleshy outer portion of the thigh.
Accidentally injecting epinephrine into your hands or feet may result in a loss of blood flow to those areas, and resulting numbness. If this occurs, seek emergency medical attention.
Twinject Auto-Injector (epinephrine injection) side effects
Before using epinephrine a second time, call your doctor if your first injection caused a side effect such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Common side effects may include:
nausea and vomiting;
feeling short of breath;
weakness or tremors;
feeling nervous or anxious.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Twinject side effects (in more detail)
What other drugs will affect Twinject Auto-Injector (epinephrine injection)?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with epinephrine, especially:
a diuretic or "water pill";
an antidepressant--amitriptyline, doxepin, imipramine, nortriptyline, and others;
a beta-blocker--atenolol, carvedilol, labetalol, metoprolol, nadolol, propranolol, sotalol, and others;
cold or allergy medicine that contains an antihistamine;
ergot medicine--ergotamine, dihydroergotamine, ergonovine, methylergonovine (Methergine);
heart rhythm medication such as quinidine (Quin-G); or
an MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine.
This list is not complete. Other drugs may interact with epinephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More Twinject Auto-Injector resources
- Twinject Auto-Injector Prescribing Information (FDA)
- Adrenaclick Prescribing Information (FDA)
- Adrenaclick auto-injector MedFacts Consumer Leaflet (Wolters Kluwer)
- Adrenaclick Advanced Consumer (Micromedex) - Includes Dosage Information
- Adrenalin solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Asthmahaler aerosol MedFacts Consumer Leaflet (Wolters Kluwer)
- Auvi-Q Prescribing Information (FDA)
- Auvi-Q Consumer Overview
- Epinephrine Monograph (AHFS DI)
- Epinephrine Professional Patient Advice (Wolters Kluwer)
- Epinephrine (Mydriatic) eent Monograph (AHFS DI)
- Medihaler-Epi Prescribing Information (FDA)
Compare Twinject Auto-Injector with other medications
Where can I get more information?
- Your doctor or pharmacist can provide more information about epinephrine injection.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 7.01. Revision Date: 2013-03-05, 2:19:44 PM.