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tretinoin topical

Pronunciation

Generic Name: tretinoin topical (TRET in oin)
Brand Name: Altinac, Atralin, Avita, Refissa, Renova, Retin-A, Retin-A Micro Microsphere Pump, Tretinoin Emollient Topical, Tretin-X, ...show all 17 brand names

What is tretinoin topical?

Tretinoin is a form of vitamin A that helps the skin renew itself.

Tretinoin topical (for the skin) is used to treat acne, to smooth rough facial skin, and to reduce the appearance of fine wrinkles and mottled skin discoloration.

Tretinoin topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about tretinoin topical?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

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What should I discuss with my healthcare provider before using tretinoin topical?

You should not use tretinoin topical if you are allergic to it.

FDA pregnancy category C. It is not known whether tretinoin topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether tretinoin topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use tretinoin topical?

Do not take by mouth. Tretinoin topical is for use only on the skin. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects.

Wash your hands before and after applying tretinoin topical. Before applying, clean and dry the skin area to be treated.

Applying tretinoin topical to wet skin may cause skin irritation. If you use Renova, wait at least 20 minutes after washing your face before applying a thin layer of the medication.

Do not wash the treated area for at least 1 hour after applying tretinoin topical. Avoid the use of other skin products on the treated area for at least 1 hour following application of tretinoin topical.

Applying an excessive amount of tretinoin gel may result in "pilling" of the medication. If this occurs, use a thinner layer of gel with the next application.

Tretinoin topical should be used as part of a complete skin care program that includes avoiding sunlight and using an effective sunscreen and protective clothing.

Use this medication for the full prescribed length of time, even if you think it is not working.

It may take up to several weeks before you notice improvement in your skin. Keep using the medication as directed and tell your doctor if your symptoms do not improve. If you are using tretinoin topical to treat acne, your condition may get slightly worse for a short time when you first start using the medication.

Call your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Tretinoin topical gel is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tretinoin topical?

Avoid exposure to sunlight or tanning beds. Tretinoin topical can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors, even on a cloudy day.

Avoid getting this medication in your eyes, nose, mouth, or in the creases of your nose.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid using other medications on the areas you treat with tretinoin topical unless your doctor tells you to.

Tretinoin topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using tretinoin topical and call your doctor at once if you have:

  • severe burning, stinging, or irritation of treated skin;

  • severe redness, swelling, blistering, peeling, or crusting;

Your skin may be more sensitive to weather extremes such as cold and wind while using this medicine.

Common side effects may include:

  • mild warmth or stinging where the medicine was applied; or

  • changes in color of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Tretinoin topical dosing information

Usual Adult Dose for Acne:

Initial dose: Apply a small amount lightly to the entire affected area once a day at bedtime.
Maintenance dose: An apparent exacerbation of the acne may also occur during the initial phase of therapy (3 to 4 weeks) as a result of tretinoin's action on subclinical comedones, but should subside with prolonged use. Improvement is gradual and often not evident for 6 to 12 weeks or more. Therapy should be continued until the patient is free of new lesions for several months, although less frequent applications or a switch to a less potent formulation may be adequate for maintenance once a satisfactory therapeutic response is obtained.

Tretinoin lacks antibacterial activity and may therefore be combined with an antibiotic in the treatment of inflammatory acne. In severe cystic acne, the addition of benzoyl peroxide may be beneficial if the patient has tolerated tretinoin without significant inflammation. The benzoyl peroxide should be applied in the morning and the tretinoin at bedtime. Initially, the two agents may be applied on alternate days of each other.

Usual Adult Dose for Dermatoheliosis:

Initial dose: Apply a small amount lightly to the entire affected area once a day at bedtime.
Maintenance dose: The duration of active treatment will depend on the extent of the photodamage. Often it will take 3 to 4 months before significant improvement is seen. When maximal clinical benefits have been obtained (usually after 8 months to 1 year of therapy), the patient may be maintained on a schedule of 2 to 4 applications per week. Perpetual maintenance therapy is essential in order to sustain the clinical improvements, although safety has not been established for use beyond 48 weeks for the 0.05% cream and 52 weeks for the 0.02% cream.

Greater than 50 years: Safety and efficacy have not been established for the 0.05% emollient cream

Usual Geriatric Dose for Dermatoheliosis:

Greater than 71 years: Safety and efficacy have not been established for the 0.02% emollient cream

Usual Pediatric Dose for Acne:

Less than 12 years: Safety and efficacy have not been established.
12 to 18 years:
Initial dose: Apply a small amount lightly to the entire affected area once a day at bedtime.
Maintenance dose: An apparent exacerbation of the acne may also occur during the initial phase of therapy (3 to 4 weeks) as a result of tretinoin's action on subclinical comedones, but should subside with prolonged use. Improvement is gradual and often not evident for 6 to 12 weeks or more. Therapy should be continued until the patient is free of new lesions for several months, although less frequent applications or a switch to a less potent formulation may be adequate for maintenance once a satisfactory therapeutic response is obtained.

Tretinoin lacks antibacterial activity and may therefore be combined with an antibiotic in the treatment of inflammatory acne. In severe cystic acne, the addition of benzoyl peroxide may be beneficial if the patient has tolerated tretinoin without significant inflammation. The benzoyl peroxide should be applied in the morning and the tretinoin at bedtime. Initially, the two agents may be applied on alternate days of each other.

What other drugs will affect tretinoin topical?

Do not use skin products that contain benzoyl peroxide, sulfur, resorcinol, or salicylic acid unless otherwise directed by your doctor. These products can cause severe skin irritation if used with tretinoin topical.

It is not likely that other drugs you take orally or inject will have an effect on topically applied tretinoin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your pharmacist can provide more information about tretinoin topical.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 7.08. Revision Date: 2014-06-09, 1:21:34 PM.

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