Generic Name: tocilizumab (TOE si LIZ oo mab)
Brand Name: Actemra
What is tocilizumab?
Tocilizumab reduces the effects of a substance in the body that can cause inflammation.
Tocilizumab is used to treat moderate to severe rheumatoid arthritis in adults. It is sometimes given together with other arthritis medicines.
Tocilizumab is also used to treat systemic juvenile idiopathic arthritis (or "Still disease") in children who are at least 2 years old. It is sometimes given together with methotrexate (Rheumatrex, Trexall).
Tocilizumab is usually given after other medications have been tried without successful treatment of symptoms.
Tocilizumab may also be used for purposes not listed in this medication guide.
What is the most important information I should know about tocilizumab?
Serious and sometimes fatal infections may occur during treatment with tocilizumab. Stop using this medicine and call your doctor right away if you have signs of infection such as: fever, chills, body aches, flu symptoms, cough, sweating, feeling short of breath, diarrhea, weight loss, sores on your skin, painful urination, or feeling very tired.
Before you start treatment with tocilizumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections. While using tocilizumab, you may need frequent medical tests.
What should I discuss with my healthcare provider before I receive tocilizumab?
You should not use tocilizumab if you are allergic to it.
Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common (Ohio River Valley, Mississippi River Valley, and the Southwest).
To make sure tocilizumab is safe for you, tell your doctor if you have:
an active or recent infection (such as herpes, pneumonia, or yeast infection);
signs of infection such as fever, chills, cough, body aches, tiredness, open sores or skin wounds, diarrhea, stomach pain, weight loss, painful urination, or coughing up blood;
diverticulitis, stomach ulcer, or a history of stomach or intestinal bleeding;
HIV or AIDS;
a weak immune system;
hepatitis B (or if you are a carrier of the virus);
a nerve-muscle disease such as multiple sclerosis;
a history of cancer; or
if you are scheduled to receive any vaccines.
Treatment with tocilizumab may increase your risk of developing certain types of cancer. Talk to your doctor about your specific risk.
FDA pregnancy category C. It is not known whether tocilizumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of tocilizumab on the baby.
It is not known whether tocilizumab passes into breast milk. You should not breast-feed while you are using tocilizumab.
How is tocilizumab given?
Before you start treatment with tocilizumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Tocilizumab is injected into a vein through an IV. A healthcare provider will give you this type of injection.
Tocilizumab is sometimes injected under the skin. You may be shown how to use this type of injection at home using a prefilled syringe. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.
Tocilizumab is usually given every 2 to 4 weeks. Follow your doctor's instructions.
Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Do not use tocilizumab if it has changed colors or has particles in it. Call your pharmacist for new medication.
Each tocilizumab prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Store the prefilled syringes in their original container in a refrigerator. Protect from moisture and light. Do not freeze. Throw away any prefilled syringes not used before the expiration date on the medicine label.
Tocilizumab can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.
Some infections are more likely to occur in certain areas of the world. Tell your doctor where you live and where you have recently traveled or plan to travel to during treatment.
If you need surgery, tell the surgeon ahead of time that you are using tocilizumab. You may need to stop using the medicine for a short time.
Tocilizumab can have long lasting effects on your body. You may need certain medical tests every 6 months after you stop using this medication.
If you have ever had hepatitis B, tocilizumab can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.
You may be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your tocilizumab injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving tocilizumab?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using tocilizumab, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Tocilizumab side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest pain, difficulty breathing, feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur during treatment with tocilizumab. Call your doctor right away if you have signs of infection such as:
fever, chills, muscle pain, night sweats, mouth sores, white patches in your throat, weight loss, feeling very tired;
fast heart rate, rapid breathing, chest pain, wheezing, cough, shortness of breath;
redness or swelling under your skin, painful skin sores, blistering skin rash with burning or tingly feeling;
watery diarrhea, pain or burning when you urinate; or
blurred vision, bone pain, confusion, headache, nausea, swollen glands.
Also call your doctor at once if you have:
severe stomach cramps, bloating, diarrhea or constipation;
black, bloody, or tarry stools; or
coughing up blood or vomit that looks like coffee grounds.
Common side effects may include:
runny or stuffy nose, sinus pain, sore throat;
high blood pressure (blurred vision, buzzing in your ears, anxiety, confusion, shortness of breath, uneven heartbeats).; or
pain, swelling, burning, or irritation around the IV needle or where an injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Tocilizumab dosing information
Usual Adult Dose for Rheumatoid Arthritis:
When used in combination with disease-modifying antirheumatic drugs (DMARDs) or as monotherapy:
Recommended IV Dosage Regimen:
Starting dose: 4 mg/kg given once every 4 weeks as a 60-minute single intravenous drip infusion, followed by an increase to 8 mg/kg based on clinical response
Doses exceeding 800 mg per infusion are not recommended.
Recommended Subcutaneous Dosage Regimen:
Patients less than 100 kg: 162 mg subcutaneously every other week, followed by an increase to every week based on clinical response.
Patients 100 kg or greater: 162 mg administered subcutaneously every week.
When transitioning from intravenous therapy to subcutaneous administration, give the first subcutaneous dose instead of the next scheduled intravenous dose.
Usual Pediatric Dose for Juvenile Idiopathic Arthritis:
Polyarticular Juvenile Idiopathic Arthritis:
2 years or older:
Less than 30 kg: 10 mg/kg given once every 4 weeks as a 60-minute single intravenous infusion.
30 kg or more: 8 mg/kg given once every 4 weeks as a 60-minute single intravenous infusion.
Systemic Juvenile Idiopathic Arthritis
2 years or older:
Less than 30 kg: 12 mg/kg given once every 2 weeks as a 60-minute single intravenous drip infusion.
30 kg or more: 8 mg/kg given once every 2 weeks as a 60-minute single intravenous drip infusion.
-A patient's weight may fluctuate; therefore, a dose adjustment should not be based on a single visit body weight measurement.
-Tocilizumab may be used as monotherapy or in combination with methotrexate.
-Not recommended for use in children less than 2 years of age.
What other drugs will affect tocilizumab?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with tocilizumab, especially:
any other medicines to treat rheumatoid arthritis, such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, or rituximab.
This list is not complete and many other drugs can interact with tocilizumab. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Not all possible interactions are listed in this medication guide.
More about tocilizumab
- Other brands: Actemra
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about tocilizumab.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 3.03. Revision Date: 2014-01-24, 8:48:59 AM.