Generic Name: ticarcillin and clavulanate potassium (injection) (TYE kar SIL in KLAV ue la nate poe TAS ee um)
Brand Name: Timentin
What is ticarcillin and clavulanate potassium?
Ticarcillin is a penicillin antibiotic that fights bacteria in the body.
Clavulanate potassium is a form of clavulanic acid, which is similar to penicillin. Clavulanate potassium fights bacteria that are often resistant to penicillins and other antibiotics.
Ticarcillin and clavulanate potassium is a combination medicine used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, stomach infections, skin infections, and others.
Ticarcillin and clavulanate potassium may also be used for purposes not listed in this medication guide.
What is the most important information I should know about ticarcillin and clavulanate potassium?
You should not use this medication if you are allergic to any penicillin or cephalosporin antibiotic.
What should I discuss with my healthcare provider before using ticarcillin and clavulanate potassium?
You should not use this medication if you are allergic to ticarcillin or clavulanate potassium, or if you are allergic to:
a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others; or
a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), ticarcillin (Ticar, Timentin), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).
To make sure ticarcillin and clavulanate potassium is safe for you, tell your doctor if you have:
a bleeding or blood clotting disorder;
an electrolyte imbalance such as low levels of potassium in your blood;
a history of any type of allergy; or
if you are on a low-salt diet.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium.
It is not known whether ticarcillin and clavulanate potassium passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is ticarcillin and clavulanate potassium given?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Ticarcillin and clavulanate potassium is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Ticarcillin and clavulanate potassium is usually given for 10 to 14 days, depending on the infection being treated. Follow your doctor's instructions.
Ticarcillin and clavulanate potassium must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Shake the mixture well to dissolve the medicine completely. The mixture should appear light to dark yellow. Do not use the mixture if it has changed colors or has particles in it. Call your pharmacist for new medication.
Do not mix ticarcillin and clavulanate potassium with other injectable antibiotics in the same IV bag.
After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture (at room temperature, or in a refrigerator). Carefully follow the mixing and storage instructions provided with your medicine. Ask your pharmacist if you have questions.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ticarcillin and clavulanate potassium will not treat a viral infection such as the common cold or flu.
While using ticarcillin and clavulanate potassium, you may need frequent blood tests. Your kidney function may also need to be checked.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using ticarcillin and clavulanate potassium.
Store unmixed medicine and the liquid diluent at cool room temperature, away from moisture and heat.
If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.
What happens if I miss a dose?
Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using ticarcillin and clavulanate potassium?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking ticarcillin and clavulanate potassium and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Ticarcillin and clavulanate potassium side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
diarrhea that is watery or bloody;
blood in your urine, feeling an urgent need to urinate, painful or difficult urination;
low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
signs of a new infection--fever, chills, sore throat, flu symptoms, easy bruising or unusual bleeding, loss of appetite, mouth sores.
Common side effects may include:
vaginal itching or discharge;
nausea, mild diarrhea; or
bruising, swelling, or redness where the injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Timentin side effects (in more detail)
What other drugs will affect ticarcillin and clavulanate potassium?
Other drugs may interact with ticarcillin and clavulanate potassium, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More Timentin resources
Compare Timentin with other medications
Where can I get more information?
- Your doctor or pharmacist can provide more information about ticarcillin and clavulanate potassium.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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