tiludronate
Generic Name: tiludronate (til UD ro nayt)
Brand names: Skelid
What is tiludronate?
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Tiludronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Tiludronate slows bone loss while increasing bone mass, which may prevent bone fractures.
Tiludronate is used to treat Paget's disease of bone.
Tiludronate may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about tiludronate?
Take tiludronate on an empty stomach, at least 2 hours before or 2 hours after eating.Your doctor may ask you to take the medicine first thing in the morning, before you eat or drink anything or take any other medicine.
Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tiludronate tablet.Wait at least 2 hours after taking tiludronate before you eat or take other medicines including vitamins, calcium, or antacids. Do not take tiludronate if it has been less than 2 hours since your last meal or other medication.
Some people using medicines similar to tiludronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.
What should I discuss with my healthcare provider before taking tiludronate?
Do not take this medication if you are allergic to tiludronate.Before using tiludronate, tell your doctor if you have:
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low blood calcium (hypocalcemia);
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a vitamin D deficiency;
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kidney disease; or
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an ulcer in your stomach or esophagus.
If you have any of these conditions, you may not be able to use tiludronate, or you may need a dosage adjustment or special tests during treatment.
Some people using medicines similar to tiludronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.
You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and dental surgery or pre-existing dental problems.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether tiludronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.How should I take tiludronate?
Take tiludronate exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor.
Tiludronate tablets are usually taken once each day for at least 3 months.
Take tiludronate on an empty stomach, at least 2 hours before or 2 hours after eating.Your doctor may ask you to take the medicine first thing in the morning, before you eat or drink anything or take any other medicine.
Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tiludronate tablet.Wait at least 2 hours after taking tiludronate before you eat or take other medicines including vitamins, calcium, or antacids. Do not take tiludronate if it has been less than 2 hours since your last meal or other medication.
Do not crush, chew, or suck the tiludronate tablet. Swallow the pill whole.Your doctor may want you to take calium or vitamin D supplements while you are taking tiludronate. Follow your medication and dose schedules very closely.
Store tiludronate tablets at room temperature away from moisture and heat.What happens if I miss a dose?
Take the missed dose as soon as you remember. Do not take tiludronate within 2 hours before or after eating, or taking other medicines. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.Symptoms of a tiludronate overdose may include nausea, heartburn, stomach pain, diarrhea, muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.
What should I avoid while taking tiludronate?
For at least 2 hours after taking tiludronate, avoid taking antacids, supplements, or medicines that contain aluminum, calcium, magnesium, or other minerals. They can make it harder for your body to absorb tiludronate.
Aspirin or indomethacin (Indocin) can also lower your body's absorption of tiludronate. If you use these other medicines, do not that take them for at least 2 hours after taking tiludronate.
Tiludronate side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tiludronate and call your doctor at once if you have any of these serious side effects:-
chest pain;
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difficulty or pain when swallowing;
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pain or burning under the ribs or in the back;
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new or worsening heartburn;
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severe joint, bone, or muscle pain; or
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jaw pain, numbness, or swelling.
Continue using tiludronate and talk with your doctor if you have any of these less serious side effects:
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mild heartburn or stomach upset;
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diarrhea, gas, or constipation;
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mild joint or back pain; or
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headache.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect tiludronate?
Do not take any other medicines including vitamins, calcium, or antacids for at least 2 hours before or 2 hour after taking tiludronate.There may be other drugs that can affect tiludronate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
- Your pharmacist has information about tiludronate written for health professionals that you may read.
What does my medication look like?
Tiludronate is available with a prescription under the brand name Skelid. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
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Skelid 200 mg-round, white tablets
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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More tiludronate resources:
Tiludronate - Includes detailed dosage instructions.
