ticarcillin

Generic Name: ticarcillin (tye KAR sil in)
Brand Name: Ticar

What is ticarcillin?

Ticarcillin is an antibiotic in a group of drugs called penicillins. Ticarcillin fights bacteria in the body.

The combination of ticarcillin is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, and skin infections.

Ticarcillin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about ticarcillin?

Do not use this medication if you are allergic to ticarcillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

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Before using ticarcillin tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, a history of any type of allergy, or if you are on a salt-restricted diet.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin will not treat a viral infection such as the common cold or flu.

Ticarcillin can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin.

What should I discuss with my healthcare provider before using ticarcillin?

Do not use this medication if you are allergic to ticarcillin or to any other penicillin antibiotic, such as:

  • amoxicillin (Amoxil, Augmentin);

  • ampicillin (Omnipen, Principen);

  • carbenicillin (Geocillin);

  • dicloxacillin (Dycill, Dynapen);

  • oxacillin (Bactocill); or

  • penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

Before using ticarcillin, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

  • kidney disease;

  • a bleeding or blood clotting disorder;

  • an electrolyte imbalance such as low levels of potassium in your blood;

  • a history of any type of allergy; or

  • if you are on a salt-restricted diet.

If you have any of these conditions, you may not be able to use ticarcillin, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Ticarcillin can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin.

It is not known whether ticarcillin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ticarcillin?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Ticarcillin is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to inject your medicine at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.

Ticarcillin must be mixed with a liquid (diluent) before injecting it. Do not mix the medicine until you are ready to give yourself an injection.

Ticarcillin is usually given for 10 to 14 days, depending on the infection being treated. Follow your doctor's instructions.

Use each needle only one time. Throw away used needles and syringes in a puncture-proof container. If your medicine does not come with such a container, ask your pharmacist where you can get one. Keep this container out of the reach of children and pets. Your pharmacist can tell you how to properly dispose of the container.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ticarcillin will not treat a viral infection such as the common cold or flu.

Store unmixed ticarcillin, and the liquid diluent, at cool room temperature.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a ticarcillin overdose may include drowsiness, hyperactivity, or seizure (convulsions).

What should I avoid while using ticarcillin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Ticarcillin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;

  • easy bruising or bleeding, unusual weakness;

  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;

  • fever, chills, body aches, flu symptoms; or

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness.

Less serious side effects may be more likely to occur, such as:

  • mild diarrhea, gas, stomach pain;

  • nausea or vomiting;

  • headache;

  • skin rash or itching;

  • pain, swelling, or burning where the injection was given; or

  • vaginal yeast infection (itching or discharge).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Ticarcillin Dosing Information

Usual Adult Dose for Febrile Neutropenia:

3 g IV every 4 hours. Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has been greater than 500 cells/mm3.

Ticarcillin should be used in combination with another anti-infective agent, usually an aminoglycoside, for the empiric treatment of febrile patients.

Usual Adult Dose for Intraabdominal Infection:

3 g IV every 4 hours, for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Joint Infection:

3 g IV every 4 hours for up to 3 or 4 weeks, depending on the nature and severity of the infection. Longer therapy, sometimes up to 6 weeks, may be necessary for prosthetic joint infections.

Usual Adult Dose for Osteomyelitis:

3 g IV every 4 hours. Therapy should be continued for 4 to 6 weeks. Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly up to 6 months.

Usual Adult Dose for Pelvic Inflammatory Disease:

3 g IV every 4 to 6 hours. Parenteral therapy should continue for 48 hours after clinical improvement is observed, at which time oral therapy may be initiated and continued for a total of 14 days of treatment.

If the patient is not pregnant, appropriate treatment for possible chlamydia infection should be initiated and any sexual partner(s) should be evaluated.

The Centers for Disease Control and Prevention currently recommend cefotetan or cefoxitin plus doxycycline, or clindamycin plus gentamicin for the treatment of pelvic inflammatory disease.

Usual Adult Dose for Peritonitis:

3 g IV every 4 hours. Ticarcillin is generally used as part of combination therapy when treating peritonitis. Therapy should be continued for approximately 10 to 14 days.

Intraperitoneal cefazolin plus ceftazidime are recommended for treatment of peritoneal dialysis-associated peritonitis.

Usual Adult Dose for Pneumonia:

3 g IV every 4 hours for 21 to 28 days, depending on the nature and severity of the infection.

Usual Adult Dose for Pyelonephritis:

3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Septicemia:

3 g IV every 4 hours for 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection:

3 g IV every 4 hours for 7 to 10 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Usual Adult Dose for Urinary Tract Infection:

Complicated: 3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.
Uncomplicated: 1 g IM or IV every 6 hours

Usual Pediatric Dose for Intraabdominal Infection:

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Pneumonia:

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Skin or Soft Tissue Infection:

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Septicemia:

Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:
< 40 kg: 200 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose

Usual Pediatric Dose for Urinary Tract Infection:

Uncomplicated infections:
1 month to 12 years:
< 40 kg: 50 to 100 mg/kg/day IV or IM in equally divided doses every 6 to 8 hours.
> 40 kg: Adult dose.

Complicated infections:
1 month to 12 years:
< 40 kg: 150 to 200 mg/kg/day IV in equally divided doses every 4 to 6 hours.
> 40 kg: Adult dose.

What other drugs will affect ticarcillin?

There may be other drugs that can affect ticarcillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist has information about ticarcillin written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.05. Revision Date: 2010-12-15, 5:01:39 PM.

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