ticarcillin and clavulanate potassium

Generic Name: ticarcillin and clavulanate potassium (injection) (TYE kar SIL in KLAV ue la nate poe TAS ee um)
Brand Name: Timentin, Timentin ADD-Vantage

What is ticarcillin and clavulanate potassium?

Ticarcillin is a penicillin antibiotic that fights bacteria in the body.

Clavulanate potassium is a form of clavulanic acid, which is similar to penicillin. Clavulanate potassium fights bacteria that are often resistant to penicillins and other antibiotics.

Ticarcillin and clavulanate potassium is a combination medicine used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, stomach infections, skin infections, and others.

Ticarcillin and clavulanate potassium may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ticarcillin and clavulanate potassium?

You should not use this medication if you are allergic to any penicillin or cephalosporin antibiotic.

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What should I discuss with my healthcare provider before using ticarcillin and clavulanate potassium?

You should not use this medication if you are allergic to ticarcillin or clavulanate potassium, or if you are allergic to:

  • a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others; or

  • a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), ticarcillin (Ticar, Timentin), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).

To make sure ticarcillin and clavulanate potassium is safe for you, tell your doctor if you have:

  • kidney disease;

  • a bleeding or blood clotting disorder;

  • an electrolyte imbalance such as low levels of potassium in your blood;

  • a history of any type of allergy; or

  • if you are on a low-salt diet.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium.

It is not known whether ticarcillin and clavulanate potassium passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is ticarcillin and clavulanate potassium given?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Ticarcillin and clavulanate potassium is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Ticarcillin and clavulanate potassium is usually given for 10 to 14 days, depending on the infection being treated. Follow your doctor's instructions.

Ticarcillin and clavulanate potassium must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Shake the mixture well to dissolve the medicine completely. The mixture should appear light to dark yellow. Do not use the mixture if it has changed colors or has particles in it. Call your pharmacist for new medication.

Do not mix ticarcillin and clavulanate potassium with other injectable antibiotics in the same IV bag.

After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture (at room temperature, or in a refrigerator). Carefully follow the mixing and storage instructions provided with your medicine. Ask your pharmacist if you have questions.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ticarcillin and clavulanate potassium will not treat a viral infection such as the common cold or flu.

While using ticarcillin and clavulanate potassium, you may need frequent blood tests. Your kidney function may also need to be checked.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using ticarcillin and clavulanate potassium.

Store unmixed medicine and the liquid diluent at cool room temperature, away from moisture and heat.

If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using ticarcillin and clavulanate potassium?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking ticarcillin and clavulanate potassium and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ticarcillin and clavulanate potassium side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery or bloody;

  • blood in your urine, feeling an urgent need to urinate, painful or difficult urination;

  • seizure (convulsions);

  • low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or

  • signs of a new infection--fever, chills, sore throat, flu symptoms, easy bruising or unusual bleeding, loss of appetite, mouth sores.

Common side effects may include:

  • vaginal itching or discharge;

  • mild rash;

  • nausea, mild diarrhea; or

  • bruising, swelling, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Ticarcillin and clavulanate potassium Dosing Information

Usual Adult Dose for Aspiration Pneumonia:

3.1 g IV every 4 to 6 hours
Duration: Therapy of documented anaerobic pleuropulmonary infections should be continued until after the infiltrate has cleared or a residual scar forms, sometimes requiring 2 to 4 months of therapy.

Usual Adult Dose for Bacteremia:

3.1 g IV every 4 hours
Duration: 14 days

Usual Adult Dose for Septicemia:

3.1 g IV every 4 hours
Duration: 14 days

Usual Adult Dose for Deep Neck Infection:

3.1 g IV every 4 to 6 hours
Duration: 3 or 4 weeks, depending on the nature and severity of the infection

Usual Adult Dose for Endometritis:

Moderate infection: 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours

Duration: Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients (breast-feeding should be discontinued).

Usual Adult Dose for Febrile Neutropenia:

3.1 g IV every 4 to 6 hours
Duration: Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has been greater than 500 cells/mm3.

Usual Adult Dose for Intraabdominal Infection:

3.1 g IV every 4 to 6 hours
Duration: Therapy should be continued for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Peritonitis:

3.1 g IV every 4 to 6 hours
Duration: Therapy should be continued for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Joint Infection:

3.1 g IV every 4 to 6 hours
Duration: Therapy should be continued for 3 or 4 weeks, depending on the nature and severity of the infection. Longer therapy, sometimes up to 6 weeks, may be necessary for prosthetic joint infections.

Usual Adult Dose for Osteomyelitis:

3.1 g IV every 4 hours
Duration: Therapy should be continued for 4 to 6 weeks. Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly up to 6 months.

Usual Adult Dose for Pelvic Inflammatory Disease:

Moderate infection: 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours

Duration: Parenteral therapy should continue for 24 hours after clinical improvement is observed at which time oral therapy may be initiated and continued for a total of 14 days of treatment.

If the patient is not pregnant, appropriate treatment for possible chlamydial infection should be initiated and any sexual partner(s) should be evaluated/treated.

Usual Adult Dose for Pneumonia:

3.1 g IV every 4 to 6 hours
Duration: 7 to 10 days if pneumococcus is suspected organism, up to 21 days if another microbe is suspected

Usual Adult Dose for Pyelonephritis:

3.1 g IV every 4 to 6 hours
Duration: 14 days

Usual Adult Dose for Skin or Soft Tissue Infection:

3.1 g IV every 4 to 6 hours
Duration: Therapy should be continued for up to 3 days after acute inflammation resolves, depending on the nature and severity of the infection. For more severe infections, such as diabetic soft tissue infections, up to 21 days of therapy may be required.

Usual Adult Dose for Urinary Tract Infection:

3.1 g IV every 4 to 6 hours
Duration: 14 days, depending on the nature and severity of the infection

Usual Pediatric Dose for Intraabdominal Infection:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Joint Infection:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Osteomyelitis:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Pelvic Inflammatory Disease:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Pneumonia:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Skin or Soft Tissue Infection:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Bacterial Infection:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Urinary Tract Infection:

Neonates:
0 to 4 weeks, birthweight 1199 g or less: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 12 hours
0 to 6 days, birthweight 2001 g or more: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 1200 to 2000 g: 75 mg/kg (ticarcillin component) IV every 8 hours
7 days to 4 weeks, birthweight 2001 g or more: 100 mg/kg (ticarcillin component) IV every 8 hours

Alternatively, 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours has been recommended for full term neonates.

2 months or less: 200 to 300 mg/kg/day (ticarcillin component) IV divided every 6 to 8 hours

3 months or older:
59 kg or less:
Mild to moderate infection: 25 to 50 mg/kg (ticarcillin component) IV every 6 hours
Severe infection: 50 mg/kg (ticarcillin component) IV every 4 hours; alternatively, 50 to 75 mg/kg (ticarcillin component) IV every 6 hours has been recommended

60 kg or more:
Mild to moderate infections: 3.1 g IV every 6 hours
Severe infection: 3.1 g IV every 4 hours

Usual Pediatric Dose for Pneumonia with Cystic Fibrosis:

350 to 450 mg/kg/day (ticarcillin component) IV in divided doses every 6 hours

What other drugs will affect ticarcillin and clavulanate potassium?

Other drugs may interact with ticarcillin and clavulanate potassium, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about ticarcillin and clavulanate potassium.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.02. Revision Date: 2013-11-19, 10:55:00 AM.

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