Stelazine

Pronunciation

Generic Name: trifluoperazine (TRYE floo oh PER a zeen)
Brand Name: Stelazine

What is Stelazine (trifluoperazine)?

Trifluoperazine is an anti-psychotic medicine in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Trifluoperazine is used to treat anxiety or psychotic disorders such as schizophrenia.

Trifluoperazine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Stelazine (trifluoperazine)?

Trifluoperazine is not approved for use in psychotic conditions related to dementia. Trifluoperazine may increase the risk of death in older adults with dementia-related conditions.

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You should not use trifluoperazine if you have bone marrow suppression, liver disease, a blood cell disorder, or if you have drowsiness, slow breathing, weak pulse, or decreased alertness (such as after drinking alcohol or taking medicines that make you sleepy).

What should I discuss with my healthcare provider before taking oral Stelazine (trifluoperazine)?

You should not use trifluoperazine if you are allergic to it, or if you have:

  • bone marrow suppression;

  • liver disease;

  • a blood cell disorder such as anemia, low white blood cell counts, or low platelets; or

  • drowsiness, slow breathing, weak pulse, or decreased alertness (such as after drinking alcohol or taking medicines that make you sleepy).

Trifluoperazine is not approved for use in psychotic conditions related to dementia. Trifluoperazine may increase the risk of death in older adults with dementia-related conditions.

Long-term use of trifluoperazine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take trifluoperazine, the more likely you are to develop this movement disorder. The risk of this side effect is higher in women and older adults.

To make sure trifluoperazine is safe for you, tell your doctor if you have:

  • a brain tumor;

  • heart disease, high blood pressure;

  • kidney disease;

  • blockage in your digestive tract (stomach or intestines);

  • past or present breast cancer;

  • glaucoma;

  • seizures or epilepsy;

  • pheochromocytoma (tumor of the adrenal gland);

  • an enlarged prostate or urination problems; or

  • if you also take lithium or a blood thinner (warfarin, Coumadin, Jantoven).

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking trifluoperazine.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking trifluoperazine, do not stop taking it without your doctor's advice.

Trifluoperazine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Talk with your doctor before giving this medicine to a child who has been ill with a fever or flu symptoms.

How should I take Stelazine (trifluoperazine)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Call your doctor if your symptoms do not improve, or if they get worse while using trifluoperazine.

Do not stop using trifluoperazine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using trifluoperazine.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, constipation, extreme drowsiness or feeling restless and agitated, changes in heart rate, fainting, and seizure (convulsions).

What should I avoid while taking Stelazine (trifluoperazine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of trifluoperazine.

Avoid exposure to sunlight or tanning beds. Trifluoperazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Stelazine (trifluoperazine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • stiffness in your neck, tightness in your throat, trouble breathing or swallowing;

  • feeling restless, jittery, or agitated;

  • sudden weakness or ill feeling, fever, chills, sore throat, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough;

  • pale skin, easy bruising or bleeding;

  • decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

  • seizure (black-out or convulsions);

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • dizziness, drowsiness, tired feeling;

  • blurred vision;

  • dry mouth, loss of appetite;

  • sleep problems (insomnia);

  • muscle weakness;

  • itching or rash;

  • missed menstrual periods; or

  • breast swelling or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Stelazine (trifluoperazine)?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking trifluoperazine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with trifluoperazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with trifluoperazine.

Where can I get more information?

  • Your pharmacist can provide more information about trifluoperazine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01. Revision Date: 2014-08-12, 1:39:04 PM.

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