Rescriptor

Generic Name: delavirdine (de la VIR deen)
Brand Name: Rescriptor

What is Rescriptor (delavirdine)?

Delavirdine is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Delavirdine is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Delavirdine is not a cure for HIV or AIDS.

Delavirdine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Rescriptor (delavirdine)?

There are many other drugs that can cause serious or life threatening medical problems if you take them together with delavirdine. Tell your doctor about all other medicines you use, especially: a sedative, cholesterol-lowering medication, seizure medication, tuberculosis medication, or migraine headache medicine.

Slideshow: Flashback: FDA Drug Approvals 2013

Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What should I discuss with my healthcare provider before taking Rescriptor (delavirdine)?

You should not use this medication if you are allergic to delavirdine, or if you are using any of the following drugs:

  • cisapride (Propulsid);

  • pimozide (Orap);

  • St. John's wort;

  • alprazolam (Xanax), midazolam (Versed) or triazolam (Halcion);

  • carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin) or phenobarbital (Solfoton);

  • lovastatin (Advicor, Altoprev, Mevacor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync);

  • rifabutin (Mycobutin) or rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

  • ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), or methylergonovine (Methergine).

Using any of these medicines while you are taking delavirdine can cause serious medical problems or death.

To make sure delavirdine is safe for you, tell your doctor if you have any of these other conditions:

  • liver disease;

  • high cholesterol or triglycerides;

  • low stomach acid production; or

  • if you have ever taken efavirenz (Sustiva), etravirine (Intelence), nevirapine (Viramune), or rilpivirine (Edurant) and they were not effective in treating your condition.

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take Rescriptor (delavirdine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not take delavirdine as your only HIV medication. HIV/AIDS is usually treated with a combination of different drugs. Your disease may become resistant to delavirdine if you do not take it in combination with other HIV medicines your doctor has prescribed.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Delavirdine can be taken with or without food. If you have a condition of decreased stomach acid, your doctor may recommend taking delavirdine with an acidic beverage such as orange or cranberry juice.

The 100-milligram delavirdine tablets may be dissolved in water to make swallowing easier. Place 4 tablets into at least 3 ounces (just under 1/3 cup) of water. Let the liquid stand for a few minutes, then stir to allow the tablets to disperse evenly in the liquid. Drink this mixture right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

The 200-milligram delavirdine tablets must be swallowed whole. Do not crush, chew, or disperse the tablets in water.

Use delavirdine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To best treat your condition, use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

You may need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Rescriptor (delavirdine)?

Avoid taking an antacid within 1 hour before or after you take delavirdine. Some antacids can make it harder for your body to absorb delavirdine.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Rescriptor (delavirdine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • signs of an infection such as fever, chills, night sweats, sore throat, flu symptoms, weakness, easy bruising or unusual bleeding, loss of appetite, mouth sores;

  • rapid heart rate, tremors, sleep problems (insomnia), feeling anxious or irritable;

  • severe diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;

  • swelling in your neck or throat (enlarged thyroid);

  • weakness or prickly feeling in your fingers or toes;

  • problems with balance or eye movement, trouble speaking or swallowing;

  • severe lower back pain, loss of bladder or bowel control;

  • muscle weakness, tired feeling, joint or muscle pain, feeling short of breath; or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild itching or rash;

  • headache, nausea;

  • cold symptoms such as stuffy nose, sneezing, sore throat; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Rescriptor (delavirdine)?

Tell your doctor about all other medicines you use, especially:

  • methadone (Methadose, Dolophine);

  • sildenafil (Viagra, Revatio);

  • ADHD medication such as Adderall;

  • an antibiotic such as clarithromycin (Biaxin) or rifapentine (Priftin);

  • an antidepressant such as nefazodone or trazodone (Desyrel);

  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend);

  • atorvastatin (Lipitor, Caduet) or fluvastatin (Lescol);

  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal);

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • heart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;

  • heart rhythm medicine such as amiodarone (Cordarone), flecainide (Tambocor), or propafenone (Rythmol), or quinidine (Quin-G);

  • the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek);

  • HIV/AIDS medication such as didanosine (Videx), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), saquinavir (Invirase);

  • medicine to treat or prevent organ transplant rejection;

  • steroid medicine such as dexamethasone (Cortastat, Dexasone, Solurex, DexPak) or fluticasone (Advair, Flovent, Flonase); or

  • stomach medications such as Axid, Pepcid, Prevacid, Prilosec, Tagamet, or Zantac.

This list is not complete and there are many other medicines that can interact with delavirdine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about delavirdine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 8.01. Revision Date: 2012-10-15, 10:39:24 PM.

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