Generic Name: promethazine (injection) (pro METH a zeen)
Brand Name: Adgan, Anergan 50, Phenergan
What is Pentazine (promethazine (injection))?
Promethazine is in a group of drugs called phenothiazines (feen-oh-THYE-oh-zeens).
Promethazine is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures.
Promethazine injection is usually given when a person cannot take the medication orally (by mouth).
Promethazine injection may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Pentazine (promethazine (injection))?
Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.
You should not receive this medication if you are allergic to promethazine or to similar medicines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Tell your doctor right away if you have serious side effects while receiving promethazine injection, such as slow, shallow breathing, feeling light-headed, fainting, severe burning or skin irritation where the injection was given, confusion, hallucinations, muscle twitching, or muscle movements you cannot control.
What should I discuss with my health care provider before I receive Pentazine (promethazine (injection))?
You should not use this medication if you are allergic to promethazine or to similar medicines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).
To make sure you can safely use promethazine, tell your doctor if you have any of these other conditions:
asthma, sleep apnea, or other breathing problems;
epilepsy or other seizure disorder;
a weak immune system (bone marrow depression);
enlarged prostate or problems with urination;
stomach ulcer or obstruction;
heart disease or high blood pressure;
adrenal gland tumor (pheochromocytoma);
low levels of calcium in your blood (hypocalcemia); or
if you have ever had a serious side effect while using promethazine or any other phenothiazine.
FDA pregnancy category C. It is not known whether promethazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether promethazine passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.
How is promethazine injection given?
Promethazine is given as an injection deep into a muscle. You will receive this injection in a clinic or hospital setting. This medication is usually given every 2 to 4 hours depending on the condition it is used for.
Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by mouth.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you have recently received promethazine injection.
What happens if I miss a dose?
Since promethazine injection is given by a healthcare professional, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include slow or shallow breathing, extreme drowsiness or weakness, feeling light-headed, or fainting.
What should I avoid while receiving Pentazine (promethazine (injection))?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid exposure to sunlight or tanning beds. Promethazine injection can make your skin more sensitive to sunlight and sunburn may result.
Pentazine (promethazine (injection)) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
feeling restless, jittery, or agitated;
slow, shallow breathing, feeling like you might pass out;
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
pain, burning, severe irritation, muscle weakness, or skin changes where the injection was given;
confusion, hallucinations, hysteria, seizure (black-out or convulsions);
fast or slow heartbeats;
fever, chills, body aches, flu symptoms;
urinating less than usual or not at all;
easy bruising or bleeding, unusual weakness; or
jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
drowsiness, dizziness, tired feeling;
ringing in your ears;
problems with balance or coordination;
feeling nervous or shaky;
sleep problems (insomnia);
skin rash or itching; or
dry mouth, stuffy nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Pentazine side effects (in more detail)
What other drugs will affect Pentazine (promethazine (injection))?
Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can interact with promethazine and cause medical problems or increase side effects. Tell your doctor if you regularly use any of these medicines.
Tell your doctor about all other medicines you use, especially:
lithium (Eskalith, Lithobid);
atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
blood pressure medication such as guanadrel (Hylorel), propranolol (Inderal), and others;
a blood thinner such as warfarin (Coumadin, Jantoven);
bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others;
an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or
medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma); or
medicine to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine).
This list is not complete and there are many other medicines that can interact with promethazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
More about promethazine
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Where can I get more information?
- Your doctor or pharmacist has information about promethazine injection.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Revision Date: 2011-08-04, 2:44:01 PM.