naltrexone

Pronunciation

Generic Name: naltrexone (oral) (nal TREX own)
Brand Name: ReVia

What is naltrexone oral?

Naltrexone oral is an special narcotic drug that blocks the effects of other narcotic medicines and alcohol.

Naltrexone oral is used to treat narcotic drug or alcohol addiction..

Naltrexone oral may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about naltrexone oral?

Your doctor may recommend that naltrexone oral be given to you by a family member or other caregiver. This is to make sure you are using the medicine as it was prescribed as part of your treatment.

Do not use narcotic drugs or alcohol while taking naltrexone oral. Never try to overcome the effects of the medication by taking large doses of narcotic drugs or alcohol. Doing so could result in dangerous effects, including coma and death. Ask your doctor before using any prescription or over-the-counter medicine to treat a cold, cough, diarrhea, or pain while taking naltrexone oral. These medicines may contain narcotics or alcohol.

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Naltrexone oral can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Carry an ID card or wear a medical alert bracelet stating that you are using naltrexone, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are using this medication.

Additional forms of counseling and/or monitoring may be recommended during treatment with naltrexone oral.

What should I discuss with my health care provider before using naltrexone oral?

Do not take this medicine if you are allergic to naltrexone, or if you have:

  • an addiction to narcotics;

  • a history of alcohol or narcotic drug use within the past 7-10 days; or

  • drug or alcohol withdrawal symptoms.

Before taking naltrexone, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney disease;

  • liver disease; or

  • a bleeding disorder such as hemophilia (if you are using naltrexone oral injection).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether naltrexone oral passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use naltrexone oral?

Use naltrexone oral exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.

Take the naltrexone oral tablet with a full glass of water.

You may take the naltrexone oral tablet with food to decrease stomach upset.

It is important to take naltrexone oral regularly to get the most benefit.

Your doctor may recommend that naltrexone oral be given to you by a family member or other caregiver. This is to make sure you are using the medicine as it was prescribed as part of your treatment.

Carry an ID card or wear a medical alert bracelet stating that you are using naltrexone, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are using this medication.

Additional forms of counseling and/or monitoring may be recommended during treatment with naltrexone oral.

Store naltrexone oral tablets at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, stomach pain, dizziness, or seizure (convulsions).

What should I avoid while using naltrexone oral?

Naltrexone oral can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not use narcotic drugs or alcohol while taking naltrexone oral. Never try to overcome the effects of the medication by taking large doses of narcotic drugs or alcohol. Doing so could result in dangerous effects, including coma and death. Ask your doctor before using any prescription or over-the-counter medicine to treat a cold, cough, diarrhea, or pain while taking naltrexone oral. These medicines may contain narcotics or alcohol.

Naltrexone oral side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naltrexone oral and call your doctor at once if you have any of these serious side effects:

  • blurred vision or eye problems;

  • fast heartbeat;

  • mood changes, hallucinations (seeing or hearing things), confusion, thoughts of hurting yourself;

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • ear pain, ringing in your ears;

  • skin rash or itching; or

  • wheezing, difficulty breathing.

Less serious side effects may include:

  • feeling anxious, nervous, restless, or irritable;

  • feeling light-headed, fainting;

  • increased thirst;

  • muscle or joint aches;

  • weakness or tiredness;

  • sleep problems (insomnia); or

  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Naltrexone dosing information

Usual Adult Dose for Alcohol Dependence:

Oral Tablets:
50 mg orally once a day

Extended-release injectable suspension:
380 mg every 4 weeks (or once a month) via intramuscular gluteal injection, alternating buttocks

Usual Adult Dose for Opiate Dependence:

Treatment should not be attempted unless the patient has remained free of opioids for at least 7 to 10 days. Opioid abstinence should be verified by analysis of urine for absence of opioids. The patient should not be manifesting withdrawal signs or reporting withdrawal symptoms. If there is any question of occult opioid dependence, perform a naloxone challenge test and do not initiate naltrexone therapy until the naloxone challenge is negative. The naloxone challenge test should not be performed in a patient showing clinical signs or symptoms of opioid withdrawal, or whose urine contains opioids. The naloxone challenge can be repeated in 24 hours.

Initial dose: 25 mg orally one time.
Maintenance dose: If no withdrawal signs occur, 50 mg orally once a day may be started.
Alternative dose schedules: (to improve compliance) 50 mg orally on week days and 100 mg orally on Saturday; or 100 mg orally every other day; or 150 mg orally every third day.

Extended-release injectable suspension: 380 mg every 4 weeks (or once a month) via intramuscular gluteal injection, alternating buttocks

What other drugs will affect naltrexone oral?

The pain-relieving effects of any narcotic pain medications you use will be blocked if you use them during your treatment with naltrexone oral. Harmful side effects could also occur.

Before using naltrexone, tell your doctor if you use any of the following drugs:

  • buprenorphine (Buprenex, Subutex);

  • butorphanol (Stadol);

  • codeine (Tylenol with codeine);

  • hydrocodone (Lortab, Vicodin);

  • dezocine (Dalgan);

  • hydromorphone (Dilaudid);

  • levorphanol (Levo-Dromoran);

  • meperidine (Demerol);

  • methadone (Dolophine, Methadose);

  • morphine (Kadian, MS Contin, Roxanol);

  • nalbuphine (Nubain);

  • nalmefene (Revex);

  • naloxone (Narcan);

  • oxycodone (OxyContin, Roxicodone, Percocet);

  • oxymorphone (Numorphan); or

  • propoxyphene (Darvon, Darvocet).

This list it not complete and there may be other drugs that can interact with naltrexone oral. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about naltrexone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.06. Revision Date: 2010-12-15, 5:01:39 PM.

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