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Mozobil

Generic Name: plerixafor (pler IX a fore)
Brand Name: Mozobil

What is plerixafor?

Plerixafor works by helping your bone marrow release stem cells into your bloodstream so they can be collected and transplanted back into the body.

Plerixafor is used in people with non-Hodgkin's lymphoma or multiple myeloma.

Plerixafor may also be used for purposes not listed in this medication guide.

What is the most important information I should know about plerixafor?

Do not receive plerixafor without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

You should not receive this medication if you are allergic to plerixafor, or if you have leukemia.

Slideshow: Flashback: FDA Drug Approvals 2013

Before receiving plerixafor, tell your doctor if you have kidney disease.

Plerixafor is given as an injection in a hospital or clinic setting. Before receiving plerixafor, you will be given another medication that will help your bone marrow produce stem cells and certain white blood cells that help support your immune system.

To be sure this medication is not causing harmful effects, your blood will need to be tested often.

What should I discuss with my health care provider before receiving plerixafor?

You should not receive this medication if you are allergic to plerixafor, or if you have leukemia.

To make sure you can safely use plerixafor, tell your doctor if you have kidney disease.

FDA pregnancy category D. Do not receive plerixafor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether plerixafor passes into breast milk or if it could harm a nursing baby. You should not breast-feed while receiving this medication.

How is plerixafor given?

Plerixafor is injected under the skin. You will receive this injection in a hospital or clinic setting.

Before receiving plerixafor, you will be given a medication called a granulocyte (GRAN-yoo-loe-site) colony stimulating factor, also called G-CSF. Some examples of a G-CSF are filgrastim (Neupogen), pegfilgrastim (Neulasta), and sargramostim (Leukine).

A G-CSF will cause your bone marrow to produce stem cells and certain white blood cells called granulocytes, which help support your immune system.

Plerixafor works together with the G-CSF by causing stem cells and granulocytes produced in the bone marrow to circulate into your blood stream where they can be collected in blood drawn from your vein.

After your blood is drawn, it will be processed so that the needed stem cells and granulocytes can be separated from other unneeded parts of the blood. These stem cells and granulocytes will then be "transplanted" back into your vein through an IV injection.

To be sure plerixafor is not causing harmful effects, your blood will need to be tested often during your treatment.

What happens if I miss a dose?

Because you will receive plerixafor in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include stomach discomfort, severe dizziness, or fainting.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving plerixafor?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Plerixafor side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • easy bruising or bleeding, unusual weakness;

  • feeling like you might pass out; or

  • pain in your upper stomach, spreading to your shoulder or back.

Less serious side effects may include:

  • nausea, vomiting;

  • diarrhea, constipation;

  • dry mouth, numbness in or around your mouth;

  • upset stomach, bloating, gas;

  • tired feeling, trouble sleeping;

  • headache, dizziness;

  • joint or muscle pain;

  • increased sweating; or

  • itching, rash, or other irritation where the medication was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect plerixafor?

There may be other drugs that can interact with plerixafor. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about plerixafor.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.02. Revision Date: 2010-12-15, 5:01:39 PM.

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