Loxitane C

Generic Name: loxapine (LOX a peen)
Brand Name: Loxitane

What is Loxitane C (loxapine)?

Loxapine is an antipsychotic medication. It affects the actions of chemicals in your brain.

Loxapine is used to treat schizophrenia.

Loxapine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Loxitane C (loxapine)?

Loxapine is not for use in psychotic conditions related to dementia. Loxapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use this medication if you are allergic to loxapine, or if you have decreased alertness caused by taking certain medications or drinking alcohol.

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Call your doctor at once if you have restless muscle movements in your eyes, tongue, jaw, or neck.

Loxapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol. You should not take loxapine if you are under the effects of alcohol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Loxapine can decrease perspiration and you may be more prone to heat stroke.

What should I discuss with my healthcare provider before taking Loxitane C (loxapine)?

Loxapine is not for use in psychotic conditions related to dementia. Loxapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use this medication if you are allergic to loxapine, or if you have decreased alertness caused by taking certain medications or drinking alcohol.

To make sure loxapine is safe for you, tell your doctor if you have:

  • epilepsy or other seizure disorder;

  • a history of low white blood cell (WBC) counts;

  • glaucoma;

  • urination problems;

  • heart disease; or

  • a history of breast cancer;

Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking loxapine, do not stop taking it without your doctor's advice.

It is not known whether loxapine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Loxitane C (loxapine)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take loxapine with a full glass of water.

You may not start feeling better right away when you start taking loxapine. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Loxitane C (loxapine)?

Loxapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. You should not take loxapine if you are under the effects of alcohol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Loxapine can decrease perspiration and you may be more prone to heat stroke.

Loxitane C (loxapine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using loxapine and call your doctor at once if you have:

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;

  • restless muscle movements in your eyes, tongue, jaw, or neck;

  • tremor (uncontrolled shaking);

  • trouble swallowing;

  • seizure (convulsions);

  • easy bruising or bleeding, unusual weakness;

  • fever, chills, body aches, flu symptoms;

  • vision changes;

  • severe constipation; or

  • little or no urinating.

Other common side effects may include:

  • dizziness or drowsiness;

  • blurred vision;

  • puffiness in your face;

  • feeling restless or agitated;

  • sleep problems (insomnia);

  • breast swelling or discharge;

  • changes in your menstrual periods;

  • nausea, vomiting, constipation;

  • changes in weight;

  • dry mouth, stuffy nose; or

  • mild skin rash, itching, or flaking.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Loxitane C (loxapine)?

Taking loxapine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking loxapine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with loxapine, especially:

  • bladder or urinary medicines such as darifenacin, tolterodine, solifenacin;

  • bronchodilators such as ipratropium or tiotropium;

  • cold or allergy medicine that contains an antihistamine;

  • medication for Parkinson's disease; or

  • medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome.

This list is not complete. Other drugs may interact with loxapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about loxapine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01. Revision Date: 2013-01-07, 11:56:43 AM.

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