Generic Name: granisetron (oral) (gra NIS e tron)
Brand Name: Granisol, Kytril
What is granisetron?
Granisetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Granisetron is used to prevent nausea and vomiting that may be caused by medicine to treat cancer (chemotherapy or radiation).
Granisetron may be used for other purposes not listed in this medication guide.
What is the most important information I should know about granisetron?
You should not use this medication if you are allergic to granisetron or to similar medicines such as dolasetron (Anzemet), ondansetron (Zofran), or palonosetron (Aloxi).
Before taking granisetron, tell your doctor if you have liver disease, a heart rhythm disorder, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a personal or family history of Long QT syndrome.
Granisetron is usually started up to 1 hour before chemotherapy. Tell your doctor if you forget to take the medication within the specified amount of time before your procedure.
What should I discuss with my health care provider before taking granisetron?
You should not use this medication if you are allergic to granisetron, to similar medicines such as dolasetron (Anzemet), ondansetron (Zofran), or palonosetron (Aloxi).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take granisetron:
a heart rhythm disorder;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
a personal or family history of Long QT syndrome.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether granisetron passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take granisetron?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Granisetron is usually started up to 1 hour before chemotherapy. Follow your doctor's instructions.
Measure the liquid form of granisetron with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Store granisetron at room temperature away from moisture and heat.
What happens if I miss a dose?
Tell your doctor if you forget to take your dose within 1 hour before chemotherapy. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have received too much of this medicine.
Overdose symptoms may include headache.
What should I avoid while taking granisetron?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Granisetron side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
fast or pounding heartbeats;
fever, body aches, flu symptoms; or
easy bruising or bleeding; unusual weakness.
Less serious side effects may include:
stomach pain or upset, loss of appetite;
diarrhea or constipation;
sleep problems (insomnia);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Kytril side effects (in more detail)
What other drugs will affect granisetron?
There may be other drugs that can interact with granisetron. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
More Kytril resources
- Kytril Consumer Overview
- Kytril Monograph (AHFS DI)
- Kytril Advanced Consumer (Micromedex) - Includes Dosage Information
- Kytril Prescribing Information (FDA)
- Kytril MedFacts Consumer Leaflet (Wolters Kluwer)
- Granisetron Prescribing Information (FDA)
- Granisol Prescribing Information (FDA)
- Sancuso Prescribing Information (FDA)
- Sancuso Advanced Consumer (Micromedex) - Includes Dosage Information
- Sancuso Consumer Overview
- Sancuso MedFacts Consumer Leaflet (Wolters Kluwer)
Compare Kytril with other medications
Where can I get more information?
- Your pharmacist can provide more information about granisetron.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 9.02. Revision Date: 2010-12-15, 5:01:39 PM.