insulin glulisine

Generic Name: insulin glulisine (IN su lin GLOO lis een)
Brand Name: Apidra, Apidra OptiClik Cartridge, Apidra SoloStar Pen

What is insulin glulisine?

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glulisine is a faster-acting form of insulin than regular human insulin.

Insulin glulisine is used to treat diabetes in adults and children who are at least 4 years old. It is usually given together with a long-acting insulin.

Insulin glulisine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about insulin glulisine?

You should not use this medicine if you are having an episode of hypoglycemia (low blood sugar).

Slideshow: 2013 Drug News Round-Up - Top 20 Stories

What should I discuss with my healthcare provider before using insulin glulisine?

You should not use this medicine if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

To make sure insulin glulisine is safe for you, tell your doctor if:

  • you have liver or kidney disease; or

  • if you also take certain oral diabetes medicine (pioglitazone, rosiglitazone, Actos, Avandia).

Insulin glulisine is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

FDA pregnancy category C. It is not known whether insulin glulisine is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether insulin glulisine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use insulin glulisine?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Insulin glulisine is a fast-acting insulin that begins to work very quickly. You should use it within 15 minutes before or 20 minutes after you start eating a meal.

Insulin glulisine is injected under the skin using a needle and syringe, an injection pen, or an insulin pump. It may also be given through a needle placed into a vein. You will be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use a different place on your stomach, thigh, or upper arm each time you give the injection. Your care provider will show you the best places on your body to inject the medicine. Do not inject into the same place two times in a row.

Infusion pump tubing, catheters, and the needle location on your skin should be changed every 48 hours.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Storing unopened vials, cartridges, or injection pens: Keep in the carton and store in a refrigerator, protected from light. Throw away any insulin not used before the expiration date on the medicine label. Do not freeze insulin glulisine, and throw away the medication if it has become frozen.

Unopened vials, cartridges, or injection pens may also be stored at room temperature for up to 28 days, away from heat and bright light. Throw away any insulin not used within 28 days.

Storing after your first use: You may keep "in-use" vials in the refrigerator or at room temperature, protected from light. Use within 28 days.

In-use cartridges or injection pens must be stored at room temperature, away from heat and bright light. Do not refrigerate an in-use cartridge or injection pen. Keep it at room temperature and use within 28 days.

An infusion set should be stored at room temperature and used within 48 hours.

What happens if I miss a dose?

Since insulin glulisine is used before meals, you may not be on a timed dosing schedule. Whenever you use insulin glulisine, be sure to eat a meal within 15 minutes. Do not use extra insulin glulisine to make up a missed dose.

Use insulin glulisine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An insulin overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, seizure (convulsions), or coma.

What should I avoid while using insulin glulisine?

Avoid drinking alcohol. It can affect your blood sugar levels.

Insulin glulisine side effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Call your doctor at once if you have:

  • itching, swelling, redness, or thickening of the skin where you inject insulin glulisine; or

  • low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

  • low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Insulin glulisine dosing information

Usual Adult Dose for Diabetes Type 1:

Individualize dose based on metabolic needs and frequent monitoring of blood glucose
-Total daily insulin requirements (prandial plus basal) are generally between 0.5 to 1 unit/kg/day
-Use HbA1c values to guide therapy; consult current guidelines for optimal target ranges

Multiple-dose injection (MDI):
-Administer subcutaneously 3 to 4 times a day with meals and/or snacks; as a prandial insulin, it should be used in combination with a basal insulin
-Match prandial insulin dose to carbohydrate intake, pre-meal blood glucose, and anticipated activity

Continuous Subcutaneous Infusion (Insulin Pump)
-Initial programming should be based on the total daily insulin dose of previous MDI regimen; check with pump labeling to ensure the pump has been evaluated with this insulin

Intravenous Administration
-Dilute to a concentration of 0.05 to 1 unit/mL in normal saline in an infusion system using polyvinyl chloride (PVC) bags; closely monitor blood glucose and serum potassium during administration

Use: To improve glycemic control in adult patients with diabetes mellitus.

Usual Adult Dose for Diabetes Type 2:

Individualize dose based on metabolic needs and frequent monitoring of blood glucose
-Use HbA1c values to guide therapy; consult current guidelines for optimal target ranges.
-Administer subcutaneously with meals; as a prandial insulin, it should be used in combination with an intermediate or long-acting insulin or basal insulin analog and can be used with oral hypoglycemic agents.

Continuous Subcutaneous Infusion (Insulin Pump)
-Initial programming should be based on the total daily insulin dose of previous MDI regimen; check with pump labeling to ensure the pump has been evaluated with this insulin

Intravenous Administration
-Dilute to a concentration of 0.05 to 1 unit/mL in normal saline in an infusion system using polyvinyl chloride (PVC) bags; closely monitor blood glucose and serum potassium during administration

Use: To improve glycemic control in patients with diabetes mellitus.

Usual Pediatric Dose for Diabetes Type 1:

4 years and older: Individualize dose based on metabolic needs and frequent monitoring of blood glucose
-Use HbA1c values to guide therapy; consult current guidelines for optimal target ranges

Multiple-dose injection (MDI):
-Administer subcutaneously 3 to 4 times a day with meals and/or snacks; as a prandial insulin, it should be used in combination with a basal insulin
-Match prandial insulin dose to carbohydrate intake, pre-meal blood glucose, and anticipated activity

Continuous Subcutaneous Infusion (Insulin Pump)
-Initial programming should be based on the total daily insulin dose of previous MDI regimen; check with pump labeling to ensure the pump has been evaluated with this insulin

Intravenous Administration
-Dilute to a concentration of 0.05 to 1 unit/mL in normal saline in an infusion system using polyvinyl chloride (PVC) bags; closely monitor blood glucose and serum potassium during administration

Use: To improve glycemic control in pediatric patients 4 years or older with type 1 diabetes mellitus.

What other drugs will affect insulin glulisine?

Many other medicines can increase or decrease the effects of insulin glulisine on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about insulin glulisine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.04. Revision Date: 2014-08-28, 1:57:47 PM.

Hide
(web1)