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Gadobenate dimeglumine

Generic name: gadobenate dimeglumine [ GAD-oh-BEN-ate-dye-MEG-loo-meen ]
Brand name: Multihance
Dosage form: intravenous solution (529 mg/mL)
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by Drugs.com on Apr 15, 2024. Written by Cerner Multum.

What is gadobenate dimeglumine?

Gadobenate dimeglumine is a contrast agent that has magnetic properties. It is used in combination with magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on MRI or MRA.

Gadobenate dimeglumine is used to help diagnose certain disorders of the brain and spine (central nervous system).

Gadobenate dimeglumine is also used in adults to diagnose atherosclerosis (clogged arteries).

Gadobenate dimeglumine may also be used for purposes not listed in this medication guide.

Gadobenate dimeglumine side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects of gadobenate dimeglumine may occur up to several days after injection.

Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

Gadobenate dimeglumine may cause serious side effects. Call your doctor at once if you have:

Common side effects of gadobenate dimeglumine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gadobenate dimeglumine side effects (more detail)

Warnings

Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. Before receiving gadobenate dimeglumine, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadobenate dimeglumine. Also tell your doctor if you have recently received any contrast agents similar to gadobenate dimeglumine.

Before taking this medicine

Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. Ask your doctor about your individual risk.

Gadobenate dimeglumine can stay in your body for months or years after you receive gadobenate dimeglumine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive gadobenate dimeglumine if you are allergic to it.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is gadobenate dimeglumine given?

Gadobenate dimeglumine is given as an infusion into a vein. A healthcare provider will give you this injection.

You will be watched for a short time to make sure you do not have an allergic reaction.

Gadobenate dimeglumine dosing information

Usual Adult Dose for CNS Magnetic Resonance Imaging:

0.1 mmol/kg (0.2 mL/kg) as a rapid bolus intravenous injection. To ensure complete injection of the medium, the injection should be followed by a saline flush of at least 5 mL.

Usual Adult Dose for Magnetic Resonance Angiography:

MRA of renal and aorto-ilio-femoral vessels:

0.1 mmol/kg (0.2 mL/kg) as a rapid bolus intravenous injection followed by a saline flush of at least 20 mL either manually or using an automatic injector system.

Imaging may be started immediately after the administration of gadobenate meglumine, with scan delay calculated by test bolus or automatic bolus detection technique. If bolus timing is not determined by an automatic contrast detection pulse sequence, then a test bolus injection of 1-2 ml of gadobenate meglumine should be used to calculate the scan delay.

Usual Pediatric Dose for CNS Magnetic Resonance Imaging:

2 years and older:
0.1 mmol/kg (0.2 mL/kg) as a rapid bolus intravenous injection. To ensure complete injection of the medium, the injection should be followed by a saline flush of at least 5 mL.

Detailed Gadobenate dimeglumine dosage information

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid after receiving gadobenate dimeglumine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect gadobenate dimeglumine?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect gadobenate dimeglumine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Gadobenate dimeglumine drug interactions (more detail)

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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