fibrinolysis inhibitor-thrombin topical

Generic Name: fibrin sealant topical (FYE brin SEE lant TOP i kal)
Brand Name: Artiss, Artiss Duo Set, Artiss Duploject, Tisseel, Tisseel Duploject Kit, Tisseel Valupak Kit, Tisseel VH Kit

What is fibrin sealant topical?

Fibrin sealant is made of two substances from human plasma that work together to help your blood clot.

Fibrin sealant topical is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. Fibrin sealant topical may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed.

Fibrin sealant topical is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery.

Fibrin sealant topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about fibrin sealant topical?

You should not be treated with fibrin sealant topical if you are allergic to cows or products made from cows.

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What should I discuss with my healthcare provider before I receive fibrin sealant topical?

You should not be treated with fibrin sealant topical if you are allergic to cows or products made from cows.

FDA pregnancy category C. It is not known whether fibrin sealant topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether fibrin sealant topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use fibrin sealant topical?

Fibrin sealant topical can be sprayed or dripped onto the affected skin or surgical area. This medicine is applied by a healthcare professional in a surgical or clinical setting.

Fibrin sealant topical is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Some people develop symptoms of a viral infection after being treated with fibrin sealant topical. Call your doctor if you have flu-like symptoms such as fever, chills, drowsiness, or a runny nose. You may also have joint pain and a skin rash about 2 weeks after the start of your flu symptoms.

What happens if I miss a dose?

Because you will receive fibrin sealant topical in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after being treated with fibrin sealant topical?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Fibrin sealant topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching, warmth, redness, numbness, tingly feeling; nausea, vomiting, feeling light-headed, fast or slow heartbeats; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Fibrin sealant is sometimes applied with a spray device that uses gas pressure. High pressure may cause the release of air or gas under the skin tissues, where it can then travel throughout the body. This may be more likely when high pressure settings are improperly used by a healthcare provider during the spray application of fibrin sealant. Air or gas trapped within the body can cause serious or life-threatening effects. Talk with your doctor about this risk.

Tell your caregivers at once if you have:

  • chest pain, cough, trouble breathing, gasping for breath;

  • confusion, agitation, panic, extreme fear;

  • sudden numbness or weakness (especially on one side of the body);

  • sudden severe headache, slurred speech, problems with vision or balance;

  • blue-colored appearance under of your skin or lips;

  • nausea, dizziness or spinning sensation;

  • a light-headed feeling, like you might pass out; or

  • redness, itching, irritation, or slow healing of the skin wound or treated area;

Common side effects may include:

  • itching; or

  • swelling or bruising.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Fibrinolysis inhibitor-thrombin topical dosing information

Usual Adult Dose for Hemostasis:

Before application, the wound surface should be as dry as possible.

Apply fibrin sealant topical as a thin layer. The initial amount of the product to be applied should be sufficient to entirely cover the intended application area. The application can be repeated, if necessary.

The required dose of fibrin sealant topical depends on the size of the surface to be covered.

After the two components have been applied, fix or hold the sealed parts in the desired position for at least three to five minutes to ensure the setting fibrin sealant topical adheres firmly to the surrounding tissue.

Usual Adult Dose for Closure of Colostomy:

Before application, the wound surface should be as dry as possible.

Apply fibrin sealant topical as a thin layer. The initial amount of the product to be applied should be sufficient to entirely cover the intended application area. The application can be repeated, if necessary.

The required dose of fibrin sealant topical depends on the size of the surface to be covered.

After the two components have been applied, fix or hold the sealed parts in the desired position for at least three to five minutes to ensure the setting fibrin sealant topical adheres firmly to the surrounding tissue.

What other drugs will affect fibrin sealant topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied fibrin sealant. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about fibrin sealant topical.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Revision Date: 2014-06-06, 2:11:56 PM.

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