Generic Name: dolasetron (injection) (doe LAY se tron)
Brand Name: Anzemet
What is dolasetron?
Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Dolasetron injection is used to prevent nausea and vomiting caused by surgery.
Dolasetron injection may also be used for purposes not listed in this medication guide.
What is the most important information I should know about dolasetron injection?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What should I discuss with my healthcare provider before receiving dolasetron injection?
You should not receive dolasetron if you are allergic to it.
Dolasetron can cause serious heart rhythm problems. You should not use this medicine if you have a history of Long QT syndrome. Tell your doctor if anyone in your family has ever had this condition.
To make sure dolasetron is safe for you, tell your doctor if you have:
a serious heart condition such as "sick sinus syndrome";
a heart rhythm disorder such as slow heartbeats, or atrial fibrillation (fast, irregular heart rhythm);
congestive heart failure; or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
FDA pregnancy category B. Dolasetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether dolasetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is dolasetron injection given?
For adults, dolasetron is injected into a vein through an IV. For children, the medicine may be mixed with apple juice and given orally (by mouth). You will receive this injection in a clinic or hospital setting before or during surgery.
In most cases, only one dose of dolasetron is given while you are still under anesthesia, or as soon as you have symptoms of nausea or vomiting.
Dolasetron injection is not for preventing nausea or vomiting that is caused by chemotherapy or factors other than surgery.
What happens if I miss a dose?
Since dolasetron injection is usually given as single dose by a healthcare professional, you will not be on a frequent dosing schedule.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include depression, tremors, feeling light-headed, fainting, or seizure (convulsions).
What should I avoid after receiving dolasetron injection?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dolasetron injection side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have:
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
a light-headed feeling, like you might pass out;
slow heart rate, weak pulse, slow breathing;
little or no urinating; or
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Common side effects may include:
fast or slow heart rate;
chills, shivering, anxiety;
upset stomach, diarrhea;
tired feeling; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Dolasetron dosing information
Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:
100 mg orally may be given for prevention within one hour before chemotherapy.
Approved indication: For the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy (including initial and repeat courses) in adults and children age 2 and older.
Usual Adult Dose for Nausea/Vomiting -- Postoperative:
12.5 mg IV given for prevention 15 minutes before the cessation of anesthesia or for treatment as soon as nausea or vomiting presents.
Approved indications: For the prevention or treatment of postoperative nausea and/or vomiting.
Usual Pediatric Dose for Nausea/Vomiting -- Postoperative:
2 years and older: 0.35 mg/kg (maximum: 12.5 mg) IV given for prevention 15 minutes before the cessation of anesthesia or for treatment as soon as nausea or vomiting presents.
Alternatively, 1.2 mg/kg (maximum: 100 mg) orally may be given for prevention within 2 hours before surgery.
Approved indications: For the prevention or treatment of postoperative nausea and/or vomiting in pediatric patients 2 years and older.
Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:
2 years and older:
1.8 mg/kg (maximum of 100 mg) orally within one hour before chemotherapy
Maximum dose: 100 mg
For children who cannot swallow tablets or in whom the 100 mg tablet is inappropriate based on their weight, the injection solution may be mixed into apple or apple-grape juice and taken orally. The mixture is stable for up to 2 hours at room temperature. However, due to dose dependent QT prolongation, the IV solution is contraindicated in adult and pediatric patients for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
Approved indication: For the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy (including initial and repeat courses) in pediatric patients 2 years and older.
What other drugs will affect dolasetron injection?
There are many other medicines that can increase your risk of heart rhythm problems if you use them together with dolasetron.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with dolasetron, especially:
an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
cancer medicine--arsenic trioxide, vandetanib;
an antidepressant--citalopram, escitalopram;
anti-malaria medication--chloroquine, halofantrine;
heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine.
This list is not complete. Other drugs may interact with dolasetron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about dolasetron
- Dolasetron tablets
- Dolasetron (Advanced Reading)
- Dolasetron Oral, Intravenous (Advanced Reading)
- Other brands: Anzemet
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about dolasetron injection.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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