dexamethasone intravitreal implant

Pronunciation

Generic Name: dexamethasone intravitreal implant (DEX a METH a sone IN tra VIT ree al IM plant)
Brand Name: Ozurdex

What is dexamethasone intravitreal implant?

Dexamethasone is a steroid used to treat inflammation.

Dexamethasone intravitreal is an implant injected into the eye to treat swelling that may occur when there is a blockage of certain blood vessels in your eyes.

Dexamethasone intravitreal implant is also used to treat posterior uveitis, inflammation that affects the back part of the eye.

Dexamethasone intravitreal implant may also be used for purposes not listed in this medication guide.

What is the most important information I should know about dexamethasone intravitreal implant?

Dexamethasone intravitreal is a steroid implant injected into the eye to treat swelling that may occur when there is a blockage of certain blood vessels in your eyes.

You should not receive this implant if you have an eye infection, advanced glaucoma, an artificial lens implanted in your eye, or a history of eye ulcer, surgery, or wound that has injured or removed the lens in your eye.

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Dexamethasone intravitreal implant can increase your risk of certain eye problems. Call your doctor at once if you have vision changes, eye pain or redness, increased sensitivity to light, or seeing halos around lights.

What should I discuss with my healthcare provider before receiving dexamethasone intravitreal implant?

You should not receive this medication if you are allergic to dexamethasone, or if you have:

  • an eye infection;

  • advanced glaucoma;

  • an artificial lens implanted in your eye; or

  • a history of eye ulcer, surgery, or wound that has injured or removed the lens in your eye.

To make sure dexamethasone intravitreal is safe for you, tell your doctor if you have ever had herpes infection of the eyes.

FDA pregnancy category C. It is not known whether dexamethasone intravitreal implant will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether dexamethasone intravitreal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is dexamethasone intravitreal implant given?

Dexamethasone intravitreal implant will be injected into your eye by healthcare professional in a clinic setting.

After the implant is put in place, you will be watched closely for any swelling, inflammation, or increased pressure in your eye.

What happens if I miss a dose?

Since dexamethasone intravitreal is a surgical implant, it does not have a daily dosing schedule.

What happens if I overdose?

Since the dexamethasone intravitreal implant contains a specific amount of the medication, you are not likely to receive an overdose.

What should I avoid after receiving dexamethasone intravitreal implant?

This medication may cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Dexamethasone intravitreal implant side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • vision problems, eye pain, or seeing halos around lights;

  • eye redness, increased sensitivity of your eyes to light; or

  • vision changes.

Common side effects may include blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Dexamethasone intravitreal implant dosing information

Usual Adult Dose for Iritis:

For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Adult Dose for Keratitis:

For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Adult Dose for Conjunctivitis:

For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Adult Dose for Cyclitis:

For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Adult Dose for Acute Otitis Externa:

Instill 3 to 4 drops in the affected ear 2 to 3 times a day. Dosage may be reduced gradually as symptoms improve.

Alternatively, a cotton wick may be saturated with the solution or suspension and inserted into the ear canal. The wick should be kept moist with the ear drops and replaced every 12 to 24 hours.

Usual Adult Dose for Uveitis:

For the treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) and for the treatment of noninfectious uveitis affecting the posterior segment of the eye:

1 implant, containing 0.7 mg of dexamethasone, to be surgically injected into the vitreous cavity of the affected eye.

Usual Adult Dose for Macular Edema:

For the treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) and for the treatment of noninfectious uveitis affecting the posterior segment of the eye:

1 implant, containing 0.7 mg of dexamethasone, to be surgically injected into the vitreous cavity of the affected eye.

Usual Pediatric Dose for Iritis:

1 year or older: For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Pediatric Dose for Keratitis:

1 year or older: For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Pediatric Dose for Conjunctivitis:

1 year or older: For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Pediatric Dose for Cyclitis:

1 year or older: For steroid responsive inflammatory ocular conditions:
Solution: For severe conditions, initially instill 1 to 2 drops in the lower conjunctival sac up to every hour during the day and every 2 hours during the night. Once improvement is observed, dosage may be decreased to 1 drop every 3 to 4 hours, then 1 drop 3 to 4 times daily.

Suspension: For severe conditions, instill 1 to 2 drops in the lower conjunctival sac up to every hour. Once improvement is observed, dosage may be decreased to 4 to 6 times daily, and gradually reduced further until discontinuation.

Ointment: Apply small amount to the conjunctiva 3 to 4 times a day. Once improvement is observed, may gradually reduce frequency before discontinuation.

Usual Pediatric Dose for Acute Otitis Externa:

1 year or older:
Instill 3 to 4 drops in the affected ear 2 to 3 times a day. Dosage may be reduced gradually as symptoms improve.

Alternatively, a cotton wick may be saturated with the solution or suspension and inserted into the ear canal. The wick should be kept moist with the ear drops and replaced every 12 to 24 hours.

What other drugs will affect dexamethasone intravitreal implant?

It is not likely that other drugs you take orally or inject will have an effect on dexamethasone used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about dexamethasone intravitreal implant.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.02. Revision Date: 2013-12-03, 9:50:40 AM.

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