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dexamethasone intravitreal implant

Pronunciation

Generic Name: dexamethasone intravitreal implant (DEX a METH a sone IN tra VIT ree al IM plant)
Brand Name: Ozurdex

What is dexamethasone intravitreal implant?

Dexamethasone is a steroid used to treat inflammation.

Dexamethasone intravitreal is an implant injected into the eye to treat swelling that may occur when there is a blockage of certain blood vessels in your eyes.

Dexamethasone intravitreal implant is also used to treat posterior uveitis, inflammation that affects the back part of the eye.

Dexamethasone intravitreal implant may also be used for purposes not listed in this medication guide.

What is the most important information I should know about dexamethasone intravitreal implant?

You should not receive this implant if you have an eye infection, advanced glaucoma, an artificial lens implanted in your eye, or a history of eye ulcer, surgery, or wound that has injured or removed the lens in your eye.

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What should I discuss with my healthcare provider before receiving dexamethasone intravitreal implant?

You should not receive this implant if you are allergic to dexamethasone, or if you have:

  • an eye infection;

  • advanced glaucoma;

  • an artificial lens implanted in your eye; or

  • a history of eye ulcer, surgery, or wound that has injured or removed the lens in your eye.

To make sure dexamethasone intravitreal is safe for you, tell your doctor if you have ever had herpes infection of the eyes.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Dexamethasone can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is dexamethasone intravitreal implant given?

Dexamethasone intravitreal implant will be injected into your eye by healthcare professional in a clinic setting.

After the implant is put in place, you will be watched closely for any swelling, inflammation, or increased pressure in your eye.

What happens if I miss a dose?

Since dexamethasone intravitreal is a surgical implant, it does not have a daily dosing schedule.

What happens if I overdose?

Since the dexamethasone intravitreal implant contains a specific amount of the medicine, you are not likely to receive an overdose.

What should I avoid after receiving dexamethasone intravitreal implant?

This medicine may cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Dexamethasone intravitreal implant side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • vision problems, eye pain, or seeing halos around lights;

  • eye redness, increased sensitivity of your eyes to light; or

  • vision changes.

Common side effects may include blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Dexamethasone intravitreal implant dosing information

Usual Adult Dose for Iritis:

Suspension: Instill one or two drops topically in the conjunctival sac(s).

Comments:
-In severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation decreases.
-In mild disease, drops may be used up to four to six times a day, being tapered to discontinuation as the inflammation decreases.

Ointment: Apply a one-half to one inch ribbon of ointment into the conjunctival sac(s) up to four times a day

Comments:
-When improvement is observed, use may be reduced gradually to once a day application for several days.
-Ointment may be used in conjunction with suspension.

Uses:
-Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe (including allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivities, corneal injury from chemical or thermal burns, or penetration of foreign bodies)

Usual Adult Dose for Keratitis:

Suspension: Instill one or two drops topically in the conjunctival sac(s).

Comments:
-In severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation decreases.
-In mild disease, drops may be used up to four to six times a day, being tapered to discontinuation as the inflammation decreases.

Ointment: Apply a one-half to one inch ribbon of ointment into the conjunctival sac(s) up to four times a day

Comments:
-When improvement is observed, use may be reduced gradually to once a day application for several days.
-Ointment may be used in conjunction with suspension.

Uses:
-Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe (including allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivities, corneal injury from chemical or thermal burns, or penetration of foreign bodies)

Usual Adult Dose for Conjunctivitis:

Suspension: Instill one or two drops topically in the conjunctival sac(s).

Comments:
-In severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation decreases.
-In mild disease, drops may be used up to four to six times a day, being tapered to discontinuation as the inflammation decreases.

Ointment: Apply a one-half to one inch ribbon of ointment into the conjunctival sac(s) up to four times a day

Comments:
-When improvement is observed, use may be reduced gradually to once a day application for several days.
-Ointment may be used in conjunction with suspension.

Uses:
-Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe (including allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivities, corneal injury from chemical or thermal burns, or penetration of foreign bodies)

Usual Adult Dose for Cyclitis:

Suspension: Instill one or two drops topically in the conjunctival sac(s).

Comments:
-In severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation decreases.
-In mild disease, drops may be used up to four to six times a day, being tapered to discontinuation as the inflammation decreases.

Ointment: Apply a one-half to one inch ribbon of ointment into the conjunctival sac(s) up to four times a day

Comments:
-When improvement is observed, use may be reduced gradually to once a day application for several days.
-Ointment may be used in conjunction with suspension.

Uses:
-Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe (including allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivities, corneal injury from chemical or thermal burns, or penetration of foreign bodies)

Usual Adult Dose for Uveitis:

One implant, containing 0.7 mg of dexamethasone, to be surgically injected into the vitreous cavity of the affected eye

Comments:
-Following the intravitreal injection, patients should be monitored for elevation in intraocular pressure and for endophthalmitis.

Uses: Treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO), non-infectious uveitis affecting the posterior segment of the eye, and diabetic macular edema

Usual Adult Dose for Macular Edema:

One implant, containing 0.7 mg of dexamethasone, to be surgically injected into the vitreous cavity of the affected eye

Comments:
-Following the intravitreal injection, patients should be monitored for elevation in intraocular pressure and for endophthalmitis.

Uses: Treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO), non-infectious uveitis affecting the posterior segment of the eye, and diabetic macular edema

What other drugs will affect dexamethasone intravitreal implant?

It is not likely that other drugs you take orally or inject will have an effect on dexamethasone used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about dexamethasone intravitreal implant.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Revision Date: 2015-01-14, 1:06:51 PM.

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