darifenacin

Generic Name: darifenacin (dar e FEN a sin)
Brand Name: Enablex

What is darifenacin?

Darifenacin reduces muscle spasms of the bladder and urinary tract.

Darifenacin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage).

Darifenacin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about darifenacin?

You should not take darifenacin if you are have untreated or uncontrolled narrow-angle glaucoma, a stomach disorder causing delayed emptying, or if you have trouble emptying your bladder.

Slideshow: How to Manage Your Overactive Bladder

What should I discuss with my health care provider before taking darifenacin?

You should not take darifenacin if you are allergic to it, or if you have:

  • untreated or uncontrolled narrow-angle glaucoma;

  • a stomach disorder causing delayed emptying; or

  • if you have trouble emptying your bladder.

To make sure darifenacin is safe for you, tell your doctor if you have:

  • glaucoma;

  • liver disease;

  • ulcerative colitis;

  • a blockage in your stomach or intestines;

  • a muscle disorder such as myasthenia gravis; or

  • if you have very little urine or a weak stream of urine.

FDA pregnancy category C. It is not known whether darifenacin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether darifenacin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take darifenacin?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with water.

Darifenacin can be taken with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause vision problems.

What should I avoid while taking darifenacin?

This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Darifenacin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using darifenacin and call your doctor at once if you have:

  • severe stomach pain or constipation;

  • confusion, hallucinations;

  • little or no urinating;

  • pain or burning when you urinate; or

  • signs of dehydration--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects may include:

  • nausea, indigestion;

  • constipation;

  • headache, dizziness;

  • dry mouth; or

  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Darifenacin dosing information

Usual Adult Dose for Urinary Incontinence:

Initial dose: 7.5 mg orally once daily with liquid

The dosage may be increased to 15 mg orally once daily two weeks after starting therapy.

Usual Adult Dose for Urinary Frequency:

Initial dose: 7.5 mg orally once daily with liquid

The dosage may be increased to 15 mg orally once daily two weeks after starting therapy.

What other drugs will affect darifenacin?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with darifenacin, especially:

  • clarithromycin;

  • flecainide;

  • thioridazine;

  • an antidepressant--amitriptyline, clomipramine, desipramine, doxepin, imipramine, nefazodone, nortriptyline;

  • antifungal medicine--itraconazole, ketoconazole; or

  • HIV or AIDS medicine--nelfinavir, ritonavir.

This list is not complete. Other drugs may interact with darifenacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about darifenacin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Revision Date: 2014-03-13, 2:59:37 PM.

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