Crixivan

Generic Name: indinavir (in DIN a veer)
Brand Name: Crixivan

What is Crixivan (indinavir)?

Indinavir is a protease (PRO-tee-ayz) inhibitor antiviral medicine that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Indinavir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Indinavir is not a cure for HIV or AIDS.

Indinavir may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Crixivan (indinavir)?

Life-threatening side effects may occur if you take indinavir with certain other medicines. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with indinavir, and some drugs should not be used together.

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What should I discuss with my healthcare provider before taking Crixivan (indinavir)?

You should not use indinavir if you are allergic to it.

Some medicines can cause dangerous or life-threatening side effects when used with indinavir. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • alfuzosin (Uroxatral);

  • atazanavir (Reyataz);

  • amiodarone (Cordarone, Pacerone);

  • pimozide (Orap);

  • rifampin (Rifadin, Rifamate, Rifater, Rimactane);

  • St. John's wort;

  • alprazolam (Xanax), oral midazolam (Versed), or triazolam (Halcion);

  • atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev, Advicor), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin, Juvisync);

  • dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), ergotamine (Ergomar, Migergot, Wigraine), or methylergonovine (Methergine);

  • sildenafil (Revatio, for treating pulmonary arterial hypertension); or

  • sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) for erectile dysfunction.

To make sure indinavir is safe for you, tell your doctor if you have:

  • cirrhosis or other liver disease;

  • kidney disease, or a history of kidney stones;

  • diabetes;

  • a bleeding disorder such as hemophilia; or

  • high cholesterol or triglycerides.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take Crixivan (indinavir)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Indinavir should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.

Indinavir is usually taken every 8 hours around the clock. Take the medicine at the same time each day.

Take indinavir with a full glass (8 ounces) of water or skim milk. You may also drink juice, coffee, or tea with this medicine. Drink at least 6 glasses of water each day to prevent kidney stones while you are taking indinavir.

If you prefer to take the medicine with food, eat only a light meal, such as dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

Use indinavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

While using indinavir, you will need frequent blood tests.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the capsules in their original container, along with the packet or canister of moisture-absorbing preservative. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 2 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Symptoms of an indinavir overdose may include nausea, vomiting, diarrhea, lower back pain, and blood in your urine.

What should I avoid while taking Crixivan (indinavir)?

If you also take didanosine, take it 1 hour before or after you take indinavir, on an empty stomach.

Taking indinavir will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Crixivan (indinavir) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Indinavir may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with indinavir. Tell your doctor if you have:

  • signs of a new infection--fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;

  • chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;

  • cold sores, sores on your genital or anal area;

  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

  • trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

Call your doctor at once if you have:

  • pain in your side or lower back, blood in your urine;

  • painful or difficult urination;

  • blood cell disorders--pale or yellowed skin, fever, easy bruising or bleeding (nosebleeds, bleeding gums), confusion or weakness;

  • high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss;

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • (if you also use a "statin" cholesterol medicine)--unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Common side effects may include:

  • stomach pain, nausea, vomiting, diarrhea;

  • indigestion, heartburn;

  • changes in appetite;

  • headache, dizziness, feeling weak or tired;

  • back pain;

  • rash, itching, dry skin;

  • altered sense of taste;

  • cold symptoms such as stuffy nose, sneezing, sore throat; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Crixivan (indinavir)?

Many drugs can interact with indinavir. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • midazolam given by injection;

  • rifabutin;

  • antifungal medicine--itraconazole, ketoconazole;

  • heart or blood pressure medication--amlodipine, felodipine, quinidine;

  • other HIV medicines--efavirenz, delavirdine;

  • seizure medicine--carbamazepine, phenobarbital, phenytoin; or

  • steroid medicine--dexamethasone, prednisone, and others.

This list is not complete and many other drugs can interact with indinavir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about indinavir.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 10.01. Revision Date: 2015-02-04, 9:00:36 AM.

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