creatine

Pronunciation

Generic Name: creatine (KREE ah tin)
Brand Name:

What is creatine?

The use of creatine in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal/health supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

Creatine is produced naturally in the kidney, liver, and pancreas of humans. Creatine is also supplied in meat and fish. Most creatine in the body is stored in the muscles, in the form of phosphocreatine. Creatine is a quickly available source of energy for muscle contraction. Creatine is also involved in muscle growth.

Creatine has been used to enhance athletic performance.

Creatine has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of creatine may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Creatine may also have uses other than those listed in this product guide.

What is the most important information I should know about creatine?

Drink plenty of fluid while taking creatine. Although it has not been proven, dehydration, heat-related illnesses, muscle cramps, reduced blood volume, and electrolyte imbalances are expected to be more likely to occur while taking creatine.

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Creatine has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of creatine may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Who should not take creatine?

Before taking creatine, talk to your doctor, pharmacist, or health care professional if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements. Creatine may not be recommended in some situations.

Do not take creatine without first talking to your doctor if you are pregnant or could become pregnant.

Do not take creatine without first talking to your doctor if you are breast-feeding a baby.

There is no information available regarding the use of creatine by children. Do not give any herbal/health supplement to a child without first talking to the child's doctor.

How should I take creatine?

The use of creatine in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal/health supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

If you choose to take creatine, use it as directed on the package or as directed by your doctor, pharmacist, or other health care provider.

One method of supplementing with creatine is called the "loading method". This consists of taking larger doses of creatine for 3 to 4 days. This method has been used by athletes when a short term rise in force is needed, such as before a football game or a weight lifting competition. Another method supplementing with creatine has been to use smaller doses over an extended training period. This method has been used by athletes who are more endurance focused or for long term training such as body building.

Different formulations of creatine may be available to be used internally (orally). Do not use different formulations (e.g., tablets, liquid, and powder) of creatine at the same time, unless specifically directed to do so by a health care professional. Using different formulations together increases the risk of an overdose of creatine.

It has been reported that creatine may be more effective if taken with carbohydrates.

Drink plenty of fluid while taking creatine. Although it has not been proven, dehydration, heat-related illnesses, muscle cramps, reduced blood volume, and electrolyte imbalances are expected to be more likely to occur while taking creatine.

Store creatine as directed on the package. In general, creatine should be protected from light and moisture and stored in a sealed container.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra creatine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Symptoms of a creatine overdose are not known. Long-term use of creatine may cause kidney damage.

What should I avoid while taking creatine?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Creatine side effects

Although uncommon, serious side effects have been reported with the use of creatine. Stop taking creatine and seek emergency medical attention or notify your doctor immediately if you experience:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or

  • symptoms of kidney problems such as decreased or little urine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect creatine?

Interactions between creatine and other prescription or over-the-counter medicines or herbal/health supplements have not been reported. Theoretically, creatine and other medicines that affect the kidneys may interact. Before taking creatine, talk to your doctor if you are taking:

  • a nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), diflunisal (Dolobid), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), ketoprofen (Orudis KT, Orudis, Oruvail), ketorolac (Toradol), nabumetone (Relafen), naproxen (Aleve, Anaprox, Naprosyn, Naprelan, others), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), and others;

  • trimethoprim (Bactrim, Sulfatrim, Trimpex, Proloprim);

  • probenecid (Benemid); or

  • cimetidine (Tagamet, Tagamet HB).

You may not be able to take creatine, or you may require special monitoring or dosage adjustments if you take creatine with any of the medicines listed above.

Drugs other than those listed here may also interact with creatine. Talk to your doctor, pharmacist, or health care professional before taking any other prescription or over-the-counter medicines or herbal/health supplements.

Where can I get more information?

  • Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Revision Date: 2011-01-10, 12:53:49 PM.

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