Medication Guide App

benzocaine and trimethobenzamide

Generic Name: benzocaine and trimethobenzamide (rectal) (BENZ o kain and try meth o BENZ uh myd)
Brand Name: Tigan Adult, Tigan Pediatric, Navogan, Tebamide, Triban, Tebamide Pediatric

What is benzocaine and trimethobenzamide?

Benzocaine and trimethobenzamide affects the areas of the brain that stimulate nausea and vomiting.

Benzocaine and trimethobenzamide is used to treat nausea and vomiting.

Benzocaine and trimethobenzamide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about benzocaine and trimethobenzamide?

Use caution when driving, operating machinery, or performing other hazardous activities. Benzocaine and trimethobenzamide may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities.

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Avoid drinking alcohol, which may increase drowsiness and dizziness while you are taking benzocaine and trimethobenzamide.

What should I discuss with my healthcare provider before using benzocaine and trimethobenzamide?

Before using this medication, tell your doctor if you have:

  • kidney or liver disease;

  • an enlarged prostate;

  • difficulty urinating;

  • bladder problems;

  • glaucoma;

  • asthma; or

  • heart disease or a heart rhythm disorder.

If you have any of these conditions, you may not be able to use benzocaine and trimethobenzamide, or you may need a dosage adjustment or special tests during treatment.

It is not known whether benzocaine and trimethobenzamide will be harmful to an unborn baby. Do not take benzocaine and trimethobenzamide without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether benzocaine and trimethobenzamide passes into breast milk. Do not take benzocaine and trimethobenzamide without first talking to your doctor if you are breast-feeding a baby.

Do not give this medicine to a child, especially if the child has a fever or has recently had chicken pox.

How should I use benzocaine and trimethobenzamide?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor.

The suppositories are for rectal use. Do not take them by mouth.

Unwrap the suppository when you are ready to insert it. You may wet the tip of the suppository with cold water. Lie down on your side and use your finger to insert the suppository into your rectum. Hold in the suppository and remain lying down for a few minutes while the medicine dissolves.

To make the rectal suppository easier to insert, you may chill it in the refrigerator for 30 minutes before use.

Benzocaine and trimethobenzamide is normally used three or four times a day. You may also be using the medicine only as needed. Follow your doctor's instructions.

Do not take more of this medication than is prescribed for you.

Store benzocaine and trimethobenzamide suppositories at room temperature away from moisture and heat.

What happens if I miss a dose?

Since benzocaine and trimethobenzamide is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a benzocaine and trimethobenzamide overdose may include drowsiness, uncontrollable movements, muscle spasms, blurred vision, seizures or convulsions, difficulty breathing, and death.

What should I avoid while using benzocaine and trimethobenzamide?

Use caution when driving, operating machinery, or performing other hazardous activities. Benzocaine and trimethobenzamide may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities.

Avoid drinking alcohol, which may increase drowsiness and dizziness while you are taking benzocaine and trimethobenzamide.

Benzocaine and trimethobenzamide side effects

Get emergency medical help if you have any of these signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

If you experience any of the following serious side effects, stop taking benzocaine and trimethobenzamide and seek emergency medical attention or contact your doctor immediately:

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • jaundice (yellowing of the skin or eyes);

  • seizure (convulsions); or

  • easy bruising or bleeding, unusual weakness;

  • tremor (uncontrolled shaking); or

  • muscle cramps, severe muscle spasms.

Other less serious side effects are more likely to occur. Continue using benzocaine and trimethobenzamide and talk with your doctor if you have any of these less serious side effects:

  • drowsiness or dizziness;

  • headache;

  • feeling depressed or disoriented; or

  • blurred vision.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

See also: Side effects (in more detail)

Benzocaine and trimethobenzamide dosing information

Usual Adult Dose for Nausea/Vomiting:

200 mg rectally 3 to 4 times a day as needed.

Usual Pediatric Dose for Nausea/Vomiting:

1 to 12 years: 15 to 20 mg/kg/day (400 to 500 mg/m2/day) rectally administered in equally divided doses 3 to 4 times a day as needed.

Alternatively:
1 to 12 years:
< 13.6 kg (30 lbs): 100 mg rectally 3 to 4 times a day as needed.
13.6 to 41 kg (30 to 90 lbs): 100 to 200 mg rectally 3 to 4 times a day as needed.

What other drugs will affect benzocaine and trimethobenzamide?

Benzocaine and trimethobenzamide may increase the side effects of other drugs that make you sleepy (such as alcohol, cold medicine, pain medication, muscle relaxants, and medicine for seizures, depression or anxiety). Before using benzocaine and trimethobenzamide, tell your doctor if you are using any of these medicines.

There may be other drugs that can affect benzocaine and trimethobenzamide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has more information about benzocaine and trimethobenzamide written for health professionals that you may read.

What does my medication look like?

Benzocaine and trimethobenzamide is available with a prescription generically and under the brand name Tigan. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.02. Revision Date: 5/17/06 3:16:21 PM.

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