amoxicillin, clarithromycin, and lansoprazole

Generic Name: amoxicillin, clarithromycin, and lansoprazole (a MOX i SIL in, kla RITH roe MYE sin, LAN soe PRA zole)
Brand Name: Prevpac

What is amoxicillin, clarithromycin, and lansoprazole?

Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body.

Lansoprazole decreases the amount of acid produced in the stomach.

The combination of amoxicillin, clarithromycin, and lansoprazole is used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and lansoprazole may also be used for purposes not listed in this medication guide.

What is the most important information I should know about amoxicillin, clarithromycin, and lansoprazole?

You should not take this medication if you are allergic to amoxicillin (Amoxil, Trimox, Dispermox), clarithromycin (Biaxin), lansoprazole (Prevacid), or to certain other antibiotics.

Before you take this medication, tell your doctor if you have kidney or liver disease, myasthenia gravis, or if you are allergic to any drugs.

There are many other drugs that can interact with this medication. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

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While you are taking amoxicillin, clarithromycin, and lansoprazole, do not take any of the following medications: ergotamine (Ergomar, Cafergot, Ercaf, Migergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), or pimozide (Orap).

A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and lansoprazole, especially if you are an older adult with kidney disease.

What should I discuss with my healthcare provider before taking amoxicillin, clarithromycin, and lansoprazole?

You should not take this medication if you are allergic to amoxicillin (Amoxil, Trimox, Dispermox), clarithromycin (Biaxin), lansoprazole (Prevacid), or to any of the following antibiotics:

  • ampicillin (Omnipen, Principen);

  • azithromycin (Zithromax, Zmax, Z-Pack);

  • carbenicillin (Geocillin);

  • dicloxacillin (Dycill, Dynapen);

  • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole);

  • oxacillin (Bactocill);

  • penicillin (Bicillin L-A, PC Pen VK, Pfizerpen); or

  • telithromycin (Ketek).

Taking any of the following medicines together with amoxicillin, clarithromycin, and lansoprazole can cause a life-threatening side effect on your heart:

  • cisapride (Propulsid);

  • ergotamine (Ergomar, Cafergot, Ercaf, Migergot);

  • dihydroergotamine (D.H.E. 45, Migranal Nasal Spray); or

  • pimozide (Orap).

To make sure amoxicillin, clarithromycin, and lansoprazole is safe for you, tell your doctor if you have any of these other conditions:

  • kidney disease;

  • liver disease;

  • myasthenia gravis; or

  • if you are allergic to any drugs (especially an antibiotic).

FDA pregnancy category C. It is not known whether amoxicillin, clarithromycin, and lansoprazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

This medication can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using amoxicillin, clarithromycin, and lansoprazole.

How should I take amoxicillin, clarithromycin, and lansoprazole?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Each dose of this combination medication contains 4 pills ( 3 capsules and 1 tablet). Take all 4 pills twice daily before you eat, unless your doctor tells you otherwise.

Do not crush, chew, break, or open the pills. Swallow each pill whole. You may swallow the pills one at a time.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Amoxicillin will not treat a viral infection such as the common cold or flu.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using amoxicillin, clarithromycin, and lansoprazole.

Store at room temperature, away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include stomach pain, diarrhea, nausea, vomiting, or urinating less than usual.

What should I avoid while taking amoxicillin, clarithromycin, and lansoprazole?

If you also take sucralfate (Carafate), avoid taking it within 30 minutes after you take amoxicillin, clarithromycin, and lansoprazole. Sucralfate can make it harder for your body to absorb lansoprazole.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Amoxicillin, clarithromycin, and lansoprazole side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody;

  • signs of new infection, such as fever, chills, body aches, flu symptoms, mouth sores;

  • easy bruising or bleeding, unusual weakness;

  • agitation, confusion, unusual thoughts or behavior;

  • dizziness, fainting, fast or pounding heartbeat; or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • unusual or unpleasant taste in your mouth;

  • headache;

  • nausea, vomiting, stomach pain;

  • constipation, dark colored stools;

  • dry mouth, increased thirst; or

  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Amoxicillin, clarithromycin, and lansoprazole Dosing Information

Usual Adult Dose for Helicobacter pylori Infection:

1000 mg amoxicillin, 500 mg clarithromycin, and 30 mg lansoprazole, orally two times daily (morning and evening) for 10 to 14 days.

What other drugs will affect amoxicillin, clarithromycin, and lansoprazole?

Many drugs can interact with amoxicillin, clarithromycin, and lansoprazole. Below is just a partial list. Tell your doctor if you are using:

  • alfentanil (Alfenta);

  • ampicillin (Omnipen, Principen);

  • bromocriptine (Cycloset, Parlodel);

  • cilostazol (Pletal), clopidogrel (Plavix);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • digoxin (Lanoxin, Lanoxicaps);

  • fluconazole (Diflucan) or ketoconazole (Nizoral);

  • methylprednisolone (Medrol);

  • probenecid (Benemid);

  • sildenafil (Viagra, Revatio);

  • tacrolimus (Prograf);

  • theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);

  • an antibiotic such as azithromycin (Zithromax, Zmax, Z-Pack), clarithromycin (Biaxin), doxycycline (Doryx, Oracea, Periostat, Vibramycin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), minocycline (Dynacin, Minocin, Solodyn), rifabutin (Mycobutin), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • cholesterol lowering medicines such as atorvastatin (Lipitor, Caduet), lovastatin (Mevacor, Altoprev, Advicor), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin, Juvisync);

  • a heart rhythm medication such as disopyramide (Norpace) or quinidine (Quin-G);

  • HIV/AIDS medications such as atazanavir (Reyataz), ritonavir (Norvir), or zidovudine (Retrovir);

  • iron supplements (Feosol, Mol-Iron, Fergon, Femiron, and others);

  • a sedative such as alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion);

  • seizure medication such as carbamazepine (Equetro, Carbatrol, Tegretol), phenytoin (Dilantin), or valproate (Depakote, Depakene); or

  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others).

This list is not complete and other drugs may interact with amoxicillin, clarithromycin, and lansoprazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about amoxicillin, clarithromycin, and lansoprazole.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01. Revision Date: 2012-10-04, 8:07:25 AM.

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