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Lodoxamide (Monograph)

Brand name: Alomide
Drug class: Antiallergic Agents
- Mast-cell Stabilizers
ATC class: S01GX05
VA class: OP900
Chemical name: N,N′-2-(chloro-5-cyano-m-phenylene)dioxamic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:2)
Molecular formula: C11H6ClN3O6•2C4H11NO3
CAS number: 63610-09-3

Medically reviewed by Drugs.com on Jul 24, 2023. Written by ASHP.

Introduction

Mast-cell stabilizer.

Uses for Lodoxamide

Allergic Ocular Disorders

Symptomatic treatment of certain allergic ocular disorders including vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis (designated an orphan drug by FDA for such use).

Lodoxamide Dosage and Administration

Administration

Ophthalmic Administration

Apply topically to the eye as an ophthalmic solution. Not for injection. Not for subconjunctival injection or introduction directly into anterior chamber of the eye.

Avoid contamination of the solution container.

Dosage

Available as lodoxamide tromethamine; dosage expressed in terms of lodoxamide.

Pediatric Patients

Allergic Ocular Disorders
Ophthalmic

Children ≥2 years of age: 1 or 2 drops of a 0.1% solution in the affected eye(s) 4 times daily for up to 3 months.

Adults

Allergic Ocular Disorders
Ophthalmic

1 or 2 drops of a 0.1% solution in the affected eye(s) 4 times daily for up to 3 months.

Cautions for Lodoxamide

Contraindications

Warnings/Precautions

General Precautions

Ocular Effects

Possible ocular burning or stinging upon installation. (See Advice to Patients.)

Specific Populations

Pregnancy

Category B.

Lactation

Not known whether lodoxamide is distributed into milk. Use with caution in nursing women.

Pediatric Use

Safety and efficacy not established in children <2 years of age.

Geriatric Use

No substantial differences in safety and efficacy relative to younger adults.

Common Adverse Effects

Ocular burning, stinging, discomfort.

Lodoxamide Pharmacokinetics

Absorption

Bioavailability

Plasma concentrations are undetectable following topical application to the eye.

Distribution

Extent

Not known whether lodoxamide is distributed into milk.

Elimination

Elimination Route

Excreted principally in urine after oral administration.

Half-life

8.5 hours following oral administration.

Stability

Storage

Ophthalmic

Solution

15–27°C.

Actions

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Lodoxamide Tromethamine

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Ophthalmic

Solution

0.1% (of lodoxamide)

Alomide (with benzalkonium chloride)

Alcon

AHFS DI Essentials™. © Copyright 2024, Selected Revisions August 1, 2005. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

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