Skip to main content

Ampicillin (Monograph)

Drug class: Aminopenicillins
Chemical name: [2S-[2α,5α,6β(S*)]]-6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Molecular formula: C16H19N3O4SC16H19N3O4S•NaC16H19N3O4S•3H2O
CAS number: 69-53-4

Medically reviewed by Drugs.com on Jan 23, 2024. Written by ASHP.

Introduction

Antibacterial; β-lactam antibiotic; aminopenicillin.

Uses for Ampicillin

Endocarditis

Treatment of enterococcal endocarditis; used in conjunction with an aminoglycoside.

Treatment of endocarditis caused by susceptible staphylococci, streptococci, E. coli, P. mirabilis, or Salmonella.

For treatment of endocarditis caused by Enterococcus faecalis, E. faecium, or other enterococci susceptible to penicillin and gentamicin, AHA states IV penicillin G (or IV ampicillin) in conjunction with gentamicin is a regimen of choice; streptomycin can be substituted for gentamicin if enterococci are susceptible to penicillin and streptomycin, but resistant to gentamicin.

For treatment of endocarditis caused by viridans group streptococci [off-label] or nonenterococcal group D streptococci [off-label], including Streptococcus gallolyticus [off-label] (formerly S. bovis), AHA states that IV ampicillin is a reasonable alternative to IV penicillin G. May be used alone if caused by highly penicillin-susceptible strains (penicillin MIC ≤0.12 mcg/mL); use in conjunction with gentamicin if strains are relatively resistant (penicillin MIC >0.12 mcg/mL but <0.5 mcg/mL).

Because fastidious gram-negative bacilli of the HACEK group [off-label] (i.e., Haemophilus, Aggregatibacter, Cardiobacterium hominis, Eikenella corrodens, Kingella) resistant to penicillins are being reported with increasing frequency, AHA states that IV ampicillin (with or without an aminoglycoside) should be used for the treatment of endocarditis caused by these organisms only if in vitro susceptibility is confirmed.

Consult current guidelines from AHA for information on management of endocarditis.

Prevention of α-hemolytic (viridans group) streptococcal bacterial endocarditis [off-label] in patients undergoing certain dental procedures (i.e., procedures that involve manipulation of gingival tissue or periapical region of teeth or perforation of oral mucosa) or certain invasive respiratory tract procedures (i.e., procedures involving incision or biopsy of respiratory mucosa) who have certain cardiac conditions that put them at highest risk of adverse outcomes from endocarditis. AHA recommends oral amoxicillin as drug of choice; ampicillin is an alternative in those unable to take oral medication.

Consult most recent AHA recommendations for information on which cardiac conditions are associated with highest risk of adverse outcomes from endocarditis and specific recommendations regarding use of prophylaxis to prevent endocarditis in these patients.

Meningitis and Other CNS Infections

Treatment of meningitis caused by susceptible Neisseria meningitidis, Streptococcus agalactiae (group B streptococci; GBS), Listeria monocytogenes, E. coli, or H. influenzae.

A drug of choice for empiric treatment of neonatal S. agalactiae meningitis; consider concomitant use of an aminoglycoside.

A drug of choice for L. monocytogenes meningitis; used alone or in conjunction with an aminoglycoside (e.g., gentamicin).

Respiratory Tract Infections

Treatment of respiratory tract infections caused by susceptible Staphylococcus aureus (including penicillinase-producing strains), Streptococcus (including S. pneumoniae), S. pyogenes (group A β-hemolytic streptococci), or H. influenzae (nonpenicillinase-producing strains only).

Generally should not be used for the treatment of streptococcal or staphylococcal infections when a natural penicillin would be effective. Should not be used alone for empiric treatment of respiratory tract infections when ampicillin-resistant H. influenzae may be involved.

Septicemia

Treatment of septicemia caused by susceptible staphylococci, streptococci, enterococci, E. coli, P. mirabilis, or Salmonella.

Urinary Tract Infections (UTIs)

Treatment of UTIs caused by susceptible enterococci, E. coli, or Proteus mirabilis.

A drug of choice for enterococcal UTIs. Because of high urinary concentrations, may be effective when used alone, but consider that enterococci resistant to ampicillin have been reported.

Eikenella Infections

Treatment of infections caused by Eikenella corrodens; drug of choice.

Listeria Infections

Treatment of infections caused by Listeria monocytogenes; used alone or in conjunction with an aminoglycoside.

A drug of choice for Listeria infections occurring during pregnancy, granulomatosis infantiseptica, sepsis, endocarditis, meningitis, and foodborne infections. (See Meningitis and Other CNS Infections under Uses.)

Pertussis

Has been used to treat and prevent secondary pulmonary infections in patients with pertussis. Erythromycin generally considered drug of choice for treatment of catarrhal stage of pertussis and to shorten the period of communicability of the disease. Ampicillin, like most other anti-infectives, does not shorten clinical course of pertussis.

Typhoid Fever and Other Salmonella Infections

Alternative for treatment of typhoid fever (enteric fever) caused by susceptible Salmonella typhi. Drugs of choice are third generation cephalosporins (e.g., ceftriaxone, cefotaxime) or fluoroquinolones (e.g., ciprofloxacin, ofloxacin); consider that multidrug-resistant strains of S. typhi (strains resistant to ampicillin, amoxicillin, chloramphenicol, and/or co-trimoxazole) reported with increasing frequency.

Treatment of chronic carriers of S. typhi; drugs of choice are fluoroquinolones (e.g., ciprofloxacin), ampicillin, or amoxicillin (with probenecid).

Treatment of gastroenteritis caused by susceptible Salmonella.

Shigella Infections

Treatment of GI infections caused by susceptible Shigella.

Anti-infectives generally indicated in addition to fluid and electrolyte replacement for severe shigellosis. Previously considered a drug of choice for shigellosis (especially in children), but strains of S. flexneri and S. sonnei resistant to ampicillin reported with increasing frequency. Fluoroquinolones, ceftriaxone, or co-trimoxazole now considered drugs of choice for empiric treatment, especially in areas where ampicillin-resistant strains of Shigella have been reported.

Prevention of Perinatal Group B Streptococcal Disease

Prevention of early-onset neonatal group B streptococcal (GBS) disease.

ACOG, AAP, and others recommend routine universal prenatal screening for GBS colonization (e.g., vaginal and rectal cultures) in all pregnant women at 36 through 37 weeks of gestation (i.e., performed within the time period of 36 weeks 0 days to 37 weeks 6 days of gestation), unless intrapartum anti-infective prophylaxis already planned because the woman had known GBS bacteriuria during any trimester of current pregnancy or has history of a previous infant with GBS disease. Anti-infective prophylaxis for prevention of early-onset perinatal GBS indicated in all women identified as having positive GBS cultures during routine prenatal GBS screening during current pregnancy, unless a cesarean delivery is performed before onset of labor in the setting of intact membranes. Also indicated in women with unknown GBS status at time of onset of labor (cultures not performed or results unknown) who have risk factors for perinatal GBS infection (e.g., preterm birth at <37 weeks’ gestation, duration of membrane rupture ≥18 hours, intrapartum fever ≥38°C).

IV penicillin G is drug of choice and IV ampicillin is preferred alternative for intrapartum GBS anti-infective prophylaxis. Penicillin G has a narrower spectrum of activity and is less likely to select for antibiotic-resistant organisms.

Regardless of whether the mother received anti-infective prophylaxis, initiate appropriate diagnostic evaluations and anti-infective therapy in the neonate if signs or symptoms of active infection develop.

Consult current ACOG guidelines available at [Web] for additional information regarding prevention of neonatal early-onset GBS disease.

Ampicillin Dosage and Administration

Administration

Administer orally, by slow IV injection or infusion, or by IM injection.

Oral Administration

Administer orally with a full glass of water 1 hour before or 2 hours after meals.

IV Administration

For solution and drug compatibility information, see Compatibility under Stability.

Reconstitution

Reconstitute vials containing 125, 250, or 500 mg with 5 mL of sterile or bacteriostatic water for injection. Alternatively, reconstitute vials containing 1 or 2 g with 7.4 or 14.8 mL, respectively, of sterile or bacteriostatic water for injection.

Rate of Administration

Solutions reconstituted from 125-, 250-, or 500-mg vials may be given by IV injection over a period of 3–5 minutes. Solutions reconstituted from 1- or 2-g vials should be given IV over a period of ≥10–15 minutes.

For IV infusion, concentration and rate of administration should be adjusted so that the total dose is administered before the drug is inactivated in the IV solution.

IM Administration

Reconstitution

Reconstitute with sterile or bacteriostatic water for injection according to manufacturer’s directions to provide solutions containing 125 or 250 mg/mL.

Dosage

Available as ampicillin trihydrate and ampicillin sodium ; dosage expressed in terms of ampicillin.

Duration of therapy depends on type and severity of infection and should be determined by clinical and bacteriologic response of the patient. For most infections, therapy should be continued for ≥48–72 hours after patient becomes asymptomatic or evidence of eradication of the infection has been obtained. More prolonged therapy may be necessary for some infections.

Pediatric Patients

General Pediatric Dosage
Oral

Children beyond neonatal age with mild to moderate infections: AAP recommends 50–100 mg/kg daily given in 4 divided doses.

Children beyond neonatal age with severe infections: AAP states oral route inappropriate.

IV or IM

Neonates <7 days of age: AAP recommends 50 mg/kg every 12 hours in those weighing ≤2 kg or 50 mg/kg every 8 hours in those weighing >2 kg. Higher dosage may be needed for treatment of meningitis.

Neonates 8–28 days of age: AAP recommends 50 mg/kg every 8 hours in those weighing ≤2 kg or 50 mg/kg every 6 hours in those weighing >2 kg. Higher dosage may be needed for treatment of meningitis.

Children beyond neonatal age: AAP recommends 100–150 mg/kg daily given in 4 divided doses for mild to moderate infections or 200–400 mg/kg daily given in 4 divided doses for severe infections. Use highest dosage for treatment of CNS infections.

Endocarditis
Treatment of Endocarditis Caused by Viridans Streptococci or S. bovis
IV

200–300 mg/kg daily (up to 12 g daily) given in 4–6 divided doses for 4 weeks. Used in conjunction with IM or IV gentamicin.

Treatment of Enterococcal Endocarditis
IV

200–300 mg/kg daily (up to 12 g daily) given in 4–6 divided doses for 4–6 weeks. Used in conjunction with IM or IV gentamicin.

Prevention of Bacterial Endocarditis in Patients Undergoing Certain Dental or Respiratory Tract Procedures†
IV or IM

50 mg/kg as a single dose given 30–60 minutes prior to the procedure.

GI Infections
Oral

Children weighing ≤20 kg: 100 mg/kg daily in 4 divided doses.

Children weighing >20 kg: 500 mg 4 times daily. Severe or chronic infections may require higher dosage.

IV or IM

Children weighing <40 kg: 50 mg/kg daily in divided doses every 6–8 hours.

Children weighing ≥40 kg: 500 mg every 6 hours. Severe or chronic infections may require higher dosage.

Meningitis and Other CNS Infections
Empiric Treatment of Meningitis
IV

Neonates and children <2 months of age: 100–300 mg/kg daily given in divided doses; with or without gentamicin.

Children 2 months to 12 years of age: 200–400 mg/kg daily given in divided doses every 4–6 hours; used in conjunction with IV chloramphenicol.

Treatment of Meningitis Caused by S. agalactiae (GBS)
IV

Neonates: AAP recommends 200–300 mg/kg daily given in 3 divided doses in those ≤7 days of age or 300 mg/kg daily given in 4 divided doses in those >7 days of age.

Neonates ≤28 days of age: Some experts recommend 75 mg/kg every 6 hours, regardless of weight.

Respiratory Tract Infections
Oral

Children weighing ≤20 kg: 50 mg/kg daily in 3 or 4 divided doses.

Children weighing >20 kg: 250 mg 4 times daily.

IV or IM

Children weighing <40 kg: 25–50 mg/kg daily in divided doses every 6–8 hours.

Children weighing ≥40 kg: 250–500 mg every 6 hours.

Septicemia
IV or IM

150–200 mg/kg daily.

Skin and Skin Structure Infections
IV or IM

Children weighing <40 kg: 25–50 mg/kg daily in divided doses every 6–8 hours.

Children weighing ≥40 kg: 250–500 mg every 6 hours.

Urinary Tract Infections (UTIs)
Oral

Children weighing ≤20 kg: 100 mg/kg daily in 4 divided doses.

Children weighing >20 kg: 500 mg 4 times daily. Severe or chronic infections may require higher dosage.

IV or IM

Children weighing <40 kg: 50 mg/kg daily in divided doses every 6–8 hours.

Children weighing ≥40 kg: 500 mg every 6 hours. Severe or chronic infections may require higher dosage.

Adults

Endocarditis
Treatment of Enterococcal Endocarditis
IV

2 g every 4 hours in conjunction with IM or IV gentamicin. Treatment with both drugs generally should be continued for 4–6 weeks, but patients who had symptoms of infection for >3 months before treatment was initiated and patients with prosthetic heart valves require ≥6 weeks of therapy with both drugs.

Treatment of Endocarditis Caused by HACEK group (i.e., Haemophilus, Aggregatibacter, Cardiobacterium hominis, Eikenella corrodens, Kingella)†
IV

2 g every 12 hours.

Prevention of Bacterial Endocarditis in Patients Undergoing Certain Dental or Respiratory Tract Procedures†
IV or IM

2 g as a single dose given 30–60 minutes prior to the procedure.

GI Infections
Oral

500 mg 4 times daily.

IV or IM

Adults weighing <40 kg: 50 mg/kg daily in divided doses every 6–8 hours.

Adults weighing ≥40 kg: 500 mg every 6 hours.

Meningitis and Other CNS Infections
IV, then IM

150–200 mg/kg daily in divided doses every 3–4 hours. Use IV initially, may switch to IM after 3 days.

Respiratory Tract Infections
Oral

250 mg 4 times daily.

IV or IM

Adults weighing <40 kg: 25–50 mg/kg daily in divided doses every 6–8 hours.

Adults weighing ≥40 kg: 250–500 mg every 6 hours.

Septicemia
IV or IM

150–200 mg/kg daily.

Skin and Skin Structure Infections
IV or IM

Adults weighing <40 kg: 25–50 mg/kg daily in divided doses every 6–8 hours.

Adults weighing ≥40 kg: 250–500 mg every 6 hours.

Urinary Tract Infections (UTIs)
Oral

500 mg 4 times daily.

IV or IM

Adults weighing <40 kg: 50 mg/kg daily in divided doses every 6–8 hours.

Adults weighing ≥40 kg: 500 mg every 6 hours.

Prevention of Perinatal Group B Streptococcal (GBS) Disease†
IV

An initial 2-g dose (at time of labor or rupture of membranes) followed by 1 g every 4 hours until delivery.

Prescribing Limits

Pediatric Patients

Pediatric dosage should not exceed adult dosage.

Special Populations

Renal Impairment

Dosage adjustments necessary in patients with renal impairment.

Some clinicians suggest that adults with GFR 10–50 mL/minute receive the usual dose every 6–12 hours and that adults with GFR <10 mL/minute receive the usual dose every 12–16 hours. Alternatively, some clinicians suggest that modification of usual dosage is unnecessary in adults with Clcr ≥ 30 mL/minute, but that adults with Clcr ≤10 mL/minute should receive the usual dose every 8 hours.

Patients undergoing hemodialysis should receive a supplemental dose after each dialysis period.

Geriatric Patients

No dosage adjustments except those related to renal impairment. (See Renal Impairment under Dosage and Administration.)

Cautions for Ampicillin

Contraindications

Warnings/Precautions

Warnings

Superinfection/Clostridioides difficile-associated Colitis

Possible emergence and overgrowth of nonsusceptible bacteria or fungi. Discontinue and institute appropriate therapy if superinfection occurs.

Treatment with anti-infectives alters normal colon flora and may permit overgrowth of C. difficile. C. difficile infection (CDI) and C. difficile-associated diarrhea and colitis (CDAD; also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) reported with nearly all anti-infectives and may range in severity from mild diarrhea to fatal colitis. Consider CDAD if diarrhea develops during or after therapy and manage accordingly.

If CDAD suspected or confirmed, discontinue anti-infectives not directed against C. difficile as soon as possible. Initiate appropriate anti-infective therapy directed against C. difficile (e.g., fidaxomicin, vancomycin, metronidazole), appropriate supportive therapy (e.g., fluid and electrolyte management, protein supplementation), and surgical evaluation as clinically indicated.

Sensitivity Reactions

Hypersensitivity Reactions

Serious and occasionally fatal hypersensitivity reactions, including anaphylaxis, reported with penicillins.

Prior to initiation of therapy, make careful inquiry regarding previous hypersensitivity reactions to penicillins, cephalosporins, or other drugs. Partial cross-allergenicity occurs among penicillins and other β-lactam antibiotics including cephalosporins and cephamycins.

If a severe hypersensitivity reaction occurs, discontinue immediately and institute appropriate therapy as indicated (e.g., epinephrine, corticosteroids, maintenance of an adequate airway and oxygen).

General Precautions

Selection and Use of Anti-infectives

To reduce development of drug-resistant bacteria and maintain effectiveness of ampicillin and other antibacterials, use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria.

When selecting or modifying anti-infective therapy, use results of culture and in vitro susceptibility testing. In the absence of such data, consider local epidemiology and susceptibility patterns when selecting anti-infectives for empiric therapy.

Mononucleosis

Possible increased risk of rash in patients with mononucleosis; use in these patients not recommended.

Ampicillin-resistant Haemophilus influenzae

Because of increasing prevalence of ampicillin-resistant H. influenzae, the drug should not be used alone for empiric treatment of serious infections (e.g., meningitis, pneumonia) when H. influenzae may be involved.

Laboratory Monitoring

Periodically assess organ system functions, including renal, hepatic, and hematopoietic, during prolonged therapy.

Sodium Content

Powder for injection contains 2.9 mEq of sodium per g of ampicillin.

Specific Populations

Pregnancy

Category B.

Lactation

Distributed into milk. Use with caution.

Pediatric Use

Renal clearance of ampicillin may be delayed in neonates and young infants because of incompletely developed renal function. Use lowest effective dosage.

Renal Impairment

Dosage adjustments necessary in renal impairment. (See Renal Impairment under Dosage and Administration.)

Common Adverse Effects

GI effects (diarrhea, nausea), rash.

Drug Interactions

Specific Drugs and Laboratory Tests

Drug or Test

Interaction

Comments

Allopurinol

Possible increased incidence of rash

Clinical importance has not been determined; some clinicians suggest that concomitant use of the drugs should be avoided if possible

Aminoglycosides

In vitro evidence of synergistic antibacterial effects against enterococci; used to therapeutic advantage in treatment of endocarditis and other severe enterococcal infections

Potential in vitro and in vivo inactivation of aminoglycosides

Chloramphenicol

In vitro evidence of antagonism

Clinical importance unclear

Hormonal contraceptives

Possible decreased efficacy of estrogen-containing oral contraceptives and increased incidence of breakthrough bleeding

Some clinicians suggest that a supplemental method of contraception be used in patients receiving oral contraceptives and ampicillin concomitantly, other clinicians state that most women taking oral contraceptives probably do not need to use alternative contraceptive precautions while receiving ampicillin

Methotrexate

Possible decreased renal clearance of methotrexate with penicillins; possible increased methotrexate concentrations and hematologic and GI toxicity

Monitor closely if used concomitantly

Probenecid

Decreased renal tubular secretion of ampicillin; increased and prolonged ampicillin concentrations may occur

Sulbactam

Synergistic bactericidal effect against many strains of β-lactamase-producing bacteria

Sulfonamides

In vitro evidence of antagonism

Clinical importance unclear

Tests for glucose

Possible false-positive reactions in urine glucose tests using Clinitest, Benedict’s solution, or Fehling’s solution

Use glucose tests based on enzymatic glucose oxidase reactions (e.g., Clinistix, Tes-Tape)

Tests for uric acid

Possible falsely increased serum uric acid concentrations when copper-chelate method is used; phosphotungstate and uricase methods appear to be unaffected by the ampicillin

Ampicillin Pharmacokinetics

Absorption

Bioavailability

30–55% of an oral dose absorbed from the GI tract in fasting adults; peak serum concentrations attained within 1–2 hours.

Following IM administration, peak serum concentrations generally attained more quickly and are higher than following equivalent oral doses.

Food

Food generally decreases rate and extent of absorption.

Distribution

Extent

Distributed into ascitic, synovial, and pleural fluids. Also distributed into liver, lungs, gallbladder, prostate, muscle, middle ear effusions, bronchial secretions, maxillary sinus secretions. and tonsils.

Distributed into CSF in concentrations 11–65% of simultaneous serum concentrations; highest CSF concentrations occur 3–7 hours after an IV dose.

Readily crosses the placenta. Distributed into milk in low concentrations.

Plasma Protein Binding

15–25%.

Protein binding is lower in neonates than in children or adults; ampicillin reportedly 8–12% bound to serum proteins in neonates.

Elimination

Metabolism

Partially metabolized by hydrolysis of the β-lactam ring to penicilloic acid which is microbiologically inactive.

Elimination Route

Eliminated in urine by renal tubular secretion and to a lesser extent by glomerular filtration. Small amounts also excreted in feces and bile.

In adults with normal renal function, approximately 20–64% of a single oral dose excreted unchanged in urine within 6–8 hours. Approximately 60–70% of a single IM dose or 73–90% of a single IV dose excreted unchanged in urine.

Half-life

0.7–1.5 hours in adults with normal renal function.

Half-life is 4 hours in neonates 2–7 days of age, 2.8 hours in neonates 8–14 days of age, and 1.7 hours in neonates 15–30 days of age.

Special Populations

Serum concentrations higher and more prolonged in premature or full-term neonates <6 days of age than in full-term neonates ≥6 days of age.

Renal clearance decreased in geriatric patients because of diminished tubular secretory ability; serum concentrations may be higher and half-life prolonged. In those 67–76 years of age, half-life ranges from 1.4–6.2 hours.

Serum concentrations are higher and half-life prolonged in patients with impaired renal function. Half-life may range from 7.4–21 hours in patients with Clcr <10 mL/minute.

Stability

Storage

Oral

Capsules

Tight container at 15–30°C; avoid excessive heat.

For Suspension

Tight container at 15–30°C. After reconstitution, discard after 7 days if stored at room temperature or after 14 days if refrigerated.

Parenteral

Powder for Injection or Infusion

Solutions for IM injection or IV injection or infusion should be used within 1 hour after reconstitution and should not be frozen.

Compatibility

Parenteral

Solution CompatibilityHID

Compatible

Isolyte M or P with dextrose 5%

Incompatible

Amino acids 4.25%, dextrose 25%

Dextran 40 10% in sodium chloride 0.9%

Dextran 40 10% in dextrose 5% in water

Dextrose 5% in sodium chloride 0.45 or 0.9%

Dextrose 5 or 10% in water

Fat emulsion 10%, IV

Fructose 5.25%

Hetastarch 6% in sodium chloride 0.9%

Ringer’s injection, lactated

Sodium bicarbonate 1.4%

Sodium lactate (1/6) M

Variable

Ringer’s injection

Sodium chloride 0.9%

Drug Compatibility
Admixture CompatibilityHID

Compatible

Clindamycin phosphate

Erythromycin lactobionate

Furosemide

Lincomycin HCl

Metronidazole

Incompatible

Amikacin sulfate

Chlorpromazine HCl

Dopamine HCl

Gentamicin sulfate

Hetastarch in sodium chloride 0.9%

Hydralazine HCl

Prochlorperazine mesylate

Variable

Aztreonam

Cefepime HCl

Heparin sodium

Hydrocortisone sodium succinate

Ranitidine HCl

Verapamil HCl

Y-Site CompatibilityHID

Compatible

Acyclovir sodium

Alprostadil

Amifostine

Anidulafungin

Aztreonam

Bivalirudin

Cyclophosphamide

Dexmedetomidine HCl

Docetaxel

Doxapram HCl

Doxorubicin HCl liposome injection

Enalaprilat

Esmolol HCl

Etoposide phosphate

Famotidine

Filgrastim

Fludarabine phosphate

Foscarnet sodium

Gemcitabine HCl

Granisetron HCl

Heparin sodium

Heparin sodium with hydrocortisone sodium succinate

Hetastarch in lactated electrolyte injection (Hextend)

Hydroxyethyl starch 130/0.4 in sodium chloride 0.9%

Insulin, regular

Labetalol HCl

Levofloxacin

Linezolid

Magnesium sulfate

Melphalan HCl

Meperidine HCl

Milrinone lactate

Morphine sulfate

Multivitamins

Pantoprazole sodium

Pemetrexed disodium

Phytonadione

Potassium chloride

Propofol

Remifentanil HCl

Tacrolimus

Teniposide

Theophylline

Thiotepa

Incompatible

Amphotericin B cholesteryl sulfate complex

Caspofungin acetate

Epinephrine HCl

Fenoldopam mesylate

Fluconazole

Hydralazine HCl

Midazolam HCl

Nicardipine HCl

Ondansetron HCl

Sargramostim

Verapamil HCl

Vinorelbine tartrate

Variable

Calcium gluconate

Cisatracurium besylate

Diltiazem HCl

Hetastarch in sodium chloride 0.9%

Hydromorphone HCl

Vancomycin HCl

Actions and Spectrum

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Ampicillin (Trihydrate)

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Capsules

250 mg (of ampicillin)*

Ampicillin Capsules

500 mg (of ampicillin)*

Ampicillin Capsules

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Ampicillin Sodium

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

For injection

125 mg (of ampicillin)*

Ampicillin Sodium for Injection

250 mg (of ampicillin)*

Ampicillin Sodium for Injection

500 mg (of ampicillin)*

Ampicillin Sodium for Injection

1 g (of ampicillin)*

Ampicillin Sodium for Injection

2 g (of ampicillin)*

Ampicillin Sodium for Injection

10 g (of ampicillin) pharmacy bulk package*

Ampicillin Sodium for Injection

For injection, for IV infusion

1 g (of ampicillin)*

Ampicillin Sodium ADD-Vantage

Ampicillin Sodium Piggyback

2 g (of ampicillin)*

Ampicillin Sodium ADD-Vantage

Ampicillin Sodium Piggyback

AHFS DI Essentials™. © Copyright 2024, Selected Revisions February 2, 2022. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.

Reload page with references included