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Resorcinol and Sulfur (Topical)


VA CLASSIFICATION
Primary: DE752
Secondary: DE500{07}{11}

Commonly used brand name(s): Acne-Aid Gel; Acnomel Acne Cream; Acnomel Cake; Acnomel Cream; Acnomel Vanishing Cream; Bensulfoid Cream; Clearasil Adult Care Medicated Blemish Cream; Clearasil Adult Care Medicated Blemish Stick; Night Cast Special Formula Mask-lotion; Rezamid Acne Treatment; Rezamid Lotion; Sulforcin.

Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).



Category:


Antiacne agent (topical)—

keratolytic (topical)—

Indications

Accepted

Acne vulgaris (treatment) or
Skin conditions related to acne (treatment)—Resorcinol and sulfur combination is indicated as an aid in the drying and peeling of blemishes in acne and related skin conditions. {22} {23} {24}


Pharmacology/Pharmacokinetics

Resorcinol—See Resorcinol (Topical)

Sulfur—See Sulfur (Topical)


Precautions to Consider

Resorcinol—See Resorcinol (Topical)

Sulfur—See Sulfur (Topical)


Side/Adverse Effects
Resorcinol—See Resorcinol (Topical)
Sulfur—See Sulfur (Topical)



Patient Consultation
As an aid to patient consultation, refer to Advice for the Patient, Resorcinol and Sulfur (Topical).

In providing consultation, consider emphasizing the following selected information (» = major clinical significance):

Before using this medication
»   Conditions affecting use, especially:
Sensitivity to resorcinol or sulfur





Use in children—Resorcinol may be absorbed through the skin and should not be used on large areas of the bodies of infants and children; resorcinol should not be used on wounds, since it may cause methemoglobinemia


Proper use of this medication
» Importance of not using more medication than the amount recommended

Proper administration
Before using—Washing affected areas thoroughly; gently patting dry

Applying small amount to affected areas; spreading on gently; not rubbing in
Washing hands immediately after application to remove any medication that may be on them

Avoiding contact with the eyes

» Proper dosing
Missed dose: Applying as soon as possible; not applying if almost time for next dose

» Proper storage

Precautions while using this medication
» Avoiding simultaneous use with other topical acne preparations or preparations containing peeling agents, alcohol-containing preparations, abrasive soaps or cleansers, cosmetics or soaps with drying effect, medicated cosmetics, or other topical skin medication, unless otherwise directed by physician

» Avoiding concurrent use with topical mercury-containing preparations

Resorcinol may darken light-colored hair


Side/adverse effects
Signs of potential side effects, especially skin irritation not present before therapy or symptoms of resorcinol poisoning


General Dosing Information
This medication is not recommended for application over large areas of the body, especially when used in high concentrations or on infants and children.

Prolonged use may lead to myxedema because of the antithyroid action of resorcinol, particularly when used on ulcerated surfaces.

Resorcinol is not recommended for use in blacks, since it may cause hyperpigmentation.

Resorcinol may darken light-colored hair, but resorcinol monoacetate does not have this action on light-colored hair.


Topical Dosage Forms

RESORCINOL AND SULFUR CAKE

Usual adult and adolescent dose
Antiacne agent or
Keratolytic
Topical, to the skin, two or three times a day. {02}


Usual pediatric dose
See Usual adult and adolescent dose.

Strength(s) usually available
U.S.—
Not commercially available.

Canada—


1% resorcinol and 4% sulfur (OTC) [Acnomel Cake{02}]

Packaging and storage:
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a well-closed container, unless otherwise specified by manufacturer. Protect from freezing.

Auxiliary labeling:
   • For external use only.


RESORCINOL AND SULFUR CREAM

Usual adult and adolescent dose
Antiacne agent or
Keratolytic
Topical, to the skin, one to three times a day. {22} {23}


Usual pediatric dose
See Usual adult and adolescent dose.

Strength(s) usually available
U.S.—


2% resorcinol and 8% sulfur (OTC) [Acnomel Acne Cream{10} (alcohol 11%)] [Bensulfoid Cream (alcohol 10%){22}] [Clearasil Adult Care Medicated Blemish Cream{04}{23} (alcohol 10%)]

Canada—


2% resorcinol and 8% sulfur (OTC) [Acnomel Cream (isopropyl alcohol 11%){13}] [Acnomel Vanishing Cream{20}]

Packaging and storage:
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a well-closed container, unless otherwise specified by manufacturer. Protect from freezing.

Auxiliary labeling:
   • For external use only.


RESORCINOL AND SULFUR GEL

Usual adult and adolescent dose
Antiacne agent or
Keratolytic
Topical, to the skin. {01}


Usual pediatric dose
See Usual adult and adolescent dose.

Strength(s) usually available
U.S.—
Not commercially available.

Canada—


1.25% resorcinol and 2.5% sulfur (OTC) [Acne-Aid Gel{01}{24}]

Packaging and storage:
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a well-closed container, unless otherwise specified by manufacturer. Protect from freezing.

Auxiliary labeling:
   • For external use only.


RESORCINOL AND SULFUR LOTION USP

Usual adult and adolescent dose
Antiacne agent or
Keratolytic
Topical, to the skin, one or two times a day, preferably in the morning and at bedtime. {25}


Usual pediatric dose
See Usual adult and adolescent dose.

Strength(s) usually available
U.S.—


2% resorcinol and 5% colloidal sulfur (OTC) [Sulforcin (alcohol 11.65%){05}{17}]


2% resorcinol and 5% sulfur (OTC) [Rezamid Acne Treatment (alcohol 28.5%){06}]


2% resorcinol and 8% sulfur (OTC) [Night Cast Special Formula Mask-lotion (alcohol 31%){21}]

Canada—


2% resorcinol and 5% colloidal sulfur (OTC) [Rezamid Lotion (alcohol 19.4%) (butylparaben) (methylparaben) (sodium bisulfite){08}{25}]

Packaging and storage:
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a tight container, unless otherwise specified by manufacturer. Protect from freezing.

Auxiliary labeling:
   • Shake well.
   • For external use only.


RESORCINOL AND SULFUR STICK

Usual adult and adolescent dose
Antiacne agent or
Keratolytic
Topical, to the skin. {03}


Usual pediatric dose
See Usual adult and adolescent dose.

Strength(s) usually available
U.S.—


1% resorcinol and 8% sulfur (OTC) [Clearasil Adult Care Medicated Blemish Stick{03}{17}]

Canada—
Not commercially available.

Packaging and storage:
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a well-closed container, unless otherwise specified by manufacturer. Protect from freezing.

Auxiliary labeling:
   • For external use only.



Revised: 07/26/1993



References
  1. Acne-Aid Gel package insert (Stiefel—Canada). In: CPS 1990: 9.
  1. Acnomel Cake package insert (SKF–Canada). In: CPS 1990: 9.
  1. Clearasil Adult Care Stick package insert (Richardson-Vicks—US), Rec 7/88.
  1. Clearasil Adult Care Cream package insert (Richardson-Vicks—US), Rec 7/88.
  1. Sulforcin Lotion package insert (Owen—US), Rec 6/88.
  1. Rezamid Lotion package insert (Dermik—US), Rec 4/88.
  1. Fleeger CA, editor. USAN 1993. USAN and the USP dictionary of drug names. Rockville, MD: The United States Pharmacopeial Convention, Inc., 1992.
  1. Rezamid Lotion package insert (Rorer—Canada). In: CPS 1990: 938.
    1. Acnomel Cream package insert (SmithKline Consumer—US), Rec 5/88.
    1. Writer's notes, 8/88.
      1. Acnomel Cream package insert (SKF—Canada). In: CPS 1990: 9.
            1. Olin BR, editor. Drug facts and comparisons. St. Louis: Facts and Comparisons Inc, 1992: 547.
                1. Acnomel Vanishing Cream package insert (SK&F—Canada). In: CPS 1990: 9.
                1. Night Cast Special Formula Mask-lotion package insert (Seres—US).
                1. Bensulfoid Cream package insert (Poythress—US).
                1. Acnomel Acne Cream package insert (Menley & James—US). In: PDR for nonprescription drugs 1993: 602.
                1. Acne-Aid Gel package insert (Stiefel—Canada). In: CPS 1993: 15.
                1. Rezamid Lotion package insert (Rhone-Poulenc Rorer—Canada). In: CPS 1993: 1044.
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