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Cough/Cold Combinations (Systemic)

This monograph includes information on the following:


Note: Products containing phenylpropanolamine were removed from the U.S. and Canadian Markets in November 2000.{61}

1) Brompheniramine, Phenylephrine and Codeine
2) Brompheniramine, Phenylephrine, Codeine and Guaifenesin *
3) Brompheniramine, Phenylephrine, Hydrocodone and Guaifenesin *
4) Brompheniramine, Pseudoephedrine, and Dextromethorphan 
5) Carbinoxamine, Pseudoephedrine, and Dextromethorphan 
6) Chlorpheniramine and Codeine *
7) Chlorpheniramine and Dextromethorphan 
8) Chlorpheniramine and Hydrocodone 
9) Chlorpheniramine, Ephedrine, and Guaifenesin 
10) Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane 
11) Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan, Ammonium Chloride, and Ipecac 
12) Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide, Caffeine, and Ascorbic Acid 
13) Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride 
14) Chlorpheniramine, Phenylephrine, Codeine, and Potassium Iodide 
15) Chlorpheniramine, Phenylephrine, and Dextromethorphan 
16) Chlorpheniramine, Phenylephrine, Dextromethorphan, and Guaifenesin 
17) Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and Ammonium Chloride 
18) Chlorpheniramine, Phenylephrine, and Hydrocodone 
19) Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine 
20) Chlorpheniramine, Pseudoephedrine, and Codeine
21) Chlorpheniramine, Pseudoephedrine, Codeine and Acetaminophen *
22) Chlorpheniramine, Pseudoephedrine, and Dextromethorphan
23) Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
24) Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Guaifenesin *
25) Chlorpheniramine, Pseudoephedrine, and Hydrocodone 
26) Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine and Hydrocodone 
27) Codeine, Ammonium Chloride, and Guaifenesin *
28) Codeine and Guaifenesin  
29) Dextromethorphan and Acetaminophen
30) Dextromethorphan and Guaifenesin
31) Dextromethorphan and Iodinated Glycerol 
32) Diphenhydramine, Codeine, and Ammonium Chloride *
33) Diphenhydramine, Dextromethorphan, and Ammonium Chloride *
34) Doxylamine, Codeine, and Acetaminophen *
35) Doxylamine, Etafedrine, and Hydrocodone *
36) Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
37) Ephedrine and Guaifenesin  
38) Hydrocodone and Guaifenesin  
39) Hydrocodone and Homatropine  
40) Hydrocodone and Potassium Guaiacolsulfonate 
41) Hydrocodone *
42) Pheniramine, Codeine, and Guaifenesin *
43) Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, and Caffeine 
44) Pheniramine, Phenylephrine, and Dextromethorphan *
45) Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid 
46) Pheniramine, Pyrilamine and Phenyltoloxamine 
47) Phenylephrine, Codeine and Guaifenesin 
48) Phenylephrine and Guaifenesin  
49) Phenylephrine and Hydrocodone
50) Phenylephrine, Hydrocodone, and Guaifenesin
51) Phenyltoloxamine and Hydrocodone *
52) Promethazine and Codeine  
53) Promethazine, Codeine, and Potassium Guaiacolsulfonate *
54) Promethazine and Dextromethorphan  
55) Promethazine and Potassium Guaiacolsulfonate *
56) Promethazine and Phenylephrine 
57) Promethazine, Phenylephrine, and Codeine 
58) Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate *
59) Pseudoephedrine, Codeine, and Guaifenesin
60) Pseudoephedrine and Dextromethorphan
61) Pseudoephedrine, Dextromethorphan, and Acetaminophen
62) Pseudoephedrine, Dextromethorphan, and Guaifenesin
63) Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen
64) Pseudoephedrine and Guaifenesin
65) Pseudoephedrine, Hydrocodone, and Guaifenesin 
66) Pseudoephedrine, Hydrocodone, and Potassium Guaiacolsulfonate 
67) Pyrilamine and Codeine  
68) Pyrilamine, Phenylephrine, Hydrocodone, and Ammonium Chloride *
69) Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen 
70) Triprolidine, Pseudoephedrine, and Codeine
71) Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin *
{62}
VA CLASSIFICATION
Brompheniramine, Phenylephrine and Codeine (Systemic)
Primary: RE502

Brompheniramine, Phenylephrine, Codeine, and Guaifenesin (Systemic)
Primary: RE504

Brompheniramine, Phenylephrine, Hydrocodone and Guaifenesin (Systemic)
Primary: RE504

Brompheniramine, Pseudoephedrine, and Dextromethorphan (Systemic)
Primary: RE502

Carbinoxamine, Pseudoephedrine, and Dextromethorphan (Systemic)
Primary: RE502

Chlorpheniramine and Codeine (Systemic)
Primary: RE507

Chlorpheniramine and Dextromethorphan (Systemic)
Primary: RE507

Chlorpheniramine, Ephedrine, and Guaifenesin (Systemic)
Primary: RE503

Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane (Systemic)
Primary: RE502

Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan, Ammonium Chloride, and Ipecac (Systemic)
Primary: RE504

Chlorpheniramine and Hydrocodone (Systemic)
Primary: RE301

Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide, Caffeine, and Ascorbic Acid (Systemic)
Primary: RE301

Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride (Systemic)
Primary: RE301

Chlorpheniramine, Phenylephrine, Codeine, and Potassium Iodide (Systemic)
Primary: RE301

Chlorpheniramine, Phenylephrine, and Dextromethorphan (Systemic)
Primary: RE502

Chlorpheniramine, Phenylephrine, Dextromethorphan, and Guaifenesin (Systemic)
Primary: RE504

Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and Ammonium Chloride (Systemic)
Primary: RE504

Chlorpheniramine, Phenylephrine, and Hydrocodone (Systemic)
Primary: RE301

Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine (Systemic)
Primary: RE301

Chlorpheniramine, Pseudoephedrine, and Codeine (Systemic)
Primary: RE301

Chlorpheniramine, Pseudoephedrine, Codeine, and Acetaminophen (Systemic)
Primary: RE506

Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Acetaminophen (Systemic)
Primary: RE506

Chlorpheniramine, Pseudoephedrine, and Dextromethorphan (Systemic)
Primary: RE502

Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Guaifenesin (Systemic)
Primary: RE504

Chlorpheniramine, Pseudoephedrine, and Hydrocodone (Systemic)
Primary: RE301

Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine and Hydrocodone (Systemic)
Primary: RE502

Codeine, Ammonium Chloride, and Guaifenesin (Systemic)
Primary: RE301

Codeine and Guaifenesin (Systemic)
Primary: RE301

Dextromethorphan and Acetaminophen (Systemic)
Primary: RE302

Dextromethorphan and Guaifenesin (Systemic)
Primary: RE302

Dextromethorphan and Iodinated Glycerol (Systemic)
Primary: RE302

Diphenhydramine, Codeine, and Ammonium Chloride (Systemic)
Primary: RE301

Diphenhydramine, Dextromethorphan, and Ammonium Chloride (Systemic)
Primary: RE502

Doxylamine, Codeine, and Acetaminophen (Systemic)
Primary: RE509

Doxylamine, Etafedrine, and Hydrocodone (Systemic)
Primary: RE502

Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen (Systemic)
Primary: RE506

Ephedrine and Guaifenesin (Systemic)
Primary: RE516

Hydrocodone and Guaifenesin (Systemic)
Primary: RE301

Hydrocodone and Homatropine (Systemic)
Primary: RE301

Hydrocodone and Potassium Guaiacolsulfonate (Systemic)
Primary: RE301

Pheniramine, Codeine, and Guaifenesin (Systemic)
Primary: RE301

Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, and Caffeine (Systemic)
Primary: RE301

Pheniramine, Phenylephrine, and Dextromethorphan (Systemic)
Primary: RE502

Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid (Systemic)
Primary: RE301

Pheniramine, Pyrilamine, and Phenyltoloxamine (Systemic)
Primary: RE501

Phenylephrine, Codeine and Guaifenesin (Systemic)
Primary: RE513

Phenylephrine and Guaifenesin (Systemic)
Primary: RE516

Phenylephrine and Hydrocodone (Systemic)
Primary: RE512

Phenylephrine, Hydrocodone, and Guaifenesin (Systemic)
Primary: RE301

Phenyltoloxamine and Hydrocodone (Systemic)
Primary: RE301

Promethazine and Codeine (Systemic)
Primary: RE301

Promethazine, Codeine, and Potassium Guaiacolsulfonate (Systemic)
Primary: RE301

Promethazine and Dextromethorphan (Systemic)
Primary: RE507

Promethazine and Potassium Guaiacolsulfonate (Systemic)
Primary: RE599

Promethazine and Phenylephrine (Systemic)
Primary: RE501

Promethazine, Phenylephrine, and Codeine (Systemic)
Primary: RE301

Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate (Systemic)
Primary: RE503

Pseudoephedrine, Codeine, and Guaifenesin (Systemic)
Primary: RE301

Pseudoephedrine and Dextromethorphan (Systemic)
Primary: RE512

Pseudoephedrine, Dextromethorphan, and Acetaminophen (Systemic)
Primary: RE515

Pseudoephedrine, Dextromethorphan, and Guaifenesin (Systemic)
Primary: RE513

Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen (Systemic)
Primary: RE514

Pseudoephedrine and Guaifenesin (Systemic)
Primary: RE516

Pseudoephedrine, Hydrocodone, and Guaifenesin (Systemic)
Primary: RE301

Pseudoephedrine, Hydrocodone, and Potassium Guaiacolsulfonate
Primary: RE301

Pyrilamine and Codeine (Systemic)
Primary: RE301

Pyrilamine, Phenylephrine, Hydrocodone, and Ammonium Chloride (Systemic)
Primary: RE301

Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen (Systemic)
Primary: RE506

Triprolidine, Pseudoephedrine, and Codeine (Systemic)
Primary: RE301

Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin (Systemic)
Primary: RE301



Note: Due to the large number of cough/cold products available and the different ingredients they contain, the listing that normally appears in this section has been omitted to save space. To aid the reader in readily finding the combination(s) and/or product(s) of interest, these have been grouped in the Category section and in the Advice for the Patient monograph according to the following major categories:

• Antihistaminic (H 1-receptor)-decongestant-antitussive


• Antihistaminic (H 1-receptor)-decongestant-expectorant


• Antihistaminic (H 1-receptor)-decongestant-antitussive-expectorant


• Antihistaminic (H 1-receptor)-decongestant-antitussive-expectorant-analgesic


• Antihistaminic (H 1-receptor)-decongestant-antitussive-analgesic


• Antihistaminic (H 1-receptor)-decongestant-expectorant-analgesic


• Antihistaminic (H 1-receptor)-antitussive


• Antihistaminic (H 1-receptor)-antitussive-expectorant


• Antihistaminic (H 1-receptor)-antitussive-analgesic


• Antihistaminic (H 1-receptor)-expectorant


• Antitussive-expectorant


• Antitussive-analgesic


• Antitussive-anticholinergic


• Decongestant-antitussive


• Decongestant-antitussive-expectorant


• Decongestant-antitussive-expectorant-analgesic


• Decongestant-antitussive-analgesic


• Decongestant-expectorant


• Decongestant-expectorant-analgesic

Other combination products that are used in the symptomatic treatment of colds, but which do not contain either an antitussive or an expectorant, can be found in Antihistamines and Decongestants (Systemic) ; Antihistamines, Decongestants, and Analgesics (Systemic) ; Antihistamines, Decongestants, and Anticholinergics (Systemic) ; and Decongestants and Analgesics (Systemic) .

Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).

*Not commercially available in the U.S.

Not commercially available in Canada.



Category:


Antihistaminic (H 1-receptor)-decongestant—Pheniramine, Pyrilamine, and Phenyltoloxamine; Promethazine and Phenylephrine;

Antihistaminic (H 1-receptor)-decongestant-antitussive— Brompheniramine, Phenylephrine and Codeine; Brompheniramine, Pseudoephedrine, and Dextromethorphan; Carbinoxamine, Pseudoephedrine, and Dextromethorphan; Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine and Hydrocodone; Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane; Chlorpheniramine, Phenylephrine, and Dextromethorphan; Chlorpheniramine, Phenylephrine, and Hydrocodone; Chlorpheniramine, Pseudoephedrine, and Codeine; Chlorpheniramine, Pseudoephedrine, and Dextromethorphan; Chlorpheniramine, Pseudoephedrine, and Hydrocodone; Doxylamine, Etafedrine, and Hydrocodone; Pheniramine, Phenylephrine, and Dextromethorphan; Promethazine, Phenylephrine, and Codeine; Triprolidine, Pseudoephedrine, and Codeine;

Antihistaminic (H 1-receptor)-decongestant-expectorant— Chlorpheniramine, Ephedrine, and Guaifenesin; Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate;

Antihistaminic (H 1-receptor)-decongestant-antitussive-expectorant—Brompheniramine, Phenylephrine, Codeine, and Guaifenesin ; Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin; Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan, Ammonium Chloride, and Ipecac; Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride ; Chlorpheniramine, Phenylephrine, Codeine, and Potassium Iodide; Chlorpheniramine, Phenylephrine, Dextromethorphan, and Guaifenesin; Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and Ammonium Chloride; Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Guaifenesin; Pyrilamine, Phenylephrine, Hydrocodone, and Ammonium Chloride; Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin;

Antihistaminic (H 1-receptor)-decongestant-antitussive-expectorant-analgesic—Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, and Caffeine;

Antihistaminic (H 1-receptor)-decongestant-antitussive-analgesic—Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide, Caffeine, and Ascorbic Acid; Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine; Chlorpheniramine, Pseudoephedrine, Codeine, and Acetaminophen; Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Acetaminophen; Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen; Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen ;

Antihistaminic (H 1-receptor)-antitussive—Chlorpheniramine and Codeine; Chlorpheniramine and Dextromethorphan ; Chlorpheniramine and Hydrocodone; Phenyltoloxamine and Hydrocodone; Promethazine and Codeine; Promethazine and Dextromethorphan; Pyrilamine and Codeine ;

Antihistaminic (H 1-receptor)-antitussive-expectorant— Diphenhydramine, Codeine, and Ammonium Chloride; Diphenhydramine, Dextromethorphan, and Ammonium Chloride; Pheniramine, Codeine, and Guaifenesin; Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid; Promethazine, Codeine, and Potassium Guaiacolsulfonate;

Antihistaminic (H 1-receptor)-antitussive-analgesic— Doxylamine, Codeine, and Acetaminophen;

Antitussive-expectorant—Codeine, Ammonium Chloride, and Guaifenesin; Codeine and Guaifenesin; Dextromethorphan and Guaifenesin; Dextromethorphan and Iodinated Glycerol; Hydrocodone and Guaifenesin;

Antitussive-analgesic—Dextromethorphan and Acetaminophen;

Antitussive-anticholinergic—Hydrocodone and Homatropine;

Decongestant-antitussive—Phenylephrine and Hydrocodone; Pseudoephedrine and Dextromethorphan;

Decongestant-antitussive-expectorant —Phenylephrine, Codeine and Guaifenesin ; Phenylephrine, Hydrocodone, and Guaifenesin ; Pseudoephedrine, Codeine, and Guaifenesin ; Pseudoephedrine, Dextromethorphan, and Guaifenesin; Pseudoephedrine, Hydrocodone, and Guaifenesin; Pseudoephedrine, Hydrocodone, and Potassium Guaiacolsulfonate;

Decongestant-antitussive-expectorant-analgesic —Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen;

Decongestant-antitussive-analgesic —Pseudoephedrine, Dextromethorphan, and Acetaminophen;

Decongestant-expectorant—Ephedrine and Guaifenesin; Phenylephrine and Guaifenesin; Pseudoephedrine and Guaifenesin; {62}

Indications

Accepted

Note: Products containing phenylpropanolamine were removed from the U.S. and Canadian Markets in November 2000.{61}

Cough (treatment)—Combination products containing antitussives and/or expectorants may be indicated for the symptomatic relief of cough due to colds and minor upper respiratory infections. {01}

Cough and nasal congestion (treatment)—Combination products containing antitussives and/or expectorants, and nasal decongestants may be indicated for the symptomatic relief of cough and nasal congestion due to the common cold and other respiratory infections. Also, products containing antihistamines may provide relief of the cough, nasal congestion, rhinorrhea, and sneezing associated with allergy and the common cold. However, controlled clinical studies have not demonstrated that antihistamines are significantly more effective than placebo in relieving cold symptoms. {02}

Cold symptoms (treatment)—Combination products containing antihistamines, antitussives or expectorants, nasal decongestants, and analgesics may be indicated for the temporary relief of coughs, nasal congestion, and associated aches, pains, and general discomfort due to colds, flu, or allergy. The antihistamine in these cold combinations may provide relief of nasal congestion, rhinorrhea, and sneezing. It may also serve as an adjunct because of its anticholinergic drying effects. However, in many cough/cold combinations, the dosage level of the antihistamine is below that required to obtain a significant effect. Also, controlled clinical studies have not demonstrated that antihistamines are significantly more effective than placebo in relieving cold symptoms. {02}

Unaccepted
Cough/cold combination products that contain both an antitussive and an expectorant usually do not offer any advantage over products that contain only one of these agents. In some cases, their combination may be detrimental in the treatment of coughs, since antitussives should be used only in the treatment of dry coughs and not for productive coughs.

Some products containing an anticholinergic have been used to help dry excessive nasal secretions associated with the common cold and allergic rhinitis; however, the efficacy of anticholinergics for this use in these combination products has not been established. In most products, the anticholinergic is included in doses below the therapeutic level in an attempt to prevent abuse by deliberate overdosage (e.g., in combinations containing a narcotic antitussive) {23}.

Combination products that contain an analgesic are generally not recommended for regular use for the treatment of cold symptoms during the common cold or acute allergic rhinitis since they may mask fever, which may indicate a secondary bacterial infection.

Ammonium chloride, calcium iodide, citric acid, guaiacol carbonate, iodinated glycerol, ipecac, potassium citrate, potassium guaiacolsulfonate, potassium iodide, and sodium citrate are included as expectorants in these combinations; however, the Food and Drug Administration (FDA) has not found them to be useful for this indication. Therefore, FDA has requested manufacturers to reformulate their products to replace these ingredients with guaifenesin. {08}


Pharmacology/Pharmacokinetics

Antihistamine-containing—See Antihistamines (Systemic) .

Decongestant-containing—See:

Ephedrine in Bronchodilators, Adrenergic (Systemic) .


Pseudoephedrine (Systemic).


Dextromethorphan-containing—See Dextromethorphan (Systemic) .

Opioid (narcotic) antitussive–containing—See Opioid (Narcotic) Analgesics (Systemic) .

Expectorant-containing—See:

Guaifenesin (Systemic).


Analgesic-containing—See:

Acetaminophen (Systemic).


Acetaminophen and Salicylates (Systemic).


Salicylates (Systemic).


Homatropine-containing—See Anticholinergics/Antispasmodics (Systemic) .


Precautions to Consider

Antihistamine-containing—See Antihistamines (Systemic) .

Antihistamine- and decongestant-containing—See Antihistamines and Decongestants (Systemic) .

Decongestant-containing—See:

Ephedrine in Bronchodilators, Adrenergic (Systemic) .
Note: Products containing phenylpropanolamine were removed from the U.S. and Canadian Markets in November 2000.{61}




Pseudoephedrine (Systemic).


Dextromethorphan-containing—See Dextromethorphan (Systemic) .

Opioid (narcotic) antitussive–containing—See Opioid (Narcotic) Analgesics (Systemic) .

Expectorant-containing—See:

Guaifenesin (Systemic).


Analgesic-containing—See:

Acetaminophen (Systemic).


Acetaminophen and Salicylates (Systemic).


Salicylates (Systemic).


Homatropine-containing—See Anticholinergics/Antispasmodics (Systemic) .


Laboratory value alterations

Table 1. Laboratory value alterations



The following have been selected on the basis of their potential clinical significance (possible effect in parentheses where appropriate)—not necessarily inclusive (» = major clinical significance):  Legend:
I=Antihistamine-containing
II=Decongestant-containing
III=Antitussive-containing
IV=Expectorant-containing
V=Analgesic-containing

  I
 
II
 
III
 
IV
 
V
 
With diagnostic test results
 
         
Copper sulfate urine sugar tests
(false-positive test results may occur with chronic use of salicylates in doses equivalent in salicylate content to 2.4 grams or more of aspirin a day)
       
Gastric emptying studies
(opioids delay gastric emptying, thereby invalidating test results)
   
   
Gerhardt test for urine aceto-acetic acid
(aspirin or sodium salicylate may cause interference because reaction with ferric chloride produces a reddish color that persists after boiling)
       
Glucose, blood
(acetaminophen may cause falsely decreased blood glucose values when measured by the glucose oxidase/peroxidase method but probably not when measured by the hexokinase/glucose-6-phosphate dehydrogenase [G6PD] method)
         
(values may be falsely increased when certain instruments are used in glucose analysis if high acetaminophen concentrations are present; consult manufacturer's instruction manual)
       
Glucose enzymatic urine sugar tests
(false-negative test results may occur with chronic use of salicylates in doses equivalent in salicylate content to 2.4 grams or more of aspirin a day)
       
Hepatobiliary imaging using technetium Tc 99m disofenin, technetium Tc 99m lidofenin, technetium Tc 99m mebrofenin
(delivery of these technetium Tc 99m–labeled radiopharmaceuticals to the small bowel may be prevented because opioids may cause constriction of the sphincter of Oddi and increased biliary tract pressure; these actions result in delayed visualization and thus resemble obstruction of the common bile duct)
   
   
5-hydroxyindoleacetic acid (5-HIAA), urine
(urinary determinations may be falsely increased when nitrosonaphthol reagent is used because of color interference by guaifenesin metabolites) {15} {16}
(acetaminophen may cause false-positive results in qualitative screening tests using nitrosonaphthol reagent; the quantitative test is unaffected)
         
(aspirin may alter results when fluorescent method is used)
       
Pancreatic function determinations using bentiromide
(administration of acetaminophen prior to the bentiromide test will invalidate test results because acetaminophen is also metabolized to an arylamine and will thus increase the apparent quantity of para-aminobenzoic acid [PABA] recovered; it is recommended that acetaminophen be discontinued at least 3 days prior to administration of bentiromide)
       
Skin tests using allergen extracts
(antihistamines contained in these combinations may inhibit the cutaneous histamine response thus producing false-negative results; it is recommended that antihistamine-containing medication be discontinued at least 72 hours before testing begins)

       
Thyroid function tests
(iodides may alter the results of these tests, and a high intake of inorganic iodides has also been shown to interfere with determination of protein bound iodine [PBI]; these effects have not been reported with iodinated glycerol in usual recommended doses, but they should be kept in mind for patients receiving prolonged therapy)
     
 
Uric acid, serum
(acetaminophen may cause falsely increased values when the phosphotungstate uric acid test method is used)
       
Vanillylmandelic acid (VMA), urine
(guaifenesin or its metabolites may cause color interference with urinary determinations) {15}
(values may be falsely increased or decreased by salicylates, depending on the method used)
       
With physiology/laboratory test values
 
         
Amylase activity, plasma, and
Lipase activity, plasma
(may be increased because opioids can cause contractions of the sphincter of Oddi and increased biliary tract pressure; the diagnostic utility of determinations of these enzymes may be compromised for up to 24 hours after the medication has been given)
   
   
Bilirubin, serum, and
Lactate dehydrogenase (LDH), serum, and
Prothrombin time and
Transaminase, serum
(prothrombin time and concentrations of bilirubin, LDH, and transaminase may be increased indicating acetaminophen-induced hepatotoxicity, especially in alcoholics, patients taking hepatic enzyme–inducing agents, or those with pre-existing hepatic disease, when single toxic doses [>8–10 grams] are taken or with prolonged use of lower doses [>3–5 grams a day])
       
Bleeding time
(may be prolonged by aspirin for 4 to 7 days because of suppressed platelet aggregation; as little as 40 mg of aspirin affects platelet function for at least 96 hours following administration; however, clinical bleeding problems have not been reported with small doses [150 mg or less])
       
Platelet aggregation
(may be transiently decreased by guaifenesin; however, effects on bleeding time are unlikely)
     
 
Potassium, serum
(concentrations may be decreased by aspirin or sodium salicylate because of increased potassium excretion caused by direct effect on renal tubules)
       
Protirelin-induced thyroid-stimulating hormone (TSH) release
(TSH response to protirelin may be decreased by aspirin in doses of 2 to 3.6 grams daily; peak TSH concentrations occur at the same time after administration but are reduced)
       
Uric acid, serum
(concentrations may be increased with doses of aspirin or sodium salicylate producing plasma salicylate concentrations below 100 to 150 mcg per mL or decreased with doses producing plasma salicylate concentrations above 100 to 150 mcg per mL)
       



Side/Adverse Effects
Antihistamine-containing—See Antihistamines (Systemic) .

Antihistamine- and decongestant-containing—See Antihistamines and Decongestants (Systemic) .

Decongestant-containing—See:

Ephedrine in Bronchodilators, Adrenergic (Systemic) .


Pseudoephedrine (Systemic).


Dextromethorphan-containing—See Dextromethorphan (Systemic) .

Opioid (narcotic) antitussive–containing—See Opioid (Narcotic) Analgesics (Systemic) .

Expectorant-containing—See:

Guaifenesin (Systemic).


Analgesic-containing—See:

Acetaminophen (Systemic).


Acetaminophen and Salicylates (Systemic).


Salicylates (Systemic).


Homatropine-containing—See Anticholinergics/Antispasmodics (Systemic) .



Patient Consultation

Note: Products containing phenylpropanolamine were removed from the U.S. and Canadian Markets in November 2000.

Table 2. Patient Consultation



As an aid to patient consultation, refer to Advice for the Patient, Cough/Cold Combinations (Systemic) .
In providing consultation, consider emphasizing the following selected information (» = major clinical significance):
Legend
I=Antihistamine-containing
II=Decongestantcontaining


III=Opioid (Narcotic)
Antitussive–containing
IV=Non-opioid Anti-
tussive–containing
V=Expectorant-containing

VI=Analgesic-
containing 1
VII=Anticholi-
nergic containing

I
 
II
 
III
 
IV
 
V
 
VI
 
VII
 
Before using this medication
» Conditions affecting use, especially:
             
Sensitivity to any of the medications in the combination being taken







Pregnancy—
Concern for the fetus or newborn infant, especially with high-dose and/or long-term usage







Physical dependence in the neonate possible with regular use
   
       
Iodinated glycerol not recommended, because may induce fetal goiter
       
   
Breast-feeding—
Antihistamines may cause excitement or irritability in nursing infant

           
High risk for infants from sympathomimetic amines
 
         
Concern with high doses and chronic use because of high salicylate intake by infant
          2
 
Iodinated glycerol not recommended, because may induce skin rash and thyroid suppression in nursing infant
       
   
Use in children—
Increased susceptibility to anticholinergic effects

         
Increased susceptibility to vasopressor effects of sympathomimetic amines
 
         
Paradoxical reaction (hyperexcitability)

 
     
Increased susceptibility to toxic effects of salicylates, especially if fever and dehydration present
          2
 
Possible association between aspirin usage and Reye's syndrome
          2
 
Increased susceptibility to goitrogenic effects of iodides
        3
   
Increased susceptibility to respiratory depressant effects of opioids in children up to 2 years of age
   
       
Use in the elderly—
Anticholinergic effects more likely to occur

         
Increased sensitivity to CNS and vasopressor effects of sympathomimetic amines
 
         
Increased susceptibility to toxic effects of salicylates
          2
 
Increased susceptibility to respiratory depressant effects of opioids
   
       
Other medications, especially:
Alcohol

 
4
 
 
Alkalizers, urinary
          2
 
Anticholinergics

         
Anticoagulants
          2
 
Antidepressants, tricyclic


         
Antidiabetic agents, oral
          2
 
Antihypertensives
 
         
Anti-inflammatory drugs, nonsteroidal
          2
 
Antithyroid agents
        3
   
Beta-adrenergic blocking agents, oral
 
         
CNS depressants

    4
     
CNS stimulants
 
         
Heparin
          2
 
Lithium
        3
   
Methotrexate
          2
 
Monoamine oxidase (MAO) inhibitors


  4
   
Platelet aggregation inhibitors
          2
 
Probenecid
          2
 
Rauwolfia alkaloids
 
         
Sulfinpyrazone
          2
 
Thrombolytic agents
          2
 
Vancomycin
         
 
Zidovudine
         
 
Other medical problems, especially:
             
Alcoholism, active 9
          8
 
Asthma
   
4
  2
 
Bleeding problems
          2
 
Cardiovascular disease
 
         
Diabetes
 
         
Diarrhea
   
       
Gastritis or peptic ulcer
          2
 
Glaucoma

         
Hypertension
 
         
Inflammatory bowel disease
   
       
Prostatic hypertrophy

         
Thyroid disease
 
         
Proper use of this medication
Taking with food, water, or milk to minimize gastric irritation

        2
 
» Importance of drinking a glass of water after each dose of medication to help loosen mucus in lungs







» Importance of not taking more medication than the amount recommended


5


5

Swallowing extended-release dosage form whole






 
» Not taking combinations containing aspirin if a strong vinegar-like odor is present
         
 
Missed dose: If on scheduled dosing regimen—Taking as soon as possible; not taking if almost time for next dose; not doubling doses







» Proper storage







Precautions while using this medication
» Checking with physician if symptoms persist after medication has been used for 7 days or if high fever, skin rash, or continuing headache is present with cough







Possible interference with skin tests using allergens; need to inform physician of use of medication

           
» Avoiding use of alcohol or other CNS depressants

 
       
» Caution if drowsiness or dizziness occurs

  6
       
Lying down if nausea occurs
   
       
Possible dryness of mouth; using sugarless candy or gum, ice, or saliva substitute for relief; checking with physician or dentist if dry mouth continues for more than 2 weeks

         
May mask ototoxic effects of large doses of salicylates

           
» Caution if taking appetite suppressants
 
         
» Possible insomnia; taking the medication a few hours before bedtime
  7
         
» Caution during exercise and hot weather; overheating may result in heat stroke
           
Caution when getting up suddenly from a lying or sitting position
   
       
Need to inform physician or dentist of use of medication if any kind of surgery (including dental surgery) or emergency treatment is required
 

       
» Caution if other medications containing acetaminophen, aspirin, or other salicylates (including diflunisal) are used
         
 
Diabetics: Salicylates present in some of these combinations may cause false urine sugar tablet test results with use of larger doses
         
 
Not taking products containing aspirin for 5 days prior to any kind of surgery, unless otherwise directed by physician
         
 
Side/adverse effects
Signs of potential side effects, especially:
Allergic reactions







Anemia
         
 
Anticholinergic effects

         
Blood dyscrasias

           
Gastrointestinal irritation or bleeding
          2
 
Jaundice
          8
 
Parotitis, acute
        3
   
1 In children the use of combinations containing both acetaminophen and salicylates is controversial. Also, studies have suggested that aspirin usage may be associated with the development of Reye's syndrome in children/adolescents with acute febrile illnesses, especially influenza and varicella. It is recommended that salicylate therapy not be initiated in febrile pediatric or adolescent patients until after the presence of such an illness has been ruled out. Also, it is recommended that chronic salicylate therapy in these patients be discontinued if a fever occurs, and not resumed until it has been determined that an illness that may predispose to Reye's syndrome is not present or has run its course. In addition, pediatric patients, especially those with fever and dehydration, may be more susceptible to the toxic effects of salicylates.
2 Applies to salicylates only, particularly aspirin.
3 Applies to iodides (e.g., calcium iodide, iodinated glycerol, potassium iodide) only.
4  Applies to dextromethorphan.
5 Danger of overdose of acetaminophen, salicylates, or opioid (narcotic) antitussives; also, acetaminophen may cause liver damage with long-term or high-dose use.
6 In addition to drowsiness and dizziness, a false sense of well-being may also occur with the opioid (narcotic) antitussives.
7 The possibility of insomnia may be minimized with preparations containing an antihistamine or an opioid (narcotic) antitussive.
8 Applies to acetaminophen only.
9 Caution should be exercised whether alcoholism is active or in remission with all alcohol-containing products.


COUGH COLD COMBINATIONS


Oral Dosage Forms

Note: Products containing phenylpropanolamine were removed from the U.S. and Canadian Markets in November 2000.{61}

Table 3. Oral Dosage Forms


Note: Content per capsule, tablet, or 5 mL, unless otherwise stated.



Brand or
generic name
[availability]
Antihistamines
Decongestants
Antitussives
Expec-
torants
Analgesics
Other
content
information
as per product
label
Usual adult
and
adolescent
dose prn
Usual
pediatric
dose prn
Packaging,
storage and
auxiliary
labeling §
Opioid
Non-opioid
Alka-Seltzer Plus Cold and Cough Effervescent Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCL
5 mg
  Dextrometh-
orphan HBr
10 mg
  Phenylalanine
11.2 mg
Sodium
507 mg
  a, e
Alka-Seltzer Plus Cold & Cough Medicine Liqui-Gels Capsules (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
325 mg
  6–12 yrs:
1 cap q 4 hr
(max 4
caps/day)
a, e
 
Alka-Seltzer Plus Flu & Body Aches Medicine Liqui-Gels Capsules (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
250 mg
  2 caps q 4 hr
(max 8 caps/day)
6–12 yrs:
1 cap q 4 hr
(max 4 caps/day)
a, e
 
Alka-Seltzer Plus Night Time Cold Effervescent Tablets (OTC)
[U.S.]
Doxylamine
succinate 6.25 mg
Phenylephrine
HCL 5 mg
  Dextrometh-
orphan HBr
10 mg
  Aspirin
500 mg
Sodium
506 mg
Phenylalanine
16.2 mg
a, e
 
Alka-Seltzer Plus Night-Time Cold Liqui-Gels Capsules (OTC)
[U.S.]
Doxylamine
succinate 6.25 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
Alcohol free
b, e
 
Ami-Tex LA Extended-release
Tablets (Rx)
[U.S.]
  Phenylephrine
HCl 30 mg
    Guaifenesin
600 mg
  Scored
1 tab q 12 hr
6–12 yrs:
1/2 tab
q 12 hr
a1 , d
 
Anatuss LA Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
400 mg
  Scored
1 tab q 12 hr
6–12 yrs:
1/2 tab
q 12 hr
b
 
Anti-Tuss DM Expectorant Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 1.4%
b, c
 
Benylin DM-D Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol free
Sodium 19 mg
Sugar free
10 mL
q 6 hr
(max 4 doses/day)
2–5 yrs:
2.5 mL,
6–11 yrs:
5 mL,
q 6 hr
(max 4 doses/day)
a
 
Benylin DM-D for Children Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
Sodium 11.04 mg
Sugar free
  2–5 yrs:
5 mL,
6–12 yrs:
10 mL,
q 6 hr
a
 
Benylin DM-D-E Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 5%
Sodium 20.6 mg
Sugar free
10 mL
q 6 hr
(max 4 doses/day)
2–5 yrs:
2.5 mL,
6–11 yrs:
5 mL,
q 6 hr
(max 4 doses/day)
a
 
Benylin DM-D-E Extra Strength Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
Guaifenesin
200 mg
  Alcohol 5%
Sodium 19.6 mg
Sugar free
10 mL
q 6 hr
(max 4 doses/day)
Not
recommended
a
 
Benylin DM-E Syrup (OTC)
[Canada]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 5%
Sodium 20.6 mg
Sugar free
10 mL
q 6 hr
(max 4 doses/day)
2–5 yrs:
2.5 mL,
6–11 yrs:
5 mL,
q 6 hr
(max 4 doses/day)
a
 
Benylin DM-E Extra Strength Syrup (OTC)
[Canada]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
200 mg
  Alcohol
Sodium 19.6 mg
Sugar free
10 mL
q 6 hr
(max 4 doses/day)
Not
recommended
a
 
Benylin Expectorant Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
Sugar free
b, c
 
Benylin 4 Flu Oral Solution (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg/15 mL
  Dextrometh-
orphan HBr
15 mg/15 mL
Guaifenesin
100 mg/
15 mL
Acetami-
nophen
500 mg/
15 mL
Alcohol 5%
Sugar free
30 mL q 6 hr
(max 4 doses/day)
Not
recommended
a, c
 
Bromfed-DM Syrup (Rx)
[U.S.]
Brompheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextromethorphan HBr
10 mg
    Alcohol free
10 mL q 4 hr
(max 6 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
(max 6 doses/day)
a, c, d, e
 
Broncholate Syrup (Rx)
[U.S.]
  Ephedrine
HCl 6.25 mg
    Guaifenesin
100 mg
    10–20 mL
q 4 hr
2–6 yrs:
2.5–5 mL,
6–12 yrs:
5–10 mL,
q 4 hr
a, c, d
 
Brontex Oral Solution
(Schedule V)
[U.S.]
    Codeine PO 4
2.5 mg
  Guaifenesin
75 mg
    20 mL q 4 hr
(max 120 mL/day)
6–12 yrs:
10 mL
q 4 hr
b, e, f
Tablets
(Schedule III)
[U.S.]
    Codeine PO 4
10 mg
  Guaifenesin
300 mg
    1 tab q 4 hr
Recommended for use in pediatric patients 12 years of age and older


b, e, f
 
Calmydone Syrup (N)
[Canada]
Doxylamine
succinate
1.2 mg/mL
Etafedrine
HCl 3.33 mg/mL
Hydrocodone
bitartrate
0.33 mg/mL
      Alcohol 5%
Sodium citrate
40 mg/mL
a, e, f
 
Calmylin #2 Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol free
Sugar free
5–10 mL
q 6–8 hr
2–5 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
a, c, e
 
Calmylin #3 Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 5%
Sugar free
10 mL q 6–8 hr
2–5 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
a, c, e
 
Calmylin #4 Syrup (OTC)
[Canada]
Diphenhydramine
HCl 12.5 mg
    Dextrometh-
orphan HBr
15 mg
Ammonium
chloride
125 mg
  Alcohol 5%
5–10 mL
q 6–8 hr
2–3 yrs:
1.25 mL,
4–12 yrs:
2.5–5 mL,
q 6–8 hr
a, c, e
 
Calmylin Cough & Flu Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg/
15 mL
  Dextrometh-
orphan HBr
15 mg/15 mL
Guaifenesin
100 mg/
15 mL
Acetamin-
ophen
325 mg/
15 mL
Alcohol free
Sugar free
15–30 mL
q 6–8 hr
(max 120 mL/day)
Not
recommended
a, c
 
Calmylin DM-D-E Extra Strength Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
Guaifenesin
200 mg
  Alcohol 5%
Sugar free
10 mL q 6 hr
Not
recommended
a, c
 
Calmylin Original with Codeine Syrup (N)
[Canada]
Diphenhydramine
HCl 12.5 mg
  Codeine PO 4
3.33 mg
  Ammonium
chloride
125 mg
  Alcohol 2.9%
5–10 mL
q 3–4 hr
  b, c, e, f
 
Calmylin Pediatric Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
Sugar free
  1–2 yrs:
2.5 mL
2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 6–8 hr
a, c
 
Carbinoxamine Compound-Drops Oral Solution (Rx)
[U.S.]
Carbinoxamine
maleate 2 mg/mL
Pseudoephedrine
HCl 25 mg/mL
  Dextrometh-
orphan HBr
4 mg/mL
    Alcohol <0.2%
  1–18 mos:
0.25–1 mL
q 6 hr
b, c, e
 
Cardec DM Syrup (Rx)
[U.S.]
Carbinoxamine
maleate 4 mg
Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol
<0.6%
5 mL q 6 hr
  b, c, e
 
Cheracol Syrup (N)
[Canada]
    Codeine PO 4
10 mg
  Ammonium
Cl 91 mg,
Guaifenesin
100 mg
  Alcohol 4.75%
10 mL q 4–6 hr
6–12 yrs:
5 mL
q 4–6 hr
a, d, e, f
 
Children's Tylenol Cold Plus Cough Multi Symptom Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
5 mg
  Acetamin-
ophen
160 mg
Alcohol free
Intended for
pediatric
use
2–5 yrs:
5 mL,
6–11 yrs:
10 mL,
q 4–6 hr
(max 4 doses/day)
b, c, e
 
Chewable Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 0.5 mg
Pseudoephedrine
HCl 7.5 mg
  Dextrometh-
orphan HBr
2.5 mg
  Acetamin-
ophen
80 mg
  Intended for
pediatric
use
2–5 yrs:
2 tabs,
6–11 yrs:
4 tabs,
q 4–6 hr
(max 4 doses/day)
b, e, i
 
Chlorgest-HD Oral Solution (Schedule III)
[U.S.]
Chlorpheniramine
maleate 4 mg
Phenylephrine HCl
5 mg
Hydrocodone
bitartrate
1.67 mg
      Alcohol free
Sugar free
10 mL q 6–8 hr
  b, c, e, f
 
CoActifed Oral Solution (N)
[Canada]
Triprolidine HCl
2 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
      Alcohol free
10 mL q 4–6 hr
<6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
b, c, d, e, f
 
Tablets (N)
[Canada]
Triprolidine HCl
4 mg
Pseudoephedrine
HCl 60 mg
Codeine PO 4
20 mg
      Scored
1 tab q 4–6 hr
<6 yrs:
See CoActifed
Syrup
6–12 yrs:
1/2 tab
q 4–6 hr
b, d, e, f
 
CoActifed Expectorant Oral Solution (N)
[Canada]
Triprolidine HCl
2 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol free
10 mL q 4–6 hr
<6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
b, c, d, e, f
 
Co-Apap Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 tabs q 6 hr
6–12 yrs:
1 tab q 6 hr
b, e
 
Comtrex Daytime Maximum Strength Cold, Cough and Flu Relief Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
Available in a
dual package
that also
contains
Comtrex Nighttime Maximum Strength Cold, Cough and Flu Relief
2 tabs q 6 hr
(max 4 tabs/day)
  b
 
Comtrex Daytime Maximum Strength Cold and Flu Relief Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
Available in a
dual package
that also
contains
Comtrex Nighttime Maximum Strength Cold and Flu Relief
2 tabs q 6 hr
(max 4 tabs/day)
  b
 
Comtrex Multi-Symptom Maximum Strength Non-Drowsy Caplets Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  2 tabs q 6 hr
(max 8 tabs/day)
Intended for
adult use
b
 
Comtrex Nighttime Maximum Strength Cold and Flu Relief Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
Available in a
dual package
that also
contains
Comtrex Daytime Maximum Strength Cold and Flu Relief
2 tabs hs
  b, e
 
Congestac Caplets Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
400 mg
    1 tab q 4 hr
(max 4 tabs/day)
  b
 
Contac Cold/Flu Day Caplets Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
30 mg
  Acetamin-
ophen
650 mg
Available in a
dual package
that also
contains
Contac Cold/Flu Night Caplets
1 tab q 6 hr
(max 4 tabs/day of any
combination of
Day or Night
caplets)
  b
 
Contac Severe Cold & Flu Caplets Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  2 tabs q 6 hr
(max 8 tabs/day)
  b, c, e
 
Coristex-DH Oral Solution (N)
[Canada]
  Phenylephrine HCl
20 mg
Hydrocodone
bitartrate
5 mg
      Alcohol 4.25%
Sucrose 33%
5 mL q 4 hr
6–12 yrs:
2.5 mL q 4 hr
a, c, d, e, f
 
Coristine-DH Oral Solution (N)
[Canada]
  Phenylephrine HCl
10 mg
Hydrocodone
bitartrate
1.7 mg
      Alcohol 4.3%
Sucrose 33%
10 mL
q 4 hr
6 mos–1 yr:
1.25–2.5 mL,
1–12 yrs:
2.5–5 mL,
q 4 hr
a, c, d, e, f
 
Cotridin Oral Solution (N)
[Canada]
Triprolidine HCl
2 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
      Alcohol free
10 mL q 4–6 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
a, d, e, f
 
Cotridin Expectorant Oral Solution (N)
[Canada]
Triprolidine HCl
2 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol free
10 mL q 6 hr
(max 4 doses/day)
2–5 yrs:
2.5 mL,
6–11 yrs:
5 mL,
q 6 hr
(max 4 doses/day)
a, d, e, f
 
Co-Tuss V Oral Solution
(Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
  Guaifenesin
100 mg
    5 mL q 4 hr
  b, c, e, f
 
Deconsal II Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
600 mg
  Scored
1–2 tabs
q 12 hr
(max 4 tabs/day)
2–6 yrs:
1/2 tab
(max 1 tab/day),
6–12 yrs:
1 tab
(max 2 tabs/day),
q 12 hr
b
 
Despec Oral Solution (Rx)
[U.S.]
  Phenylephrine
HCl 5 mg,
    Guaifenesin
100 mg
  Alcohol 5%
b, c
 
Despec-SR Caplets Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120mg
    Guaifenesin
800 mg
  Scored
a, d
 
Dimetane Expectorant-C Oral Solution (N)
[Canada]
Brompheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg,
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
a, c, d, e, f
 
Dimetane Expectorant-DC Oral Solution (N)
[Canada]
Brompheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg,
Hydrocodone
bitartrate
1.8 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
b, c, e, f
 
Dimetapp-C Syrup (N)
[Canada]
Brompheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg,
Codeine PO 4
10 mg
      Alcohol
Sodium
3.1 mg
Sugar free
a
 
Donatussin Syrup (Rx)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine HCl
10 mg
  Dextrometh-
orphan HBr
7.5 mg
Guaifenesin
100 mg
  Alcohol free
5 mL
q 4–6 hr
(max 6 doses/day)
2–6 yrs:
1.25 mL,
6–12 yrs:
2.5 mL,
q 4–6 hr
b, c, e
 
Donatussin DC Syrup (Schedule III)
[U.S.]
  Phenylephrine HCl
7.5 mg
Hydrocodone
bitartrate
2.5 mg
  Guaifenesin
50 mg
  Alcohol free
10 mL
q 4–6 hr
(max 6 doses/day)
3–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4-6 hr
b, c, d, e, f
 
Duratuss Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
600 mg
  Scored
Dye free
Film-coated
1 tab q 12 hr
6–12 yrs:
1/2 tab q 12 hr
b
Duratuss HD Elixir
(Schedule III)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Hydrocodone
bitartrate
2.5 mg
  Guaifenesin
100 mg
  Alcohol 5%
10 mL q 4–6 hr
(max 4 doses/day)
6–12 yrs:
5 mL
q 4–6 hr
(max 4 doses/day)
b, c, e, f
 
ED-TLC Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
1.67 mg
        10 mL
q 6–8 hr
6–12 yrs:
5 mL
q 6–8 hr
b, c, e, f
 
ED Tuss HC Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 4 mg
Phenylephrine
HCl 10 mg
Hydrocodone
bitartrate
2.5 mg
      Alcohol 5%
5 mL q 6 hr
2–6 yrs:
1.25 mL,
6–12 yrs:
2.5 mL,
q 4–6 hr
b, c, e, f
Endagen-HD Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
1.7 mg
      Alcohol free
10 mL
q 6–8 hr
6–12 yrs:
5 mL
q 6–8 hr
b, c, e, f
 
Endal Expectorant Syrup
(Schedule V)
[U.S.]
    Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 5%
Sugar free
Dye free
5–10 mL
q 6–8 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
b, c, e, f
 
Entex LA Extended-release
Tablets (Rx)
[U.S.]
  Phenylephrine
HCl 30 mg
    Guaifenesin
600 mg
  Scored
b
 
Father John's Medicine Plus Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
Phenylephrine HCl
2.5 mg
  Dextrometh-
orphan HBr
7.5 mg
Guaifenesin
30 mg,
Ammonium
Cl
83.3 mg
  Alcohol free
5–10 mL
q 3–4 hr
2–6 yrs:
5 mL,
6–12 yrs:
5–10 mL,
q 6–8 hr
b, c, e
 
Genatuss DM Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
10 mL q 4 hr
  b, c
GP-500 Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
500 mg
  Scored
1 tab q 12 hr
6–12 yrs:
1/2 tab q 12 hr
a, d
 
Guaifed Extended-release
Capsules (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
(extended-release)
    Guaifenesin
250 mg
(immediate
release)
    1 cap q 12 hr
Pediatric
strength not
available
a
 
Syrup (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
    Guaifenesin
200 mg
  Sugar free
10 mL q 4–6 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
b
 
Guaifenex PSE 60 Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
600 mg
  Scored
1–2 tabs
q 12 hr
(max 4 tabs/day)
2–6 yrs:
1/2 tab
(max 1 tab/day),
6–12 yrs:
1 tab
(max 2 tabs/day),
q 12 hr
a, d
 
Guaifenex PSE 120 Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
600 mg
  Scored
1 tab q 12 hr
6–12 yrs:
1/2 tab q 12 hr
a, d
 
GuaiMAX-D Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
600 mg
  Scored
1 tab q 12 hr
6–12 yrs:
1/2 tab q 12 hr
b
 
Guai-Vent/PSE Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
600 mg
  Scored
1 tab
q 12 hr
6–12 yrs:
1/2 tab
q 12 hr
a2 , d
 
Guiatuss A.C. Syrup USP (Schedule V)
[U.S.]
    Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
10 mL q 4 hr
2–6 yrs:
1.25–2.5 mL,
6–12 yrs:
2.5–5 mL,
q 4–6 hr
a, d, e, f
 
Guiatuss CF Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 30/5 mg/mL
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
  b, c
Guiatuss DAC Oral Solution
(Schedule V)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 1.9%
10 mL q 4 hr
(max 40 mL/day)
  b, c, e, f
 
Guiatuss PE Syrup (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
    Guaifenesin
100 mg
  Alcohol free
10 mL q 4 hr
(max 40 mL/day)
  b, c
 
Histenol Tablets (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
325 mg
  1–2 tabs
q 4 hr
(max 8 tabs/day)
6–12 yrs:
1/2–1 tab
q 4 hr
a
 
Histinex HC Syrup
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
2.5 mg
      Alcohol free
Sugar free
10 mL q 4 hr
(max 40 mL/day)
6–12 yrs:
5 mL q 4 hr
(max 20 mL/day)
a, d, e, f
 
Histinex PV Syrup
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
Hydrocodone
bitartrate
2.5 mg
      Alcohol free
Sugar free
10 mL q 4–6 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
a, d, f
 
Hycodan Syrup (Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
      Homatropine
MBr 1.5 mg **
5 mL q 4–6 hr
(max 30 mL/day)
6–12 yrs:
2.5 mL
q 4–6 hr
(max 15 mL/day)
b, c, e, f
 
Syrup (N)
[Canada]
    Hydrocodone
bitartrate
5 mg
      Alcohol free
5 mL
at intervals
³4 hr
(max 30 mL/day)
<2 yrs:
1.25 mL
(max 7.5 mL/day),
2–12 yrs:
2.5 mL
(max 15 mL/day),
at intervals
³4 hr
b, c, d, e, f
 
Tablets (N)
[Canada]
    Hydrocodone
bitartrate
5 mg
      Scored
1 tab
at intervals
³4 hr
(max 6 tabs/day)
<2 yrs: 1/4 tab
(max 11/2 tabs/day),
2–12 yrs: 1/2 tab
(max 3 tabs/day),
at intervals
³4 hr.
See also
Hycodan Syrup
b, d, e, f
 
Hycomine Compound Tablets (Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine HCl
10 mg
Hydrocodone
bitartrate
5 mg
    Acetamin-
ophen
250 mg
Caffeine
30 mg
Scored
1 tab
4 times/day
(at intervals
³4 hr)
6–12 yrs:
1/2 tab
4 times/day
(at intervals
³4 hr)
b, e, f
 
Hydrocodone and
Homatropine *
Syrup (Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
      Homatropine
MBr 1.5 mg **
5 mL q 4–6 hr
<2 yrs:
1.25 mL,
2–12 yrs:
2.5 mL,
q 4–6 hr
b, c, d, e, f
 
Hydropane Syrup (Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
      Homatropine
MBr 1.5 mg **
5 mL q 4–6 hr
<2 yrs:
1.25 mL,
2–12 yrs:
2.5 mL,
q 4–6 hr
b, c, d, e, f
Iobid DM Extended-release
Tablets (Rx)
[U.S.]
      Dextrometh-
orphan HBr
30 mg
Guaifenesin
600 mg
    1–2 tabs
q 12 hr
(max 4 tabs/day)
2–6 yrs:
1/2 tab,
6–12 yrs:
1 tab,
q 12 hr
(max 2 doses/day)
a, d
 
Iodal HD Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
1.67 mg
        10 mL q 4 hr
(max 40 mL/day)
6–12 yrs:
5 mL q 4 hr
(max 20 mL/day)
a, d, e, f
 
Iosal II Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
600 mg
    1–2 tabs
q 12 hr
(max 4 tabs/day)
2–5 yrs:
1/2 tab,
6–12 yrs:
1 tab,
q 12 hr
(max 2 doses/day)
a, d
Iotussin HC Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
2.5 mg
        10 mL q 4 hr
(max 40 mL/day)
6–12 yrs:
5 mL q 4 hr
(max 20 mL/day)
a, d, e, f
Kolephrin/DM Cough and Cold Medication Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
325 mg
  2 tab q 4–6 hr
(max 8 tabs/day)
6–12 yrs:
1 tab q 4–6 hr
(max 4 tabs/day)
b, e
 
Kolephrin GG/DM Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
150 mg
  Alcohol free
10 mL q 4 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
b, c
 
Kwelcof Liquid Oral Solution
(Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
  Guaifenesin
100 mg
  Alcohol free
Sugar free
Dye free
5 mL
q 4–6 hr
2–12 yrs:
2.5–5 mL
q 4–6 hr
b, c, e, f
 
Mapap Cold Formula Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 tabs q 6 hr
6–12 yrs:
1 tab q 6 hr
b, e
 
Marcof Expectorant Syrup
(Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
  Potassium
guaiacol-
sulfonate
350 mg
  Alcohol free
Sugar free
a, c, e, f
Mersyndol with Codeine Tablets (N)
[Canada]
Doxylamine
succinate 5 mg
  Codeine PO 4
8 mg
    Acetamin-
ophen
325 mg
  1–2 tabs q 4 hr
(max 12 tabs/day)
  a, e, f
 
Nalex DH Elixir
(Schedule III)
[U.S.]
  Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
1.67 mg
      Alcohol 5%
10 mL q 4–6 hr
(max 4 doses/day)
2–6 yrs:
2.5–5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
a, c, d, f
 
Neo Citran DM Coughs and Colds for Oral Solution (OTC)
[Canada]
Pheniramine
maleate 20 mg/
pouch
Phenylephrine HCl
10 mg/pouch
  Dextrometh-
orphan HBr
30 mg/
pouch
    Vitamin C
50 mg,
Tartrazine
1 pouch
dissolved in
8 oz
boiling water
q 6–8 hr
(max 3 pouches/day)
  e
 
Novahistex DH Oral Solution (N)
[Canada]
  Phenylephrine HCl
20 mg
Hydrocodone
bitartrate
5 mg
      Alcohol free
5 mL q 4 hr
  b, c, e, f
 
Novahistex DH Expectorant Oral Solution (N)
[Canada]
  Phenylephrine HCl
20 mg
Hydrocodone
bitartrate
5 mg
  Guaifenesin
200 mg
  Alcohol free
Fructose 10%,
Glucose 14.3%
5 mL q 4 hr
  b, c, e, f
 
Novahistine DH Oral Solution (N)
[Canada]
  Phenylephrine HCl
10 mg
Hydrocodone
bitartrate
1.7 mg
      Alcohol free
10 mL q 4 hr
6 mos–1 yr:
1.25–2.5 mL,
1–12 yrs:
2.5–5 mL,
q 4 hr
b, c, e, f
 
Novahistine DH Liquid Oral Solution
(Schedule V)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
      Alcohol 5%
10 mL q 4–6 hr
(max 40 mL/day)
6–12 yrs:
5 mL
q 4–6 hr
(max 20 mL/day)
a, c, d, e, f
 
Novahistine DM w/ Decongestant Oral Solution (OTC)
[Canada]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
  2–5 yrs:
5 mL
(max 20 mL/day),
6–12 yrs:
10 mL
(max 40 mL/day),
q 4–6 hr
a
 
Novahistine DM Expectorant w/ Decongestant Oral Solution (OTC)
[Canada]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
Guaifenesin
50 mg
  Alcohol free
  2–5 yrs:
5 mL
(max 20 mL/day),
6–12 yrs:
10 mL
(max 40 mL/day),
q 4–6 hr
a
 
Nucofed Capsules
(Schedule III)
[U.S.]
  Pseudoephedrine
HCl 60 mg
Codeine PO 4
20 mg
        1 cap q 6 hr
(max 4 caps/day)
Pediatric
strength not
available.
See Nucofed
Syrup
b, e, f
 
Syrup (Schedule III)
[U.S.]
  Pseudoephedrine
HCl 60 mg
Codeine PO 4
20 mg
      Alcohol free,
Sucrose
2.25 gm
5 mL q 6 hr
(max 4 doses/day)
2–6 yrs:
1.25 mL,
6–12 yrs:
2.5 mL,
q 6 hr
(max 4 doses/day)
b, c, e, f
 
Nucofed Expectorant Syrup (Schedule III)
[U.S.]
  Pseudoephedrine
HCl 60 mg
Codeine PO 4
20 mg
  Guaifenesin
200 mg
  Alcohol 12.5%
5 mL q 6 hr
(max 4 doses/day)
2–6 yrs:
1.25 mL,
6–12 yrs:
2.5 mL,
q 6 hr
(max 4 doses/day)
b, c, e, f
 
Nucofed Pediatric Expectorant Syrup (Schedule V)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 6%
10 mL q 6 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6 hr
(max 4 doses/day)
a, c, e, f
 
Nucotuss Expectorant Syrup
(Schedule III)
[U.S.]
  Pseudoephedrine
HCl 60 mg
Codeine PO 4
20 mg
  Guaifenesin
200 mg
  Alcohol 12.5%
5 mL q 6 hr
  b, c, e, f
 
Nucotuss Pediatric Expectorant Syrup (Schedule V)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 6%
  2–<12 yrs:
2.5–5 mL
q 6 hr
b, c, e, f
 
Nytcold Medicine Oral Solution (OTC)
[U.S.]
Doxylamine
succinate 1.25 mg
Pseudoephedrine
HCl 10 mg
  Dextrometh-
orphan HBr
5 mg
  Acetamin-
ophen
167 mg
Alcohol 25%
30 mL hs or
30 mL q 6 hr
  b, c, e
 
Nytime Cold Medicine Liquid Oral Solution (OTC)
[U.S.]
Doxylamine
succinate 1.2 mg
(7.5 mg/30 mL)
Pseudoephedrine
HCl 10 mg
(60 mg/30 mL)
  Dextrometh-
orphan HBr
5 mg
(30 mg/
30 mL)
  Acetamin-
ophen
166.6 mg
(1000 mg/
30 mL)
Alcohol 25%
30 mL hs or
q 6 hr
Not
recommended
b, c, e
 
Ornade Expectorant Oral Solution (OTC)
[Canada]
Chlorpheniramine
maleate 2 mg
      Guaifenesin
100 mg
  Alcohol 7%
Sugar free
5–10 mL
q 6–8 hr
1–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
b, c, e
 
Ornex Severe Cold No Drowsiness Caplets Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  2 tabs q 6 hr
(max 8 tabs/day)
  b
 
PanMist-JR {58} Extended-release Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 45 mg
    Guaifenesin
600 mg
    1–2 tabs
q 12 hrs
(max 4 tabs/day)
6–12 yrs:
1 tab q 12 hrs
(max 2 tabs/day)
b, d
 
PediaCare Cough-Cold Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
5 mg
    Alcohol free
Intended for
pediatric use
2–3 yrs:
5 mL,
4–5 yrs:
7.5 mL,
6–8 yrs:
10 mL,
9–10 yrs:
12.5 mL,
11 yrs:
15 mL,
q 4–6 hr
b, c, e
 
Chewable Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
5 mg
    Phenylalanine
6 mg
Intended for
pediatric use
2–3 yrs:
1 tab,
4–5 yrs:
11/2 tabs,
6–8 yrs:
2 tabs,
9–10 yrs:
21/2 tabs,
11 yrs:
3 tabs,
q 6–8 hr
b, e, i
 
PediaCare NightRest Cough-Cold Liquid Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
Intended for
pediatric use
2–3 yrs:
5 mL,
4–5 yrs:
7.5 mL,
6–8 yrs:
10 mL,
9–10 yrs:
12.5 mL,
11 yrs:
15 mL,
q 6–8 hr
b, c, e
 
Pediacof Cough Syrup (Schedule V)
[U.S.]
Chlorpheniramine
maleate 0.75 mg
Phenylephrine HCl
2.5 mg
Codeine PO 4
5 mg
  Potassium
iodide
75 mg
  Alcohol 5%
Intended for
pediatric use
6 mos–1 yr:
1.25 mL,
1–3 yrs:
2.5–5 mL,
3–6 yrs:
5–10 mL,
6–12 yrs:
10 mL,
q 4–6 hr
b, c, e, f
 
Penntuss Oral Suspension (N)
[Canada]
Chlorpheniramine
maleate
4 mg
(as polistirex)

  Codeine
10 mg
(as polistirex)

      Alcohol free,
Sodium
4.6 mg
10–15 mL
q 12 hr
(max 30 mL/day)
2–5 yrs:
2.5 mL
(max 5 mL/day),
6–12 yrs:
5 mL
(max 10 mL/day),
q 12 hr
b, e, f, g
 
Phanatuss Syrup (OTC) [U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
Sugar free
10 mL q 3–4 hr
(max 8 doses/day)
2–6 yrs:
2.5 mL
q 4 hr,
6–12 yrs:
5 mL,
q 3–4 hr
(max 6 doses/day)
b, c
 
Pharmasave Children's Cough Syrup Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
Sugar free
  2–5 yrs:
5 mL,
6–11 yrs:
10 mL,
q 6–8 hr
(max 4 doses/day)
a, d
 
Phenameth VC Syrup
[U.S.]
Promethazine
HCl 6.25 mg
Phenylephrine HCl
5 mg
      Alcohol 7%
5 mL q 4–6 hr
2–6 yrs:
1.25–5 mL,
6–12 yrs:
2.5–5 mL,
q 4–6 hr
a, c, d, e, f
Phenergan with Codeine Syrup (Schedule V)
[U.S.]
Promethazine
HCl 6.25 mg
  Codeine PO 4
10 mg
      Alcohol 7%
5 mL q 4–6 hr
(max 30 mL/day)
2–6 yrs:
1.25–2.5 mL,
6–12 yrs:
2.5–5 mL,
q 4–6 hr
a, c, d, e, f
 
Phenergan with Dextromethorphan Syrup (Rx)
[U.S.]
Promethazine
HCl 6.25 mg
    Dextrometh-
orphan HBr
15 mg
    Alcohol 7%
5 mL q 4–6 hr
(max 30 mL/day)
2–6 yrs:
1.25–2.5 mL
(max 10 mL/day),
6–12 yrs:
2.5–5 mL
(max 20 mL/day)
q 4–6 hr
a, c, d, e
 
Phenergan Expectorant w/Codeine Syrup (N)
[Canada]
Promethazine
HCl 5.65 mg
  Codeine PO 4
10 mg
  Potassium
guaiacol-
sulfonate
40 mg
    5–10 mL
q 4–6 hr
>2 yrs:
2.5–5 mL
q 4–6 hr
a, d, e, f, g
 
Phenergan VC with Codeine Syrup (Schedule V)
[U.S.]
Promethazine
HCl 6.25 mg
Phenylephrine HCl
5 mg
Codeine PO 4
10 mg
      Alcohol 7%
5 mL q 4–6 hr
(max 30 mL/day)
2–6 yrs:
1.25–2.5 mL
(max 6–9 mL/day),
6–12 yrs:
2.5–5 mL
(max 15 mL/day),
q 4–6 hr
a, c, d, e, f
 
Pneumotussin HC Syrup (Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
  Guaifenesin
100 mg
  Alcohol free
Sugar free
5 mL q 4 hr
  b, c, e, f
Poly-Histine Syrup
[U.S.]
Pheniramine
maleate 4 mg
Pyrilamine
4mg
Phenyltoloxamine
citrate 4mg
      Alcohol free
b, c, e, f
Primatuss Cough Mixture 4 Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
    Dextrometh-
orphan HBr
15 mg
    Alcohol 10%
10 mL q 8 hr
  b, c, e
 
Primatuss Cough Mixture 4D Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 20 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
67 mg
  Alcohol 10%
15 mL q 6 hr
  b, c
 
Profen II Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 40 mg
    Guaifenesin
800 mg
  Scored
Dye free
b
 
Promethazine and
Codeine *
Syrup (Schedule V)
[U.S.]
Promethazine
HCl 6.25 mg
  Codeine PO 4
10 mg
      May contain
alcohol
5 mL q 4–6 hr
2–6 yrs:
1.25–2.5 mL,
6–12 yrs:
2.5–5 mL,
q 4–6 hr
a, c, d, e, f
Promethazine DM Oral Solution (Rx)
[U.S.]
Promethazine
HCl 6.25 mg
    Dextrometh-
orphan HBr
15 mg
    Alcohol
5 mL q 4–6 hr
  b, c, e
 
Promethazine VC w/ Codeine Oral Solution
(Schedule V)
[U.S.]
Promethazine
HCl 6.25 mg
Phenylephrine
HCl 5 mg
Codeine PO 4
10 mg
      Alcohol
5 mL q 4–6 hr
  b, c, e, f
 
Prometh VC with Codeine Oral Solution (Schedule V)
[U.S.]
Promethazine
HCl 6.25 mg
Phenylephrine HCl
5 mg
Codeine PO 4
10 mg
      Alcohol 7%
5 mL q 4–6 hr
2–6 yrs:
1.25–2.5 mL,
6–12 yrs:
2.5–5 mL,
q 4–6 hr
a, c, d, e, f
 
Protuss-D Oral Solution
(Schedule III)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Hydrocodone
bitartrate
5 mg
  Potassium
guaiacol-
sulfonate
300 mg
  Alcohol free
Dye free
Sugar free
5–7.5 mL
q 6 hr
3–6 yrs:
1.25–2.5 mL,
6–12 yrs:
2.5–5 mL,
q 6 hr
a, e, f
 
Pseudo-Car DM Syrup (Rx)
[U.S.]
Carbinoxamine
maleate 4 mg
Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol 0.19%
5 mL q 6 hr
18 mos–6 yrs:
2.5 mL,
>6 yrs:
5 mL,
q 4–6 hr
a, c, d, e
 
P-V-Tussin Syrup (Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
Hydrocodone
bitartrate
2.5 mg
      Alcohol 5%
10 mL q 4–6 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
a, c, e, f
 
Tablets (Schedule III)
[U.S.]
  Pseudoephedrine
60 mg
Hydrocodone
bitartrate
5 mg
      Scored
1 tab q 4–6 hr
(max 4 doses/day)
  a, d, e, f
 
Quelidrine Cough Syrup (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Ephedrine
HCl 5 mg,
Phenylephrine
HCl 5 mg
  Dextrometh-
orphan HBr
10 mg
Ammonium
Cl 40 mg,
Ipecac
fluidextract
0.005 mL
  Alcohol 2%
5 mL q 4–6 hr
2–6 yrs:
1.25 mL,
6–12 yrs:
2.5 mL,
q 4–6 hr
a2 , c, e
 
Rentamine Pediatric Oral Suspension (Rx)
[U.S.]
Chlorpheniramine
tannate 4 mg
Ephedrine
tannate 5 mg,
Phenylephrine
tannate 5 mg
  Carbetapen-
tane
tannate
30 mg
      Intended
for
pediatric
use
2–6 yrs:
2.5–5 mL,
6–12 yrs:
5–10 mL,
q 12 hr
b, c, e, g
 
Rescon-DM Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
    Alcohol free
Sugar free
Dye free
10 mL q 4–6 hr
  b, c, e
 
Rescon-GG Oral Solution (OTC)
[U.S.]
  Phenylephrine
HCl 5 mg
    Guaifenesin
100 mg
  Alcohol free
Sugar free
10 mL q 4–6 hr
  b, c
 
Respa-1st Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
600 mg
  Scored
1–2 tabs
q 12 hr
6–12 yrs:
1 tab q 12 hr
b
 
Respa-DM Extended-release
Tablets (Rx)
[U.S.]
      Dextrometh-
orphan HBr
30 mg
Guaifenesin
600 mg
  Scored
1–2 tabs
q 12 hr
6–12 yrs:
1 tab q 12 hr
b
 
Respaire-60 SR Extended-release
Capsules (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
(extended-release)
    Guaifenesin
200 mg
(immediate-
release)
    2 caps q 12 hr
6–12 yrs:
1 cap q 12 hr
b
 
Respaire-120 SR Extended-release
Capsules (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
(extended-release)
    Guaifenesin
250 mg
(immediate-
release)
    1 cap q 12 hr
Intended for
adult use.
See Respaire-60 SR
b
 
Rhinosyn-DM Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol 1.4%
Dye free
10 mL q 6 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6 hr
b, c, e
 
Rhinosyn-DMX Expectorant Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 6%
Dye free
10 mL q 6 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6 hr
a, c, d
 
Rhinosyn-X Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol 7.5%
Dye free
10 mL q 4 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
b, c, d
 
Robafen AC Cough Syrup USP
(Schedule V)
[U.S.]
    Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
5–10 mL
q 4–6 hr
  a, c, d, e, f
 
Robafen DAC Syrup
(Schedule V)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 1.4%
10 mL q 4 hr
(max 40 mL/day)
  b, c, e, f
 
Robafen DM Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol 1.4%
5–10 mL q 4 hr
  b, c
 
Robitussin A-C Syrup USP (Schedule V)
[U.S.]
    Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
Sugar free
10 mL q 4 hr
(max 6 doses/day)
6–12 yrs:
5 mL q 4 hr
(max 6 doses/day)
a, c, d,
e, f
Syrup (N)
[Canada]
Pheniramine maleate
7.5 mg
  Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
5–10 mL
q 4–6 hr
6–12 yrs:
2.5–5 mL
q 4–6 hr
b, c, e, f
 
Robitussin with Codeine Syrup (N)
[Canada]
Pheniramine maleate
7.5 mg
  Codeine PO 4
3.3 mg
  Guaifenesin
100 mg
  Alcohol 3.5%
15 mL
q 4–6 hr
6–12 yrs:
7.5 mL
q 4–6 hr
b, c, e, f
 
Robitussin Cold and Cough Liqui-Gels Capsules USP (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
200 mg
    2 caps q 4 hr
(max 8 caps/day)
6–12 yrs:
1 cap q 4 hr
(max 4 caps/day)
a, d
 
Robitussin Cold, Cough & Flu Liqui-Gels Capsules (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
Acetamin-
ophen
250 mg
  2 caps q 4 hr
(max 8 caps/day)
6–12 yrs:
1 cap q 4 hr
(max 4 caps/day)
b
 
Robitussin Cough & Cold Oral Solution (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol
10 mL q 6–8 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
(max 4 doses/day)
b, c
 
Robitussin Cough & Cold Liqui-Fills Capsules USP (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
200 mg
    2 caps q 6 hr
(max 4 doses/day)
6–12 yrs:
1 cap q 6 hr
(max 4 doses/day)
a
Robitussin-DAC Syrup (Schedule V)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol 1.9%
Sugar free
10 mL q 4 hr
(max 40 mL/day)
6–12 yrs:
5 mL q 4 hr
a, c, e, f
 
Robitussin-DM Oral Solution (OTC)
[U.S]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
10 mL q 4 hr
(max 60 mL/day)
2–6 yrs:
2.5 mL
(max 15 mL/day),
6–12 yrs:
5 mL
(max 30 mL/day),
q 4 hr
b, c
 
Syrup (N)
[Canada]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 1.4%
10 mL q 6–8 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
b, c
 
Robitussin Night Relief Oral Solution (OTC)
[U.S.]
Pyrilamine maleate
50 mg/30 mL
Pseudoephedrine
HCl 60 mg/
30 mL
  Dextrometh-
orphan HBr
30 mg/
30 mL
  Acetamin-
ophen
650 mg/
30 mL
Alcohol free
30 mL hs
or q 6 hr
  b, e
 
Robitussin Night-Time Cold Formula Capsules (OTC)
[U.S.]
Doxylamine
succinate
6.25 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 caps q 6 hr
Not
recommended
b
 
Robitussin-PE Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
    Guaifenesin
100 mg
  Alcohol free
10 mL q 4 hr
(max 40 mL/day)
2–6 yrs:
2.5 mL
(max 10 mL/day),
6–12 yrs:
5 mL
(max 20 mL/day),
q 4 hr
b, c
 
Robitussin Pediatric Cough & Cold Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
20 mL q 6 hr
(max 80 mL/day)
2–6 yrs:
5 mL
(max 20 mL/day),
6–12 yrs:
10 mL
(max 40 mL/day),
q 6 hr
b, c
 
Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
20 mL q 6–8 hr
2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 6–8 hr
b, c
 
Robitussin Severe Congestion Liqui-Gels Capsules USP (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
    Guaifenesin
200 mg
    2 caps q 4 hr
(max 8 caps/day)
6–12 yrs:
1 cap q 4 hr
(max 4 caps/day)
a, d
 
Rondamine-DM Drops Oral Solution (Rx)
[U.S.]
Carbinoxamine
maleate 2 mg/mL
Pseudoephedrine
HCl 25 mg/mL
  Dextrometh-
orphan HBr
4 mg/mL
        1–18 mos:
0.25–1 mL
q 6 hr
b, c, e
 
Rondec-DM Syrup (Rx)
[U.S.]
Carbinoxamine
maleate 4 mg
Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol free
Sugar free
5 mL q 6 hr
18 mos–6 yrs:
2.5 mL,
>6 yrs: 5 mL,
q 6 hr
a1 , c, d, e
 
Rondec-DM Drops Oral Solution (Rx)
[U.S.]
Carbinoxamine
maleate
2 mg/mL
Pseudoephedrine
HCl
25 mg/mL
  Dextrometh-
orphan HBr
4 mg/mL
    Alcohol free
Sugar free
Intended for
pediatric use.
See Rondec-DM Syrup
1–3 mos:
0.25 mL,
3–6 mos:
0.50 mL,
6–9 mos:
0.75 mL,
9–18 mos:
1 mL,
q 6 hr
>18 mos:
See Rondec-DM Syrup
a1 , c, e, h
 
Ru-Tuss DE Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
600 mg
  Scored
1 tab q 12 hr
6–12 yrs:
1/2 tab
q 12 hr
b
 
Ru-Tuss Expectorant Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol 10%
10 mL q 4–6 hr
(max 40 mL/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
b, c, e, f
 
Ryna-C Liquid Oral Solution
(Schedule V)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
      Alcohol free
Dye free
Sugar free
10 mL q 6 hr
(max 40 mL/day)
6–12 yrs:
5 mL
q 6 hr
b, c, e, f
 
Ryna-CX Liquid Oral Solution
(Schedule V)
[U.S.]
  Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol free
Dye free
Sugar free
10 mL q 6 hr
(max 40 mL/day)
6–12 yrs:
5 mL
q 6 hr
b, c, e, f
Rynatuss Tablets (Rx)
[U.S.]
Chlorpheniramine
tannate 5 mg
Ephedrine
tannate 10 mg,
Phenylephrine
tannate 10 mg
  Carbeta-
pentane
tannate
60 mg
    Scored
1–2 tabs q 12 hr
6–12 yrs:
1/2–1 tab
q 12 hr
b, e
Rynatuss Pediatric Oral Suspension (Rx)
[U.S.]
Chlorpheniramine
tannate 4 mg
Ephedrine
tannate 5 mg,
Phenylephrine
tannate 5 mg
  Carbeta-
pentane
tannate
30 mg
      Intended for
pediatric use.
See Rynatuss
Tablets
2–6 yrs:
2.5–5 mL,
6–12 yrs:
5–10 mL,
q 12 hr
b, c, e, g
 
Safe Tussin 30 Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
30 mg
Guaifenesin
200 mg
  Alcohol free
Sodium free
Sugar free
Dye free
10 mL q 6 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6 hr
(max 4 doses/day)
b, c
 
Scot-Tussin DM Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
    Dextrometh-
orphan HBr
15 mg
    Alcohol free
Sugar free
5 mL q 4 hr or
10 mL q 6–8 hr
  b, c, e
 
Scot-Tussin Senior Clear Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
200 mg
  Phenylalanine
Alcohol free
Sugar free
5 mL q 4 hr
(max 30 mL/day)
  a
 
Sildec-DM Syrup (Rx)
[U.S.]
Brompheniramine
4 mg
Pseudoephedrine
HCl 45 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol free
a, d, e
 
Silexin Cough Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
Sugar free
20 mL q 6–8 hr
6–12 yrs:
10 mL
q 6–8 hr
b, c
 
Siltussin DM Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
5–10 mL q 4 hr
  b, c
 
Sinufed Timecelles Extended-release
Capsules (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
300 mg
    1–2 caps
q 12 hr
6–12 yrs:
1 cap q 12 hr
b
 
Sinutab with Codeine Tablets (N)
[Canada]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
Codeine
8 mg
    Acetamin-
ophen
325 mg
  1–2 tabs
q 4–6 hr
(max 8 tabs/day)
  b, e, f
Sinutab Non-Drying No Drowsiness Liquid Caps Capsules USP (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
    Guaifenesin
200 mg
    2 caps q 4 hr
(max 8 caps/day)
  a 2
 
Stamoist E Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
500 mg
  Dye free
Scored
1 tab q 12 hr
  b
 
Statuss Green Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
2 mg/ 5 mL,
Pyrilamine
maleate 3.3 mg
Phenylephrine
HCl 5 mg,
Pseudoephedrine
HCl 3.3 mg/ 5mL
Hydrocodone
bitartrate
2.5 mg
      Alcohol 5%
  b, c, e, f
 
S-T Forte 2 Oral Solution
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
  Hydrocodone
bitartrate
2.5 mg
      Glycerin 99.7%
Alcohol free
Sugar free
Dye free
5 mL
q 6–8 hr
(max 20 mL/day)
6 mos–1 yr:
10 drops,
1–3 yrs:
20 drops,
3–12 yrs:
2.5 mL,
q 6–8 hr
b, c, e, f
 
Sudafed Children's Cold & Cough Syrup (OTC)
[U.S.]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
5 mg
Guaifenesin
100 mg
  Alcohol free
Sugar free
20 mL q 4 hr
(max 4 doses/day)
2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 4 hr
(max 4 doses/day)
b, c, d
 
Sudafed Children's Non-Drowsy Cold & Cough Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
5 mg
Guaifenesin
100 mg
  Alcohol Free
Sugar free
20 mL q 4 hr
(max 4 doses/day)
2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 4 hr
(max 4 doses/day)
b, c, d
 
Sudafed Cold & Cough Liquid Caps Capsules (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
Acetamin-
ophen
250 mg
  2 caps q 4 hr
(max 8 caps/day)
Not
recommended
b, c, d
 
Sudafed Cold & Flu Gelcaps Capsules (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
Acetamin-
ophen
250 mg
  2 caps q 4 hr
  b, d
 
Sudafed Cough & Cold Extra Strength Caplets Tablets (OTC)
[Canada]
  Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
30 mg
  Acetamin-
ophen
500 mg
Scored
1 tab q 4–6 hr
(max 4 tabs/day)
  b, d
 
Sudafed DM Oral Solution (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol
10 mL
q 4–6 hr
(max 40 mL/day)
4 mos–2 yr:
1.25 mL
2–5 yrs:
2.5 mL,
6–11 yrs:
5 mL,
q 4–6 hr
(max 4 doses/day)
b, c
 
Sudal 60/500 Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
500 mg
  Scored
1–2 tabs
q 12 hr
6–12 yrs:
1/2–1 tab
q 12 hr
a, d
Syracol CF Tablets (OTC)
[U.S.]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
200 mg
    2 tabs q 6–8 hr
(max 8 tabs/day)
2–6 yrs:
1/2 tab,
6–12 yrs:
1 tab,
q 6–8 hr
b
 
Tanta Cough Syrup Syrup (OTC)
[Canada]
      Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 1.4%
10 mL q 6–8 hr
(max 4 doses/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 6–8 hr
(max 4 doses/day)
a
 
TheraFlu Flu, Cold & Cough Medicine for Oral Solution
(OTC)
[U.S.]
Chlorpheniramine
maleate
4 mg/packet
Pseudoephedrine
HCl 60 mg/packet
  Dextrometh-
orphan HBr
20 mg/packet
  Acetamin-
ophen
650 mg
packet
  1 packet
dissolved in
6-oz cup of
hot water
q 4 hr
(max 4
packets/day)
  b, e
 
TheraFlu Maximum Strength Non-Drowsy Formula Flu, Cold & Cough Medicine for Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 60 mg/packet
  Dextrometh-
orphan HBr
30 mg/packet
  Acetamin-
ophen
1000 mg/
packet
  1 packet
dissolved in
6-oz cup of
hot water
q 6 hr
(max 4
packets/day)
Not
recommended
b
 
TheraFlu Maximum Strength Non-Drowsy Formula Flu, Cold & Cough Medicine Caplets Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  2 tabs q 6 hr
(max 8 tabs/day)
  b
 
TheraFlu Nighttime Maximum Strength Flu, Cold & Cough for Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 4 mg/
packet
Pseudoephedrine
HCl 60 mg/packet
  Dextrometh-
orphan HBr
30 mg/packet
  Acetamin-
ophen
1000 mg/
packet
  1 packet
dissolved in
6-oz cup of
hot water
q 6 hr
(max 4
packets/day)
  b, e
 
Tolu-Sed DM Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol 10%
Sugar free
10 mL q 4 hr
1–6 yrs:
1.25–2.5 mL,
6–12 yrs:
2.5–5 mL,
q 4 hr
b, c
 
Touro DM {59} Extended-release
Tablets (Rx)
[U.S.]
      Dextrometh-
orphan HBr
30 mg
Guaifenesin
575 mg
    1–2 tabs
q 12 hrs
(max 4 tabs/day)
2–6 yrs:
1/2 tab
q 12 hrs
(max 1 tab/day)
6–12 yrs:
1 tab q 12 hrs
(max 2 tabs/day)
b, d
 
Touro LA Caplets Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
525 mg
  Scored
  b
 
Triacin C Cough Syrup (Schedule V)
[U.S.]
Triprolidine
HCl 1.25 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
      Alcohol 4.3%
10 mL q 4–6 hr
(max 40 mL/day)
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4–6 hr
b, c, d, e, f
 
Triafed w/Codeine Syrup
(Schedule V)
[U.S.]
Triprolidine
HCl 1.25 mg
Pseudoephedrine
HCl 30 mg
Codeine PO 4
10 mg
        10 mL q 4–6 hr
(max 40 mL/day)
  b, c, e, f
 
Triaminic AM Non-Drowsy Cough and Decongestant Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
Dye free
20 mL q 6 hr
(max 80 mL/day)
2–6 yrs:
5 mL
(max 20 mL/day),
6–12 yrs:
10 mL
(max 40 mL/day),
q 6 hr
b
 
Triaminic DM DayTime for Children Syrup (OTC)
[Canada]
      Dextrometh-
orphan HBr
7.5 mg
Guaifenesin
37.5 mg
  Alcohol 5.5%
  2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 6–8 hr
a, e
 
Triaminic-DM Expectorant Oral Solution (OTC)
[Canada]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
Guaifenesin
100 mg
  Alcohol 7.1%
10 mL q 6 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
b, c, e
 
Triaminic DM NightTime for Children Syrup (OTC)
[Canada]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15.0 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
20 mL
q 6–8 hr
2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 6–8 hr
a, d, e
 
Triaminic Night Time Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
    Alcohol free
20 mL q 6 hr
(max 4 doses/day)
6–12 yrs:
10 mL
q 6 hr
(max 4 doses/day)
b, c, e
 
Triaminic Sore Throat Formula Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
  Acetamin-
ophen
160 mg
Alcohol free
20 mL q 6 hr
(max 4 doses/day)
2–6 yrs:
5 mL,
6–12 yrs:
10 mL,
q 6 hr
(max 4 doses/day)
b, c
 
Triaminicol Syrup (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 12.5 mg
  Dextrometh-
orphan HBr
10 mg
    20 mL q 4–6 hr
(max 6 doses/day)
6–12 yrs:
10 mL q 4–6 hr
(max 6 doses/day)
b, c, e
 
Tri-Tannate Plus Pediatric Oral Suspension (Rx)
[U.S.]
Chlorpheniramine
tannate 4 mg
Ephedrine
tannate 5 mg,
Phenylephrine
tannate 5 mg
  Carbeta-
pentane
tannate
30 mg
        2–<6 yrs:
2.5–10 mL
q 12 hr
b, c, e
 
Tussafed Syrup (Rx)
[U.S.]
Carbinoxamine
maleate 4 mg
Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol free
Sugar free
5 mL q 4–6 hr
18 mos–6 yrs:
2.5 mL,
>6 yrs:
5 mL,
q 4–6 hr
a, c, d, e
 
Tussafed Drops Oral Solution (Rx)
[U.S.]
Carbinoxamine
maleate 2 mg/mL
Pseudoephedrine
HCl 25 mg/mL
  Dextrometh-
orphan HBr
4 mg/mL
    Alcohol free
Sugar free
  1–18 mos:
0.25–1 mL
q 6 hr
b, c, e
 
Tussar DM Syrup (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
  Dextrometh-
orphan HBr
15 mg
    Alcohol free
b, c, e
 
Tussex Cough Syrup (OTC)
[U.S.]
  Phenylephrine
HCl 5 mg
  Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
    10 mL q 4 hr
  b
 
Tussigon Tablets (Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
      Homatropine
MBr ** 1.5 mg
Scored
1 tab q 4–6 hr
6–12 yrs:
1/2 tab q 4–6 hr
b, d, e, f
 
Tussilyn DM Syrup (OTC)
[Canada]
Chlorpheniramine
maleate 2.5 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
      10 mL q 8 hr
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 8 hr
a
 
Tussionex Oral Suspension (N)
[Canada]
Phenyltoloxamine
as resin complex
10 mg
  Hydrocodone
as resin
complex
5 mg
      Sugar free
5 mL q 8–12 hr
(max 2 doses/day)
1–5 yrs:
2.5 mL,
>5 yrs: 5 mL,
q 12 hr
(max 2 doses/day)
b, c, e, f, g
 
Tablets (N)
[Canada]
Phenyltoloxamine
as resin complex
10 mg
  Hydrocodone
as resin
complex
5 mg
      Scored
1 tab
q 8–12 hr
(max 2 tabs/day)
  b, e, f
 
Tussionex Pennkinetic Oral Suspension
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 8 mg
(as polistirex)
  Hydrocodone
bitartrate
10 mg
(as polistirex)
      Alcohol free
5 mL q 12 hr
>6 yrs:
2.5 mL
q 12 hr
b, c, e, f, g
 
Tussi-Organidin DM NR Liquid Oral Solution (Rx)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
Sugar free
10 mL q 4 hr
(max 6 doses/day)
6 mos–2 yrs:
0.6–1.25 mL,
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
(max 6 doses/day)
a, c, d
 
Tussi-Organidin DM-S NR Liquid Oral Solution (Rx)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
Sugar free
10 mL q 4 hr
(max 6 doses/day)
6 mos–2 yrs:
0.6–1.25 mL,
2–6 yrs:
2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
(max 6 doses/day)
a, c, d
 
Tussi-Organidin-S NR Liquid Oral Solution
(Schedule V)
[U.S.]
    Codeine PO 4
10 mg
  Guaifenesin
100 mg
  Alcohol free
Sugar free
10 mL q 4 hr
(max 6 doses/day)
2–6 yrs:
1 mg/kg/day
of codeine
given in
4 divided
doses
6–12 yrs:
5 mL q 4 hr
(max 6 doses/day)
a, c, d, e, f
 
Tussirex Oral Solution
(Schedule V)
[U.S.]
Pheniramine
maleate 13.3 mg
Phenylephrine HCl
4.2 mg
Codeine PO 4
10 mg
  Sodium
citrate
83.3 mg
Sodium
salicylate
83.3 mg
Caffeine
citrate 25 mg
Alcohol free
With or
without sugar
5 mL q 8 hr
  b, c, e, f
Tuss-LA Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
500 mg
  Scored
1 tab q 12 hr
2–6 yrs:
Not
recommended
6–12 yrs:
1/2 tab q 12 hr
b
 
Tusso-DM Oral Solution (Rx)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Iodinated
glycerol
30 mg
  Alcohol free
Sugar free
5–10 mL q 4 hr
2–6 yrs:
1.25–2.5 mL,
6–12 yrs:
5 mL,
q 4 hr
a, c
 
Tylenol Children's Cold DM Medication Oral Solution (OTC)
[Canada]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
  Acetamin-
ophen
160 mg
Alcohol free
Intended for
pediatric use
2–5 yrs:
5 mL,
6–12 yrs:
10 mL,
q 4–6 hr
(max 4 doses/day)
a
 
Chewable Tablets (OTC)
[Canada]
Chlorpheniramine
maleate 0.5 mg
Pseudoephedrine
HCl 7.5 mg
  Dextrometh-
orphan HBr
3.75 mg
  Acetamin-
ophen
80 mg
Phenylalanine
Intended for
pediatric use
2–5 yrs:
2 tabs,
6–12 yrs:
4 tabs,
q 4–6 hr
(max 4 doses/day)
b, i
 
Tylenol Cold and Flu for Oral Solution (OTC)
[Canada]
Chlorpheniramine
maleate 4 mg/pouch
Pseudoephedrine
HCl 60 mg/
pouch
  Dextrometh-
orphan HBr
30 mg/pouch
  Acetamin-
ophen
650 mg/
pouch
Phenylalanine,
Sugar
19 grams/pouch
1 pouch
dissolved
in 225 mL of
hot water
q 4–6 hr
(max 3 pouches/day)
Intended for
adult use
b, e
Tylenol Cold and Flu No Drowsiness Powder for Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 60 mg/
packet
  Dextrometh-
orphan HBr
30 mg/packet
  Acetamin-
ophen
650 mg/packet
Phenylalanine
11 mg/packet
1 packet
dissolved
in 180 mL of
hot water q 6 hr
  b, c
 
Tylenol Cold Medication Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 0.66 mg
(2 mg/15 mL)
Pseudoephedrine
HCl 10 mg
(30 mg/15 mL)
  Dextrometh-
orphan HBr
5 mg
(15 mg/15 mL)
  Acetamin-
ophen
108.3 mg
(325 mg/
15 mL)
Alcohol 7%
15–30 mL
q 6 hr
Intended for
adult use
b, c, e
 
Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 tabs q 6 hr
(max 8 tabs/day)
6–11 yrs:
1 tab q 6 hr
(max 4 tabs/day)
b, e
 
Tylenol Cold Medication Caplets Tablets (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 tabs q 6 hr
(max 8 tabs/day)
6–11 yrs:
1 tab q 6 hr
(max 4 tabs/day)
b, e
 
Tylenol Cold Medication Extra Strength Daytime Caplets Tablets (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  1–2 tabs q 6 hr
(max 8 tabs/day)
Intended for
adult use
b
Tylenol Cold Medication Extra Strength Nighttime Caplets Tablets (OTC)
[Canada]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  1–2 tabs q 6 hr
(max 8 tabs/day)
Intended for
adult use
b, e
 
Tylenol Cold Medication, Non-Drowsy Caplets Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 tabs q 6 hr
(max 8 tabs/day)
6–11 yrs:
1 tab q 6 hr
(max 4 tabs/day)
b, e
Tylenol Cold Medication, Non-Drowsy Gelcaps Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  2 tabs q 6 hr
(max 8 tabs/day)
6–11 yrs:
1 tab q 6 hr
(max 4 tabs/day)
b, e
 
Tylenol Cold Medication Regular Strength Daytime Caplets Tablets (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  1–2 tabs q 6 hr
(max 8 tabs/day)
Intended for
adult use
b
 
Tylenol Cold Medication Regular Strength Nighttime Caplets Tablets (OTC)
[Canada]
Chlorpheniramine
maleate 2 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
325 mg
  1–2 tabs q 6 hr
(max 8 tabs/day)
Intended for
adult use
b, e
 
Tylenol Cold Multi-Symptom for Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 4 mg/packet
Pseudoephedrine
HCl 60 mg/
packet
  Dextrometh-
orphan HBr
30 mg/packet
  Acetamin-
ophen
650 mg/
packet
Phenylalanine
11 mg/packet
1 packet
dissolved
in 180 mL of
hot water q 6 hr
Intended for
adult use
b, e
 
Tylenol Cough Extra Strength Caplets Tablets (OTC)
[Canada]
      Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  2 tabs q 6–8 hr
(max 8 tabs/day)
  b
 
Tylenol Cough Medication with Decongestant, Regular Strength Oral Suspension (OTC)
[Canada]
  Pseudoephedrine
HCl 60 mg/15 mL
  Dextrometh-
orphan HBr
30 mg/15 mL
  Acetamin-
ophen
650 mg/
15 mL
  15 mL q 6–8 hr
(max 60 mL/day)
  a, c
 
Tylenol Cough Medication Regular Strength Oral Suspension (OTC)
[Canada]
      Dextrometh-
orphan HBr
30 mg/15 mL
  Acetamin-
ophen
650 mg/
15 mL
  15 mL q 6–8 hr
(max 60 mL/day)
Intended for
adult use
a, c
Tylenol Extra Strength Cold and Flu Medication Powder for Oral Solution (OTC)
[Canada]
Chlorpheniramine
maleate 4 mg/pouch
Pseudoephedrine
HCl 60 mg/
pouch
  Dextrometh-
orphan HBr
30 mg/pouch
  Acetamin-
ophen
1000 mg/
pouch
Sugar
17.5 grams/
pouch
(honey/lemon
flavor)
Sodium
1.2 grams/
pouch
(chicken
soup flavor)
1 pouch
dissolved
in 225 mL of
hot water
q 4–6 hr
(max 3 pouches/day)
  b, e
 
Tylenol Junior Strength Cold DM Medication Chewable Tablets (OTC)
[Canada]
Chlorpheniramine
maleate 1 mg
Pseudoephedrine
HCl 15 mg
  Dextrometh-
orphan HBr
7.5 mg
  Acetamin-
ophen
160 mg
Phenylalanine
Scored
  2–5 yrs:
1 tab,
6–11 yrs:
2 tabs,
q 4–6 hr
(max 4 doses/day)
b, i
 
Tylenol Maximum Strength Flu Gelcaps Tablets (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
15 mg
  Acetamin-
ophen
500 mg
  2 tabs q 6 hr
(max 8 tabs/day)
Not
recommended
b
 
Tylenol Multi-Symptom Cough Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
217 mg
Alcohol 5%
15 mL q 6–8 hr
(max 4 doses/day)
6–11 yrs:
7.5 mL
q 6–8 hr
(max 4 doses/day)
b, c
 
Tylenol Multi-Symptom Cough with Decongestant Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 20 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
217 mg
Alcohol 5%
15 mL
q 6–8 hr
(max 4 doses/day)
6–11 yrs:
7.5 mL
q 6–8 hr
(max 4 doses/day)
b, c
 
Uni-tussin DM Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
10 mg
Guaifenesin
100 mg
  Alcohol free
10 mL q 4 hr
  b, c
 
Vanex-HD Syrup
(Schedule III)
[U.S.]
Chlorpheniramine
maleate 2 mg
Phenylephrine
HCl 5 mg
Hydrocodone
bitartrate
1.7 mg
      Alcohol free
Dye free
10 mL q 6–8 hr
6–12 yrs:
5 mL
q 6–8 hr
b, c, e, f
 
V-Dec-M Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
500 mg
  Scored
1 tab q 12 hr
  b
 
Versacaps Extended-release
Capsules (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
300 mg
    1–2 caps
q 12 hr
  b
 
Vicks Children's NyQuil Oral Solution (OTC)
[Canada]
Chlorpheniramine
maleate 2 mg/15 mL
Pseudoephedrine
HCl 30 mg/15 mL
  Dextrometh-
orphan HBr
15 mg/
15 mL
    Alcohol free
Intended for
pediatric use
1–5 yrs:
7.5 mL,
6–11 yrs:
15 mL hs
b, c, e
 
Vicks Children's NyQuil Cold/Cough Relief Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 2 mg/15 mL
Pseudoephedrine
HCl 30 mg/15 mL
  Dextrometh-
orphan HBr
15 mg/15 mL
    Alcohol free
30 mL q 6 hr
(max 4 doses/day)
6–11 yrs:
15 mL
q 6 hr
(max 4 doses/day)
b, c, e
 
Vicks 44 Cough and Cold Relief Non-Drowsy LiquiCaps Capsules (OTC)
[U.S.]
  Pseudoephedrine
HCl 60 mg
  Dextrometh-
orphan HBr
30 mg
    Alcohol free
1 cap q 6 hr
(max 4 caps/day)
Not
recommended
b
 
Vicks 44D Cough and Head Congestion Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 20 mg
(60 mg/15 mL)
  Dextrometh-
orphan HBr
10 mg
(30 mg/15 mL)
    Alcohol 10%
15 mL q 6 hr
  b, c
 
Vicks DayQuil Liquicaps Capsules (OTC)
[Canada]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Acetamin-
ophen
250 mg
Alcohol free
2 caps q 4–6 hr
(max 8 caps/day)
  a
 
Vicks DayQuil Multi-Symptom Cold/Flu LiquiCaps Capsules (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
Acetamin-
ophen
250 mg
  2 caps q 4 hr
(max 8 caps/day)
6–11 yrs:
1 cap q 4 hr
(max 4 caps/day)
b, c
 
Vicks DayQuil Multi-Symptom Cold/Flu Relief Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 30 mg/15 mL
  Dextrometh-
orphan HBr
10 mg/
15 mL
Acetamin-
ophen
325 mg/
15 mL
Alcohol free
30 mL q 4 hr
(max 4 doses/day)
6–11 yrs:
15 mL q 4 hr
(max 4 doses/day)
b, c
 
Vicks 44E Cough & Chest Congestion Oral Solution (OTC)
[U.S.]
      Dextrometh-
orphan HBr
6.67 mg
(20 mg/
15 mL)
Guaifenesin
66.7 mg
(200 mg/
15 mL)
  Alcohol 10%
15 mL q 4 hr
(max 90 mL/day)
  b
 
Vicks Formula 44-D Oral Solution(OTC)
[Canada]
  Pseudoephedrine
HCl
60 mg/15 mL
  Dextrometh-
orphan HBr
30 mg/15 mL
    Alcohol
15 mL q 6–8 hr
(max 60 mL/day)
  b, d, g
Vicks Formula 44-D Pediatric Syrup (OTC)
[Canada]
  Pseudoephedrine
HCl 10 mg
(30 mg/15 mL)
  Dextrometh-
orphan HBr
5 mg
(15 mg/15 mL)
    Alcohol free
  1–5 yrs:
7.5 mL,
6–11 yrs:
15 mL,
q 6–8 hr
(max 4 doses/day)
b, d, g
 
Vicks Formula 44E Syrup (OTC)
[Canada]
      Dextrometh-
orphan HBr
20 mg/15 mL
Guaifenesin
200 mg/
15 mL
  Alcohol
15 mL q 4 hr
(max 90 mL/day)
  b, d, g
 
Vicks Formula 44e Pediatric Syrup (OTC)
[Canada]
      Dextrometh-
orphan HBr
3.3 mg
(10 mg/15 mL)
Guaifenesin
33.3 mg
(100 mg/
15 mL)
  Alcohol free
  1–5 yrs:
7.5 mL,
6–11 yrs:
15 mL,
q 4 hr
(max 6 doses/day)
b, d, g
 
Vicks Formula 44M Syrup (OTC)
[Canada]
Chlorpheniramine
maleate 1 mg
(4 mg/20 mL)
Pseudoephedrine
HCl 15 mg
(60 mg/20 mL)
  Dextrometh-
orphan HBr
7.5 mg
(30 mg/20 mL)
  Acetamin-
ophen
162.5 mg
(650 mg/
20 mL)
Alcohol
20 mL q 6–8 hr
(max 80 mL/day)
  b, d, e, g
 
Vicks 44M Cough, Cold and Flu Relief Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 1 mg
(4 mg/20 mL)
Pseudoephedrine
HCl 15 mg
(60 mg/20 mL)
  Dextrometh-
orphan HBr
7.5 mg
(30 mg/20 mL)
  Acetamin-
ophen
162.5 mg
(650 mg/
20 mL)
Alcohol 10%
20 mL q 6 hr
(max 80 mL/day)
  b, c
 
Vicks NyQuil Oral Solution (OTC)
[Canada]
Doxylamine
succinate
12.5 mg/30 mL
Pseudoephedrine
HCl 60 mg/30 mL
  Dextrometh-
orphan HBr
30 mg/30 mL
  Acetamin-
ophen
1000 mg/
30 mL
Alcohol
30 mL hs or
q 6–8 hr
(max 90 mL/day)
  b, c, e
 
Vicks NyQuil Hot Therapy for Oral Solution (OTC)
[U.S.]
Doxylamine
succinate 12.5 mg/
packet
Pseudoephedrine
HCl 60 mg/
packet
  Dextrometh-
orphan HBr
30 mg/
packet
  Acetamin-
ophen
1000 mg/
packet
  1 packet
dissolved
in 6-oz cup
of hot water
hs or q 6 hr
Intended for
adult use
b, e
 
Vicks NyQuil LiquiCaps Capsules (OTC)
[Canada]
Doxylamine
succinate 6.25 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
250 mg
Sugar free
2 caps hs or
q 4–6 hr
(max 8 caps/day)
  b, e
 
Vicks NyQuil Multi-Symptom Cold/Flu LiquiCaps Capsules (OTC)
[U.S.]
Doxylamine
succinate 6.25 mg
Pseudoephedrine
HCl 30 mg
  Dextrometh-
orphan HBr
10 mg
  Acetamin-
ophen
250 mg
  2 caps q 4 hr
(max 8 caps/day)
Intended for
adult use
b, e
 
Vicks NyQuil Multi-Symptom Cold/Flu Relief Oral Solution (OTC)
[U.S.]
Doxylamine
succinate 2 mg
(12.5 mg/30 mL)
Pseudoephedrine
HCl 10 mg
(60 mg/30 mL)
  Dextrometh-
orphan HBr
5 mg
(30 mg/
30 mL)
  Acetamin-
ophen
166.6 mg
(1000 mg/
30 mL)
Alcohol 10%
30 mL hs or
q 6 hr
(max 4 doses/day)
Not
recommended
b, c, e
 
Vicks Pediatric 44D Cough & Head Decongestion Oral Solution (OTC)
[U.S.]
  Pseudoephedrine
HCl 10 mg
  Dextrometh-
orphan HBr
5 mg
    Alcohol free
30 mL q 6 hr
(max 4 doses/day)
2–5 yrs:
7.5 mL,
6–11 yrs:
15 mL,
q 6 hr
(max 4 doses/day)
b, c
 
Vicks Children's Cough Syrup (OTC)
[U.S.]
      Dextrometh-
orphan HBr
3.3 mg
Guaifenesin
33.3 mg
  Alcohol free
b, c
 
Vicks Pediatric 44M Multi-Symptom Cough & Cold Oral Solution (OTC)
[U.S.]
Chlorpheniramine
maleate 0.67 mg
Pseudoephedrine
HCl 10 mg
  Dextrometh-
orphan HBr
5 mg
    Alcohol free
30 mL q 6 hr
(max 4 doses/day)
6–11 yrs:
15 mL q 6 hr
(max 4 doses/day)
b, c, e
Vicodin Tuss Syrup (Schedule III)
[U.S.]
    Hydrocodone
bitartrate
5 mg
  Guaifenesin
100 mg
  Alcohol free
Sugar free
Dye free
5 mL q 4 hr
(max 6 doses/day)
6–12 yrs:
2.5–5 mL
q 4 hr
(max 6 doses/day)
b, c, e, f
 
Zephrex Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 60 mg
    Guaifenesin
400 mg
    1 tab q 6 hr
Pediatric
strength not
available
b
 
Zephrex-LA Extended-release
Tablets (Rx)
[U.S.]
  Pseudoephedrine
HCl 120 mg
    Guaifenesin
600 mg
  Scored
1 tab q 12 hr
Pediatric
strength not
available
b
 
{62} * Specific formulations may vary among the different manufacturers, check product labeling.
 Efficacy as expectorant has not been established.
 Geriatric patients may be more sensitive to effects of usual adult dose.
§ For appropriate Packaging and storage and Auxiliary labeling information refer to designated letters as follows:

• a—Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a tight container, unless otherwise specified by manufacturer.


• a 1—Store below 30 °C (86 °F), unless otherwise specified by manufacturer. Avoid exposure to excessive heat.


• a 2—Store below 25 °C (77 °F), unless otherwise specified by manufacturer.


• b—Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), in a well-closed container, unless otherwise specified by manufacturer.


• c—Protect from freezing.


• d—Protect from light.


• e—Auxiliary labeling: o May cause drowsiness. o Avoid alcoholic beverages.


• f—Auxiliary labeling: o May be habit forming.


• g—Auxiliary labeling: o Shake well.


• h—Dispense in dropper bottle.


• i—Chew well before swallowing.

** Included in subtherapeutic amount to discourage deliberate overdosage.




Strength(s) usually available
U.S.—
See above table.



Revised: 05/27/2002



References
  1. Product packaging or insert.
  1. Antihistamines monograph, USP-D1 1991.
  1. Histalet X package insert (Solvay—US), Rev 5/91, Rec 9/94.
  1. Triaminic DM Daytime/Nighttime Children's product labels (Sandoz—Canada), Rec 5/94.
  1. Cotridin Cough Syrup and Expectorant product labels (Technilab—Canada), Rec 7/94.
  1. NeoCitran product label (Sandoz—Canada), Rec 5/94.
  1. Calmylin dextromethorphan preparations product monograph (Technilab—Canada), Rev 10/94, Rec 11/94.
  1. FDA Register; HHS News 2/27/89.
  1. Calmylin Codeine product label (Technilab—Canada), Rec 7/94.
  1. Benylin product labels (Warner-Lambert—Canada), Rec 11/94.
  1. Vicks NyQuil Hot Therapy (Procter & Gamble). In: PDR Physicians' desk reference for nonprescription drugs. 15th ed. 1994. Montvale, NJ: Medical Economics Data Production Co, 1994: 642.
  1. Safe Tussin 30 product label (Kramer—US), Rec 12/94.
  1. Drixoral Liquid Caps product label (Schering-Plough—US), Rec 11/94.
  1. Bromfed-DM package insert (Muro—US), Rec 11/94.
  1. Bronkaid product label (Sterling—US), Rec 10/93.
  1. Atuss DM, EX, HD package inserts (Atley—US), Rec 11/94.
  1. Sudal 60/500, 120/600 package inserts (Atley—US), Rev 5/94, Rec 11/94.
  1. Benylin Multi-Symptom product label (Parke-Davis—US), Rec 12/94 and 2/95.
  1. Fenesin DM package insert (Dura—US), Rev 94, Rec 12/94.
  1. Tussilyn DM product label (Vachon—Canada), Rec 12/94.
  1. Dimetapp-C product label (Whitehall-Robins—Canada), Rec 12/94.
  1. Alka-Seltzer Plus Liqui-Gels product labels (Miles—US), Rec 11/94.
  1. Hycodan package insert (Du Pont). In: PDR Physicians' desk reference. 45th ed. 1991. Oradell, NJ: Medical Economics Data, 1991: 687.
  1. Actifed DM tablets product label (Wellcome—Canada), Rec 11/94.
  1. Sudafed Cough & Cold Non-Drowsy product label (Wellcome—Canada), Rec 11/94.
  1. Sudafed Expectorant Tablets product label (Wellcome—Canada), Rec 11/94.
  1. Triaminic AM product label (Sandoz—US), Rec 11/94.
  1. TheraFlu Non-Drowsy Flu, Cold, & Cough tablets product label (Sandoz—US), Rec 11/94.
  1. Histinex HC package insert (Ethex—US), Rev 6/94, Rec 12/94.
  1. HycoClear Tuss package insert (Ethex—US), Rev 3/94, Rec 12/94.
  1. Contac Severe Cold & Flu Non-Drowsy package label (SmithKline Beecham—US), Rec 12/94.
  1. Contac Severe Cold & Flu Hot Medicine package label (SmithKline Beecham—US), Rec 12/94.
  1. Ambenyl product label (Parke-Davis—Canada), Rec 12/94.
  1. Brontex product labels (Procter & Gamble—US), Rec 12/94.
  1. Contac Day/Night Cold & Flu (SmithKline Beecham). In: PDR Physicians' desk reference for nonprescription drugs. 15th ed. 1994. Montvale, NJ: Medical Economics Data Production Co, 1994: 704.
  1. Cheracol (Roberts). In: Krogh CME, editor. CPS Compendium of pharmaceuticals and specialties. 29th ed. Ottawa: Canadian Pharmaceutical Association, 1994: 235.
  1. Olin BR, editor. Drug facts and comparisons. St. Louis: Facts and Comparisons Inc, January 1995: 856.
  1. Guai-Vent/PSE package insert (Dura—US), Rev 94, Rec 1/95.
  1. Phenergan product labels (Rhone-Poulenc Rorer—Canada), Rec 1/95.
  1. Nasabid package insert (Abana—US), Rev 4/94, Rec 1/95.
  1. Respa-1st package insert (Respa—US), Rev 1/94, Rec 1/95.
  1. Respa-DM package insert (Respa—US), Rev 1/94, Rec 1/95.
  1. CoSudafed product information (Burroughs Wellcome—Canada), Rec 1/95.
  1. Tussi-Organidin liquids package insert (Wallace—US), Rec 8/94, Rec 1/95.
  1. Novahistex product monographs (Merrell Dow—Canada), Rev 5/90, Rec 1/95.
  1. Novahistine product monographs (Merrell Dow—Canada), Rev 5/90, Rec 1/95.
  1. Tylenol product labels (McNeil—Canada), Rec 1/95.
  1. Saleto-CF product label (Roberts—US), Rev 9/94, Rec 1/95.
  1. Syracol CF product label (Roberts—US), Rev 9/94, Rec 1/95.
  1. Sinutab Non-Drying product label (Warner Wellcome—US), Rec 2/95.
  1. Dimacol (Whitehall—US), per correspondence 9/94.
  1. Despec-SR package insert (International Ethical—US), Rev 12/93, Rec 3/95.
  1. SYN-Rx product information (Adams—US), Rec 3/95.
  1. Tussar product information (Rhone-Poulenc Rorer—US), Rec 7/94.
  1. Robitussins (Whitehall-Robins). In: Krogh CME, editor. CPS Compendium of pharmaceuticals and specialties. 30th ed. Ottawa: Canadian Pharmaceutical Association, 1995: 1183.
  1. Statuss Expectorant package insert (Huckaby—US), Rev 7/93, Rec 4/95.
  1. Humibid Guaifenesin Plus product box (Menly & James—US), Rec 1/98.
  1. PanMist-JR package insert (Pan American Labs—US), Rev 9/97, Rec 9/98.
  1. Touro DM package insert (Dartmouth—US), Rev 7/97, Rec 2/98.
  1. Product Information: Brontex, codeine phosphate/guaifenesin. Proctor and Gamble Pharmaceuticals, Cincinnati, OH, USA (PI revised 10/98), reviewed 6/2000.
  1. FDA Talk Paper: FDA issues public health warning on phenylpropanolamine. United States Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD 11/2000.
  1. Red book 2002 Online. Montvale, NJ: Medical Economics Data; 5/13/2002.
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