Professional Information

Corticosteroids (Systemic)

This monograph includes information on the following:

1) Betamethasone
2) Budesonide ^*
3) Cortisone
4) Dexamethasone
5) Hydrocortisone
6) Methylprednisolone
7) Prednisolone
8) Prednisone
9) Triamcinolone

INN:
Hydrocortisone— Cortisol
^{14}
BAN:
Hydrocortisone—Cortisol
^{14}

JAN:
Hydrocortisone—Cortisol
^{14}Prednisolone tebutate—Prednisolone butylacetate
^{14}
VA CLASSIFICATION
Betamethasone
Primary: HS051
Secondary: IM403

Budesonide
Primary: HS051

Cortisone
Primary: HS051
Secondary: IM403

Dexamethasone
Primary: HS051
Secondary: DX900; GA609; IM403

Hydrocortisone
Primary: HS051
Secondary: GA609; IM403

Methylprednisolone
Primary: HS051
Secondary: IM403

Prednisolone
Primary: HS051
Secondary: IM403

Prednisone
Primary: HS051
Secondary: GA609; IM403

Triamcinolone
Primary: HS051
Secondary: IM403

Commonly used brand name(s): A-Hydrocort⁵; A-MethaPred⁶; A-hydroCort⁵; Acetocot⁹; Amcort⁹; Apo-Prednisone⁸; Aristocort⁹; Aristocort Forte⁹; Aristocort Intralesional⁹; Aristopak⁹; Aristospan⁹; Articulose-50⁷; Articulose-L.A.⁹; Betnesol¹; Celestone¹; Celestone Phosphate¹; Celestone Soluspan¹; Cinalone 40⁹; Cinonide 40⁹; Clinacort⁹; Clinalog⁹; Cordrol⁸; Cortastat⁴; Cortastat 10⁴; Cortastat LA⁴; Cortef⁵; Cortisone Acetate-ICN³; Cortone³; Cortone Acetate³; Cotolone⁷; Dalalone⁴; Dalalone D.P.⁴; Dalalone L.A.⁴; Decadrol⁴; Decadron⁴; Decadron Elixir⁴; Decadron Phosphate⁴; Decadron-LA⁴; Decaject⁴; Decaject LA⁴; Delta-Cortef⁷; Deltasone⁸; DepMedalone 40⁶; DepMedalone 80⁶; Depo-Medrol⁶; Depo-Predate⁶; Depoject-40⁶; Depoject-80⁶; Depopred⁶; Deronil⁴; Dexacorten⁴; Dexacorten-LA⁴; Dexamethasone Intensol⁴; Dexasone⁴; Dexasone L.A.⁴; Dexone⁴; Dexone 0.75⁴; Dexone 1.5⁴; Dexone 4⁴; Dexone LA⁴; Duralone-40⁶; Duralone-80⁶; Entocort²; Hexadrol⁴; Hexadrol Phosphate⁴; Hydrocortone⁵; Hydrocortone Acetate⁵; Hydrocortone Phosphate⁵; Ken-Jec 40⁹; Kenacort⁹; Kenacort Diacetate⁹; Kenaject-40⁹; Kenalog-10⁹; Kenalog-40⁹; Key-Pred⁷; Key-Pred SP⁷; Liquid Pred⁸; Med-Jec-40⁶; Medralone 80⁶; Medrol⁶; Meprolone⁶; Methacort 40⁶; Methacort 80⁶; Methylcotolone⁶; Meticorten⁸; Mymethasone⁴; Nor-Pred T.B.A.⁷; Oradexon⁴; Orasone 1⁸; Orasone 10⁸; Orasone 20⁸; Orasone 5⁸; Orasone 50⁸; Pediapred⁷; Pred-Ject-50⁷; Pred-Pak 45⁸; Pred-Pak 79⁸; Predacort 50⁷; Predacorten⁶; Predacorten 80⁶; Predalone 50⁷; Predalone T.B.A.⁷; Predate S⁷; Predate TBA⁷; Predate-50⁷; Predcor-25⁷; Predcor-50⁷; Predcor-TBA⁷; Predicort-RP⁷; Predisone Intensol⁸; Prednicot⁸; Prelone⁷; Primethasone⁴; Robalog⁹; Scheinpharm Triamcine-A⁹; Selestoject¹; Solu-Cortef⁵; Solu-Medrol⁶; Solurex⁴; Solurex LA⁴; Sterapred⁸; Sterapred DS⁸; Tac-3⁹; Tramacort-D⁹; Tri-Kort⁹; Triam-A⁹; Triam-Forte⁹; Triamolone 40⁹; Triamonide 40⁹; Trilog⁹; Trilone⁹; Tristoject⁹; Winpred⁸.

Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).

^*Not commercially available in the U.S.

Category:

Corticosteroid—Betamethasone; Budesonide; Cortisone; Dexamethasone; Hydrocortisone; Methylprednisolone; Prednisolone; Prednisone; Triamcinolone;

Anti-inflammatory (steroidal)—Betamethasone; Budesonide; Cortisone; Dexamethasone; Hydrocortisone; Methylprednisolone; Prednisolone; Prednisone; Triamcinolone;

Diagnostic aid (Cushing's syndrome)—Dexamethasone;

Immunosuppressant—Betamethasone; Cortisone; Dexamethasone; Hydrocortisone; Methylprednisolone; Prednisolone; Prednisone; Triamcinolone;

Antiemetic, in cancer chemotherapy—Dexamethasone; Hydrocortisone; Prednisone;

Diagnostic aid (endogenous depression)—Dexamethasone;

Indications

Accepted

Allergic disorders—Indicated for the treatment of severe or incapacitating allergic disorders intractable to adequate trials of conventional treatment
Allergic reactions, drug-induced (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Anaphylactic or anaphylactoid reactions (treatment adjunct)—Dexamethasone (sodium phosphate injection ^{33}); hydrocortisone (sodium succinate for injection ^{13}); and methylprednisolone (sodium succinate for injection ^{45}) are indicated as adjunctive treatment in prolonged reactions (those not responding to other forms of treatment within 1 hour), reactions requiring cardiovascular or respiratory resuscitation, or situations in which there is a significant risk of relapse.
—Epinephrine is the drug of choice for this indication. ^{33} ^{45}

Angioedema (treatment adjunct)—Betamethasone (tablets ^{61}) is indicated as an adjunct in the treatment of angioedema. Treatment should be initiated with intramuscular or intravenous administration of a rapid-acting preparation.

Edema, laryngeal, acute noninfectious (treatment adjunct)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05}); dexamethasone (sodium phosphate injection ^{08} ^{33}); hydrocortisone (sodium phosphate injection, ^{12} sodium succinate for injection ^{13}); and methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection ^{18} ^{43}) are indicated as adjuncts in the treatment of acute noninfectious laryngeal edema. Treatment should be initiated with intramuscular or intravenous administration of a rapid-acting preparation.
—Epinephrine is the drug of choice for this indication. ^{03} ^{04} ^{05} ^{08} ^{12} ^{13} ^{18} ^{26} ^{30} ^{43}

Rhinitis, allergic, perennial or seasonal, severe (treatment) —Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{58} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (acetonide injectable suspension, ^{51} tablets ^{49}).

Serum sickness (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Transfusion reactions, urticarial (treatment)— Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (sodium phosphate injection, ^{12} sodium succinate for injection ^{13}); and methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection ^{18} ^{43}) are indicated in the treatment of urticarial transfusion reactions. Treatment should be initiated with intramuscular or intravenous administration of a rapid-acting preparation.

Collagen disorders—Indicated during an acute exacerbation or as maintenance therapy
Arteritis, giant cell (treatment)—Methylprednisolone (tablets ^{41}); and prednisone (tablets ^{47}).

Carditis, rheumatic [or nonrheumatic ]¹, acute (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (oral solution, tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Dermatomyositis, systemic (polymyositis) (treatment)—Cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); and prednisone (tablets ^{46} ^{47} ^{48}).

Lupus erythematosus, systemic (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

[Connective tissue disease, mixed (treatment)]¹
[Polyarteritis nodosa (treatment) ]¹
[Polychondritis, relapsing (treatment) ]¹ and
[Vasculitis (treatment)]¹—Betamethasone; cortisone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; prednisone; and triamcinolone.
[Depression, mental, endogenous (diagnosis) ]¹—Dexamethasone is indicated to diagnose endogenous depression and to evaluate the efficacy of treatment. Dexamethasone reduces plasma cortisol to a greater extent in control subjects than in hospitalized patients with diagnosed depression; values return toward those of control subjects as the patient responds to therapy. However, the dexamethasone suppression test is less sensitive in patients with mild to moderate depression. Also, many medications, medical problems, and other psychiatric disorders have been reported to interfere with the test results. The Health and Public Policy Committee of the American College of Physicians recommends that the dexamethasone suppression test not be used as a screening test for depression.

Dermatologic disorders
Alopecia areata (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Dermatitis, atopic (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Dermatitis, contact (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Dermatitis, exfoliative (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Dermatitis herpetiformis, bullous (treatment)— Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{30} tablets ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Dermatitis, seborrheic, severe (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Dermatoses, inflammatory, severe (treatment)—Betamethasone (tablets ^{58}) and triamcinolone (acetonide injectable suspension, ^{51} tablets ^{49}).

Erythema multiforme, severe (Stevens-Johnson syndrome) (treatment) —Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Granuloma annulare (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}) methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Keloids (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Lichen planus (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Lichen simplex chronicus (neurodermatitis) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Lupus erythematosus, discoid (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Mycosis fungoides (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Necrobiosis lipoidica diabeticorum (treatment)— Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

Pemphigus (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Psoriasis, severe (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Psoriatic plaques (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension ^{03}); dexamethasone (acetate injectable suspension, ^{09} sodium phosphate injection ^{08} ^{33}); hydrocortisone (acetate injectable suspension ^{10}); methylprednisolone (acetate injectable suspension ^{26}); and triamcinolone (acetonide injectable suspension ^{50}).

[Eczema, severe (treatment)]—Betamethasone (tablets ^{58}); cortisone ¹; dexamethasone¹; hydrocortisone¹; methylprednisolone¹; prednisolone¹; prednisone¹; and triamcinolone¹.

[Pemphigoid (treatment)]¹—Betamethasone; cortisone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; prednisone; and triamcinolone.

[Sarcoid, localized cutaneous (treatment) ]¹—Betamethasone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; and triamcinolone.

Endocrine disorders
Adrenocortical insufficiency, acute (treatment) and
Adrenocortical insufficiency, chronic primary (Addison's disease) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}) are indicated in the treatment of adrenocortical insufficiency. However, hydrocortisone and cortisone are preferred as replacement therapy ^{01} ^{03} ^{04} ^{05} ^{06} ^{07} ^{08} ^{11} ^{12} ^{13} ^{18} ^{19} ^{21} ^{25} ^{26} ^{27} ^{28} ^{30} ^{31} ^{34} ^{36} ^{37} ^{41} ^{43} ^{44} ^{46} ^{47} ^{48} ^{49} ^{61} because of their significant mineralocorticoid activity. A rapid-acting preparation should be administered intramuscularly or intravenously initially. Administration of sodium (as dietary salt) and fluids also is required. In some patients, additional mineralocorticoid replacement also may be necessary. Rarely, a patient will have only a glucocorticoid deficiency and will not require mineralocorticoid or sodium supplementation.

Adrenocortical insufficiency, secondary (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47}); and triamcinolone (tablets ^{49}) are indicated in the treatment of secondary adrenocortical insufficiency. Glucocorticoid replacement usually is sufficient. Mineralocorticoid replacement is not always required.

Congenital adrenal hyperplasia (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); and prednisone (oral solution, tablets ^{46} ^{47} ^{48}) are indicated to reduce the virilization caused by enzyme deficiency–induced adrenal androgen hypersecretion. Corticosteroid and supplemental therapy depend upon the enzyme deficiency involved and the form of disease present. In salt-losing forms, hydrocortisone or cortisone plus increased sodium intake may be preferred. However, additional mineralocorticoid supplementation may be required. In salt-retaining or hypertensive forms, a glucocorticoid having minimal mineralocorticoid activity is preferred. However, long-acting glucocorticoids are best avoided because of the increased risk of growth retardation and difficulty in dosage adjustment.

Cushing's syndrome (diagnosis)—Dexamethasone (elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} ^{60} tablets ^{07} ^{25} ^{34}) is indicated in the diagnosis of Cushing's syndrome and to distinguish Cushing's syndrome caused by excessive corticotropin secretion from that due to other causes.

Hypercalcemia associated with neoplasms [ or sarcoidosis]¹ (treatment)— Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and trimacinolone (tablets ^{49}).

Thyroiditis, nonsuppurative (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} tablets ^{11} ^{36} ^{37}); methylprednisolone (sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Gastrointestinal disorders
Colitis, ulcerative (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{58} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} ^{45} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}) are indicated when systemic therapy is required during a critical period of the disease. Long-term use is not recommended.

Crohn's disease (regional enteritis) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}) are indicated when systemic therapy is required during a critical period of the disease. Long-term use is not recommended.
—Budesonide (capsules) is indicated for the induction and maintenance of remission in patients with mild to moderate Crohn's disease affecting the ileum and/or the ascending colon. ^{29}

[Sprue, refractory (treatment)]—Betamethasone (tablets ^{61}).

Hematologic disorders
Anemia, hemolytic, acquired (autoimmune) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Anemia, hypoplastic, congenital (erythroid) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Anemia, red blood cell (erythroblastopenia) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Thrombocytopenia, secondary, in adults (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (tablets ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Thrombocytopenic purpura, idiopathic, in adults (treatment)—Betamethasone (syrup, ^{01} tablets ^{27} ^{61}); cortisone (tablets ^{31}); dexamethasone (elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

[Hemolysis (treatment)]¹—Betamethasone; cortisone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; prednisone; and triamcinolone.

[Hepatic disease]¹—Use is controversial
[Hepatitis, alcoholic, with encephalopathy (treatment)]¹
[Hepatitis, chronic, active (treatment) ]¹
[Hepatitis, nonalcoholic, in women (treatment)]¹ and
[Necrosis, hepatic, subacute (treatment) ]¹—Methylprednisolone; prednisolone; and prednisone.

Inflammatory disorders, nonrheumatic—Indicated during an acute episode or exacerbation. Local injections are preferred when only a few joints or areas are involved
Bursitis, acute or subacute (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} ^{39} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (acetate injectable suspension, ^{10} cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (acetonide injectable suspension, ^{50} ^{51} hexacetonide injectable suspension, ^{54} tablets ^{49}).

Epicondylitis (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (acetate injectable suspension, ^{10} cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (acetonide injectable suspension, ^{50} ^{51} hexacetonide injectable suspension, ^{54} tablets ^{49}).

Tenosynovitis, acute nonspecific (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} ^{39} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (acetate injectable suspension, ^{10} cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (acetonide injectable suspension, ^{50} ^{51} hexacetonide injectable suspension, ^{54} tablets ^{49}).

[Fibrositis (treatment)] and
[Myositis (treatment)]—Betamethasone (sodium phosphate and acetate injectable suspension ^{39}) and dexamethasone (sodium phosphate injection ^{60}).
[Nausea and vomiting, cancer chemotherapy–induced (prophylaxis)]—Dexamethasone (sodium phosphate injection, ^{33} tablets ^{34}); [ hydrocortisone]¹; and [ prednisone]¹ are indicated to prevent nausea and vomiting induced by antineoplastic agents. The medication is administered prior to and following each course of chemotherapy. However, the advisability of administering a potent glucocorticoid to a cancer patient, unless indicated for palliation of the disease, has been questioned. Although an increased incidence of infection has not been reported in patients receiving such therapy, the possibility must be considered.
—The combination of dexamethasone plus ondansetron has been shown to provide better emetic control over cisplatin-induced emesis than ondansetron alone. ^{65} ^{87} ^{88} ^{89}

Neoplastic disease—Indicated in conjunction with appropriate specific antineoplastic disease therapy for palliative management
Leukemia, acute or chronic lymphocytic (treatment) ^{80}—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (oral solution, tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Lymphomas, Hodgkin's or non-Hodgkin's (treatment) ^{80}—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Waldenström's macroglobulinemia (treatment) ^{80} ^{81} ^{82}—Prednisone. ^{81}

[Carcinoma, breast (treatment)]¹ ^{80}
[Carcinoma, prostatic (treatment) ]¹ ^{80}
[Fever, due to malignancy (treatment adjunct)]¹
[Multiple myeloma (treatment)]¹ ^{80} and
[Tumors, brain, primary (treatment adjunct)]¹ ^{83}—Betamethasone; cortisone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; prednisone; and triamcinolone.
Nephrotic syndrome (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{58}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (oral solution, tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}) are indicated to induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome (without uremia), and to improve renal function in patients with lupus erythematosus. In idiopathic nephrotic syndrome, long-term therapy may be required to prevent frequent relapses.

Neurologic disease
Meningitis, tuberculous (treatment adjunct)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}) are indicated in patients with concurrent or impending subarachnoid block.
—The corticosteroid should be administered concurrently with appropriate antituberculosis chemotherapy.

Multiple sclerosis (treatment)—Hydrocortisone (tablets ^{36} ^{40}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup); prednisone (oral solution, tablets ^{47} ^{48}); and triamcinolone (tablets ^{49}) are indicated in acute exacerbations of the disease.

[Myasthenia gravis (treatment)]¹—Betamethasone; cortisone; dexamethasone; hydrocortisone; methylprednisolone; prednisolone; prednisone; and triamcinolone are indicated for treatment of severe cases not controlled by antimyasthenic agents alone. Glucocorticoid therapy may be more effective following thymectomy and in patients having disease onset after 40 years of age. Long-term therapy may be required.

Neurotrauma
Edema, cerebral, especially when associated with primary or metastatic brain tumor, craniotomy, or head injury ( [prophylaxis ]¹ and treatment)Dexamethasone (elixir, oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); methylprednisolone (sodium succinate for injection ^{45}); and [prednisone ]¹ are indicated to prevent neurosurgery-associated cerebral edema and to treat edema caused by glioblastomas or metastatic brain tumors. These medications may be less effective in treating edema caused by astrocytomas or meningiomas. Efficacy in closed head injury or ischemic brain edema has not been established. Because very high doses are required, only those glucocorticoids having little or no mineralocorticoid activity should be used.
[Ischemia, cerebral (treatment)]¹—Dexamethasone.

[Pseudotumor cerebri (treatment)]¹—Dexamethasone.

[Spinal cord injury, acute (treatment)]—Methylprednisolone (sodium succinate for injection ^{45}) is indicated in the treatment of spinal cord injury. A large study concluded that patients receiving high-dose methylprednisolone therapy within 8 hours of acute spinal cord injury recover more motor and sensory function, as compared with those receiving naloxone or placebo. ^{55} ^{66} However, methylprednisolone did not improve patient prognosis when it was administered more than 8 hours after the spinal cord injury. ^{55} ^{66}

Ophthalmic disorders—Indicated in the treatment of severe acute or chronic allergic and inflammatory ophthalmic conditions
Chorioretinitis (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Choroiditis, posterior, diffuse (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Conjunctivitis, allergic (not controlled topically) (treatment) —Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Herpes zoster ophthalmicus (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Inflammation, anterior segment (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Iridocyclitis (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Iritis (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Keratitis (not associated with herpes simplex or fungal infection) (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} ^{30} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension, ^{26} sodium succinate for injection, ^{18} ^{43} tablets ^{28} ^{41}); prednisolone (sodium phosphate oral solution, ^{19} syrup ^{21}); prednisone (tablets ^{46} ^{47} ^{48}); and triamcinolone (tablets ^{49}).

Neuritis, optic (treatment)—Betamethasone (sodium phosphate and acetate injectable suspension, ^{03} syrup, ^{01} tablets ^{27} ^{61}); cortisone (acetate injectable suspension, ^{04} tablets ^{05} ^{31}); dexamethasone (acetate injectable suspension, ^{09} elixir, ^{06} oral solution, ^{25} sodium phosphate injection, ^{08} ^{33} tablets ^{07} ^{25} ^{34}); hydrocortisone (cypionate oral suspension, ^{44} sodium phosphate injection, ^{12} sodium succinate for injection, ^{13} tablets ^{11} ^{36} ^{37}); methylprednisolone (acetate injectable suspension

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