Label Changes for:

Lopressor (metoprolol tartrate) tablets and ampules for injection

November 2009

Changes have been made to the WARNINGS and PRECAUTIONS sections of the safety label.

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – November 2009

WARNINGS

Ischemic Heart Disease
  • box placed around this section
Pheochromocytoma (revised)
  • If Lopressor is used in the setting pheochromocytoma, it should be given in combination with an alpha blocker, and only after the alpha blocker has been initiated. Administration of beta blockers alone in the setting of pheochromocytoma has been associated with a paradoxical increase in blood pressure due to the attenuation of beta-mediated vasodilatation in skeletal muscle.
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