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Trisodium Citrate Anhydrous

Excipient (pharmacologically inactive substance)

What is it?

Trisodium citrate anhydrous (C6H5O7Na3) is the tribasic sodium salt of citric acid. Anhydrous means that the water has been removed from the molecule. It has a sour taste similar to citric acid, and is salty as well. It is often used as a food preservative, and as a flavoring in the food industry. In the pharmaceutical industry it is used to control pH. It may be used as an alkalizing agent, buffering agent, emulsifier, or sequestering agent.[1] The anhydrous form is used for purposes such as water sensitive dry blends and instant beverages, surfactants, fragrances as well as in tablets and OTC products. The anhydrous form can provide particular benefit in dry products where a long shelf life is required.[2]

According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including sodium citrate salts, are generally regarded as safe when used in normal quantities.[3]

[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 Accessed 08/19/2011

[2] Jungbunzlauer Suisse AG. Trisodium Citrate Anhydrous. Accessed March 26, 2012.

[3] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; Accessed March 26, 2012.

Top Medications with this excipient