Triacetin
Excipient (pharmacologically inactive substance)
What is Triacetin?
Triacetin (C9H14O6), also known as glyceryl triacetate, is pharmaceutical excipient used in manufacturing of capsules and tablets, and has been used as a humectant, plasticizer, and solvent. It is a liquid, and has been approved by the FDA as a food additive. Triacetin is a water-soluble short-chain triglyceride that may also have a role as a parenteral nutrient according to animal studies.[1][2] It is also used in the perfume and cosmetic industries.
Triacetin is listed on the FDA Generally Regarded As Safe (GRAS) List. According to the FDA, triacetin has been found to be non-toxic in long-term feeding tests in rats at levels that were several orders of magnitude greater than those to which consumers are exposed.[2] Additionally, in a toxicology report from 2002, triacetin and a group of related triglycerides did not represent a hazard to human health based on the anticipated daily intake of 7.8 mg/day/adult, and other available data. One case of skin toxicity (allergic contact eczema) due to industrial use in cigarette filter production has been reported.[1][3]
There is no evidence in the available information on triacetin that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed March 19, 2012.
[2] FDA’s SCOGS database; propylene glycol; SCOGS-Report Number: 30; http://www.fda.gov/Food/FoodIngredientsPackaging/GenerallyRecognizedasSafeGRAS/GRASSubstancesSCOGSDatabase/ucm261045.htm. Accessed March 19, 2012.
[3] SIDS. Screening Information Data Set for High Production Volume Chemicals. (2005) p. 169 Triacetin. http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~uyt6aD:1Accessed March 17, 2012
Top Medications Containing Triacetin
- Cialis 20 mg (Lilly, Eli and Company)
- Concerta 36 mg (ALZA Corporation)
- Concerta 54 mg (ALZA Corporation)
- Cyclobenzaprine Hydrochloride 10 mg (Mylan Pharmaceuticals Inc.)
- Cyclobenzaprine Hydrochloride 5 mg (Mylan Pharmaceuticals Inc.)
- Hydrocodone Bitartrate and Ibuprofen 7.5 mg / 200 mg (Watson Laboratories, Inc.)
- Metoprolol Tartrate 50 mg (Mylan Pharmaceuticals Inc.)
- Metoprolol Tartrate 50 mg (Mylan Pharmaceuticals Inc.)
- Morphine Sulfate SR 30 mg (Mallinckrodt Pharmaceuticals)
- Morphine Sulfate SR 15 mg (Mallinckrodt Pharmaceuticals)
- Morphine Sulfate SR 60 mg (Mallinckrodt Pharmaceuticals)
- Morphine Sulfate SR 100 mg (Mallinckrodt Pharmaceuticals)
- OxyContin 80 mg (Purdue Pharma LP)
- OxyContin 20 mg (Purdue Pharma LP)
- OxyContin 40 mg (Purdue Pharma LP)
- OxyContin 10 mg (Purdue Pharma LP)
- OxyContin 160 mg (Purdue Pharma LP)
- Viagra 100 mg (Pfizer U.S. Pharmaceuticals Group)
- Zolpidem Tartrate 10 mg (Mylan Pharmaceuticals Inc.)
- Zolpidem Tartrate 10 mg (Vintage Pharmaceuticals Inc.)
