Silicon Dioxide Colloidal
Excipient (pharmacologically inactive substance)
What is Silicon Dioxide Colloidal?
Silicon dioxide (SiO2), or silica, is known in nature as sand or quartz. It occurs naturally in the earth’s crust, and silicates are present in water, animals and plants. Silicates are also consumed as part of the natural human diet.
In the pharmaceutical industry, silicon dioxide (also known as colloidal silicon dioxide) has many uses in tablet-making: some include as an anti-caking agent, adsorbent, disintegrant, or glidant to allow powder to flow freely when tablets are processed. These compounds appear to be biologically inert. Silicon dioxide is generally recognized as safe by the FDA.[1][2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] FDA’s SCOGS database; Silicon dioxides, Report No. 61, 1979.; ID Code: 14808-60-7; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=276; accessed August 12, 2011.
Top Medications Containing Silicon Dioxide Colloidal
- Acetaminophen and Codeine Phosphate 300 mg / 30 mg (Teva Pharmaceuticals USA)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg (Watson Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg (Watson Pharmaceuticals)
- Acetaminophen and Propoxyphene Napsylate 650 mg / 100 mg (Teva Pharmaceuticals USA)
- Alprazolam 1 mg (Actavis)
- Alprazolam 0.5 mg (Actavis)
- Amphetamine and Dextroamphetamine 20 mg (Teva Pharmaceuticals USA)
- Amphetamine and Dextroamphetamine 10 mg (Teva Pharmaceuticals USA)
- Amphetamine and Dextroamphetamine 30 mg (Teva Pharmaceuticals USA)
- Cyclobenzaprine Hydrochloride 10 mg (Watson Pharmaceuticals)
- HydrOXYzine Pamoate 25 mg (Sandoz Pharmaceuticals Inc.)
- Meloxicam 15 mg (Lupin Pharmaceuticals, Inc)
- Meloxicam 7.5 mg (Lupin Pharmaceuticals, Inc)
- Methocarbamol 750 mg (West-Ward Pharmaceutical Corporation)
- Metronidazole 500 mg (Teva Pharmaceuticals USA)
- Propacet 100 650 mg / 100 mg (Teva Pharmaceuticals USA)
- Tizanidine Hydrochloride 4 mg (Sandoz Pharmaceuticals Inc.)
- Tramadol Hydrochloride 50 mg (Teva Pharmaceuticals USA)
- Tramadol Hydrochloride 50 mg (Zydus Pharmaceuticals)
- Tramadol Hydrochloride 50 mg (Mylan Pharmaceuticals Inc.)
