Povidone K29/32
Excipient (pharmacologically inactive substance)
What is Povidone K29/32?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.[1]
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
Top Medications Containing Povidone K29/32
- Anastrozole 1 mg (Cypress Pharmaceutical Inc)
- Avandamet 1000 mg / 4 mg (GlaxoSmithKline)
- Cetirizine Hydrochloride 10 mg (Northstar Rx LLC)
- Clonidine Hydrochloride 0.1 mg (Unichem Pharmaceuticals)
- Clonidine Hydrochloride 0.2 mg (Unichem Pharmaceuticals)
- Clonidine Hydrochloride 0.3 mg (Unichem Pharmaceuticals)
- Dipyridamole 75 mg (Lannett Company, Inc.)
- Diurex Aquagels pamabrom (solubilized) 50 mg (Alva-Amco Pharmacal Companies, Inc.)
- Janumet 500 mg / 50 mg (Merck & Company Inc.)
- Janumet 1000 mg / 50 mg (Merck & Company Inc.)
- Lithium Carbonate 300 mg (Roxane Laboratories, Inc.)
- Metoprolol Tartrate 100 mg (Mutual Pharmaceutical Company, Inc.)
- Metoprolol Tartrate 50 mg (Mutual Pharmaceutical Company, Inc.)
- Pramipexole Dihydrochloride 1.5 mg (Watson Pharmaceuticals)
- Pravastatin Sodium 40 mg (Cobalt Laboratories Inc)
- Pravastatin Sodium 20 mg (Cobalt Laboratories Inc)
- Pravastatin Sodium 10 mg (Cobalt Laboratories Inc)
- Pravastatin Sodium 80 mg (Cobalt Laboratories Inc)
- Terbutaline Sulfate 2.5 mg (Global Pharmaceuticals)
- Terbutaline Sulfate 5 mg (Global Pharmaceuticals)
