[saf]

need to no what prophylactic treatment one should give to those who came into contact with someone who has isoniazid resistant tb?

[Geriwong]

How about BCG vaccine?

[saf]

thanks... now why didnt i think of that... so simple and plus eliminates the possibility of creating a new mutant strain... thanks alot

[bugga]

How much contact? Casual contact with someone who is not actively coughing may not require prophylaxis.

The BCG vaccine is not indicated for TB prophylaxis as you are describing. It won't work. Don't bother with it.

[saffiya]

The patient haas full blown TB... will the BCG vaccine still work? if not what other prophylactic approaches are there?

[Geriwong]

For close contacts of patients with pulmonary TB, apart from the 9 month isoniazid treatment, 4 months of daily rifampicin can be used if close lab monitoring is available or 2 months of treatment with rifampicin and pyrazinamide (watch out for hepatotoxicity) or 3 months of isoniazid and rifampicin are other options.

But note the strong association of rifampicin resistance and isoniazid resistane, implying that the bacteria may be resistant to rifampicin too.

Hope this could help.