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Which is Worse
Which is Worse
withdrawals fromn Oxycontin, MS Contin, or from >>>>>>, they both are going to suck, no matter what but I am curious if anyoneinfo/feedback for me, w3hat is stronger OC, or >>>>>>, i believe OC lasts longer,snorted, than H, snorted. What is the half life of Both of these extremely potent opiates? Very Curoius, thanks all. G/L
Pathophysiology: >>>>>> is a highly addictive semisynthetic opioid that is derived from morphine. When used intravenously, it is 3-5 times more potent than its parent compound and is able to modulate pain perception and cause euphoria. Similar to morphine, >>>>>> has mu, kappa, and delta receptor activity. In general, stimulation of the mu receptors results in analgesia, euphoria, respiratory depression, and miosis. The mu receptor is also involved in the development of physical dependence. Stimulation of the delta and kappa receptors also results in analgesia. The kappa receptors are mostly involved in spinal analgesia. Their stimulation may result in dysphoria and psychotomimetic effects. Patients who are dependent on narcotics generally use >>>>>> because of its euphoric effects, which are mediated by mu receptor activation.
The onset of action, peak effects, and duration of action vary with the different methods of use. Patients experience >>>>>>'s effect within 1-2 minutes when injected intravenously and within 15-30 minutes when injected intramuscularly. Its peak therapeutic and toxic effects are generally reached within 10 minutes when injected intravenously, within 30 minutes when injected intramuscularly or when snorted, and within 90 minutes when injected subcutaneously. Analgesic effects generally last 3-5 hours.
When injected intravenously, patients experience a rush or a sensation of intense pleasure, which begins within one minute of the injection and lasts from one to a few minutes. This is followed by a period of sedation lasting about an hour.
The initial rush is due to >>>>>>'s high lipid solubility and rapid penetration to the brain. The half-life of >>>>>> is 15-30 minutes. It is rapidly converted to 6-mono-acetyl-morphine (6-MAM) by the liver, brain, heart, and kidney and may not be detected in the blood at the time of blood draw. 6-MAM is then converted to morphine. Morphine is metabolized by the liver and excreted as a glucuronide product or in its free form by the kidneys. Morphine's half-life is considerably longer than >>>>>>'s, ie, on the order of 2-3 hours. A small amount of 6-MAM is excreted in the urine unchanged for up to 24 hours after >>>>>> use. Because 6-MAM can only originate from >>>>>>, its detection in the urine can only mean that the patient either used >>>>>> or 6-MAM itself.
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OxyContinÃ‚Â® 10 mg tablets - Round, biconvex, white, film-coated tablet with OC on one side and 10 on the other.
OxyContinÃ‚Â® 20 mg tablets - Round biconvex, pink, film-coated tablet with OC on one side and 20 on the other.
OxyContinÃ‚Â® 40 mg tablets - Round, biconvex, yellow, film coated tablet with OC on one side and 40 on the other.
OxyContinÃ‚Â® 80 mg tablets - Round, biconvex, green, film-coated tablet with OC on one side and 80 on the other.
Oxycodone is a full opioid agonist with no antagonist properties. It has an affinity for kappa, mu, and delta opiate receptors in the brain and spinal cord. Oxycodone is similar to morphine in its action. The therapeutic effect is mainly analgesic, anxiolytic, antitussive and sedative.
Compared with morphine, which has an absolute bioavailability of approximately 30 %, oxycodone has a high absolute bioavailability of up to 87 % following oral administration. Oxycodone has an apparent elimination half-life of approximately 4.5 hours following administration of OxyContinÃ‚Â® tablets, and is metabolised principally to noroxycodone and oxymorphone. Oxymorphone has some analgesic activity but is present in the plasma in low concentrations and is not considered to contribute to oxycodone's pharmacological effect.
The release of oxycodone from OxyContinÃ‚Â® tablets is biphasic with an initial relatively fast release providing an early onset of analgesia followed by a more controlled release which determines the 12 hour duration of action. The mean apparent elimination half-life of OxyContinÃ‚Â® tablets is 4.5 hours which leads to steady-state being achieved in about one day.
Release of oxycodone from OxyContinÃ‚Â® tablets is independent of pH.
OxyContinÃ‚Â® tablets have an oral bioavailability comparable with conventional oral oxycodone, but the former achieve maximal plasma concentrations at about 3 hours rather than about 1 to 1.5 hours. Peak and trough concentrations of oxycodone from OxyContinÃ‚Â® tablets 10 mg administered 12-hourly are equivalent to those achieved from conventional oxycodone 5 mg administered 6-hourly.
Following absorption, oxycodone is distributed throughout the entire body. Approximately 45 % is bound to plasma protein.
OxyContinÃ‚Â® tablets 10 mg, 20 mg, 40 mg and 80 mg are bioequivalent in terms of both rate and extent of absorption. Ingestion of a standard high-fat meal does not alter the peak oxycodone concentration or the extent of oxycodone absorption from OxyContinÃ‚Â® tablets.
The active drug and its metabolites are excreted in both urine and faeces.
The plasma concentrations of oxycodone are only nominally affected by age, being 15 % greater in elderly as compared to young subjects.
Females have, on average, plasma oxycodone concentrations up to 25 % higher than males on a body weight adjusted basis. Oxycodone penetrates the placenta and can be found in breast milk.
When compared to normal subjects, patients with mild to severe hepatic dysfunction may have higher plasma concentrations of oxycodone and noroxycodone, and lower plasma concentrations of oxymorphone. There may be an increase in the elimination half-life of oxycodone, and this may be accompanied by an increase in drug effects.
When compared to normal subjects, patients with mild to severe renal dysfunction (creatinine clearance <60 ml/min) may have higher plasma concentrations of oxycodone and its metabolites. There may be an increase in the elimination half-life of oxycodone, and this may be accompanied by an increase in drug effects.
I hopre this is what you wanted and best luck...