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Aspirin Overdose
  1. #1
    withwhomilivalie is offline Junior Member
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    Default Aspirin Overdose

    In the event of an aspirin overdose, how long is aspirin detectable in the blood and urine?

    Also do symptoms continue after the aspirin has left the system and is no longer detectable?


  2. #2
    sweetchikk05 is offline Banned
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    WHAT IS YOUR DEAL WITH ASPRIN AND OVERDOSING???? I BELIEVE THIS IS THE THIRD TIME YOU ASK CUZ YOU SAY YOUR FRIEND OVERDOSED, THEN YOU WERE WRITING A PAPER...NOW WHAT IS IT? YOU ARENT TRYING TO KILL YOURSELF ARE YOU? CUZ I GAVE YOU ALL THE INFORMATION BEFORE, I GAVE YOU WHAT DOSES WERE LETHAL AND SO ON AND SO FORTH? WHY ARE YOU SO OBSSESSEFD WITH ASPRIN AND WHETHER OR NOT ITS DETECTABLE IN YOUR URINE OR BLOOD? HONSTLY IF YOU ABUSE IT OR SOMETHING DONT BE ASHAMED...ITS NOT LIKE ITS CRACK OR SOMETHING BUT I AM CURIOUS AS TO KNOW WHY YOU CONTINUE TO ASK....

    LIZ ANN

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    withwhomilivalie is offline Junior Member
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    My friend ODed on tylenol which is what you gave information for. Aceteminophen and aspirin are not the same drug. Also, the only information you gave me was how much acetominophen you need to overdose..and I now need to know how long aspirin stays in the blood and urine and if symptoms persist after the drug is out of your system. I ask again because I did not get either of those things answered in my previous post. If I wanted to kill myself I would just take a bottle of aspirin but I need specific information on this for the same report. I got my second draft back and it was not thorough enough.
    -Katie

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    cluelessNJ is offline Senior Member
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    Katie~ I'm looking for ya babe! Bare with me! I don't have any history with asprin aside from taking it for headaches and such! I'll let ya know what I came up with!

    Not so clueless,

    CLEAN DATE 1/23/06

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    cluelessNJ is offline Senior Member
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    Hey check this site out! I don't know if its exactly what you need but I think its a start!


    http://www.mercksource.com/pp/us/cns...Sz002542zPzhtm

    Not so clueless,

    CLEAN DATE 1/23/06

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    withwhomilivalie is offline Junior Member
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    hey clueless!
    Thanks so much for looking..I'm still trying to get some more specifics but this is a good start

  7. #7
    sweetchikk05 is offline Banned
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    I didnt mean anything offensive I hope you didnt take it that way, I was just wondering why you were continuosly asking about it and I am sorry you were right you were asking about 2 different things, I just assumed your paper would have been done by now....I will look and see what I find, did you ever call a pharmacy in your area and ask them ?? or even a dr, if you had a drs appointment in the meantime before your papers due you could ask them, anyhow I will look and see what I find hun....take care


    Liz ann

  8. #8
    withwhomilivalie is offline Junior Member
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    Liz Ann,
    No no I didn't mean my response in a defensive way and I didn't take any offense to your response I can totally understand how it could kind of look odd how I've been asking about these pills..This paper's 2nd draft was actually due like a week ago but I haven't found the information on aspirin that I need to make the corrections that I need to do before I can turn it back in so I'm just desperately trying to find the answers to those two questions. Thanks so much for looking .
    -Katie

  9. #9
    zippysgoddess is offline Platinum Member
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  10. #10
    withwhomilivalie is offline Junior Member
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    Thanks Zippy, thats great

    I still really really need to know how long after aspirin is ingested it can be detected in the blood and urine but I just can't find that information anywhere. Would anyone hazard a guess to say that abnormal amounts of aspirin could be detected in blood up to 72 hours after injestions? More? Less?

    I'm grateful for any information I can get on the matter
    Thanks everyone so much for trying to help me with this
    -Katie

  11. #11
    zippysgoddess is offline Platinum Member
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    You are probably not searching under the correct terms, to find that information, you would need to research the half life of Aspiring in the plasma concentrations and go from there, then you would be able to figure out the duration according to how much a person took.

    On this page, you can see a regular dose only has a half-life of approximately 15 minutes, so there is a very short period of time that it would be detectable.

    http://www.rxlist.com/cgi/generic/asa_cp.htm



    Some more information I found: (By the way, did I tell anyone that I love to do research?)

    http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20A)/ASPIRIN.html

    http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

    http://www.migraines.org/treatment/proasprn.htm

    http://www.npcts.edu/math/PreCalculu...els/index.html

    http://www.clusterbusters.com/thoughts.htm

    http://www.chw.healthinkonline.com/m...SA;%20Caffeine

    http://www.inchem.org/documents/pims/pharm/aspirin.htm

    http://www.raysahelian.com/phenolic.html



    There, hope that helps. If you need me to find anything, just let me know, make a post here or send me an email!



    My information is not guaranteed correct. I do not get them right all the time, but I do enjoy the hunt~

  12. #12
    withwhomilivalie is offline Junior Member
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    Thanks so much for all your help, zippy.

    In my own research about aspirin I came across something that said that in combination with an acetaminophen overdose, the two collective overdoses can cause kidney cancer. Does anyone know if that's really true? I didn't know drug overdoses could cause cancer.

  13. #13
    sweetchikk05 is offline Banned
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    I know it can cause Kindeny failure and damage but I have never heard of it causing cancer....I can imagine if your liver >> continuosly exposed to the drug maybe but you wouldnt think that a one time overdose could cause that, I will look into it and see what I find, maybe if you were to look up causes of cancer in the kidney you will find something....I will look and see what I find


    Liz ann

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    withwhomilivalie is offline Junior Member
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    Yeah I'd never heard the thing about cancer before but I thought it was pretty interesting.

    Another question about aspirin overdoses (I'm not sure how easy this would be to answer):

    Would it do more damage to take a large dose of about 60 aspirin at once or to take several smaller overdoses (like 20 aspirin everday for a week)?

    -Katie

  15. #15
    zippysgoddess is offline Platinum Member
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    Well, I was actually watching a show once about Aspirin and Acetaminophen overdoses, I am fascinated with this kind of stuff, so I watch, read, and research everything I can.

    Anyway, on the show, they said that the low doses, over a longer period of time, are much more damaging, kind of like a slow poisoning.



    My information is not guaranteed correct. I do not get them right all the time, but I do enjoy the hunt~

  16. #16
    withwhomilivalie is offline Junior Member
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    So do you mean like a lower dose than something like 60 pills (like 20 or 25 pills taken over a week or so) or do you mean the recommended dose over like 30 years?

    I can't find any exact information on this so sadly I probably can't use it in my essay, but it seems like taking like 20 aspirin a day for a week could be potentially worse than popping like 60 or 100 pills at once. If you take 20 or a so a day for a week it makes it so day after day a large concentration of aspirin is hitting your system without rest or time for it to fully clear out the last overdose so it would be hard on your organs and stomach. Also a lot of the tell-tale signs of an overdose might not be as apparent and might even be absent in some cases because each individual dose probably isn't enough to trigger severe vomitting or unconciousness or any such thing. If you take a larger overdose like 60 or so pills the symptoms show up right and will be severe so treatment will also be administered more promplty. With the drawn out kind of overdosing the person who took the pills might never get treatment because there may be no reaction that causes them to be sick enough to go the ER. I'm wondering, however, if that were the case how long a serious condition as a result of the drawn-out aspirin overdoses would take to manifest and what kind of condition its most likely to be.

    Does this line of logic make sense to anyone else?

    -Katie

  17. #17
    zippysgoddess is offline Platinum Member
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    I mean using say, 20 or more pills over a shorter period of time, not a normal dose over 30years. There is a big difference. The whole reason that is the recommended usage dose, and approved by the FDA is because that amount, even with regular usage, rarely causes any kinds of problems in the long term.


    I am still site hunting for info for you, here's some more, might help, might now, but it would be great if you could find what you need to include this stuff in your paper.


    http://pediatrics.aappublications.or...tract/62/5/873

    http://www.mdpoison.com/Site/Education/Sali2.htm

    http://www.nlm.nih.gov/medlineplus/e...cle/002542.htm

    http://health.allrefer.com/health/as...dose-info.html

    http://health.allrefer.com/health/as...dose-info.html



    http://health.allrefer.com/health/as...dose-info.html

    http://www.permanente.net/homepage/h...ption_meds.htm

    http://news.bbc.co.uk/2/hi/health/443250.stm

    http://www.mhra.gov.uk/home/groups/l...con2023336.pdf

    http://www.vitalitymagazine.com/aspirin_zoltan_rona

    http://www.vitalitymagazine.com/aspirin_zoltan_rona

    http://www.healthbanks.com/PatientPo...cleID=HW5otcmp

    http://studenthealth.oregonstate.edu/selfcare/otc.htm

    http://www.inchem.org/documents/pims/pharm/pim642.htm

    http://www.scientific-alliance.org/n...als/poison.htm



    My information is not guaranteed correct. I do not get them right all the time, but I do enjoy the hunt~

  18. #18
    withwhomilivalie is offline Junior Member
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    Zippy-

    Thanks so much for all the work your doing to get info for a me this is all really really helpful..You're much better at finding these things than I am, I've been looking up info on this topic for like 2 months and haven't found half us much useful information as you have in like 2 weeks. Thanks this is all great info
    -Katie

  19. #19
    zippysgoddess is offline Platinum Member
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    You are very welcome, I am glad I could help at least a little. Like I said, this is what I spend most of my time doing, I research stuff, there are certain ways and certain search terms that enable you to find what you are looking for, and it isn't always easy to stumble on the right ones.

    If you need further help, please let me know or send me an email.



    My information is not guaranteed correct. I do not get them right all the time, but I do enjoy the hunt~

  20. #20
    greenbaby123 is offline New Member
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    Lightbulb aspirin overdose.

    well, at one point i overdosed on aspirin because i was upset with my boyfriend for leaving me for another girl after we had been together for nine months and been through ALOT (long story-not sexual) and thought it would make him feel bad for me and want to go back out with me.so i took about 71aspirin pills and went to bed.i woke up at 3:00 in the morning with my ears ringing, nausea and vomiting, headache, a burning stomache and dizziness.i got kind of worried when i thought that i actually may have hurt myself, so i went and told my parents that i did it accidently.my dad to me to the hospital and they took some blood tests and made me urinate in a cup, then they put saltwater and potassium into my blood through IVs.i was admitted into the Intensive Care Unit for about two days. they are put a tube with a balloon-like thing on the end of it up my cooter, haha, they said that this was neccesarry to make sure that my kidneys were working properly and were producing the proper amount of urine, if any.so basically, for whatever reason you are wanting to know this type of information...do NOT NOT NOT NOT NOT try this!!! it is extremely painful and i was miserable and regretful the whole entire time .


    WARNING: taking aspirin excessively or in large doses can cause kidney and liver failure.my father is a kidney dialysis clinic administrator, and i have seen how much people with kidney failure suffer.
    Last edited by greenbaby123; 03-09-2008 at 05:44 PM.

  21. #21
    somequestions is offline New Member
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    Default Asprin Overdose

    Can an asprin overdose lead to an aneurysm? If so how can you tell if it was asprin poisioning?

  22. #22
    asprinhead is offline New Member
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    Default Asprinsis detectable upto 2 days.

    Quote Originally Posted by withwhomilivalie View Post
    In the event of an aspirin overdose, how long is aspirin detectable in the blood and urine?

    Also do symptoms continue after the aspirin has left the system and is no longer detectable?
    Aspirin is detectable upto 2 days for 3g dose. For a huge dose like 30g it is likely to be fatal, but it you just happened to survive then that would be detectable upto 10 days. If you're dead then it will be always detectable, provided you haven't decomposed.

    Here is why.

    Aspirin hydrolyses to salicylic acid in the body. So it is the salicylic acid
    you detect in the blood, not the aspirin.

    If the dose is 3.0g or less, the half-life of the salicylic acid will be 4hrs at most.

    Let's guesstimate the minimum detectable level is 1 ug/mL

    There are 5 L of blood in the human body. Let's overdose by 3g (which is not fatal as you
    need >30g of aspirin to die).

    3/5 g/L = 0.6 g/L = 600 ug/mL

    It takes about 10 half-lives to get 600 ug/mL below 1 ug/mL.

    This is because 600/2^10 = 0.59 ug/mL

    Ten half-lives = 10 * 4 hrs = 40 hrs. So basically it is detectable upto 2 days.

    Now let's pretend you actually kill yourself with 30 g of aspirin. For a high dose like that
    the half-life when it hydrolyzes increases to 20 hrs or more.

    Now, the concentration in the blood = 6000 ug/mL and you need about 13 half-lives
    to bring that below 1 ug/mL.

    Therefore, 13 * 20 hrs = 260 hrs = over 10 days.

    So for a fatal case, it is always going to be detectable because once
    you're dead the the liver isn't eliminating the salicylic acid, so the half-life
    is infinite.

    But say you were lucky, and you survived the 30 g of aspirin (possible if
    you have an above average body mass), then it is going to be detectable
    for over a week.

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