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Need help - sexual side effects remain after discontinuation! Valdoxan (agomelatine)
  1. #1
    Dickensian is offline New Member
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    Default Need help - sexual side effects remain after discontinuation! Valdoxan (agomelatine)

    Hi,

    I was prescribed Valdoxan (agomelatine) for depression but didn't take them for a very long time due to negative side effects of increased insomnia, sleepiness and anxiety. I took a total of 19 pills (25 mg) over a period of maybe 26 days (since some nights I forgot to take the pill). Besides the side effects I mentioned I also experienced some sexual side effects and what worries me greatly is that these remain even after discontinuation. It is now 12 days since I took the last pill and all effects of the drug except the sexual ones have disappeared.

    The sexual side effects include lower sex drive, weakened erectile function, less sensation in genital area etc. None of these problems existed prior to the treatment so it's definitely caused by the drug.

    What do you think? Could the drug still be in my system even after 12 days and effect me in this way? I have tried several anti-depressants (various SSRIs, Cymbalta, Wellbutrin) before and sexual side effects have always disappeared just one day or two after discontinuation. Or is it possible that the drug may have damaged my sexual functions permanently?

    What do you think I should do? I won't see my doc for another two weeks. Would greatly appreciate some help.

  2. #2
    thalia45 is offline Member
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    Quote Originally Posted by Dickensian View Post
    Hi,

    I was prescribed Valdoxan (agomelatine) for depression but didn't take them for a very long time due to negative side effects of increased insomnia, sleepiness and anxiety. I took a total of 19 pills (25 mg) over a period of maybe 26 days (since some nights I forgot to take the pill). Besides the side effects I mentioned I also experienced some sexual side effects and what worries me greatly is that these remain even after discontinuation. It is now 12 days since I took the last pill and all effects of the drug except the sexual ones have disappeared.

    The sexual side effects include lower sex drive, weakened erectile function, less sensation in genital area etc. None of these problems existed prior to the treatment so it's definitely caused by the drug.

    What do you think? Could the drug still be in my system even after 12 days and effect me in this way? I have tried several anti-depressants (various SSRIs, Cymbalta, Wellbutrin) before and sexual side effects have always disappeared just one day or two after discontinuation. Or is it possible that the drug may have damaged my sexual functions permanently?

    What do you think I should do? I won't see my doc for another two weeks. Would greatly appreciate some help.
    I really sympathize but I am 67 (my poor bf) I am looking for the "viagra" for women.... That aside, women really appreciate the "sensual pleasure of touch ", don't discount this. There are a lot of books/info out there. Learn to dance! I finally gave in to m bf's bad "lead" but I love him. How important is this? I can follow, maybe that is all we need.

  3. #3
    rxqueen83 is offline Member
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    Those drugs are famous for the laundry list of side effects, and yes sexual dysfunction is normal for I'd guess up to 1-3 months following ingestion of the medicine. I'm not a doctor, but if you see my screename you'll know where I got my experience. LOL Just give it some time. You'll get better. If you don't want your sex drive affected, stay away from anti depressent medications!

  4. #4
    pophoody is offline New Member
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    Quote Originally Posted by Dickensian View Post
    Hi,

    I was prescribed Valdoxan (agomelatine) for depression but didn't take them for a very long time due to negative side effects of increased insomnia, sleepiness and anxiety. I took a total of 19 pills (25 mg) over a period of maybe 26 days (since some nights I forgot to take the pill). Besides the side effects I mentioned I also experienced some sexual side effects and what worries me greatly is that these remain even after discontinuation. It is now 12 days since I took the last pill and all effects of the drug except the sexual ones have disappeared.

    The sexual side effects include lower sex drive, weakened erectile function, less sensation in genital area etc. None of these problems existed prior to the treatment so it's definitely caused by the drug.

    What do you think? Could the drug still be in my system even after 12 days and effect me in this way? I have tried several anti-depressants (various SSRIs, Cymbalta, Wellbutrin) before and sexual side effects have always disappeared just one day or two after discontinuation. Or is it possible that the drug may have damaged my sexual functions permanently?

    What do you think I should do? I won't see my doc for another two weeks. Would greatly appreciate some help.
    Hello,

    I've only just seen your post, and I hope your side effects have already gone away. However, I wanted to set your mind at rest.

    I took Valdoxan, because of its reported lack of sexual side effects. Like you, I found this NOT to be true and experienced loss of libido and sensation on orgasm. It was worse than an SSRI for me. Melantonin is anti-libido for males so I have no idea why the drug company is reporting otherwise.

    Once I had stopped the medication, symptoms took a good 3 weeks to go away, but they did. Be patient, it's not permanent.


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    Dickensian is offline New Member
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    Wow, pophoody, that does sound hopeful! Feel free to share some more details. Did the symptoms go away gradually or did your normal function just return suddenly one day? You mention loss of libido and orgasm pleasure but not erectile dysfunction. Was your erectile function normal when you were on the drug? The ED is the biggest problem for me, libido and sensation seem almost normal now. The ED might be caused by insufficient arousal, though. But my morning erections are affected too, they're only about 50%.

    You mention melatonin as the cause of this. That sounds plausible. So it seems the melatonin level is increased even after discontinuation and goes down after a couple of weeks? Did you have any other symptoms that remained after you stopped taking the drug? Sleepiness etc?

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    Dickensian is offline New Member
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    I would like to get in contact with the member pophoody who replied in this thread. I don't seem to be able to send him an e-mail, though. Does anyone know how to do this? Or could a moderator or administrator help me with this? Thanks.

  7. #7
    pophoody is offline New Member
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    Quote Originally Posted by Dickensian View Post
    Wow, pophoody, that does sound hopeful! Feel free to share some more details. Did the symptoms go away gradually or did your normal function just return suddenly one day? You mention loss of libido and orgasm pleasure but not erectile dysfunction. Was your erectile function normal when you were on the drug? The ED is the biggest problem for me, libido and sensation seem almost normal now. The ED might be caused by insufficient arousal, though. But my morning erections are affected too, they're only about 50%.

    You mention melatonin as the cause of this. That sounds plausible. So it seems the melatonin level is increased even after discontinuation and goes down after a couple of weeks? Did you have any other symptoms that remained after you stopped taking the drug? Sleepiness etc?
    Hello,

    Apologies, I've only just seen this.

    My erections were not as strong on agomelatine, and they certainly took a while to return to normal after cessation. My libido was very much lowered, and my orgasm was much less pleasurable. I didn't have any other symptoms which annoyed me and the drug did work moderately well for my mood, but not nearly enough to justify the loss of my sexual functioning.

    You WILL return to normal. No permanent damage has been done. If you're still having difficulties it could be because your melatonin levels are still elevated. Melatonin has been should to damage sperm production, and a very similar drug (Ramelteon) has been shown to lower testosterone.

    Also, your concern and stress over this will be having an impact too. More than you might imagine possible. Relax and be comforted that all will return to normality shortly. Try not to let your depression or other psychiatric problem feed into the concern over side effects.

    Thanks. PH.

  8. #8
    Dickensian is offline New Member
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    Thanks, pophoody, it's reassuring to read your response. I hope you're right. There has been some improvement but I still have difficulties. It's not always the same thing, either. Like for a while I could get strong erections but didn't really find sex pleasurable, then pleasure returned but quality of erections went down again. At the moment it's just low libido more than anything else. Overall the last couple of weeks have been better than those closest to discontinuation, though.

    I told my doctor about this but she didn't have anything worthwhile to say about it. According to her it's unlikely that melatonin can have this effect and all sides caused by antidepressants will vanish a day or two after discontinuation. Yeah, right. At least in the case of SSRIs it's possible for side effects to remain years after treatment, maybe even permanently.

    But hopefully it's just a temporary thing with Valdoxan. Lowered testosterone levels is something I've been considering too. That could be a possibility. How long were you on the drug, pophoody? Also, where did/do you get information about this? It's quite hard to find discussions about it since it's a relatively new drug and it hasn't even been released in the US yet (I'm in Sweden myself).

    Good point about potentially making things worse by worrying about it. I try not to do that.

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    pophoody is offline New Member
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    Quote Originally Posted by Dickensian View Post
    Thanks, pophoody, it's reassuring to read your response. I hope you're right. There has been some improvement but I still have difficulties. It's not always the same thing, either. Like for a while I could get strong erections but didn't really find sex pleasurable, then pleasure returned but quality of erections went down again. At the moment it's just low libido more than anything else. Overall the last couple of weeks have been better than those closest to discontinuation, though.

    I told my doctor about this but she didn't have anything worthwhile to say about it. According to her it's unlikely that melatonin can have this effect and all sides caused by antidepressants will vanish a day or two after discontinuation. Yeah, right. At least in the case of SSRIs it's possible for side effects to remain years after treatment, maybe even permanently.

    But hopefully it's just a temporary thing with Valdoxan. Lowered testosterone levels is something I've been considering too. That could be a possibility. How long were you on the drug, pophoody? Also, where did/do you get information about this? It's quite hard to find discussions about it since it's a relatively new drug and it hasn't even been released in the US yet (I'm in Sweden myself).

    Good point about potentially making things worse by worrying about it. I try not to do that.
    Hey there,

    Did this resolve? Did you try any other antidepressants?

  10. #10
    Dickensian is offline New Member
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    Hey. Thanks for caring.

    Yeah, there has been much improvement but I'm not quite back to my former self yet. The best explanation I can come up with is that this drug messes with the hormone levels which may take a while for the body to resolve. This seem likely to you? I'm still interested to know if you researched this. You mentioned another drug that was similar to this. How long were you on this? What did you find out about it? Your recovery was quite swift. Maybe you're younger than I am?

    As for other ADs, no, I'll pass. These things aren't properly researched and the drugs companies are shady as far as sides and long-term effects are concerned.

    Thanks again for your replies in this thread. They really gave me a bit of reassurance when it was sorely needed.

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