I started on this med the end of June 2006,and stopped October. 28,2006. I stopped due to a very severe itch and very severe rash on my legs and spreading to my arm. Additionally my ankles and legs were swollen and it was extremely difficult getting out of chairs, lounge chairs and the couch. I also developed a problem with the bottom of my right foot in two different spots that prevented me from walking on it. After a week of no Lotrel, itch medicine and Benadryl the itch and rash was nearly gone. Additionally after about six days, the bottom of my foot had no pain overnight, and I was able to walk on it normally. I am also able to get up from being seated almost normally. Has any one else had a similar problem with Lotrel use??