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Old 09-05-2005, 12:18 PM
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Default Nitrostat information - please help

There is a PDR Drug information for Nitrostat tablets on Drugs.com. It is at http://www.drugs.com/pdr/nitrostat_tablets.html

It includes a table with pharmacokinetic information (table 1). There are two things I don't understand:

First, the AUC is expressed in mins. Is that correct?

Secondly, the t1/2 is shorter than tmax. It is my understanding that when you administer the drug sublingually the concentration in blood will increase, reaching a Cmax after Tmax mins, then it decreases. At t1/2, the concentration should be half of the initial concentration. So, t1/2 should be always longer than tmax. Is that correct? If not, please explain the data in the table.

Can someone help me out with these questions? (I have a project to submit by the end of this week and the only pharmacokinetic data I have found are these)

Thank you very much in advance.

Eugen

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