In doing some research on your unirectin it is a Hydrochlorothiazide which is a diuretic and Moexipril which is an ACE inhibitor, and it is different than a Betablocker which sometimes can make you feel tired. ACE inhibitors control the blood pressure but it can make your heart beat just a bit faster than normal. To let you know my mother takes premerian and Zestoredic together and she has no problems. You see premerian is estrogen wich is totally different than unirectin which is your blood pressure. Both pills do different things in your body one helps with estrogen and the other helps with blood pressure. I don't see a problem in taking both together, but if I were you, I would call my local pharmacist or dr and speak with the nurse and they would be able to tell you if they would inter act. I am no doctor but I have been around mother and she takes them both and dosen't have any problems. I hope and pray that this information is useful and is every informative.