Greetings: I have had to take almost every antihistamine/decongestant on the market until the recent crop of new ones. Most of the old ones no longer work for me because I took them for so long I got resistant to them. There are some heavy duty prescription ones that still work, but some of them have unpleasant side effects for me.
Pseudoephedrine wires me up like I have pure caffeine running in my veins instead of blood. I can't take it because it gives me a severe jumpy feeling, and a feeling like bugs are crawling all over me. Makes me totally hyper until it wears off. As a young child they gave it to me as
Benadryl, and my Mom tells me all I could do was sit or stand in one place, wringing my hands and feet and squirming, shaking my head and saying, "I can't help it, I can't help it..." over and over until it wore off. Not fun.
I could not take the sinus meds with the now-banned phenolpropanolamine (PPA) in them, because that medication gave me violent dizzyness and disorientation. I took a
Drixoral 12hour decongestant once that had PPA in it, and I had the falling down dizzy bed spins for 12 hours until it wore off. I had to lie on the couch and hang on for dear life until it stopped. Now they have pulled it off the market because they said it causes strokes in young women. NO KIDDING! I could have told them it was bad stuff 20 years ago!
Clorpheniramine Maleate, which is in Clortrimeton, I took for so long as a teenager it no longer works. If my nose and eyes are itching, it will stop that, but it does nothing for drying up the sinuses anymore. Brompheniramine Maleate, which used to be in the big blue
Dimetapp decongestant tablets, still does work to keep my sinuses draining, but it makes me angry. I was on it for a month once and was beginning to like being angry all the time. Had to stop taking it immediately that I realized that! It makes my Mom like a manic-depressive. While she taking the pills, she is depressed and morose and weepy. As soon as it wears off she feels like the world is happy and full of joy, then she takes the next dose and gets depressed again and so on. So she can't take it either.
I found that almost all the sinus/allergy meds screw up my sleep patterns something awful, I don't get a lot of rest while on them, and my dream cycles are messed up bad. They don't usually make me drowsy, though, its just that I don't seem to get good sleep while on them.
My Mom took Sudafed (pure psuedoephedrine) for years and thought she was an insomniac! It is basically a fake form of ephedrine, so it wires people up.
Histospan-D was once given to me for a bad sinus infection, it is a prescription med. It worked really well, dried up the condition in a few days, but boy was I loopy on it. I don't remember a lot of stuff that happened while I was on it, and I had an incident where I filled out my classwork in my earth science class with some of the strangest answers anyone has every seen. I sort of came to toward the end of class and looked over my work before handing it in, and found I had answered the questions with whatever had wandered through my head at that moment. I had to really quickly re-do all the questions and hand it in before the end of class. It was scary!
Now they add acetominophen to almost all the sinus/allergy meds available OTC, and it makes me psychotically violent, so I have nothing I can take without going in for a scrip. And I hate to do that, so I usually just have to suffer through allergy season. I have been controlling the sinus infections for some years now with herbal combinations of fenugreek, thyme, goldenseal, echinacea, lobelia, and a few others. I can stop the infection in about 4-5 days with those herbs. Usually if I get a sinus infection it gets all congested in a day or two and then goes straight into bronchitis within 3 days. But with the herbs, I can get it to dry up the snot before it has time to get blocked up and infected. Works pretty well for me.
I hope some of this may help you in your search for relief.